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PhD, University of Massachusetts Amherst
MS, Sichuan University
BS, Sichuan University

Websites

Research
Publications

Regulation of Retinoblastoma Protein by Prolyl Isomerase Pin1
03/15/2005 - 04/14/2008 (Dept Sponsor)
Department of Defense/Army

Regulation of p53 in Response to Genotoxic Stress
08/01/2003 - 07/31/2007 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM70017 04

Determination of Oncogenicity and Tumorigenecity of Avian Adenoviral Gene GAM1
05/10/2006 - 05/10/2007 (PI)
GlaxoSmithKline, Inc.

Functional Screening For Genom
01/31/1999 - 12/31/2002 (PI)
DPH

Mechanisms Of Environmental
09/30/1998 - 05/31/2002 (PI)
US Army

P818 Damd179717311 10/30/
06/01/1999 - 09/30/2000 (PI)
Dept of the Army

S929 Sub Bonrc 9/29/98
06/01/1999 - 09/30/2000 (PI)
BONRC

M857 Acs 6/30/98
06/01/1999 - 09/30/2000 (PI)
American Cancer Soc

Function Of Mdm2 Rb
07/01/1999 - 04/30/2000 (PI)
NIH-NCI
1 R01 CA79804-01A1

Title

Yr	Title	Project-Sub Proj	Pubs
2011	REGULATION AND FUNCTION OF P63	5P41RR010888-15-5141	259
2010	REGULATION AND FUNCTION OF P63	5P41RR010888-14-6846	259
2010	Role of MDM2 in Cell Proliferation and Tumorigenesis	5R01CA079804-09	15
2009	REGULATION AND FUNCTION OF P63	5P41RR010888-13-6203	259
2009	Role of MDM2 in Cell Proliferation and Tumorigenesis	5R01CA079804-08	15
2008	REGULATION AND FUNCTION OF P63	5P41RR010888-12-5305	259
2008	Role of MDM2 in Cell Proliferation and Tumorigenesis	5R01CA079804-07	15
2007	REGULATION AND FUNCTION OF P63	2P41RR010888-11-8126	259
2007	Role of MDM2 in Cell Proliferation and Tumorigenesis	2R01CA079804-06A2	15
2006	Regulation of p53 in reespnse to genotoxic stress	5R01GM070017-04	7

Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Wang C, Yang J, Luo H, Wang K, Wang Y, Xiao ZX, Tao X, Jiang H, Cai H. CancerTracer: a curated database for intrapatient tumor heterogeneity. Nucleic Acids Res. 2020 01 08; 48(D1):D797-D806. PMID: 31701131; PMCID: PMC7145559; DOI: 10.1093/nar/gkz1061;

Yang J, Cai H, Xiao ZX, Wang H, Yang P. Effect of radiotherapy on the survival of cervical cancer patients: An analysis based on SEER database. Medicine (Baltimore). 2019 Jul; 98(30):e16421. PMID: 31348242; PMCID: PMC6708958; DOI: 10.1097/MD.0000000000016421;

Yi Y, Zhang W, Yi J, Xiao ZX. Role of p53 Family Proteins in Metformin Anti-Cancer Activities. J Cancer. 2019; 10(11):2434-2442. PMID: 31258748; PMCID: PMC6584340; DOI: 10.7150/jca.30659;

Deng G, Yang J, Zhang Q, Xiao ZX, Cai H. MethCNA: a database for integrating genomic and epigenomic data in human cancer. BMC Genomics. 2018 02 13; 19(1):138. PMID: 29433427; PMCID: PMC5810021; DOI: 10.1186/s12864-018-4525-0;

Chen Y, Peng Y, Fan S, Li Y, Xiao ZX, Li C. A double dealing tale of p63: an oncogene or a tumor suppressor. Cell Mol Life Sci. 2018 03; 75(6):965-973. PMID: 28975366; DOI: 10.1007/s00018-017-2666-y;

Yi Y, Chen D, Ao J, Sun S, Wu M, Li X, Bergholz J, Zhang Y, Xiao ZX. Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ?Np63a Protein Expression and Inhibits Cancer Cell Viability. J Biol Chem. 2017 Mar 31; 292(13):5253-5261. PMID: 28193839; PMCID: PMC5392672; DOI: 10.1074/jbc.M116.769141;

Fei Q, Shang K, Zhang J, Chuai S, Kong D, Zhou T, Fu S, Liang Y, Li C, Chen Z, Zhao Y, Yu Z, Huang Z, Hu M, Ying H, Chen Z, Zhang Y, Xing F, Zhu J, Xu H, Zhao K, Lu C, Atadja P, Xiao ZX, Li E, Shou J. Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53. Nat Commun. 2015; 6:8651. PMID: 26471002; PMCID: PMC5426523; DOI: 10.1038/ncomms9651;

