Search Results to Christopher J. O'Donnell, MD

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Research Expertise & Professional Interests Dr. O’Donnell research is broadly focused on the epidemiology of complex cardiovascular disease (CVD), the leading cause of death and disability in men and women. More specifically, Dr. O’Donnell has focused on the genetic and genomic epidemiology of clinical and subclinical forms of atherosclerosis, ventricular hypertrophy and thrombosis. A large genome-wide association study is being directed by Dr. O’Donnell in a large, well-phenotyped prospective study of multigenerational families drawn from a general population (the NHLBI’s Framingham Heart Study SHARe Project). Heritable clinical and intermediate CVD phenotypes of interest include premature onset CVD, circulating biomarkers (e.g., hemostasis and thrombosis factors) and subclinical atherosclerosis detected by high resolution cardiovascular imaging (e.g., coronary artery calcium by cardiac computed tomography and aortic plaque detected by cardiovascular magnetic resonance imaging). Using both genome-wide linkage and newer association methods, Dr. O’Donnell’s group has identified a number of single nucleotide polymorphisms and haplotypes with evidence for causal associations with atherosclerosis, hypertrophy and thrombosis. The long-term goal for this marriage of genomic science with well-designed studies of human populations is to better understand the etiology of CVD and to discover new targets for preventing, pre-empting and treating CVD.

One or more keywords matched the following items that are connected to O'Donnell, Christopher

Item TypeName
Concept Atherosclerosis
Academic Article Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study.
Academic Article Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study.
Academic Article Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study.
Academic Article Mitral annular calcification is a predictor for incident atrial fibrillation.
Academic Article Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study.
Academic Article Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study.
Academic Article Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study.
Academic Article Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification.
Academic Article Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata.
Academic Article The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination.
Academic Article Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study.
Academic Article Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.
Academic Article Differential impact of age, sex, and hypertension on aortic atherosclerosis: the Framingham Heart Study.
Academic Article Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study.
Academic Article Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium.
Academic Article Association of colony-forming units with coronary artery and abdominal aortic calcification.
Academic Article Relationship between central and peripheral atherosclerosis and left ventricular dysfunction in a community population.
Academic Article Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
Academic Article Calcium intake is not associated with increased coronary artery calcification: the Framingham Study.
Academic Article Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study.
Academic Article Circulating CD31+ leukocyte frequency is associated with cardiovascular risk factors.
Academic Article Genetics of coronary artery calcification among African Americans, a meta-analysis.
Academic Article Genetic variation associated with circulating monocyte count in the eMERGE Network.
Academic Article Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study.
Academic Article Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden.
Academic Article Conditional linkage and genome-wide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels--the Framingham Heart Study.
Academic Article Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study.
Academic Article Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Academic Article Risk factor differences in calcified and noncalcified aortic plaque: the Framingham Heart Study.
Academic Article Association of fat density with subclinical atherosclerosis.
Academic Article Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes.
Academic Article Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.
Academic Article Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis.
Academic Article Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.
Academic Article Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study.
Academic Article Association of Coronary Artery Calcium Score vs Age With Cardiovascular Risk in Older Adults: An Analysis of Pooled Population-Based Studies.
Academic Article Observational and Genetic Associations of Resting Heart Rate With Aortic Valve Calcium.
Academic Article Postmortem Computed Tomography Findings in Ruptured Splenic Artery Aneurysm: Value of the Clinical "Sentinel Clot" Sign in Identification of Bleeding Location.
Academic Article Essential features of a surveillance system to support the prevention and management of heart disease and stroke: a scientific statement from the American Heart Association Councils on Epidemiology and Prevention, Stroke, and Cardiovascular Nursing and the Interdisciplinary Working Groups on Quality of Care and Outcomes Research and Atherosclerotic Peripheral Vascular Disease.
Academic Article Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group.
Academic Article Fetuin-A and risk of coronary heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7 prospective studies.
Academic Article Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
Academic Article Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis.
Academic Article Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization.
Academic Article Genetics of ultrasonographic carotid atherosclerosis.
Academic Article Family history, subclinical atherosclerosis, and coronary heart disease risk: barriers and opportunities for the use of family history information in risk prediction and prevention.
Academic Article HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype.

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  • atherosclerosis