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Search Results to Nikhil C. Munshi, MD

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Item TypeName
Concept Multiple Myeloma
Academic Article The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.
Academic Article The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.
Academic Article miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth.
Academic Article Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.
Academic Article A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis.
Academic Article Dysfunctional T regulatory cells in multiple myeloma.
Academic Article In vitro and in vivo activity of the maytansinoid immunoconjugate huN901-N2''-deacetyl-N2''-(3-mercapto-1-oxopropyl)-maytansine against CD56+ multiple myeloma cells.
Academic Article Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells.
Academic Article International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease.
Academic Article With equal access, African American patients have superior survival compared to white patients with multiple myeloma: a VA study.
Academic Article Emerging trends in the clinical use of bortezomib in multiple myeloma.
Academic Article Antimyeloma activity of heat shock protein-90 inhibition.
Academic Article High-dose chemotherapy with carboplatin, cyclophosphamide and etoposide and autologous transplantation for multiple myeloma relapsing after a previous transplant.
Academic Article Anti-tumor activities of selective HSP90a/ß inhibitor, TAS-116, in combination with bortezomib in multiple myeloma.
Academic Article Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo.
Academic Article Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3''-kinase/AKT signaling.
Academic Article Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide.
Academic Article Biology and therapy of multiple myeloma in 1996.
Academic Article Minimal residual disease negativity using deep sequencing is a major prognostic factor in multiple myeloma.
Academic Article Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo.
Academic Article A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.
Academic Article Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma.
Academic Article Graft-versus-myeloma effect: proof of principle.
Academic Article Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92.
Academic Article Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma.
Academic Article The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.
Academic Article A phase 2 study of modified lenalidomide, bortezomib and dexamethasone in transplant-ineligible multiple myeloma.
Academic Article In vivo and in vitro cytotoxicity of R-etodolac with dexamethasone in glucocorticoid-resistant multiple myeloma cells.
Academic Article Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling.
Academic Article MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Academic Article Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications.
Academic Article Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Academic Article Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma.
Academic Article Podocyte injury associated glomerulopathies induced by pamidronate.
Academic Article Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1.
Academic Article Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2.
Academic Article Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications.
Academic Article Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing.
Academic Article Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma.
Academic Article Development of extramedullary myeloma in the era of novel agents: no evidence of increased risk with lenalidomide-bortezomib combinations.
Academic Article Genomics in multiple myeloma.
Academic Article New strategies in the treatment of multiple myeloma.
Academic Article FQPD, a novel immunomodulatory drug, has significant in vitro activity in multiple myeloma.
Academic Article A Phase II trial of weekly bortezomib and dexamethasone in veterans with newly diagnosed multiple myeloma not eligible for or who deferred autologous stem cell transplantation.
Academic Article Widespread intronic polyadenylation diversifies immune cell transcriptomes.
Academic Article The evolving role of transplantation in multiple myeloma: the need for a heterogeneous approach to a heterogeneous disease.
Academic Article The treatment of multiple myeloma patients not eligible for asct.
Academic Article Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells.
Academic Article Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma.
Academic Article 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells.
Academic Article Clinical activity of arsenic trioxide for the treatment of multiple myeloma.
Academic Article The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.
Academic Article Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.
Academic Article The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Academic Article A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma.
Academic Article Optimizing dendritic cell-based immunotherapy in multiple myeloma.
Academic Article Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells.
Academic Article Conflicts of interest, authorship, and disclosures in industry-related scientific publications.
Academic Article Nucleotide excision repair is a potential therapeutic target in multiple myeloma.
Academic Article Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants.
Academic Article Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.
Academic Article Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma.
Academic Article Genomic heterogeneity in multiple myeloma.
Academic Article Anti-myeloma activity of pamidronate in vivo.
Academic Article The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.
Academic Article Antisense p53 transduction leads to overexpression of bcl-2 and dexamethasone resistance in multiple myeloma.
Academic Article Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
Academic Article Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma.
Academic Article Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells.
Academic Article Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping.
Academic Article Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo.
Academic Article International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma.
Academic Article Comparable engraftment kinetics following peripheral-blood stem-cell infusion mobilized with granulocyte colony-stimulating factor with or without cyclophosphamide in multiple myeloma.
Academic Article Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Academic Article Management of treatment-emergent peripheral neuropathy in multiple myeloma.
Academic Article Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial.
Academic Article Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo.
Academic Article The Medical Research Council Myeloma IX trial: the impact on treatment paradigms.
Academic Article Infection--an underappreciated cause of bone pain in multiple myeloma.
