Yi-Chen Hsieh

Visiting Researcher

Boston University Chobanian & Avedisian School of Medicine

Neurology

Websites

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Augur ZM, Fogo GM, Arbery MR, Stern AM, Benoit CR, Hsieh YC, Young-Pearse TL. Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons. Acta Neuropathol Commun. 2025 Sep 02; 13(1):188. PMID: 40898372; PMCID: PMC12406597; DOI: 10.1186/s40478-025-02103-y;

Chen KW, Hsieh YC, Tsai KC, Chen CH, Tang SC, Lin CJ, Chen YW, Lin KH, Sung PS, Tang CW, Chu HJ, Chou CL, Wei CY, Yen SY, Chen PL, Yeh HL, Chan L, Sung SF, Liu HM, Lin CH, Lee M, Jeng YW, Lee CW, Chung CP, Lai YJ, Lien LM, Lee JT, Tsai LK, Chiou HY, Jeng JS. Renal function and post-thrombectomy outcomes and safety: nationwide registry study. J Neurointerv Surg. 2025 Jul 16. PMID: 40670158

Kim BJ, Tang SC, Hsieh YC, Chen CH, Kim YS, Lin CJ, Park JM, Sung PS, Kang K, Chen YW, Lee SJ, Lin KH, Cha JK, Tang CW, Park TH, Chu HJ, Lee K, Fu CH, Lee J, Chou CL, Hong KS, Lin CH, Yu KH, Wei CY, Kim DE, Yen SY, Kim JT, Chen PL, Choi JC, Chan L, Kwon JH, Shin DI, Sohn SI, Chiou HY, Kim C, Park KY, Kim CK, Lien LM, Heo SH, Lee JT, Bae HJ, Jeng JS. Association Between Age and Endovascular Treatment Outcomes: Binational Registry of 9934 EVT Cases From Korea and Taiwan. Stroke. 2025 Sep; 56(9):2540-2549. PMID: 40620221

Chien YN, Lin LY, Lin YC, Hsieh YC, Tu SH, Chiou HY. Correction: Taxane/anthracycline combinations reduced incidence of breast cancer recurrence in young women across molecular subtypes: a real-world evidence of Taiwan from 2011 to 2019. Breast Cancer Res Treat. 2025 Jun; 211(3):755-757. PMID: 40208513

Jeng TM, Hsieh YC, Chang PY, Li YL, Tang SC, Jeng JS, Hu CJ, Chiou HY. Association between post-stroke cognitive impairment and gut microbiota in patients with ischemic stroke. Sci Rep. 2025 May 29; 15(1):18849. PMID: 40442236; PMCID: PMC12122799; DOI: 10.1038/s41598-025-03068-7;

Law YY, Hsieh YH, Hsieh YS, Lee YH, Tang CL, Lee CY, Yang SF, Chu SC, Chen PN. Theaflavin-3,3'-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway. J Cancer. 2025; 16(8):2567-2577. PMID: 40535821; PMCID: PMC12171003; DOI: 10.7150/jca.111718;

Chen JH, Chan L, Hong CT, Hu CJ, Hsieh YC. Role of apolipoprotein E (ApoE) e4 in cognitive impairment after a stroke: a prospective cohort study. Aging (Albany NY). 2025 May 08; 17(5):1261-1274. PMID: 40349252; PMCID: PMC12151514; DOI: 10.18632/aging.206248;

Sun CT, Yang YS, Lan CL, Tran HM, Pham TA, Chiang YH, Lin CM, Su YK, Hsieh YC, Lin JH. Correction: Age- and gender-dependent impact of titanium vertebral augmentation implants combined with cementing on subsequent vertebral fracture incidence: A comparative study with cementing alone. Eur Spine J. 2025 May; 34(5):2042. PMID: 40180663

Li YL, Chang PY, Chuang TW, Hsieh YC, Wang BS, Chen SY, Chiou HY. Association of long-term ozone exposure with the incidence and progression of hypertension, diabetes, and chronic kidney disease: A national retrospective cohort study. Sci Total Environ. 2025 May 01; 975:179209. PMID: 40187338

Hong CT, Chung CC, Hsieh YC, Chan L. Plasma extracellular vesicle pathognomonic proteins as the biomarkers of the progression of Parkinson's disease. Biosci Trends. 2025 Mar 06; 19(1):116-124. PMID: 39924179

