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One or more keywords matched the following properties of Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

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has minor subject area list Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Aspartic Acid Endopeptidases; bcl-Associated Death Protein; Carrier Proteins; Endopeptidases; Hippocampus; Humans; Insulin-Like Growth Factor II; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; Nerve Degeneration; Nerve Tissue Proteins; Organ Culture Techniques; Peptide Fragments; Phosphorylation; Promoter Regions, Genetic; Protease Nexins; Protein Processing, Post-Translational; PrPC Proteins; RNA, Small Interfering; tau Proteins; Transgenes
information resource reference Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci. 2004 Sep 1; 24(35):7707-17. PMID: 15342738.
label Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

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  • culture