Academic Article Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma.
Academic Article Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
Academic Article CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Academic Article MRI features of extramedullary myeloma.
Academic Article Targeting IL-17A in multiple myeloma: a potential novel therapeutic approach in myeloma.
Academic Article Deciphering the chronology of copy number alterations in Multiple Myeloma.
Academic Article Salvage autologous or allogeneic transplantation for multiple myeloma refractory to or relapsing after a first-line autograft?
Academic Article Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.
Academic Article Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide-, lenalidomide-, or bortezomib-containing regimens.
Academic Article Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study.
Academic Article Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma.
Academic Article Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.
Academic Article Management of Posterior Reversible Encephalopathy Syndrome Induced by Carfilzomib in a Patient With Multiple Myeloma.
Academic Article NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
Academic Article Association of Agent Orange With Plasma Cell Disorder: Further Evidence.
Academic Article Identification of human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte epitopes derived from HLA-DOß as a novel target for multiple myeloma.
Academic Article SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide.
Academic Article Pembrolizumab combined with lenalidomide and low-dose dexamethasone for relapsed or refractory multiple myeloma: phase I KEYNOTE-023 study.
Academic Article Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.
Academic Article Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma.
Academic Article Gene signature combinations improve prognostic stratification of multiple myeloma patients.
Academic Article Role of FDG-PET/CT in Extramedullary Multiple Myeloma: Correlation of FDG-PET/CT Findings With Clinical Outcome.
Academic Article Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu.
Academic Article Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma.
Academic Article Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Academic Article Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model.
Academic Article International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100).
Academic Article High-dose therapy with single autologous transplantation versus chemotherapy for newly diagnosed multiple myeloma: A systematic review and meta-analysis of randomized controlled trials.
Academic Article Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model.
Academic Article The potential benefits of participating in early-phase clinical trials in multiple myeloma: long-term remission in a patient with relapsed multiple myeloma treated with 90 cycles of lenalidomide and bortezomib.
Academic Article 2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Academic Article Interactions of the Hdm2/p53 and proteasome pathways may enhance the antitumor activity of bortezomib.
Academic Article A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma.
Academic Article Introduction by the Guest Editor: At a Crossroad to Cure: From Molecule to Management Strategies in Multiple Myeloma.
Academic Article Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells.
Academic Article Identification of genes modulated in multiple myeloma using genetically identical twin samples.
Academic Article Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma.
Academic Article Collection of peripheral blood stem cells after a preceding autograft: unfavorable effect of prior interferon-alpha therapy.
Academic Article Melphalan plus total body irradiation (MEL-TBI) or cyclophosphamide (MEL-CY) as a conditioning regimen with second autotransplant in responding patients with myeloma is inferior compared to historical controls receiving tandem transplants with melphalan alone.
Academic Article Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Academic Article The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.
Academic Article Dendritic cells derived from multiple myeloma patients efficiently internalize different classes of myeloma protein.
Academic Article Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma.
Academic Article A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells.
Academic Article Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma.
Academic Article Selective targeting of multiple myeloma by B cell maturation antigen (BCMA)-specific central memory CD8+ cytotoxic T lymphocytes: immunotherapeutic application in vaccination and adoptive immunotherapy.
Academic Article Preceding chemotherapy, tumour load and age influence engraftment in multiple myeloma patients mobilized with granulocyte colony-stimulating factor alone.
Academic Article Recent advances in the treatment of multiple myeloma.
Academic Article Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Academic Article Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
Academic Article Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw.
Academic Article Antitumor activity of thalidomide in refractory multiple myeloma.
Academic Article Prospective Evaluation of Magnetic Resonance Imaging and [18F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study.
Academic Article Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma.
Academic Article Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma.
Academic Article A global expression-based analysis of the consequences of the t(4;14) translocation in myeloma.
Academic Article Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma.
Academic Article A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells.
Academic Article Blockade of XBP1 splicing by inhibition of IRE1a is a promising therapeutic option in multiple myeloma.
Academic Article A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy.
Academic Article Autologous stem cell transplantation in elderly multiple myeloma patients over the age of 70 years.
Academic Article Integration of novel agents into treatment of myeloma.
Academic Article Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.
Academic Article Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma.
Academic Article Outcomes in patients with relapsed or refractory multiple myeloma in a phase I study of everolimus in combination with lenalidomide.
Academic Article Results of autologous stem cell transplant in multiple myeloma patients with renal failure.
Academic Article Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Academic Article Bortezomib in the front-line treatment of multiple myeloma.