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Chen JH, Su IC, Lu YH, Hsieh YC, Chen CH, Lin CJ, Chen YW, Lin KH, Sung PS, Tang CW, Chu HJ, Fu CH, Chou CL, Wei CY, Yan SY, Chen PL, Yeh HL, Sung SF, Liu HM, Lin CH, Lee M, Tang SC, Lee IH, Chan L, Lien LM, Chiou HY, Lee JT, Jeng JS. Predictive Modeling of Symptomatic Intracranial Hemorrhage Following Endovascular Thrombectomy: Insights From the Nationwide TREAT-AIS Registry. J Stroke. 2025 Jan; 27(1):85-94. PMID: 39916457; PMCID: PMC11834349; DOI: 10.5853/jos.2024.04119;

Hong CT, Chung CC, Hsieh YC, Chan L. Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson's disease. Biomol Biomed. 2025 Jan 30; 25(3):588-594. PMID: 39652080; PMCID: PMC12010974; DOI: 10.17305/bb.2024.11502;

Ahmed MMM, Liao CH, Venkatesan S, Liu YT, Tzou YM, Jien SH, Lin MC, Hsieh YC, Osman AI. Sulfur-functionalized sawdust biochar for enhanced cadmium adsorption and environmental remediation: A multidisciplinary approach and density functional theory insights. J Environ Manage. 2025 Jan; 373:123586. PMID: 39672047

Yen CC, Chen KY, Ahmed MMM, Syu CH, Liu YT, Hsieh YC, Jien SH, Tzou YM. Photochemical oxidation of Cr(III) to Cr(VI) in the presence of Fe(III): Influence of Fe(III) concentration and UV wavelength. J Hazard Mater. 2025 Mar 05; 485:136852. PMID: 39694014

Liao YC, Wang LH, Hung MC, Cheng TC, Lin YC, Chang J, Tu SH, Wu CH, Yen Y, Hsieh YC, Chen LC, Ho YS. Investigation of the a9-nicotinic receptor single nucleotide polymorphisms induced oncogenic properties and molecular mechanisms in breast cancer. Hum Mol Genet. 2024 Nov 08; 33(22):1948-1965. PMID: 39251229

Lin CC, Lin CJ, Hsieh YC, Lin JH, Tsai HY, Wu CY, Chiou HY. Increased risk of breast cancer among premenopausal women with pituitary gland disorders in Taiwan: a population-based matched-cohort study. J Endocrinol Invest. 2025 Mar; 48(3):681-689. PMID: 39509067

Chien YN, Lin LY, Lin YC, Hsieh YC, Tu SH, Chiou HY. Taxane/anthracycline combinations reduced incidence of breast cancer recurrence in young women across molecular subtypes: a real-world evidence of Taiwan from 2011 to 2019. Breast Cancer Res Treat. 2025 Feb; 209(3):647-658. PMID: 39487912

Majumder P, Hsu TI, Hu CJ, Huang JK, Lee YC, Hsieh YC, Ahsan A, Huang CC. Potential role of solid lipid curcumin particle (SLCP) as estrogen replacement therapy in mitigating TDP-43-related neuropathy in the mouse model of ALS disease. Exp Neurol. 2025 Jan; 383:114999. PMID: 39419433

Sun CT, Yang YS, Lan CL, Tran HM, Pham TA, Chiang YH, Lin CM, Su YK, Hsieh YC, Lin JH. Age- and gender-dependent impact of titanium vertebral augmentation implants combined with cementing on subsequent vertebral fracture incidence: A comparative study with cementing alone. Eur Spine J. 2024 Dec; 33(12):4513-4520. PMID: 39367177

Lin CY, Chu SC, Hsieh YS, Tsai WY, Chen PN. Black Tea Suppresses Invasiveness and Reverses TNF-a-Induced Invasiveness and Cell Stemness in Human Malignant Melanoma Cells. Environ Toxicol. 2025 Feb; 40(2):165-178. PMID: 39324672

Hsieh YS, Yu CH, Chu SC, Lin CY, Chen PN. Gossypol Inhibits Metastasis of Lung Cell Carcinoma by Reversing Epithelial to Mesenchymal Transition and Suppressing Proteases Activity. Environ Toxicol. 2024 Nov; 39(11):5209-5221. PMID: 39263880

