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Xia, Weiming

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Research Expertise & Professional Interests	Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD. Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

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Value

Research Expertise & Professional Interests

Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD. Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

One or more keywords matched the following items that are connected to Xia, Weiming

Item Type	Name
Concept	Alleles
Concept	Alzheimer Disease
Concept	Amino Acid Sequence
Concept	Anti-Inflammatory Agents, Non-Steroidal
Concept	Antibody Specificity
Concept	Base Sequence
Concept	Binding Sites
Concept	Cell Survival
Concept	Cell-Free System
Concept	Central Nervous System
Concept	Sterol O-Acyltransferase
Concept	Computer Simulation
Concept	Cross-Sectional Studies
Concept	Dimethyl Sulfoxide
Concept	Disease Models, Animal
Concept	Down Syndrome
Concept	Genes, Bacterial
Concept	Genes, Dominant
Concept	Molecular Sequence Data
Concept	Nervous System
Concept	Parkinson Disease
Concept	Prospective Studies
Concept	Receptors, Cell Surface
Concept	Sensitivity and Specificity
Concept	Serine Endopeptidases
Concept	Severity of Illness Index
Concept	Signal Processing, Computer-Assisted
Concept	Software
Concept	Software Design
Concept	Software Validation
Concept	Solubility
Concept	Spatial Behavior
Concept	Species Specificity
Concept	Sports
Concept	Staining and Labeling
Concept	Statistics as Topic
Concept	Stimulation, Chemical
Concept	Structure-Activity Relationship
Concept	Subcellular Fractions
Concept	Substrate Specificity
Concept	Sulfonic Acids
Concept	Suppression, Genetic
Concept	Tetrazolium Salts
Concept	United States
Concept	Cohort Studies
Concept	Signal Transduction
Concept	Case-Control Studies
Concept	Tumor Suppressor Protein p53
Concept	Mutagenesis, Site-Directed
Concept	Rats, Sprague-Dawley
Concept	Protein-Serine-Threonine Kinases
Concept	In Situ Hybridization
Concept	Protein Structure, Tertiary
Concept	Transferases (Other Substituted Phosphate Groups)
Concept	Genes, Reporter
Concept	Oxidative Stress
Concept	Disease Progression
Concept	Statistics, Nonparametric
Concept	Neurodegenerative Diseases
Concept	Amino Acid Substitution
Concept	Calcium Signaling
Concept	In Situ Nick-End Labeling
Concept	Oligonucleotide Array Sequence Analysis
Concept	Two-Hybrid System Techniques
Concept	Protein Structure, Quaternary
Concept	Alzheimer Vaccines
Concept	RNA, Small Interfering
Concept	Macromolecular Substances
Concept	Intracellular Signaling Peptides and Proteins
Concept	Cell Size
Concept	Cell Shape
Concept	Adaptor Proteins, Signal Transducing
Concept	Stathmin
Concept	Immunoglobulin J Recombination Signal Sequence-Binding Protein
Concept	Amyloid Precursor Protein Secretases
Concept	SOXB1 Transcription Factors
Concept	Shc Signaling Adaptor Proteins
Concept	Molecular Dynamics Simulation
Concept	Induced Pluripotent Stem Cells
Concept	High-Throughput Screening Assays
Academic Article	Performance characteristics of plasma amyloid-beta 40 and 42 assays.
Academic Article	Skeletal and CNS defects in Presenilin-1-deficient mice.
Academic Article	Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Academic Article	Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
Academic Article	Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Academic Article	Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Academic Article	In vivo evidence for the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli.
Academic Article	A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Academic Article	Phosphatidylinositol cannot substitute for phosphatidylglycerol in supporting cell growth of Escherichia coli.
Academic Article	Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Academic Article	Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Academic Article	Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
Academic Article	Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter.
Academic Article	The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
Academic Article	Identity of the Escherichia coli cls and nov genes.
Academic Article	A detergent-insoluble membrane compartment contains A beta in vivo.
Academic Article	Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Academic Article	Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Academic Article	Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Academic Article	Subcellular distribution and turnover of presenilins in transfected cells.
Academic Article	Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Academic Article	The search for gamma-secretase and development of inhibitors.
Academic Article	Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.
Academic Article	Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain.
Academic Article	Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Academic Article	Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Academic Article	Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes.
Academic Article	FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Academic Article	Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase.
Academic Article	Relationship between presenilinase and gamma-secretase.
Academic Article	Intramembrane proteolysis by presenilin and presenilin-like proteases.
Academic Article	Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors.
Academic Article	Amyloid metabolism and secretases in Alzheimer's disease.
Academic Article	Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
Academic Article	Presenilin-mediated modulation of capacitative calcium entry.
Academic Article	Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines.
Academic Article	APP processing is regulated by cytoplasmic phosphorylation.
Academic Article	Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
Academic Article	Amyloid inhibitors and Alzheimer''s disease.
Academic Article	Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Academic Article	Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Academic Article	Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.
Academic Article	Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
Academic Article	Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Academic Article	RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.