Academic Article APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.
Academic Article Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment.
Academic Article Minor clone provides a reservoir for relapse in multiple myeloma.
Academic Article Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Academic Article Deep Response in Multiple Myeloma: A Critical Review.
Academic Article Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients.
Academic Article The treatment of relapsed and refractory multiple myeloma.
Academic Article ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma.
Academic Article miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/ß-catenin/BCL9 pathway.
Academic Article Early or delayed transplantation for multiple myeloma in the era of novel therapy: does one size fit all?
Academic Article Expression of a free gamma heavy chain in serum following autologous stem cell transplantation for IgG kappa multiple myeloma.
Academic Article Generation of antitumor invariant natural killer T cell lines in multiple myeloma and promotion of their functions via lenalidomide: a strategy for immunotherapy.
Academic Article Focus on multiple myeloma.
Academic Article p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
Academic Article Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma.
Academic Article Mechanism of action of immunomodulatory agents in multiple myeloma.
Academic Article Gene expression profile alone is inadequate in predicting complete response in multiple myeloma.
Academic Article Pathogenesis beyond the cancer clone(s) in multiple myeloma.
Academic Article In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor.
Academic Article miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1.
Academic Article Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs.
Academic Article Recent advances in the management of multiple myeloma.
Academic Article Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor.
Academic Article 14-3-3? binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors.
Academic Article CT-guided biopsy of focal lesions in patients with multiple myeloma may reveal new and more aggressive cytogenetic abnormalities.
Academic Article Long-term outcome results of the first tandem autotransplant trial for multiple myeloma.
Academic Article Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma.
Academic Article beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Academic Article Predicting long-term (> or = 5 years) event-free survival in multiple myeloma patients following planned tandem autotransplants.
Academic Article Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication.
Academic Article Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo.
Academic Article Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays.
Academic Article Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.
Academic Article Association of Minimal Residual Disease With Superior Survival Outcomes in Patients With Multiple Myeloma: A Meta-analysis.
Academic Article Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma.
Academic Article A Phase IB multicentre dose-determination study of BHQ880 in combination with anti-myeloma therapy and zoledronic acid in patients with relapsed or refractory multiple myeloma and prior skeletal-related events.
Academic Article High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions.
Academic Article A clinically relevant SCID-hu in vivo model of human multiple myeloma.
Academic Article Oligoclonal protein bands and Ig isotype switching in multiple myeloma treated with high-dose therapy and hematopoietic cell transplantation.
Academic Article Differential and limited expression of mutant alleles in multiple myeloma.
Academic Article Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis.
Academic Article Can thalidomide improve outcome in patients with multiple myeloma?
Academic Article MGUS and smoldering myeloma: the most prevalent of plasma cell dyscrasias.
Academic Article A Phase I Trial of the Anti-KIR Antibody IPH2101 and Lenalidomide in Patients with Relapsed/Refractory Multiple Myeloma.
Academic Article The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.
Academic Article Endothelial stress products and coagulation markers in patients with multiple myeloma treated with lenalidomide plus dexamethasone: an observational study.
Academic Article In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells.
Academic Article Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.
Academic Article Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib.
Academic Article Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications.
Academic Article Novel biologically based therapies for multiple myeloma.
Academic Article CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.
Academic Article Challenges in multiple myeloma diagnosis and treatment.
Academic Article CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling.
Academic Article Lenalidomide plus dexamethasone is efficacious in patients with relapsed or refractory multiple myeloma.
Academic Article Lenalidomide in multiple myeloma: an evidence-based review of its role in therapy.
Academic Article Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.
Academic Article Novel epitope evoking CD138 antigen-specific cytotoxic T lymphocytes targeting multiple myeloma and other plasma cell disorders.
Academic Article Corrigendum to "Genomic heterogeneity in multiple myeloma" [Curr. Opin. Genet. Dev. 30 (2015) 56-65].
Academic Article Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups.
Academic Article Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.
Academic Article The research mission in myeloma.
Academic Article Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications.
Academic Article Minimal residual disease in multiple myeloma.
Academic Article A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells.
Academic Article Pyk2 promotes tumor progression in multiple myeloma.
Academic Article Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans.
Academic Article p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.
Academic Article Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment.
Academic Article ABO mismatch may affect engraftment in multiple myeloma patients receiving nonmyeloablative conditioning.
Academic Article In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma.
Academic Article Lymphomatoid granulomatosis following autologous stem cell transplantation.
Academic Article Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy.
Academic Article Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma.
