CRISPR-Cas Systems

"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.

Descriptor ID	D064113
MeSH Number(s)	G05.355.315.203.374.394
Concept/Terms	CRISPR-Cas Systems CRISPR-Cas Systems CRISPR Cas Systems CRISPR-Cas System System, CRISPR-Cas Systems, CRISPR-Cas

Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Processes [G05.355]
Gene Expression Regulation [G05.355.315]
Epigenesis, Genetic [G05.355.315.203]
Gene Silencing [G05.355.315.203.374]
CRISPR-Cas Systems [G05.355.315.203.374.394]

Below are MeSH descriptors whose meaning is related to "CRISPR-Cas Systems".

Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.

Bar chart showing 45 publications over 8 distinct years, with a maximum of 12 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2015	0	1	1
2016	4	4	8
2017	2	2	4
2018	2	1	3
2019	4	5	9
2020	1	6	7
2021	6	6	12
2022	0	1	1

Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.

Kim SS, Kycia I, Karski M, Ma RK, Bordt EA, Kwan J, Karki A, Winter E, Aktas RG, Wu Y, Emili A, Bauer DE, Sethupathy P, Vakili K. DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling. PLoS One. 2022; 17(2):e0263829. PMID: 35167623.

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Viswanatha R, Mameli E, Rodiger J, Merckaert P, Feitosa-Suntheimer F, Colpitts TM, Mohr SE, Hu Y, Perrimon N. Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos. Nat Commun. 2021 11 24; 12(1):6825. PMID: 34819517.

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Wong NM, Frias E, Sigoillot FD, Letendre JH, Hild M, Wong WW. Engineering digitizer circuits for chemical and genetic screens in human cells. Nat Commun. 2021 10 22; 12(1):6150. PMID: 34686672.

View in: PubMed
Bandyopadhyay S, Douglass J, Kapell S, Khan N, Feitosa-Suntheimer F, Klein JA, Temple J, Brown-Culbertson J, Tavares AH, Saeed M, Lau NC. DNA templates with blocked long 3' end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci. G3 (Bethesda). 2021 08 07; 11(8). PMID: 33989385.

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Werder RB, Kaserman JE, Packer MS, Lindstrom-Vautrin J, Villacorta-Martin C, Young LE, Aratyn-Schaus Y, Gregoire F, Wilson AA. Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes. Mol Ther. 2021 11 03; 29(11):3219-3229. PMID: 34217893.

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Gillmore JD, Gane E, Taubel J, Kao J, Fontana M, Maitland ML, Seitzer J, O'Connell D, Walsh KR, Wood K, Phillips J, Xu Y, Amaral A, Boyd AP, Cehelsky JE, McKee MD, Schiermeier A, Harari O, Murphy A, Kyratsous CA, Zambrowicz B, Soltys R, Gutstein DE, Leonard J, Sepp-Lorenzino L, Lebwohl D. CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis. N Engl J Med. 2021 08 05; 385(6):493-502. PMID: 34215024.

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Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V. MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development. 2021 05 15; 148(10). PMID: 34032267.

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Kim T, Weinberg B, Wong W, Lu TK. Scalable recombinase-based gene expression cascades. Nat Commun. 2021 05 11; 12(1):2711. PMID: 33976199.

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Moussa HF, Angstman JF, Khalil AS. Here to stay: Writing lasting epigenetic memories. Cell. 2021 04 29; 184(9):2281-2283. PMID: 33930295.

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Tan Q, Link PA, Meridew JA, Pham TX, Caporarello N, Ligresti G, Tschumperlin DJ. Spontaneous Lung Fibrosis Resolution Reveals Novel Antifibrotic Regulators. Am J Respir Cell Mol Biol. 2021 04; 64(4):453-464. PMID: 33493091.

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