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Search Results to Weiming Xia, PhD

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Research Expertise & Professional Interests Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD. Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

One or more keywords matched the following items that are connected to Xia, Weiming

Item TypeName
Concept Alzheimer Disease
Academic Article Performance characteristics of plasma amyloid-beta 40 and 42 assays.
Academic Article Skeletal and CNS defects in Presenilin-1-deficient mice.
Academic Article Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Academic Article Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Academic Article Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Academic Article A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Academic Article Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Academic Article Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Academic Article A detergent-insoluble membrane compartment contains A beta in vivo.
Academic Article Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Academic Article Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Academic Article Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Academic Article Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Academic Article The search for gamma-secretase and development of inhibitors.
Academic Article Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.
Academic Article Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Academic Article FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Academic Article Relationship between presenilinase and gamma-secretase.
Academic Article Intramembrane proteolysis by presenilin and presenilin-like proteases.
Academic Article Amyloid metabolism and secretases in Alzheimer's disease.
Academic Article Presenilin-mediated modulation of capacitative calcium entry.
Academic Article APP processing is regulated by cytoplasmic phosphorylation.
Academic Article Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
Academic Article Amyloid inhibitors and Alzheimer''s disease.
Academic Article Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.
Academic Article Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
Academic Article Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Academic Article RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.
Academic Article Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Academic Article The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.
Academic Article The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
Academic Article In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer''s amyloid reducing gamma-secretase inhibitors.
Academic Article The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.
Academic Article Workflow and methods of high-content time-lapse analysis for quantifying intracellular calcium signals.
Academic Article Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.
Academic Article Exploring Alzheimer''s disease in zebrafish.
Academic Article A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.
Academic Article L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.
Academic Article Alzheimer''s disease-linked presenilin mutation (PS1M146L) induces filamin expression and ?-secretase independent redistribution.
Academic Article Brain amyloid ß protein and memory disruption in Alzheimer's disease.
Academic Article The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.
Academic Article A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Academic Article Prenatal lead levels, plasma amyloid ß levels, and gene expression in young adulthood.
Academic Article Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients.
Academic Article ?-Secretase modulator in Alzheimer''s disease: shifting the end.
Academic Article Modulation of gamma-secretase for the treatment of Alzheimer''s disease.
Academic Article Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer''s disease transgenic mice.
Academic Article Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer''s patient.
Academic Article Three Dimensional Human Neuro-Spheroid Model of Alzheimer''s Disease Based on Differentiated Induced Pluripotent Stem Cells.
Academic Article Potential of tocotrienols in the prevention and therapy of Alzheimer''s disease.
Academic Article An amylin analog used as a challenge test for Alzheimer''s disease.
Academic Article Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients.
Academic Article ?-Secretase and its modulators: Twenty years and beyond.
Academic Article Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor.
Academic Article Proteomic and biological profiling of extracellular vesicles from Alzheimer''s disease human brain tissues.
Academic Article Proteomic Profiling of Plasma and Brain Tissue from Alzheimer''s Disease Patients Reveals Candidate Network of Plasma Biomarkers.
Grant Tocotrienols for Alzheimer's disease
Grant Alzheimer's Disease Stem Cell Drug Screening in 3D
Grant Early and late-life metal exposures and Alzheimer's disease
Grant Alzheimer's Disease Drug Discovery in 3D
Grant Big data and small molecules for Alzheimer's disease
Grant 3DDS: Alzheimer's Disease Pharmacomics in 3D (Year 4)
Grant Alzheimer's disease burden of illness and care pathways in the real world clinical population served by the US Veterans Affairs Healthcare System

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  • Alzheimer Disease