Neil J. Ganem, PhD
Associate Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, Geisel School of Medicine

Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

Associate Professor
Boston University School of Medicine
Hematology & Medical Oncology

Boston University
BU-BMC Cancer Center

Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2018-2018 Educator of the Year Award, BUSM
2016-2019 Aram V. Chobanian Assistant Professorship
2014-2017 Searle Scholar
2014-2017 Melanoma Research Alliance Young Investigator Award
2014-2017 Smith Family Award for Biomedical Research
2010 Andor “Insight Awards” Imaging Competition: First Place
2009 FASEB: Young Investigator Award
2006 Geisel School of Medicine at Dartmouth: John W. Strohbehn Medal for Excellence in Biomedical Research
2005 Geisel School of Medicine at Dartmouth: E. Lucille Smith Award for Excellence in Biochemistry

Defining the role of the Hippo tumor suppressor pathway in limiting melanomagenesis
05/20/2020 - 05/19/2022 (PI)
Harry J. Lloyd Charitable Trust

Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway
09/23/2016 - 06/30/2021 (PI)
NIH/National Institute of General Medical Sciences

PEP-Therapy Contract
10/08/2019 - 10/08/2020 (PI)
PEP-Therapy SAS

Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway
07/01/2016 - 06/30/2020 (PI)
American Cancer Society, Inc.

Maintenance of Chromosome Stability by the Hippo Pathway
07/01/2015 - 06/30/2018 (PI)
Searle Scholars Program

Maintenance of Genome Stability by the Hippo Tumor Suppressor Pathway
12/01/2014 - 06/30/2018 (PI)
The Medical Foundation/Richard and Susan Smith Family Foundation

Defining novel mechanisms of genome instability in human melanoma
05/01/2015 - 04/30/2018 (PI)
Melanoma Research Alliance

Defining Novel Pathways that Arrest Genetically Unstable Tetraploid Cells
09/01/2013 - 08/31/2017 (PI)
NIH/National Cancer Institute

Therapeutically targeting the hippo Pathway in Osteosarcoma
06/01/2015 - 05/31/2016 (PI)
Sarcoma Foundation of America

Defining novel mechanisms of Genome Instability in Melanoma
04/01/2015 - 03/31/2016 (PI)
The Skin Cancer Foundation

Showing 10 of 11 results. Show All Results


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature. 2021 02; 590(7846):492-497.View Related Profiles. PMID: 33505027
  2. Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 02; 22(2):246-256.View Related Profiles. PMID: 32015438
  3. Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun. 2019 04 04; 10(1):1547.View Related Profiles. PMID: 30948712
  4. Quinton RJ, Ganem NJ. CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Methods Mol Biol. 2019; 1893:203-214.View Related Profiles. PMID: 30565136
  5. Vittoria MA, Shenk EM, O'Rourke KP, Bolgioni AF, Lim S, Kacprzak V, Quinton RJ, Ganem NJ. A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation. Mol Biol Cell. 2018 07 15; 29(13):1682-1692.View Related Profiles. PMID: 29791254
  6. Bolgioni AF, Vittoria MA, Ganem NJ. Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel. J Vis Exp. 2018 05 14; (135).View Related Profiles. PMID: 29806834
  7. Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med. 2017 Nov 01; 9(414). PMID: 29093183
  8. Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget. 2017 Oct 03; 8(45):78556-78572.View Related Profiles. PMID: 29108249
  9. Lim S, Quinton RJ, Ganem NJ. Nuclear envelope rupture drives genome instability in cancer. Mol Biol Cell. 2016 Nov 01; 27(21):3210-3213.View Related Profiles. PMID: 27799497
  10. Bolgioni AF, Ganem NJ. The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res. 2016 Jan; 24(1):93-104.View Related Profiles. PMID: 26582635; PMCID: PMC4726471; DOI: 10.1007/s10577-015-9502-8;
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 15 distinct years, with a maximum of 3 publications in 2007 and 2016


Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Education Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
Google Map

Ganem's Networks
Click the "See All" links for more information and interactive visualizations
Similar People
Same Department