Search Results to Vyacheslav Labunskyy, PhD

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Research Expertise & Professional Interests The primary research focus of our lab is the biology of aging and understanding the basic mechanisms that underlie the pathogenesis of age-related diseases. We are particularly interested in studying the nature of senescence factors and understanding how stress response signaling regulates aging. In our work we utilize ribosome profiling and next-generation sequencing, and a combination of molecular and biochemical approaches to look at transcriptional and translational changes that are associated with the aging process as well as the mechanisms of such regulation in eukaryotic cells. A second major focus of the laboratory is synthetic biology and developing new bioengineering approaches that can be used to study complex traits, such as longevity, using yeast S. cerevisiae as a model organism. We hope that our studies will provide a better understanding of the mechanisms that regulate aging and will help to identify new targets for therapeutic intervention for age-related diseases.
Self-Described Keywords Molecular Mechanisms of Skin Aging

One or more keywords matched the following items that are connected to Labunskyy, Vyacheslav

Item TypeName
Concept Amino Acid Sequence
Concept Multigene Family
Concept Models, Molecular
Concept Molecular Sequence Data
Concept Molecular Weight
Concept Gene Library
Concept Genome, Human
Concept Sequence Homology, Amino Acid
Concept Genome, Microbial
Academic Article Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice.
Academic Article A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase.
Academic Article The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.
Academic Article NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.
Academic Article Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.
Academic Article Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins.
Academic Article Selenoproteins: molecular pathways and physiological roles.
Academic Article The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast.
Academic Article (Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy.
Grant Molecular mechanisms of translational regulation in aging
Grant Molecular mechanisms of translational regulation in aging

Search Criteria
  • Molecular
  • Mechanisms
  • Skin Aging