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Search Results to Weiming Xia, PhD

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Research Expertise & Professional Interests Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD. Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

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Item TypeName
Concept Alleles
Concept Alzheimer Disease
Concept Amino Acid Sequence
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Antibody Specificity
Concept Base Sequence
Concept Binding Sites
Concept Cell Survival
Concept Cell-Free System
Concept Central Nervous System
Concept Sterol O-Acyltransferase
Concept Computer Simulation
Concept Cross-Sectional Studies
Concept Dimethyl Sulfoxide
Concept Disease Models, Animal
Concept Down Syndrome
Concept Genes, Bacterial
Concept Genes, Dominant
Concept Molecular Sequence Data
Concept Nervous System
Concept Parkinson Disease
Concept Prospective Studies
Concept Receptors, Cell Surface
Concept Sensitivity and Specificity
Concept Serine Endopeptidases
Concept Severity of Illness Index
Concept Signal Processing, Computer-Assisted
Concept Software
Concept Software Design
Concept Software Validation
Concept Solubility
Concept Spatial Behavior
Concept Species Specificity
Concept Sports
Concept Staining and Labeling
Concept Statistics as Topic
Concept Stimulation, Chemical
Concept Structure-Activity Relationship
Concept Subcellular Fractions
Concept Substrate Specificity
Concept Sulfonic Acids
Concept Suppression, Genetic
Concept Tetrazolium Salts
Concept United States
Concept Cohort Studies
Concept Signal Transduction
Concept Case-Control Studies
Concept Tumor Suppressor Protein p53
Concept Mutagenesis, Site-Directed
Concept Rats, Sprague-Dawley
Concept Protein-Serine-Threonine Kinases
Concept In Situ Hybridization
Concept Protein Structure, Tertiary
Concept Transferases (Other Substituted Phosphate Groups)
Concept Genes, Reporter
Concept Oxidative Stress
Concept Disease Progression
Concept Statistics, Nonparametric
Concept Neurodegenerative Diseases
Concept Amino Acid Substitution
Concept Calcium Signaling
Concept In Situ Nick-End Labeling
Concept Oligonucleotide Array Sequence Analysis
Concept Two-Hybrid System Techniques
Concept Protein Structure, Quaternary
Concept Alzheimer Vaccines
Concept RNA, Small Interfering
Concept Macromolecular Substances
Concept Intracellular Signaling Peptides and Proteins
Concept Cell Size
Concept Cell Shape
Concept Adaptor Proteins, Signal Transducing
Concept Stathmin
Concept Immunoglobulin J Recombination Signal Sequence-Binding Protein
Concept Amyloid Precursor Protein Secretases
Concept SOXB1 Transcription Factors
Concept Shc Signaling Adaptor Proteins
Concept Molecular Dynamics Simulation
Concept Induced Pluripotent Stem Cells
Concept High-Throughput Screening Assays
Academic Article Performance characteristics of plasma amyloid-beta 40 and 42 assays.
Academic Article Skeletal and CNS defects in Presenilin-1-deficient mice.
Academic Article Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Academic Article Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
Academic Article Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Academic Article Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Academic Article In vivo evidence for the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli.
Academic Article A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Academic Article Phosphatidylinositol cannot substitute for phosphatidylglycerol in supporting cell growth of Escherichia coli.
Academic Article Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Academic Article Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Academic Article Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
Academic Article Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter.
Academic Article The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
Academic Article Identity of the Escherichia coli cls and nov genes.
Academic Article A detergent-insoluble membrane compartment contains A beta in vivo.
Academic Article Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Academic Article Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Academic Article Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Academic Article Subcellular distribution and turnover of presenilins in transfected cells.
Academic Article Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Academic Article The search for gamma-secretase and development of inhibitors.
Academic Article Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.
Academic Article Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain.
Academic Article Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Academic Article Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Academic Article Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes.
Academic Article FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Academic Article Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase.
Academic Article Relationship between presenilinase and gamma-secretase.
Academic Article Intramembrane proteolysis by presenilin and presenilin-like proteases.
Academic Article Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors.
Academic Article Amyloid metabolism and secretases in Alzheimer's disease.
Academic Article Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
Academic Article Presenilin-mediated modulation of capacitative calcium entry.
Academic Article Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines.
Academic Article APP processing is regulated by cytoplasmic phosphorylation.
Academic Article Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
Academic Article Amyloid inhibitors and Alzheimer''s disease.
Academic Article Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Academic Article Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Academic Article Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.
Academic Article Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
Academic Article Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Academic Article RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.
Academic Article An automated method for cell detection in zebrafish.