Leu YL, Cheng SF, Wang TH, Feng CH, Chen YJ, Hsieh YC, Lan YH, Chen CC. Corrigendum to "Increasing DNA damage sensitivity through corylin-mediated inhibition of homologous recombination" [Biomed. Pharmacother. 176 (2024) 116864]. Biomed Pharmacother. 2024 Aug; 177:117021. PMID: 38918141

Leu YL, Cheng SF, Wang TH, Feng CH, Chen YJ, Hsieh YC, Lan YH, Chen CC. Increasing DNA damage sensitivity through corylin-mediated inhibition of homologous recombination. Biomed Pharmacother. 2024 Jul; 176:116864. PMID: 38865847

Chen SM, Chen LY, Lin JH, Salazar N, Yeh TH, Lo WL, Lui TN, Hsieh YC, Chien LN. Comparison of endoscopic third ventriculostomy versus cerebrospinal fluid shunt procedures for the treatment of pediatric hydrocephalus in Taiwan. Childs Nerv Syst. 2024 Sep; 40(9):2883-2891. PMID: 38806857

Hsieh YC, Guan HH, Lin CC, Huang TY, Chuankhayan P, Chen NC, Wang NH, Hu PL, Tsai YC, Huang YC, Yoshimura M, Lin PJ, Hsieh YH, Chen CJ. Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. JACS Au. 2024 Jun 24; 4(6):2130-2150. PMID: 38938812; PMCID: PMC11200250; DOI: 10.1021/jacsau.4c00004;

Chen CH, Lee CW, Hsieh YC, Lin CJ, Chen YW, Lin KH, Sung PS, Tang CW, Chu HJ, Tsai KC, Chou CL, Lin CH, Wei CY, Yen SY, Chen PL, Yeh HL, Chan L, Sung SF, Lee M, Liu HM, Lin YH, Lee IH, Yeh SJ, Lien LM, Chiou HY, Lee JT, Tang SC, Jeng JS. Comparing Low- or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry. Stroke. 2024 Mar; 55(3):532-540. PMID: 38314590; PMCID: PMC10896194; DOI: 10.1161/STROKEAHA.123.045851;

Ahmed MMM, Chen KY, Tsao FY, Hsieh YC, Liu YT, Tzou YM. Promotion of phosphate release from humic acid-iron hydroxide coprecipitates in the presence of citric acid. Environ Res. 2024 Jan 01; 240(Pt 1):117517. PMID: 37914010

Lin CC, Liu YT, Chang PH, Hsieh YC, Tzou YM. Inhibition of continuous cropping obstacle of celery by chemically modified biochar: An efficient approach to decrease bioavailability of phenolic allelochemicals. J Environ Manage. 2023 Dec 15; 348:119316. PMID: 37862893

Hsiao SH, Sue YM, Kao CC, Chang HW, Lin YC, Hung CS, Hsieh YC, Hong SY, Chung CL, Chang JH, Su YS, Liu MC, Lai KS, Chien KL, Wang JC, Cheng CY, Fang TC. Comparison of Humoral Antibody Responses and Seroconversion Rates between Two Homologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination in Patients Undergoing Maintenance Hemodialysis. Vaccines (Basel). 2023 Jun 27; 11(7). PMID: 37514977; PMCID: PMC10383458; DOI: 10.3390/vaccines11071161;

Tu SH, Huang WT, Chew CH, Chen AL, Chen ST, Chen JH, Hsieh YC, Chen CC. Unveiling the Power of Anticancer Drug Screening: A Clinical Case Study Comparing the Effectiveness of Hollow Fiber Assay Microtube Array Membrane (MTAM-HFA) in Breast Cancer Patients. Cancers (Basel). 2023 May 15; 15(10). PMID: 37345100; PMCID: PMC10216413; DOI: 10.3390/cancers15102764;

Ye JC, Hsieh YS, Chen PN, Liu JY, Hsieh YH. Involvement of matrix metalloproteinase 1 and urokinase-type plasminogen activator in the PKCa-p38 MAPK pathway-mediated progression of human liver cancer cells. Drug Dev Res. 2023 Jun; 84(4):767-776. PMID: 37005497

Lee H, Aylward AJ, Pearse RV, Hsieh YC, Augur ZM, Benoit CR, Chou V, Knupp A, Pan C, Goberdhan S, Duong DM, Seyfried NT, Bennett DA, Klein HU, De Jager PL, Menon V, Young JE, Young-Pearse TL. Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1. bioRxiv. 2023 Feb 25. PMID: 36865313; PMCID: PMC9980168; DOI: 10.1101/2023.02.25.530017;

