Search Results to Simon C. Body, MBChB, MPH, FAHA

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One or more keywords matched the following properties of Body, Simon

Research Expertise & Professional Interests Dr. Body completed his residency and fellowship training in New Zealand. After nearly 30 years of experience at Brigham and Women’s and Beth Israel Hospitals, Dr. Body joined BU School of Medicine in 2020. His clinical expertise is in adult cardiac and thoracic anesthesia. In 2000, Dr. Body initiated and led a program of examining the genetic influences upon adverse clinical outcomes after coronary artery bypass graft (CABG) surgery. Along with his co-investigators at BWH (Dr. J. Daniel Muehlschlegel), he collected over 2200 patients who had undergone primary CABG as the substrate for this research. Dr. Body and his colleagues are examining the role of variation in candidate genes and their phenotypic expression on adverse postoperative outcomes, specifically atrial fibrillation. The other major focus of Dr. Body's research is the genetic causes of bicuspid aortic valve (BAV) disease and its and its consequences - calcific aortic valve disease and aortic aneurysm. Along with his colleagues at US, Canadian and European institutions he has led the International BAV Consortium which has collected over 2,500 patients with a bicuspid aortic valve. His own cohort has over 1,700 BAV patients. These cohorts along with those of the GenTAC program and others from collaborating Investigators are currently being used to determine these genetic causes of BAV. Dr. Body is a member of the GenTAC Alliance and Vice Chair of its Basic Science Working Group. Dr. Body has published more 220 papers, several book chapter and has been almost continuously funded by the NIH, AHA and other organizations since 2001. He has extensive experience mentoring clinical and research residents, fellows and staff.
Self-Described Keywords Bicuspid aortic valve
Self-Described Keywords Aortic Valve Stenosis

One or more keywords matched the following items that are connected to Body, Simon

Item TypeName
Concept Aortic Valve
Concept Aortic Valve Insufficiency
Concept DNA Repair
Concept Heart Valve Diseases
Concept Heart Valve Prosthesis
Concept Heart Valves
Concept Mitral Valve
Concept Mitral Valve Prolapse
Concept Tricuspid Valve
Concept Heart Valve Prosthesis Implantation
Concept Cardiac Valve Annuloplasty
Concept Transcatheter Aortic Valve Replacement
Academic Article Association between bicuspid aortic valve morphotype and regional dilatation of the aortic root and trunk.
Academic Article Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.
Academic Article RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.
Academic Article The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives.
Academic Article Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.
Academic Article Pathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy.
Academic Article Should the dilated ascending aorta be repaired at the time of bicuspid aortic valve replacement?
Academic Article Characterizing Risks Associated With Mitral Annular Calcification in Mitral Valve Replacement.
Academic Article A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium).
Academic Article Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline.
Academic Article Sex differences in gene expression in response to ischemia in the human left ventricular myocardium.
Academic Article A role for primary cilia in aortic valve development and disease.
Academic Article Comparison of Sex-Based Differences in Home or Nonhome Discharge Utilization of Rehabilitative Services and Outcomes Following Transcatheter Aortic Valve Implantation in the United States.
Academic Article Aortopathy and regurgitation in bicuspid valve patients increase the risk of aortopathy in relatives.
Academic Article Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia.
Academic Article Primary cilia defects causing mitral valve prolapse.
Academic Article Endothelial/Epithelial Mesenchymal Transition in Ascending Aortas of Patients With Bicuspid Aortic Valve.
Academic Article GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.
Academic Article Genome-wide analysis yields new loci associating with aortic valve stenosis.
Academic Article Molecular Genetics of Lidocaine-Containing Cardioplegia in the Human Heart During Cardiac Surgery.
Academic Article The genetic component of bicuspid aortic valve and aortic dilation. An exome-wide association study.
Academic Article Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis.
Academic Article Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Academic Article Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
Academic Article Surgical repair of bicuspid aortopathy at small diameters: Clinical and institutional factors.
Academic Article Interferon-? Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.
Academic Article Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve.
Academic Article Embryonic Development of the Bicuspid Aortic Valve.
Academic Article Risk and outcomes of aortic valve endocarditis among patients with bicuspid and tricuspid aortic valves.
Academic Article A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress.
Academic Article Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.
Academic Article Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification.
Academic Article Surgical treatment of bicuspid aortic valve disease: knowledge gaps and research perspectives.
Academic Article A shifting approach to management of the thoracic aorta in bicuspid aortic valve.
Academic Article Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon).
Academic Article Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.
Academic Article Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.
Academic Article ApoC-III is a novel inducer of calcification in human aortic valves.

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  • Transcatheter
  • valve
  • replacement
  • repair