Search Results to Maria Cardamone, PhD

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Research Expertise & Professional Interests I’m currently a Research Assistant Professor in Dr. Valentina Perissi's Laboratory at Boston University School of Medicine. I hold a “Laurea” in Molecular Biology (equivalent to a B.S. and a Master) and a PhD in Complex System in Molecular Biology from the University of Turin in Italy. As part of my doctoral fellowship, I spend the last two years of my doctorate in Dr. Rosenfeld Laboratory in La Jolla as a Visiting Graduate Student to investigate breast cancer from an epigenetic standpoint. After graduation I become a junior postoctoral fellow in Dr. Rosenfeld Lab. and after three years of training I join Dr. Perissi Lab. as a senior postdoctoral fellow. In my work as a PhD student I focused on the diverse aspects of the action of estrogen receptor alpha (ERa) in the regulation of gene expression and chromatin architecture in breast cancer. My studies help to establish that estrogen causes an ERa dependent series of interchromosomal interaction, linking transcriptional interactions, elongation and RNA processing event. Also I was able to describe a new role for ERa as a ligand-independent activator that can be essential for the determination of epithelial morphology and epithelial-mesenchymal transition (EMT) during breast cancer progression. In my most recent research I have focused on investigating the role of the nuclear receptor cofactor G Protein Suppressor 2 (GPS2), in regulating non-proteolytic ubiquitin signaling events both inside and outside of the nucleus. Thanks to this work, GPS2 has emerged as a novel and critical regulator of lipid metabolism and inflammation in the adipose tissue.

One or more keywords matched the following items that are connected to Cardamone, Maria

Item TypeName
Concept Neoplasm Proteins
Concept Nuclear Proteins
Concept Protein-Arginine N-Methyltransferases
Concept Protein Processing, Post-Translational
Concept Protein Structure, Tertiary
Concept Molecular Motor Proteins
Concept GTPase-Activating Proteins
Concept Mitochondrial Proteins
Concept Tumor Suppressor Proteins
Concept Protein Array Analysis
Concept Ubiquitin-Protein Ligases
Concept Intracellular Signaling Peptides and Proteins
Concept Proto-Oncogene Proteins c-akt
Concept Protein Stability
Academic Article A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.
Academic Article Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules.
Academic Article Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules.
Academic Article GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPAR?.
Academic Article Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.
Academic Article Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.
Academic Article Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue.
Academic Article Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.
Academic Article Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation.
Academic Article Chromatin Immunoprecipitation of Murine Brown Adipose Tissue.

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