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Research Expertise & Professional Interests Dr. Nikhil Munshi received his medical degree from Maharaja Sayajirao University, followed by an internship and residency in internal medicine at Shri Sayaji General Hospital and Maharaja University in India. He then completed an oncology fellowship at Johns Hopkins Ocology Center, and an hematology/oncology fellowhip at Indiana University Medical Center. Dr. Munshi is currently professor of medicine in the Department of Medicine at Harvard Medical School, as well as an attending physician at VA Boston Healthcare System and Dana-Farber Cancer Institute. A diplomate of American Board of Internal Medicine, Dr. Munshi is also on the Board of Directors of the International Myeloma Society. He is a member of numerous professional associations including the Indian Medical Association, Physician’s Association of India, Indian Association of Clinical Oncology, American Medical Association, American Society of Clinical Oncology, and the American Society of Hematology, among others. In addition, he is on the editorial board of Clinical Lymphoma and Myeloma and Personalized Medicine in Oncology and is an ad hoc reviewer for numerous professional journals. Dr. Munshi’s current laboratory research and clinical activities specialize in plasma cell disorders with a focus on understanding oncogenomic changes in myeloma and developing a translational research programs in myeloma. He has also established a Myeloma Initiative at Veterans Administration Hospitals, a comprehensive program bringing together, for the first time, all major VA hospitals across the country to focus on cutting-edge joint clinical studies.

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Item TypeName
Concept Antigens, Neoplasm
Concept Antigens, Viral, Tumor
Concept Bone Neoplasms
Concept Breast Neoplasms
Concept Colonic Neoplasms
Concept DNA, Neoplasm
Concept Esophageal Neoplasms
Concept Head and Neck Neoplasms
Concept Intestinal Neoplasms
Concept Jejunal Neoplasms
Concept Kidney Neoplasms
Concept Neoplasm Invasiveness
Concept Neoplasm Metastasis
Concept Neoplasm Proteins
Concept Neoplasm Recurrence, Local
Concept Neoplasm Staging
Concept Neoplasm Transplantation
Concept Neoplasms
Concept Neoplasms, Experimental
Concept Neoplasms, Glandular and Epithelial
Concept RNA, Neoplasm
Concept Spinal Neoplasms
Concept Tumor Cells, Cultured
Concept Biomarkers, Tumor
Concept Tumor Necrosis Factor-alpha
Concept Tumor Virus Infections
Concept Colorectal Neoplasms
Concept Tumor Lysis Syndrome
Concept Genes, Tumor Suppressor
Concept Tumor Suppressor Protein p53
Concept Neoplasms, Second Primary
Concept Endometrial Neoplasms
Concept Receptors, Tumor Necrosis Factor
Concept Neoplasm, Residual
Concept Drug Resistance, Neoplasm
Concept Bone Marrow Neoplasms
Concept Hematologic Neoplasms
Concept Cancer Vaccines
Concept Graft vs Tumor Effect
Concept Tumor Suppressor Proteins
Concept Cell Line, Tumor
Concept Tumor Burden
Concept Genes, Neoplasm
Concept Tumor Necrosis Factor Ligand Superfamily Member 13
Concept Neoplasms, Plasma Cell
Concept Tumor Microenvironment
Academic Article The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.
Academic Article Mast cells in Waldenstrom''s macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling.
Academic Article CD27-CD70 interactions in the pathogenesis of Waldenstrom macroglobulinemia.
Academic Article Lenalidomide and rituximab in Waldenstrom''s macroglobulinemia.
Academic Article Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström''s macroglobulinemia.
Academic Article MYD88-independent growth and survival effects of Sp1 transactivation in Waldenstrom macroglobulinemia.
Academic Article The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.
Academic Article miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth.
Academic Article Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis.
Academic Article A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis.
Academic Article Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia.
Academic Article In vitro and in vivo activity of the maytansinoid immunoconjugate huN901-N2''-deacetyl-N2''-(3-mercapto-1-oxopropyl)-maytansine against CD56+ multiple myeloma cells.
Academic Article Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells.
Academic Article Antimyeloma activity of heat shock protein-90 inhibition.
Academic Article Anti-tumor activities of selective HSP90a/ß inhibitor, TAS-116, in combination with bortezomib in multiple myeloma.
Academic Article Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo.
Academic Article Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3''-kinase/AKT signaling.
Academic Article Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide.
Academic Article Biology and therapy of multiple myeloma in 1996.
Academic Article Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo.
Academic Article A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.
Academic Article Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma.