Academic Article Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth.
Academic Article Molecular sequelae of proteasome inhibition in human multiple myeloma cells.
Academic Article JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.
Academic Article Plasma cell disorders: an historical perspective.
Academic Article Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.
Academic Article Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
Academic Article A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications.
Academic Article A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.
Academic Article A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma.
Academic Article Novel myeloma-associated antigens revealed in the context of syngeneic hematopoietic stem cell transplantation.
Academic Article Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis.
Academic Article Cytokines modulate telomerase activity in a human multiple myeloma cell line.
Academic Article Management of myeloma-associated renal dysfunction in the era of novel therapies.
Academic Article Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients.
Academic Article Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells.
Academic Article Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma.
Academic Article A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma.
Academic Article Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib.
Academic Article Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma.
Academic Article Tolerance, Kinetics, and Depth of Response for Subcutaneous Versus Intravenous Administration of Bortezomib Combination in Chinese Patients With Newly Diagnosed Multiple Myeloma.
Academic Article Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
Academic Article Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study.
Academic Article Individualized therapy in multiple myeloma: are we there?
Academic Article Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.
Academic Article Tumour lysis syndrome complicating high-dose treatment in patients with multiple myeloma.
Academic Article New drugs for myeloma.
Academic Article Immunotherapy in Multiple Myeloma: Accelerating on the Path to the Patient.
Academic Article Combination of a Selective HSP90a/ß Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells.
Academic Article Prognostic significance of copy-number alterations in multiple myeloma.
Academic Article The Role of Minimal Residual Disease Testing in Myeloma Treatment Selection and Drug Development: Current Value and Future Applications.
Academic Article Targeting PD1-PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells.
Academic Article Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients.
Academic Article Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience.
Academic Article A novel immunogenic CS1-specific peptide inducing antigen-specific cytotoxic T lymphocytes targeting multiple myeloma.
Academic Article Genomic patterns of progression in smoldering multiple myeloma.
Academic Article APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications.
Academic Article Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.
Academic Article Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups.
Academic Article Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
Academic Article The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo.
Academic Article Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.
Academic Article Bone Marker-Directed Dosing of Zoledronic Acid for the Prevention of Skeletal Complications in Patients with Multiple Myeloma: Results of the Z-MARK Study.
Academic Article Immunotherapy for multiple myeloma.
Academic Article Reply to M. Roschewski et al.
Academic Article Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.
Academic Article The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies.
Academic Article Immune therapies.
Academic Article The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions.
Academic Article A practical guide to achieving and maintaining the best response to lenalidomide in multiple myeloma: roundtable proceedings.
Academic Article Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease.
Academic Article Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance.
Academic Article A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma.
Academic Article Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.
Academic Article Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications.
Academic Article Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.
Academic Article Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
Academic Article Complete response to donor lymphocyte infusion in multiple myeloma is associated with antibody responses to highly expressed antigens.
Academic Article Management of relapsed and relapsed/refractory multiple myeloma.
Academic Article Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma.
Academic Article MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.
Academic Article Managing multiple myeloma: the emerging role of novel therapies and adapting combination treatment for higher risk settings.
Academic Article Incidence and clinical features of extramedullary multiple myeloma in patients who underwent stem cell transplantation.
Academic Article Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications.
Academic Article Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma.
Academic Article IMWG consensus on risk stratification in multiple myeloma.
Academic Article The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome.
Academic Article Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma.
Academic Article The shaping and functional consequences of the dosage effect landscape in multiple myeloma.
Academic Article Phase transitions in human IgG solutions.
Academic Article Novel therapies in the treatment of multiple myeloma.
Academic Article Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).
Academic Article Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma.
Academic Article AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.
Academic Article Significant biological role of sp1 transactivation in multiple myeloma.
Academic Article Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Academic Article Genomics of Multiple Myeloma.
Academic Article Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Academic Article The use of novel agents in the treatment of relapsed and refractory multiple myeloma.
Academic Article Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma.
Academic Article Effects of oligonucleotide N3''-->P5'' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells.
Academic Article A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Academic Article In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465.
Academic Article Variable BCL2/BCL2L1 ratio in multiple myeloma with t(11;14).
Academic Article Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.
Academic Article Biomarkers of bone remodeling in multiple myeloma patients to tailor bisphosphonate therapy.
Academic Article Patients with multiple myeloma may safely undergo autologous transplantation despite ongoing RSV infection and no ribavirin therapy.
Academic Article CSNK1a1 mediates malignant plasma cell survival.
Academic Article SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.
