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Research Expertise & Professional Interests My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.
Self-Described Keywords lung disease
Self-Described Keywords lung development

One or more keywords matched the following items that are connected to Cardoso, Wellington

Item TypeName
Concept Embryonic and Fetal Development
Concept Lung
Concept Lung Compliance
Concept Lung Diseases
Concept Lung Volume Measurements
Concept Lung Diseases, Interstitial
Concept Gene Expression Regulation, Developmental
Concept Embryonic Development
Academic Article Transcription factors and pattern formation in the developing lung.
Academic Article Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro.
Academic Article Secretory product expression during Clara cell differentiation in the rabbit and rat.
Academic Article Panacinar emphysema: CT and pathologic findings.
Academic Article Epithelial marker genes are expressed in cultured embryonic rat lung and in vivo with similar spatial and temporal patterns.
Academic Article FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium.
Academic Article Collagen and elastin in human pulmonary emphysema.
Academic Article Retinoic acid alters the expression of pattern-related genes in the developing rat lung.
Academic Article FGF-10 is a chemotactic factor for distal epithelial buds during lung development.
Academic Article Fibroblast growth factor interactions in the developing lung.
Academic Article Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in vitro.
Academic Article The molecular basis of lung morphogenesis.
Academic Article VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung.
Academic Article Molecular regulation of lung development.
Academic Article Regulation of retinoic acid signaling during lung morphogenesis.
Academic Article Lung morphogenesis revisited: old facts, current ideas.
Academic Article Basic mechanisms of lung development: Eighth Woods Hole Conference on Lung Cell Biology 2000.
Academic Article Bone marrow-derived cells as progenitors of lung alveolar epithelium.
Academic Article Development of airway epithelium. Patterns of expression for markers of differentiation.
Academic Article Growth factors in lung development and disease: friends or foe?
Academic Article Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching.
Academic Article Heparan sulfate-FGF10 interactions during lung morphogenesis.
Academic Article Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut.
Academic Article Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung.
Academic Article Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung.
Academic Article A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field.
Academic Article Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.
Academic Article Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis.
Academic Article Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis.
Academic Article Differential expression of components of the microRNA machinery during mouse organogenesis.
Academic Article Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis.
Academic Article Regulation of early lung morphogenesis: questions, facts and controversies.
Academic Article Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.
Academic Article Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.
Academic Article A comparison between the isovolume and the end-inflation occlusion methods for measurement of lung mechanics in rats.
Academic Article Regulation of Fgf10 gene expression in murine mesenchymal cells.
Academic Article Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis.
Academic Article Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction.
Academic Article The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase.
Academic Article Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function.
Academic Article Resident cellular components of the lung: developmental aspects.
Academic Article Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.
Academic Article Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation.
Academic Article Notch signaling controls the balance of ciliated and secretory cell fates in developing airways.
Academic Article Expression of glucose-dependent insulinotropic polypeptide in the zebrafish.
Academic Article Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease.
Academic Article A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium.
Academic Article miR-29 is a major regulator of genes associated with pulmonary fibrosis.
Academic Article Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.
Academic Article Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.
Academic Article Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery.
Academic Article Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.
Academic Article Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.
Academic Article Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis.
Academic Article Maternal smoking and the retinoid pathway in the developing lung.
Academic Article Molecular determinants of lung development.
Academic Article Expiratory mechanics before and after uncomplicated heart surgery.
Academic Article Mechanics in rats by end-inflation occlusion and single-breath methods.
Academic Article Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats.
Academic Article Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells.
Academic Article Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.
Academic Article Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.
Academic Article Diffuse lung disease in children: summary of a scientific conference.
Academic Article Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice.
Academic Article The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
Academic Article Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity.
Academic Article Vitamin A-retinoid signaling in pulmonary development and disease.
Academic Article An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases.
Academic Article Human airway branch variation and chronic obstructive pulmonary disease.
Academic Article Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways.
Academic Article Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life.
Academic Article 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.
Academic Article A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships.
Academic Article Yap and its subcellular localization have distinct compartment-specific roles in the developing lung.

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Search Criteria
  • Lung
  • development