Academic Article The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.
Academic Article Response assessment in Waldenström macroglobulinaemia: update from the VIth International Workshop.
Academic Article In vivo and in vitro cytotoxicity of R-etodolac with dexamethasone in glucocorticoid-resistant multiple myeloma cells.
Academic Article Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling.
Academic Article MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Academic Article Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications.
Academic Article Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Academic Article Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma.
Academic Article Podocyte injury associated glomerulopathies induced by pamidronate.
Academic Article Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2.
Academic Article Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications.
Academic Article Adeno-associated virus protects the retinoblastoma family of proteins from adenoviral-induced functional inactivation.
Academic Article Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing.
Academic Article Development of extramedullary myeloma in the era of novel agents: no evidence of increased risk with lenalidomide-bortezomib combinations.
Academic Article Genomics in multiple myeloma.
Academic Article New strategies in the treatment of multiple myeloma.
Academic Article FQPD, a novel immunomodulatory drug, has significant in vitro activity in multiple myeloma.
Academic Article The evolving role of transplantation in multiple myeloma: the need for a heterogeneous approach to a heterogeneous disease.
Academic Article Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells.
Academic Article Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma.
Academic Article 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells.
Academic Article Clinical activity of arsenic trioxide for the treatment of multiple myeloma.
Academic Article Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors.
Academic Article Genomic evolution in Barrett''s adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome.
Academic Article The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.
Academic Article Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.
Academic Article The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Academic Article Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells.
Academic Article Nucleotide excision repair is a potential therapeutic target in multiple myeloma.
Academic Article Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.
Academic Article Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma.
Academic Article Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib.
Academic Article Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis.
Academic Article The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.
Academic Article Antisense p53 transduction leads to overexpression of bcl-2 and dexamethasone resistance in multiple myeloma.
Academic Article Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
Academic Article Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells.
Academic Article Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo.
Academic Article International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma.
Academic Article Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Academic Article Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo.
Academic Article Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
Academic Article CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Academic Article MRI features of extramedullary myeloma.
Academic Article Deciphering the chronology of copy number alterations in Multiple Myeloma.
Academic Article Interaction of adeno-associated virus Rep78 with p53: implications in growth inhibition.
Academic Article Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.
Academic Article Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi''s sarcoma cells.
Academic Article Targeting homologous recombination and telomerase in Barrett''s adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth.
Academic Article Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma.
Academic Article Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.
Academic Article Management of Posterior Reversible Encephalopathy Syndrome Induced by Carfilzomib in a Patient With Multiple Myeloma.
Academic Article NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
Academic Article Deficiency of IL-17A, but not the prototypical Th17 transcription factor ROR?t, decreases murine spontaneous intestinal tumorigenesis.
Academic Article Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.
Academic Article Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome.
Academic Article Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma.
Academic Article Role of FDG-PET/CT in Extramedullary Multiple Myeloma: Correlation of FDG-PET/CT Findings With Clinical Outcome.
Academic Article Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu.
Academic Article Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Academic Article Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model.
Academic Article Analysis of Inflammatory and Anemia-Related Biomarkers in a Randomized, Double-Blind, Placebo-Controlled Study of Siltuximab (Anti-IL6 Monoclonal Antibody) in Patients With Multicentric Castleman Disease.
Academic Article 2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Academic Article Interactions of the Hdm2/p53 and proteasome pathways may enhance the antitumor activity of bortezomib.
Academic Article A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma.
Academic Article Introduction by the Guest Editor: At a Crossroad to Cure: From Molecule to Management Strategies in Multiple Myeloma.
Academic Article Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells.
Academic Article Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma.
Academic Article Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Academic Article The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.
Academic Article Dendritic cells derived from multiple myeloma patients efficiently internalize different classes of myeloma protein.
Academic Article A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells.
Academic Article The roles of homologous recombination and the immune system in the genomic evolution of cancer.
Academic Article Compartment-Specific Bioluminescence Imaging platform for the high-throughput evaluation of antitumor immune function.
Academic Article Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model.
Academic Article Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Academic Article Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
Academic Article Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw.
Academic Article Prospective Evaluation of Magnetic Resonance Imaging and [18F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study.
Academic Article Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma.
Academic Article A global expression-based analysis of the consequences of the t(4;14) translocation in myeloma.
Academic Article Dichloroacetate induces apoptosis in endometrial cancer cells.
Academic Article Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma.
Academic Article A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells.
Academic Article Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.
Academic Article Blockade of XBP1 splicing by inhibition of IRE1a is a promising therapeutic option in multiple myeloma.