Yuan L, Lv Y, Li H, Gao H, Song S, Zhang Y, Xing G, Kong X, Wang L, Li Y, Zhou T, Gao D, Xiao ZX, Yin Y, Wei W, He F, Zhang L. Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat Cell Biol. 2015 Sep; 17(9):1169-81. PMID: 26280536; DOI: 10.1038/ncb3218;

Walsh EM, Niu M, Bergholz J, Xiao ZX. Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation. Biochem Biophys Res Commun. 2015 May 29; 461(2):293-9. PMID: 25871794; PMCID: PMC4454893; DOI: 10.1016/j.bbrc.2015.04.024;

Zhang H, Hu L, Qiu W, Deng T, Zhang Y, Bergholz J, Xiao ZX. MDMX exerts its oncogenic activity via suppression of retinoblastoma protein. Oncogene. 2015 Oct 29; 34(44):5560-9. PMID: 25703327; DOI: 10.1038/onc.2015.11;

Showing 10 of 56 results. Show More

Tong Y, Ying H, Liu R, Li L, Bergholz J, Xiao ZX. Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage. Cell Death Dis. 2015; 6:e1640. PMID: 25675300; PMCID: PMC4669794; DOI: 10.1038/cddis.2015.3;

Yuan L, Chen Z, Song S, Wang S, Tian C, Xing G, Chen X, Xiao ZX, He F, Zhang L. p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling. J Biol Chem. 2015 Jan 30; 290(5):3172-82. PMID: 25505178; PMCID: PMC4317044; DOI: 10.1074/jbc.M114.619890;

Xiang X, Deng L, Zhang J, Zhang X, Lei T, Luan G, Yang C, Xiao ZX, Li Q, Li Q. A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis. PLoS One. 2014; 9(7):e101539. PMID: 25004108; PMCID: PMC4086901; DOI: 10.1371/journal.pone.0101539;

Wu J, Liang S, Bergholz J, He H, Walsh EM, Zhang Y, Xiao ZX. ?Np63a activates CD82 metastasis suppressor to inhibit cancer cell invasion. Cell Death Dis. 2014; 5:e1280. PMID: 24901051; PMCID: PMC4611714; DOI: 10.1038/cddis.2014.239;

Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, Li Q, Kirkland JL, Xiao ZX. Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell. 2014 Aug; 13(4):669-78. PMID: 25070626; PMCID: PMC4118446; DOI: 10.1111/acel.12219;

Dai Q, Luan G, Deng L, Lei T, Kang H, Song X, Zhang Y, Xiao ZX, Li Q. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation. Cell Rep. 2014 May 8; 7(3):735-46. PMID: 24768001; DOI: 10.1016/j.celrep.2014.03.053;

Li C, Xiao ZX. Regulation of p63 protein stability via ubiquitin-proteasome pathway. Biomed Res Int. 2014; 2014:175721. PMID: 24822180; PMCID: PMC4009111; DOI: 10.1155/2014/175721;

Li C, Chang DL, Yang Z, Qi J, Liu R, He H, Li D, Xiao ZX. Pin1 modulates p63a protein stability in regulation of cell survival, proliferation and tumor formation. Cell Death Dis. 2013; 4:e943. PMID: 24309930; PMCID: PMC3877541; DOI: 10.1038/cddis.2013.468;

Chen Q, Li D, Ren J, Li C, Xiao ZX. MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress. Biochem Biophys Res Commun. 2013 Oct 11; 440(1):179-83. PMID: 24055030; DOI: 10.1016/j.bbrc.2013.09.055;

Du W, Yi Y, Zhang H, Bergholz J, Wu J, Ying H, Zhang Y, Xiao ZX. Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy. PLoS One. 2013; 8(4):e63179.View Related Profiles.

Wu, Junfeng
Xiao, Zhi-Xiong

PMID: 23638184; PMCID: PMC3640086; DOI: 10.1371/journal.pone.0063179;

Bergholz J, Zhang Y, Wu J, Meng L, Walsh EM, Rai A, Sherman MY, Xiao ZX. ?Np63a regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene. 2014 Jan 9; 33(2):212-24.View Related Profiles.

Meng, Le
Sherman, Michael
Xiao, Zhi-Xiong

PMID: 23246965; PMCID: PMC3962654; DOI: 10.1038/onc.2012.564;

Luo L, Huang W, Tao R, Hu N, Xiao ZX, Luo Z. ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis. Cancer Lett. 2013 Jan 1; 328(1):114-9.View Related Profiles.

