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Research Expertise & Professional Interests My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.
Self-Described Keywords lung development

One or more keywords matched the following items that are connected to Cardoso, Wellington

Item TypeName
Concept Embryonic and Fetal Development
Concept Gene Expression Regulation, Developmental
Concept Embryonic Development
Academic Article Transcription factors and pattern formation in the developing lung.
Academic Article Secretory product expression during Clara cell differentiation in the rabbit and rat.
Academic Article Epithelial marker genes are expressed in cultured embryonic rat lung and in vivo with similar spatial and temporal patterns.
Academic Article FGF-10 is a chemotactic factor for distal epithelial buds during lung development.
Academic Article Fibroblast growth factor interactions in the developing lung.
Academic Article VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung.
Academic Article Molecular regulation of lung development.
Academic Article Regulation of retinoic acid signaling during lung morphogenesis.
Academic Article Lung morphogenesis revisited: old facts, current ideas.
Academic Article Basic mechanisms of lung development: Eighth Woods Hole Conference on Lung Cell Biology 2000.
Academic Article Bone marrow-derived cells as progenitors of lung alveolar epithelium.
Academic Article Development of airway epithelium. Patterns of expression for markers of differentiation.
Academic Article Growth factors in lung development and disease: friends or foe?
Academic Article Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching.
Academic Article Heparan sulfate-FGF10 interactions during lung morphogenesis.
Academic Article Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut.
Academic Article Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung.
Academic Article Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung.
Academic Article A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field.
Academic Article Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.
Academic Article Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis.
Academic Article Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis.
Academic Article Differential expression of components of the microRNA machinery during mouse organogenesis.
Academic Article Regulation of early lung morphogenesis: questions, facts and controversies.
Academic Article Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.
Academic Article Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.
Academic Article Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis.
Academic Article Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction.
Academic Article The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase.
Academic Article Resident cellular components of the lung: developmental aspects.
Academic Article Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.
Academic Article Notch signaling controls the balance of ciliated and secretory cell fates in developing airways.
Academic Article Expression of glucose-dependent insulinotropic polypeptide in the zebrafish.
Academic Article Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease.
Academic Article A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium.
Academic Article Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.
Academic Article Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.
Academic Article Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.
Academic Article Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.
Academic Article Molecular determinants of lung development.
Academic Article Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.
Academic Article The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
Academic Article Vitamin A-retinoid signaling in pulmonary development and disease.
Grant Basic Mechanism of Lung Development
Grant Regulation of Airway Progenitor Cell Fate in Development and Regeneration
Academic Article 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.
Academic Article Yap and its subcellular localization have distinct compartment-specific roles in the developing lung.
Academic Article Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus.
Grant Retinoic Acid Regulation of Lung Development
Grant Regulation of Airway Progenitor Cell Fate in Development and Regeneration

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