Academic Article A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy.
Academic Article Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.
Academic Article Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma.
Academic Article Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Academic Article APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.
Academic Article Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer.
Academic Article Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment.
Academic Article Minor clone provides a reservoir for relapse in multiple myeloma.
Academic Article Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Academic Article Deep Response in Multiple Myeloma: A Critical Review.
Academic Article CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis.
Academic Article ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma.
Academic Article miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/ß-catenin/BCL9 pathway.
Academic Article Generation of antitumor invariant natural killer T cell lines in multiple myeloma and promotion of their functions via lenalidomide: a strategy for immunotherapy.
Academic Article Focus on multiple myeloma.
Academic Article p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
Academic Article Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma.
Academic Article Pathogenesis beyond the cancer clone(s) in multiple myeloma.
Academic Article In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor.
Academic Article Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status.
Academic Article miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1.
Academic Article Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs.
Academic Article Expression of AAV Rep proteins in SV40-transformed and untransformed cells: reciprocal interaction with host DNA synthesis.
Academic Article Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor.
Academic Article 14-3-3? binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors.
Academic Article Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma.
Academic Article beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Academic Article Dual level inhibition of E2F-1 activity by adeno-associated virus Rep78.
Academic Article Stromal CCR6 drives tumor growth in a murine transplantable colon cancer through recruitment of tumor-promoting macrophages.
Academic Article Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo.
Academic Article Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays.
Academic Article Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.
Academic Article Association of Minimal Residual Disease With Superior Survival Outcomes in Patients With Multiple Myeloma: A Meta-analysis.
Academic Article Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma.
Academic Article A Phase IB multicentre dose-determination study of BHQ880 in combination with anti-myeloma therapy and zoledronic acid in patients with relapsed or refractory multiple myeloma and prior skeletal-related events.
Academic Article Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett''s adenocarcinoma cells: mechanism and therapeutic potential.
Academic Article A clinically relevant SCID-hu in vivo model of human multiple myeloma.
Academic Article A Phase I Trial of the Anti-KIR Antibody IPH2101 and Lenalidomide in Patients with Relapsed/Refractory Multiple Myeloma.
Academic Article The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.
Academic Article In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells.
Academic Article Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.
Academic Article Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib.
Academic Article Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications.
Academic Article CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.
Academic Article CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling.
Academic Article canEvolve: a web portal for integrative oncogenomics.
Academic Article Novel epitope evoking CD138 antigen-specific cytotoxic T lymphocytes targeting multiple myeloma and other plasma cell disorders.
Academic Article Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.
Academic Article Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications.
Academic Article Minimal residual disease in multiple myeloma.
Academic Article Pyk2 promotes tumor progression in multiple myeloma.
Academic Article Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans.
Academic Article Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment.
Academic Article Lymphomatoid granulomatosis following autologous stem cell transplantation.
Academic Article Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy.
Academic Article Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma.
Academic Article Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth.
Academic Article Molecular sequelae of proteasome inhibition in human multiple myeloma cells.
Academic Article JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.
Academic Article Plasma cell disorders: an historical perspective.
Academic Article Investigative tools for diagnosis and management.
Academic Article Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.
Academic Article Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
Academic Article Sinus tracts--an early sign of bisphosphonate-associated osteonecrosis of the jaws?
Academic Article A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications.
Academic Article A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.
Academic Article A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma.
Academic Article Telomerase inhibitors as anticancer therapy.
Academic Article Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis.
Academic Article Cytokines modulate telomerase activity in a human multiple myeloma cell line.
Academic Article Targeting PI3K and RAD51 in Barrett''s adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth.
Academic Article Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells.
Academic Article Kaposi''s sarcoma-associated herpesvirus-encoded G protein-coupled receptor activation of c-jun amino-terminal kinase/stress-activated protein kinase and lyn kinase is mediated by related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2.
Academic Article Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma.
Academic Article Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
Academic Article Tumour lysis syndrome complicating high-dose treatment in patients with multiple myeloma.
Academic Article Combination of a Selective HSP90a/ß Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells.
Academic Article The Role of Minimal Residual Disease Testing in Myeloma Treatment Selection and Drug Development: Current Value and Future Applications.
Academic Article Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients.
Academic Article A novel immunogenic CS1-specific peptide inducing antigen-specific cytotoxic T lymphocytes targeting multiple myeloma.
Academic Article APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications.
Academic Article Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.
Academic Article Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups.
Academic Article Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
Academic Article The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo.
Academic Article Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.