Luo, Zhijun
Xiao, Zhi-Xiong

PMID: 22960274; PMCID: PMC3521637; DOI: 10.1016/j.canlet.2012.08.034;

Bergholz J, Xiao ZX. Role of p63 in Development, Tumorigenesis and Cancer Progression. Cancer Microenviron. 2012 Dec; 5(3):311-22. PMID: 22847008; PMCID: PMC3460051; DOI: 10.1007/s12307-012-0116-9;

Gao WL, Li D, Xiao ZX, Liao QP, Yang HX, Li YX, Ji L, Wang YL. Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas. Hypertens Res. 2011 May; 34(5):655-61. PMID: 21326306; DOI: 10.1038/hr.2011.9;

Xiao ZX, Yin XC, Tan YF, Peng YH. [Effects of diallyl disulfide on apoptosis of human leukemia K562 cells and expression of Fas, FasL and caspase-8]. Zhongguo Dang Dai Er Ke Za Zhi. 2011 Jan; 13(1):53-6. PMID: 21251389

Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 9; 18(2):147-59. PMID: 20708156; PMCID: PMC2923652; DOI: 10.1016/j.ccr.2010.06.015;

Guo J, Zhu T, Chen L, Nishioka T, Tsuji T, Xiao ZX, Chen CY. Differential sensitization of different prostate cancer cells to apoptosis. Genes Cancer. 2010 Aug; 1(8):836-46. PMID: 21132068; PMCID: PMC2995449; DOI: 10.1177/1947601910381645;

Wu J, Bergholz J, Lu J, Sonenshein GE, Xiao ZX. TAp63 is a transcriptional target of NF-kappaB. J Cell Biochem. 2010 Mar 1; 109(4):702-10.View Related Profiles.

Sonenshein, Gail
Lu, Jining
Wu, Junfeng
Xiao, Zhi-Xiong

PMID: 20052674; PMCID: PMC2873845; DOI: 10.1002/jcb.22449;

Mineva ND, Wang X, Yang S, Ying H, Xiao ZX, Holick MF, Sonenshein GE. Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation. J Cell Physiol. 2009 Sep; 220(3):593-9.View Related Profiles.

Sonenshein, Gail
Holick, Michael
Xiao, Zhi-Xiong

PMID: 19373868; PMCID: PMC2900382; DOI: 10.1002/jcp.21765;

Du W, Wu J, Walsh EM, Zhang Y, Chen CY, Xiao ZX. Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3. J Biol Chem. 2009 Sep 25; 284(39):26315-21.View Related Profiles.

Wu, Junfeng
Xiao, Zhi-Xiong

PMID: 19648117; PMCID: PMC2785319; DOI: 10.1074/jbc.M109.046904;

Qiu W, Wu J, Walsh EM, Zhang Y, Chen CY, Fujita J, Xiao ZX. Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. Oncogene. 2008 Jul 3; 27(29):4034-43. PMID: 18332869; DOI: 10.1038/onc.2008.43;

Zhang Y, Tuzova M, Xiao ZX, Cruikshank WW, Center DM. Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP. J Immunol. 2008 Jan 1; 180(1):402-8.View Related Profiles.

Center, David
Tuzova, Marina
Cruikshank, William
Xiao, Zhi-Xiong

PMID: 18097041

Guo J, Zhu T, Xiao ZX, Chen CY. Modulation of intracellular signaling pathways to induce apoptosis in prostate cancer cells. J Biol Chem. 2007 Aug 17; 282(33):24364-72. PMID: 17573344; DOI: 10.1074/jbc.M702938200;

Chang DL, Qiu W, Ying H, Zhang Y, Chen CY, Xiao ZX. ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2. Oncogene. 2007 Jul 12; 26(32):4627-34. PMID: 17297463; DOI: 10.1038/sj.onc.1210254;

He J, Zhou F, Shao K, Hang J, Wang H, Rayburn E, Xiao ZX, Lee SW, Xue Q, Feng XL, Shi SS, Zhang CY, Zhang S. Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases. Lung Cancer. 2007 Apr; 56(1):51-8. PMID: 17275947; DOI: 10.1016/j.lungcan.2006.11.024;

Guo J, Zhu T, Collins L, Xiao ZX, Kim SH, Chen CY. Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus. Mol Carcinog. 2007 Feb; 46(2):144-54. PMID: 17131292; DOI: 10.1002/mc.20275;

Ying H, Xiao ZX. Targeting retinoblastoma protein for degradation by proteasomes. Cell Cycle. 2006 Mar; 5(5):506-8. PMID: 16552188

Sdek P, Ying H, Chang DL, Qiu W, Zheng H, Touitou R, Allday MJ, Xiao ZX. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol Cell. 2005 Dec 9; 20(5):699-708. PMID: 16337594; DOI: 10.1016/j.molcel.2005.10.017;

Murray SA, Yang S, Demicco E, Ying H, Sherr DH, Hafer LJ, Rogers AE, Sonenshein GE, Xiao ZX. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. J Cell Biochem. 2005 Aug 1; 95(5):875-84.View Related Profiles.