Academic Article Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins.
Academic Article Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Academic Article HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.
Academic Article Detection of blob objects in microscopic zebrafish images based on gradient vector diffusion.
Academic Article Computerized image analysis for quantitative neuronal phenotyping in zebrafish.
Academic Article The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.
Academic Article From presenilinase to gamma-secretase, cleave to capacitate.
Academic Article The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
Academic Article The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis.
Academic Article In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer''s amyloid reducing gamma-secretase inhibitors.
Academic Article Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
Academic Article Phenotypic analysis of images of zebrafish treated with Alzheimer''s gamma-secretase inhibitors.
Academic Article The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.
Academic Article Workflow and methods of high-content time-lapse analysis for quantifying intracellular calcium signals.
Academic Article Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.
Academic Article Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients.
Academic Article Exploring Alzheimer''s disease in zebrafish.
Academic Article A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.
Academic Article Ten-year change in plasma amyloid beta levels and late-life cognitive decline.
Academic Article L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.
Academic Article A high-throughput analysis method to detect regions of interest and quantify zebrafish embryo images.
Academic Article Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer''s amyloid beta protein.
Academic Article Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients.
Academic Article Alzheimer''s disease-linked presenilin mutation (PS1M146L) induces filamin expression and ?-secretase independent redistribution.
Academic Article Brain amyloid ß protein and memory disruption in Alzheimer's disease.
Academic Article A nasal proteosome adjuvant activates microglia and prevents amyloid deposition.
Academic Article The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.
Academic Article A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Academic Article The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions.
Academic Article Segmentation of touching cell nuclei using gradient flow tracking.
Academic Article Prenatal lead levels, plasma amyloid ß levels, and gene expression in young adulthood.
Academic Article Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model.
Academic Article Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients.
Academic Article RNAi-mediated knock-down of Dab and Numb attenuate Aß levels via ?-secretase mediated APP processing.
Academic Article Computational techniques in zebrafish image processing and analysis.
Academic Article Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study.
Academic Article Automated analysis of zebrafish images for phenotypic changes in drug discovery.
Academic Article ?-Secretase modulator in Alzheimer''s disease: shifting the end.
Academic Article Optimization of a natural product-based class of ?-secretase modulators.
Academic Article Modulation of gamma-secretase for the treatment of Alzheimer''s disease.
Academic Article Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer''s disease transgenic mice.
Academic Article Beta-amyloid deposition in chronic traumatic encephalopathy.
Academic Article Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside.
Academic Article A new iterative triclass thresholding technique in image segmentation.
Academic Article Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1.
Academic Article Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice.
Academic Article Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient''s peripheral blood mononuclear cells.
Academic Article Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer''s patient.
Academic Article Three Dimensional Human Neuro-Spheroid Model of Alzheimer''s Disease Based on Differentiated Induced Pluripotent Stem Cells.
Academic Article Potential of tocotrienols in the prevention and therapy of Alzheimer''s disease.
Academic Article Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts
Academic Article An amylin analog used as a challenge test for Alzheimer''s disease.
Academic Article Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients.
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Academic Article Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau.
Academic Article ?-Secretase and its modulators: Twenty years and beyond.
Academic Article Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor.
Academic Article Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling.
Academic Article Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy.
Academic Article Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids.
Academic Article Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype.
Academic Article Proteomic and biological profiling of extracellular vesicles from Alzheimer''s disease human brain tissues.
Academic Article Proteomic Profiling of Plasma and Brain Tissue from Alzheimer''s Disease Patients Reveals Candidate Network of Plasma Biomarkers.
Academic Article Neurofilament light chain in the vitreous humor of the eye.
Grant Tocotrienols for Alzheimer's disease
Grant Alzheimer's Disease Stem Cell Drug Screening in 3D
Grant Early and late-life metal exposures and Alzheimer's disease
Grant Alzheimer's Disease Drug Discovery in 3D
Grant Big data and small molecules for Alzheimer's disease
Grant 3DDS: Alzheimer's Disease Pharmacomics in 3D (Year 4)
Grant Alzheimer's disease burden of illness and care pathways in the real world clinical population served by the US Veterans Affairs Healthcare System
Academic Article CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy.

Highlights
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  • Alzheimer
  • s
  • disease