DNA Gyrase

"DNA Gyrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.

Descriptor ID	D027081
MeSH Number(s)	D08.811.399.403.741.149 D12.776.097.237
Concept/Terms	DNA Gyrase DNA Gyrase DNA-Gyrase DNA Gyrase B Subunit DNA Gyrase B Subunit GyrB Protein DNA Gyrase A Subunit DNA Gyrase A Subunit GyrA Protein

Below are MeSH descriptors whose meaning is more general than "DNA Gyrase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Isomerases [D08.811.399]
DNA Topoisomerases [D08.811.399.403]
DNA Topoisomerases, Type II [D08.811.399.403.741]
DNA Gyrase [D08.811.399.403.741.149]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Bacterial Proteins [D12.776.097]
DNA Gyrase [D12.776.097.237]

Below are MeSH descriptors whose meaning is more specific than "DNA Gyrase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA Gyrase" by people in this website by year, and whether "DNA Gyrase" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2010 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	0	1	1
2010	0	2	2
2012	0	1	1
2015	0	1	1
2016	2	0	2
2017	1	0	1
2021	0	1	1

Below are the most recent publications written about "DNA Gyrase" by people in Profiles.

Liu Q, Yang D, Qiu B, Martinez L, Ji Y, Song H, Li Z, Wang J. Drug resistance gene mutations and treatment outcomes in MDR-TB: A prospective study in Eastern China. PLoS Negl Trop Dis. 2021 01; 15(1):e0009068. PMID: 33471794.

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Yang Z, Hou Q, Cheng L, Xu W, Hong Y, Li S, Sun Q. RNase H1 Cooperates with DNA Gyrases to Restrict R-Loops and Maintain Genome Integrity in Arabidopsis Chloroplasts. Plant Cell. 2017 Oct; 29(10):2478-2497. PMID: 28939594.

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Malik M, Mustaev A, Schwanz HA, Luan G, Shah N, Oppegard LM, de Souza EC, Hiasa H, Zhao X, Kerns RJ, Drlica K. Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones. Nucleic Acids Res. 2016 Apr 20; 44(7):3304-16. PMID: 26984528.

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Farhat MR, Jacobson KR, Franke MF, Kaur D, Sloutsky A, Mitnick CD, Murray M. Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis. J Clin Microbiol. 2016 Mar; 54(3):727-33. PMID: 26763957.

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Nic Fhogartaigh C, Dance DA, Davong V, Tann P, Phetsouvanh R, Turner P, Dittrich S, Newton PN. A novel technique for detecting antibiotic-resistant typhoid from rapid diagnostic tests. J Clin Microbiol. 2015 May; 53(5):1758-60. PMID: 25762768.

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Chen L, Shopsin B, Zhao Y, Smyth D, Wasserman GA, Fang C, Liu L, Kreiswirth BN. Real-time nucleic acid sequence-based amplification assay for rapid detection and quantification of agr functionality in clinical Staphylococcus aureus isolates. J Clin Microbiol. 2012 Mar; 50(3):657-61. PMID: 22219302.

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Parry CM, Thuy CT, Dongol S, Karkey A, Vinh H, Chinh NT, Duy PT, Thieu Nga TV, Campbell JI, Van Minh Hoang N, Arjyal A, Bhutta ZA, Bhattacharya SK, Agtini MD, Dong B, Canh DG, Naheed A, Wain J, Tinh Hien T, Basnyat B, Ochiai L, Clemens J, Farrar JJ, Dolecek C, Baker S. Suitable disk antimicrobial susceptibility breakpoints defining Salmonella enterica serovar Typhi isolates with reduced susceptibility to fluoroquinolones. Antimicrob Agents Chemother. 2010 Dec; 54(12):5201-8. PMID: 20837759.

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Oppegard LM, Streck KR, Rosen JD, Schwanz HA, Drlica K, Kerns RJ, Hiasa H. Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. Antimicrob Agents Chemother. 2010 Jul; 54(7):3011-4. PMID: 20404126.

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Tantibhedhyangkul W, Angelakis E, Tongyoo N, Newton PN, Moore CE, Phetsouvanh R, Raoult D, Rolain JM. Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi. Int J Antimicrob Agents. 2010 Apr; 35(4):338-41. PMID: 20138477.

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Chau TT, Campbell JI, Galindo CM, Van Minh Hoang N, Diep TS, Nga TT, Van Vinh Chau N, Tuan PQ, Page AL, Ochiai RL, Schultsz C, Wain J, Bhutta ZA, Parry CM, Bhattacharya SK, Dutta S, Agtini M, Dong B, Honghui Y, Anh DD, Canh DG, Naheed A, Albert MJ, Phetsouvanh R, Newton PN, Basnyat B, Arjyal A, La TT, Rang NN, Phuong LT, Van Be Bay P, von Seidlein L, Dougan G, Clemens JD, Vinh H, Hien TT, Chinh NT, Acosta CJ, Farrar J, Dolecek C. Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob Agents Chemother. 2007 Dec; 51(12):4315-23. PMID: 17908946.

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