Search Results to David M. Center, MD

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preferred title Associate Provost of Translational Research
Research Expertise & Professional Interests Dr. Center is Boston University’s Associate Provost for Translational Research and the Director of the Clinical and Translational Research Institute funded by the NIH. He directs Boston University’s efforts to facilitate translational research and advance team science, with a focus on the use of innovative methods for drug and device discovery and delivery and developing creative tools to expedite and retool traditional research processes. His own laboratory is interested in two major themes which revolve around roles for Interleukin-16, co-discovered with Bill Cruikshank in 1982. The first theme relates to the functions of IL-16 as a immunomodulatory cytokine. Over the past several years, in collaboration with Bill Cruikshank, he has studied the role of IL-16 in recruitment and development of Regulatory T cells and demonstrated that it plays a key role in tolerance to airborne allergens. Utilizing transgenic knockout and overexpressing mice his laboratory is involved in demonstrating the patterns of CD4+ T cell trafficking through lymph nodes and lung parenchymal in normal and immunologically challenged lungs and identifying potential therapeutic implications of altering recruitment patterns of Regulatory T cells. The second major emphasis of his laboratory relates to the functional properties of the precursor protein for IL-16, Pro-IL-16 as a tumor suppressor gene. In these studies, along with Yujun Zhang he has shown that Interleukin-16 is synthesized as a precursor which is present in cytoplasm and nucleus of resting T cells. It contains a phosphorylation regulated nuclear localization motif and binds a nuclear chaperone hsc70 which is essential for transport to the nucleus where its presence induces arrest of the cell cycle at G0/G1. It inhibits the cell cycle by acting as a scaffolding protein that assembles a histone deacetylase complex targeted via binding to GA-BP to the Skp2 promoter using intermolecular PDZ binding motifs. Skp2 is an essential member of the ubiquitin ligase protein degradation pathway responsive for degrading the cell cycle cyclin dependent kinase inhibitor p27. In the presence of pro-IL-16, the complex inhibits Skp2 transcription, which in turn decreases p27 degradation resulting in rises in p27 levels and arrest of the cell cycle in G1. Current studies are directed at identifying mutations in Pro-IL-16 that predispose to T cell malignancies and determining its role is permissive exit from G1 in normal T cell activation and proliferation following antigen stimulation.
Self-Described Keywords Translational Research

One or more keywords matched the following items that are connected to Center, David

Item TypeName
Concept Asthma
Concept Protein Processing, Post-Translational
Concept Cohort Studies
Concept Case-Control Studies
Concept Translational Medical Research
Academic Article Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma.
Academic Article Processing and activation of pro-interleukin-16 by caspase-3.
Academic Article Interleukin-16.
Academic Article Involvement of IL-16 in the induction of airway hyper-responsiveness and up-regulation of IgE in a murine model of allergic asthma.
Academic Article Tissue and T cell distribution of precursor and mature IL-16.
Academic Article Identification of IL-16 as the lymphocyte chemotactic activity in the bronchoalveolar lavage fluid of histamine-challenged asthmatic patients.
Academic Article Processing and release of IL-16 from CD4+ but not CD8+ T cells is activation dependent.
Academic Article Phenotype of IL-16-producing cells in bronchial mucosa: evidence for the human eosinophil and mast cell as cellular sources of IL-16 in asthma.
Academic Article Role of B7-CD28/CTLA-4 costimulation and NF-kappa B in allergen-induced T cell chemotaxis by IL-16 and RANTES.
Academic Article Increased expression of IL-16 immunoreactivity in bronchial mucosa after segmental allergen challenge in patients with asthma.
Academic Article Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma.
Academic Article Lipopolysaccharide binding protein potentiates airway reactivity in a murine model of allergic asthma.
Academic Article Immunomodulatory effect of interleukin-16 on allergic airway inflammation.
Academic Article Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals.
Academic Article Induced sputum analysis for T helper type 2 cell regulation: closing the loop.
Academic Article Immunomodulatory cytokines in asthmatic inflammation.
Academic Article Association of asthma with a functional promoter polymorphism in the IL16 gene.
Academic Article Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model.
Academic Article Preferential migration of T regulatory cells induced by IL-16.
Academic Article A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
Academic Article Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS).
Academic Article The Role of Interleukin-16 in Asthma
Academic Article Neutrophil Chemotactic Factor in Aspirin Sensitive Asthma
Academic Article The Role of T cells in Asthma
Academic Article Eosinophil lymphocyte interactions and the pathogenesis of asthma
Academic Article Asthma
Academic Article Identification and characterization of neutrophil chemotactic activity in aspirin-induced asthma.
Academic Article Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigen-challenged asthmatics.
Academic Article When should inhaled corticosteroids be started for asthma?
Academic Article Cytokine binding to CD4+ inflammatory cells: implications for asthma.
Award or Honor Receipt Elected Treasurer
Grant Modulation of Airway Inflammation in Asthma Models
Grant Boston University Clinical and Translational Science Award (CTSA) Program KL2
Grant KL2 Boston University Clinical and Translational Science Institute (CTSA)
Grant Boston University Clinical and Translational Science Institute (Administrative Supplement)
Grant Boston University Clinical and Translational Science Institute (U Cooperative Agreement)
Grant Boston University Clinical and Translational Science Award (CTSA) Program UL1
Grant Boston University Clinical and Translational Science Award (CTSA) Program UL1
Grant Boston University Clinical and Translational Science Institute - U Program

Search Criteria
  • Asthma
  • Translational
  • Studies