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Search Results to Nikhil C. Munshi, MD

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One or more keywords matched the following items that are connected to Munshi, Nikhil C.

Item TypeName
Concept Protein Kinase C
Concept Protein Kinases
Concept Protein-Tyrosine Kinases
Concept Thymidine Kinase
Concept CDC2 Protein Kinase
Concept Protein-Serine-Threonine Kinases
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Cyclin-Dependent Kinases
Concept src-Family Kinases
Concept Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Concept Phosphatidylinositol 3-Kinases
Concept eIF-2 Kinase
Concept Mitogen-Activated Protein Kinase 1
Concept Receptor Protein-Tyrosine Kinases
Concept Mitogen-Activated Protein Kinases
Concept Mitogen-Activated Protein Kinase Kinases
Concept MAP Kinase Signaling System
Concept Glycogen Synthase Kinase 3
Concept Protein Kinase Inhibitors
Concept JNK Mitogen-Activated Protein Kinases
Concept Extracellular Signal-Regulated MAP Kinases
Concept p38 Mitogen-Activated Protein Kinases
Concept Mitogen-Activated Protein Kinase 3
Concept Casein Kinase Ialpha
Concept MAP Kinase Kinase 1
Concept MAP Kinase Kinase 2
Concept raf Kinases
Concept MAP Kinase Kinase 4
Concept Cyclin-Dependent Kinase Inhibitor Proteins
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Cyclin-Dependent Kinase 2
Concept Focal Adhesion Protein-Tyrosine Kinases
Concept Focal Adhesion Kinase 1
Concept Focal Adhesion Kinase 2
Concept I-kappa B Kinase
Concept DNA-Activated Protein Kinase
Concept Receptor-Interacting Protein Serine-Threonine Kinase 2
Concept Janus Kinases
Concept p21-Activated Kinases
Concept Class I Phosphatidylinositol 3-Kinases
Concept Phosphatidylinositol 3-Kinase
Concept TOR Serine-Threonine Kinases
Concept Aurora Kinase A
Concept Aurora Kinase B
Concept Aurora Kinases
Academic Article Vorinostat induced cellular stress disrupts the p38 mitogen activated protein kinase and extracellular signal regulated kinase pathways leading to apoptosis in Waldenström macroglobulinemia cells.
Academic Article MYD88-independent growth and survival effects of Sp1 transactivation in Waldenstrom macroglobulinemia.
Academic Article Antimyeloma activity of heat shock protein-90 inhibition.
Academic Article Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3''-kinase/AKT signaling.
Academic Article Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide.
Academic Article Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling.
Academic Article MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Academic Article Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Academic Article Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma.
Academic Article The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Academic Article Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells.
Academic Article Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells.
Academic Article Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo.
Academic Article Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
Academic Article Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.
Academic Article Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi''s sarcoma cells.
Academic Article Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.
Academic Article Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Academic Article A global expression-based analysis of the consequences of the t(4;14) translocation in myeloma.
Academic Article A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells.
Academic Article Blockade of XBP1 splicing by inhibition of IRE1a is a promising therapeutic option in multiple myeloma.
Academic Article Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.
Academic Article Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Academic Article Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Academic Article p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
Academic Article Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status.
Academic Article Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma.
Academic Article Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.
Academic Article Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.
Academic Article CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling.
Academic Article Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications.
Academic Article Pyk2 promotes tumor progression in multiple myeloma.
Academic Article p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.
Academic Article Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma.
Academic Article Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth.
Academic Article Molecular sequelae of proteasome inhibition in human multiple myeloma cells.
Academic Article JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.
Academic Article Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.
Academic Article Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
Academic Article A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.
Academic Article Targeting PI3K and RAD51 in Barrett''s adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth.
Academic Article Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma.
Academic Article Kaposi''s sarcoma-associated herpesvirus-encoded G protein-coupled receptor activation of c-jun amino-terminal kinase/stress-activated protein kinase and lyn kinase is mediated by related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2.
Academic Article Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
Academic Article Combination of a Selective HSP90a/ß Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells.
Academic Article Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
Academic Article Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.
Academic Article Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
Academic Article Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma.
Academic Article AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.
Academic Article A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Academic Article In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465.
Academic Article CSNK1a1 mediates malignant plasma cell survival.
Academic Article Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.
Academic Article Logic programming reveals alteration of key transcription factors in multiple myeloma.
Academic Article Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
Academic Article Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.
Academic Article NF-kappa B as a therapeutic target in multiple myeloma.
Academic Article A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma.
Academic Article PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.
Academic Article Latest advances and current challenges in the treatment of multiple myeloma.
Academic Article p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Academic Article c-Src mediates mitogenic signals and associates with cytoskeletal proteins upon vascular endothelial growth factor stimulation in Kaposi''s sarcoma cells.
Academic Article CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells.
Academic Article Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.
Academic Article Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir.

Highlights
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  • kinases