Academic Article Bone Marker-Directed Dosing of Zoledronic Acid for the Prevention of Skeletal Complications in Patients with Multiple Myeloma: Results of the Z-MARK Study.
Academic Article A novel rapid-onset high-penetrance plasmacytoma mouse model driven by deregulation of cMYC cooperating with KRAS12V in BALB/c mice.
Academic Article Immunotherapy for multiple myeloma.
Academic Article Reply to M. Roschewski et al.
Academic Article Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.
Academic Article Growth arrest, apoptosis, and telomere shortening of Barrett''s-associated adenocarcinoma cells by a telomerase inhibitor.
Academic Article The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions.
Academic Article Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease.
Academic Article Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance.
Academic Article A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma.
Academic Article Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.
Academic Article Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications.
Academic Article Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.
Academic Article Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
Academic Article Complete response to donor lymphocyte infusion in multiple myeloma is associated with antibody responses to highly expressed antigens.
Academic Article Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma.
Academic Article MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.
Academic Article Incidence and clinical features of extramedullary multiple myeloma in patients who underwent stem cell transplantation.
Academic Article Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications.
Academic Article Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma.
Academic Article The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome.
Academic Article Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells.
Academic Article The shaping and functional consequences of the dosage effect landscape in multiple myeloma.
Academic Article Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).
Academic Article High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties.
Academic Article Biology of telomeres: importance in etiology of esophageal cancer and as therapeutic target.
Academic Article Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma.
Academic Article AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.
Academic Article Significant biological role of sp1 transactivation in multiple myeloma.
Academic Article Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Academic Article Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Academic Article Effects of oligonucleotide N3''-->P5'' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells.
Academic Article A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Academic Article In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465.
Academic Article Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.
Academic Article Biomarkers of bone remodeling in multiple myeloma patients to tailor bisphosphonate therapy.
Academic Article CSNK1a1 mediates malignant plasma cell survival.
Academic Article SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.
Academic Article Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.
Academic Article Myeloma Minimal Residual Disease and Surrogacy-Reply.
Academic Article Telomere maintenance in laser capture microdissection-purified Barrett''s adenocarcinoma cells and effect of telomerase inhibition in vivo.
Academic Article Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
Academic Article Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.
Academic Article NF-kappa B as a therapeutic target in multiple myeloma.
Academic Article DNA repair of myeloma plasma cells correlates with clinical outcome: the effect of the nonhomologous end-joining inhibitor SCR7.
Academic Article Tumor antigen immunization of sibling stem cell transplant donors in multiple myeloma.
Academic Article A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma.
Academic Article Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma.
Academic Article Multiple myeloma: a prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment.
Academic Article p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Academic Article Immunotherapy strategies in multiple myeloma.
Academic Article Solitary Extramedullary Multiple Myeloma Presenting with Small Bowel Obstruction.
Academic Article A SCID-hu in vivo model of human Waldenström macroglobulinemia.
Academic Article Tailoring treatment for multiple myeloma patients with relapsed and refractory disease.
Academic Article Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells.
Academic Article c-Src mediates mitogenic signals and associates with cytoskeletal proteins upon vascular endothelial growth factor stimulation in Kaposi''s sarcoma cells.
Academic Article Bortezomib in the management of multiple myeloma.
Academic Article Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma.
Academic Article CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells.
Academic Article Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors.
Academic Article Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma.
Academic Article Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
Academic Article Molecular sequelae of histone deacetylase inhibition in human malignant B cells.
Academic Article An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells.
Academic Article Myeloma-specific multiple peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma and other plasma cell disorders.
Academic Article Determining therapeutic susceptibility in multiple myeloma by single-cell mass accumulation.
Academic Article The architectural transcription factor high mobility group I(Y) participates in photoreceptor-specific gene expression.
Academic Article MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma.
Academic Article Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.
Academic Article The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia.
Academic Article MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells.
Academic Article Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma.
Academic Article Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence.
Academic Article Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non-MMSET Myeloma Patients.
Academic Article Intracellular NAD? depletion enhances bortezomib-induced anti-myeloma activity.
Academic Article Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells.
Academic Article Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir.
Academic Article Next-Generation Sequencing Informing Therapeutic Decisions and Personalized Approaches.
Academic Article Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling.
Academic Article Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance.
Academic Article DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma.
Academic Article Gene Expression Profiles in Myeloma: Ready for the Real World?
Academic Article The dChip survival analysis module for microarray data.
Academic Article Multiple myeloma clonal evolution in homogeneously treated patients.

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