Search Results to Wellington V. Cardoso, MD, PhD

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Research Expertise & Professional Interests My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.
Self-Described Keywords morphogenesis

One or more keywords matched the following items that are connected to Cardoso, Wellington

Item TypeName
Concept Epithelial Cells
Concept Morphogenesis
Academic Article Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro.
Academic Article Secretory product expression during Clara cell differentiation in the rabbit and rat.
Academic Article Epithelial marker genes are expressed in cultured embryonic rat lung and in vivo with similar spatial and temporal patterns.
Academic Article FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium.
Academic Article FGF-10 is a chemotactic factor for distal epithelial buds during lung development.
Academic Article Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in vitro.
Academic Article The molecular basis of lung morphogenesis.
Academic Article Regulation of retinoic acid signaling during lung morphogenesis.
Academic Article Lung morphogenesis revisited: old facts, current ideas.
Academic Article Development of airway epithelium. Patterns of expression for markers of differentiation.
Academic Article Heparan sulfate-FGF10 interactions during lung morphogenesis.
Academic Article Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung.
Academic Article Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis.
Academic Article Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis.
Academic Article Regulation of early lung morphogenesis: questions, facts and controversies.
Academic Article Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.
Academic Article Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.
Academic Article Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.
Academic Article Notch signaling controls the balance of ciliated and secretory cell fates in developing airways.
Academic Article Molecular determinants of lung development.
Academic Article Biological effects of air pollution in São Paulo and Cubatão.
Academic Article Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells.
Academic Article Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.
Academic Article Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.
Academic Article The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
Academic Article Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity.
Academic Article Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair.
Academic Article Stem Cells Sheltered from Air-Raids Repair Airways.

Search Criteria
  • Epithelial
  • morphogenesis