Academic Article	An automated method for cell detection in zebrafish.
Academic Article	Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins.
Academic Article	Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Academic Article	HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.
Academic Article	Detection of blob objects in microscopic zebrafish images based on gradient vector diffusion.
Academic Article	Computerized image analysis for quantitative neuronal phenotyping in zebrafish.
Academic Article	The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.
Academic Article	From presenilinase to gamma-secretase, cleave to capacitate.
Academic Article	The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
Academic Article	The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis.
Academic Article	In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer''s amyloid reducing gamma-secretase inhibitors.
Academic Article	Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
Academic Article	Phenotypic analysis of images of zebrafish treated with Alzheimer''s gamma-secretase inhibitors.
Academic Article	The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.
Academic Article	Workflow and methods of high-content time-lapse analysis for quantifying intracellular calcium signals.
Academic Article	Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.
Academic Article	Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients.
Academic Article	Exploring Alzheimer''s disease in zebrafish.
Academic Article	A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.
Academic Article	Ten-year change in plasma amyloid beta levels and late-life cognitive decline.
Academic Article	L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.
Academic Article	A high-throughput analysis method to detect regions of interest and quantify zebrafish embryo images.
Academic Article	Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer''s amyloid beta protein.
Academic Article	Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients.
Academic Article	Alzheimer''s disease-linked presenilin mutation (PS1M146L) induces filamin expression and ?-secretase independent redistribution.
Academic Article	Brain amyloid ß protein and memory disruption in Alzheimer's disease.
Academic Article	A nasal proteosome adjuvant activates microglia and prevents amyloid deposition.
Academic Article	The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.
Academic Article	A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Academic Article	The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions.
Academic Article	Segmentation of touching cell nuclei using gradient flow tracking.
Academic Article	Prenatal lead levels, plasma amyloid ß levels, and gene expression in young adulthood.
Academic Article	Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model.
Academic Article	Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients.
Academic Article	RNAi-mediated knock-down of Dab and Numb attenuate Aß levels via ?-secretase mediated APP processing.
Academic Article	Computational techniques in zebrafish image processing and analysis.
Academic Article	Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study.
Academic Article	Automated analysis of zebrafish images for phenotypic changes in drug discovery.
Academic Article	?-Secretase modulator in Alzheimer''s disease: shifting the end.
Academic Article	Optimization of a natural product-based class of ?-secretase modulators.
Academic Article	Modulation of gamma-secretase for the treatment of Alzheimer''s disease.
Academic Article	Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer''s disease transgenic mice.
Academic Article	Beta-amyloid deposition in chronic traumatic encephalopathy.
Academic Article	Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside.
Academic Article	A new iterative triclass thresholding technique in image segmentation.
Academic Article	Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1.
Academic Article	Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice.
Academic Article	Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient''s peripheral blood mononuclear cells.
Academic Article	Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer''s patient.
Academic Article	Three Dimensional Human Neuro-Spheroid Model of Alzheimer''s Disease Based on Differentiated Induced Pluripotent Stem Cells.
Academic Article	Potential of tocotrienols in the prevention and therapy of Alzheimer''s disease.
Academic Article	Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts
Academic Article	An amylin analog used as a challenge test for Alzheimer''s disease.
Academic Article	Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients.
Award or Honor Receipt	Travel Award
Award or Honor Receipt	Chair & Organizer
Award or Honor Receipt	Chair & Organizer
Academic Article	Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau.
Academic Article	?-Secretase and its modulators: Twenty years and beyond.
Academic Article	Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor.
Academic Article	Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling.
Academic Article	Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy.
Academic Article	Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids.
Academic Article	Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype.
Academic Article	Proteomic and biological profiling of extracellular vesicles from Alzheimer''s disease human brain tissues.
Academic Article	Proteomic Profiling of Plasma and Brain Tissue from Alzheimer''s Disease Patients Reveals Candidate Network of Plasma Biomarkers.
Academic Article	Neurofilament light chain in the vitreous humor of the eye.
Grant	Tocotrienols for Alzheimer's disease
Grant	Alzheimer's Disease Stem Cell Drug Screening in 3D
Grant	Early and late-life metal exposures and Alzheimer's disease
Grant	Alzheimer's Disease Drug Discovery in 3D
Grant	Big data and small molecules for Alzheimer's disease
Grant	3DDS: Alzheimer's Disease Pharmacomics in 3D (Year 4)
Grant	Alzheimer's disease burden of illness and care pathways in the real world clinical population served by the US Veterans Affairs Healthcare System
Academic Article	CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy.

Highlights

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Alzheimer
s
disease