Rogers, Adrianne
Sherr, David
Sonenshein, Gail
Yang, Shi
Xiao, Zhi-Xiong

PMID: 15844214

Ying H, Chang DL, Zheng H, McKeon F, Xiao ZX. DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol Cell Biol. 2005 Jul; 25(14):6154-64. PMID: 15988026; PMCID: PMC1168832; DOI: 10.1128/MCB.25.14.6154-6164.2005;

Currier N, Solomon SE, Demicco EG, Chang DL, Farago M, Ying H, Dominguez I, Sonenshein GE, Cardiff RD, Xiao ZX, Sherr DH, Seldin DC. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicol Pathol. 2005; 33(6):726-37.View Related Profiles.

Seldin, David
Sherr, David
Sonenshein, Gail
Dominguez, Maria
Xiao, Zhi-Xiong

PMID: 16263698

Sdek P, Ying H, Zheng H, Margulis A, Tang X, Tian K, Xiao ZX. The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J Biol Chem. 2004 Dec 17; 279(51):53317-22.View Related Profiles.

Tang, Xiaoren
Xiao, Zhi-Xiong

PMID: 15485814

Gu L, Ying H, Zheng H, Murray SA, Xiao ZX. The MDM2 RING finger is required for cell cycle-dependent regulation of its protein expression. FEBS Lett. 2003 Jun 5; 544(1-3):218-22. PMID: 12782320

Zheng S, Xiao ZX, Pan YL, Han MY, Dong Q. Continuous release of interleukin 12 from microencapsulated engineered cells for colon cancer therapy. World J Gastroenterol. 2003 May; 9(5):951-5. PMID: 12717836; PMCID: PMC4611403; DOI: 10.3748/wjg.v9.i5.951;

Shao K, Xiao ZX, Tang HJ, Cheng BC, Zhang DC, Zhou F, Xiong MH, Mu BD, Huang W, Zhang CY, He J. [Transcriptional inactivation of RASSF1A in lung cancer and its clinical significance]. Zhonghua Yi Xue Za Zhi. 2003 Apr 10; 83(7):569-71. PMID: 12887746

Pan YL, Zheng S, Xiao ZX, Cao J, Yao HP. [Subcutaneous transplantation of microencapsulated Chinese hamster ovary (CHO) cells/pcDNA 3.1/mIL-12 and subcutaneous transplantation of microencapsulated CHO/pcDNA3.1/mIL-12 combined with 5-fluoro-uracil in treatment of tumor-burdened mice]. Zhonghua Yi Xue Za Zhi. 2003 Jan 10; 83(1):51-4. PMID: 12757646

Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G, Gu L, Tang X, Lu KP, Xiao ZX. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 2002 Oct 24; 419(6909):849-53.View Related Profiles.

Tang, Xiaoren
Xiao, Zhi-Xiong

PMID: 12397361

You H, Zheng H, Murray SA, Yu Q, Uchida T, Fan D, Xiao ZX. IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry. J Cell Biochem. 2002; 84(2):211-6. PMID: 11787050

Gallo-Hendrikx E, Murray SA, Vonderhaar BK, Xiao ZX. Vanadate disrupts mammary gland development in whole organ culture. Dev Dyn. 2001 Nov; 222(3):354-67. PMID: 11747071; DOI: 10.1002/dvdy.1193;

Charles A, Tang X, Crouch E, Brody JS, Xiao ZX. Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP-mediated transcription. J Cell Biochem. 2001 Aug 21-Sep 5; 83(3):414-25.View Related Profiles.

Brody, Jerome
Tang, Xiaoren
Xiao, Zhi-Xiong

PMID: 11596110

Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell. 1998 Oct; 2(4):405-15. PMID: 9809062

Xiao ZX, Ginsberg D, Ewen M, Livingston DM. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4633-7. PMID: 8643455; PMCID: PMC39330

Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR, Livingston DM. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature. 1995 Jun 22; 375(6533):694-8. PMID: 7791904; DOI: 10.1038/375694a0;

Xiao ZX, Fitzgerald-Hayes M. Functional interaction between the CSE2 gene product and centromeres in Saccharomyces cerevisiae. J Mol Biol. 1995 Apr 28; 248(2):255-63. PMID: 7739039

Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79. PMID: 7958924

McGrew JT, Xiao ZX, Fitzgerald-Hayes M. Saccharomyces cerevisiae mutants defective in chromosome segregation. Yeast. 1989 Jul-Aug; 5(4):271-84. PMID: 2675488; DOI: 10.1002/yea.320050407;

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