Academic Article Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.
Academic Article Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
Academic Article Age is not a prognostic variable with autotransplants for multiple myeloma.
Academic Article Total therapy with tandem transplants for newly diagnosed multiple myeloma.
Academic Article Logic programming reveals alteration of key transcription factors in multiple myeloma.
Academic Article A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma.
Academic Article Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
Academic Article Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.
Academic Article NF-kappa B as a therapeutic target in multiple myeloma.
Academic Article Expressed fusion gene landscape and its impact in multiple myeloma.
Academic Article DNA repair of myeloma plasma cells correlates with clinical outcome: the effect of the nonhomologous end-joining inhibitor SCR7.
Academic Article Tumor antigen immunization of sibling stem cell transplant donors in multiple myeloma.
Academic Article A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma.
Academic Article Indatuximab Ravtansine (BT062) Monotherapy in Patients With Relapsed and/or Refractory Multiple Myeloma.
Academic Article Does maintenance therapy with thalidomide benefit patients with multiple myeloma?
Academic Article Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma.
Academic Article PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.
Academic Article Latest advances and current challenges in the treatment of multiple myeloma.
Academic Article Multiple myeloma: a prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment.
Academic Article p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Academic Article Immunotherapy strategies in multiple myeloma.
Academic Article Solitary Extramedullary Multiple Myeloma Presenting with Small Bowel Obstruction.
Academic Article Tailoring treatment for multiple myeloma patients with relapsed and refractory disease.
Academic Article Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells.
Academic Article Classify hyperdiploidy status of multiple myeloma patients using gene expression profiles.
Academic Article Bortezomib in the management of multiple myeloma.
Academic Article Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma.
Academic Article CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells.
Academic Article Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors.
Academic Article Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity.
Academic Article Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma.
Academic Article A multiepitope of XBP1, CD138 and CS1 peptides induces myeloma-specific cytotoxic T lymphocytes in T cells of smoldering myeloma patients.
Academic Article Molecular sequelae of histone deacetylase inhibition in human malignant B cells.
Academic Article Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: interpretation in the context of global gene expression.
Academic Article Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities.
Academic Article Myeloma-specific multiple peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma and other plasma cell disorders.
Academic Article Determining therapeutic susceptibility in multiple myeloma by single-cell mass accumulation.
Academic Article MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma.
Academic Article Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.
Academic Article The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia.
Academic Article MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells.
Academic Article Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma.
Academic Article Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence.
Academic Article Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non-MMSET Myeloma Patients.
Academic Article Genetics of multiple myeloma: another heterogeneity level?
Academic Article Intracellular NAD? depletion enhances bortezomib-induced anti-myeloma activity.
Academic Article Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells.
Academic Article Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir.
Academic Article Next-Generation Sequencing Informing Therapeutic Decisions and Personalized Approaches.
Academic Article Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance.
Academic Article Antigen-mediated regulation in monoclonal gammopathies and myeloma.
Academic Article DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma.
Academic Article Gene Expression Profiles in Myeloma: Ready for the Real World?
Academic Article Multiple myeloma clonal evolution in homogeneously treated patients.
Academic Article The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma.
Academic Article A practical guide for mutational signature analysis in hematological malignancies.
Academic Article BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications.
Academic Article Genomic landscape and chronological reconstruction of driver events in multiple myeloma.
Academic Article A multiple myeloma classification system that associates normal B-cell subset phenotypes with prognosis.
Academic Article Phase I/II trial of the CXCR4 inhibitor plerixafor in combination with bortezomib as a chemosensitization strategy in relapsed/refractory multiple myeloma.
Academic Article Monitoring the cytogenetic architecture of minimal residual plasma cells indicates therapy-induced clonal selection in multiple myeloma.
Academic Article Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma.
Academic Article Correction: BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications.
Academic Article A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma.
Academic Article Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease.
Grant Integrative Oncogenomics of Multiple Myeloma
Grant SPORE in Multiple Myeloma
Academic Article YWHAE/14-3-3e expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma.
Academic Article Targeting of CD38 by the Tumor Suppressor miR-26a Serves as a Novel Potential Therapeutic Agent in Multiple Myeloma.
Academic Article Timing the initiation of multiple myeloma.
Academic Article Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression.
Academic Article Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant.
Academic Article Preclinical evaluation of CD8+ anti-BCMA mRNA CAR T cells for treatment of multiple myeloma.
Academic Article The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of multiple myeloma.
Academic Article Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group.
Academic Article The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models.

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