Lian IB, Chiu PF, Hsieh YC, Ou YH, Lin CM. Can chronic kidney disease staging early predict outcome of large-artery ischemic stroke with impaired renal function? Ther Adv Chronic Dis. 2023; 14:20406223231153564. PMID: 36815092

Fang YC, Hsieh YC, Hu CJ, Tu YK. Endothelial Dysfunction in Neurodegenerative Diseases. Int J Mol Sci. 2023 Feb 02; 24(3). PMID: 36769234

Chan L, Chung CC, Hsieh YC, Wu RM, Hong CT. Plasma extracellular vesicle tau, ß-amyloid, and a-synuclein and the progression of Parkinson's disease: a follow-up study. Ther Adv Neurol Disord. 2023; 16:17562864221150329. PMID: 36741351

Chen KY, Liu YT, Hung JT, Hsieh YC, Tzou YM. Synergism of Fe and Al salts for the coagulation of dissolved organic matter: Structural developments of Fe/Al-organic matter associations. Chemosphere. 2023 Mar; 316:137737. PMID: 36608877

Chang CK, Chu SC, Huang JY, Chen PN, Hsieh YS. Corrigendum: Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and ß-catenin pathway in vitro. Front Pharmacol. 2022; 13:1074693. PMID: 36467084

Liu HH, Lee CH, Hsieh YC, Zheng JH, Liu YR, Chang CH, Cho EC. Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo. Genes (Basel). 2022 Nov 14; 13(11). PMID: 36421786

Hsueh KL, Yu LK, Hsieh YC, Hsiao YY, Chen CJ. FeoC from Klebsiella pneumoniae uses its iron sulfur cluster to regulate the GTPase activity of the ferrous iron channel. Biochim Biophys Acta Proteins Proteom. 2023 Jan 01; 1871(1):140855. PMID: 36182071

Chang CK, Chu SC, Huang JY, Chen PN, Hsieh YS. Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and ß-catenin pathway in vitro. Front Pharmacol. 2022; 13:963589. PMID: 36238547

Linh TTD, Hsieh YC, Huang LK, Hu CJ. Clinical Trials of New Drugs for Vascular Cognitive Impairment and Vascular Dementia. Int J Mol Sci. 2022 Sep 21; 23(19). PMID: 36232368

Hsieh YC, Yang YS, Chien LN, Chiang YH, Lin JH. Timing of symptomatic subsequent vertebral compression fracture associated with different demographic factors. Eur Spine J. 2022 Sep; 31(9):2439-2447. PMID: 35816197

Chu SC, Hsieh YS, Hsu LS, Lin CY, Lai YA, Chen PN. Cinnamaldehyde decreases the invasion and u-PA expression of osteosarcoma by down-regulating the FAK signalling pathway. Food Funct. 2022 Jun 20; 13(12):6574-6582. PMID: 35678522

Chang CK, Hsieh YS, Chen PN, Chu SC, Huang JY, Wang YH, Wei JC. A Cohort Study: Comorbidity and Stage Affected the Prognosis of Melanoma Patients in Taiwan. Front Oncol. 2022; 12:846760. PMID: 35311079

Wu CI, Vinton EA, Pearse RV, Heo K, Aylward AJ, Hsieh YC, Bi Y, Adeleye S, Fancher S, Duong DM, Seyfried NT, Schwarz TL, Young-Pearse TL. APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons. Mol Psychiatry. 2022 Apr; 27(4):1970-1989. PMID: 35194165

Chang YH, Yang HJ, Chen HW, Hsiao CW, Hsieh YC, Chan YW, Chang SW, Hwang WL, Chen WS, Cheng HH, Chou TY, Chang FP, Ho HL, Chu FY, Lo YL, Chen CJ, Tsai HF, Shiau MY. Characterization of Collapsin Response Mediator Protein 2 in Colorectal Cancer Progression in Subjects with Diabetic Comorbidity. Cells. 2022 Feb 18; 11(4). PMID: 35203376

Lin CY, Hsieh YS, Chu SC, Hsu LS, Huang SC, Chen PN. Reduction of invasion and cell stemness and induction of apoptotic cell death by Cinnamomum cassia extracts on human osteosarcoma cells. Environ Toxicol. 2022 Jun; 37(6):1261-1274. PMID: 35146896

Chen YL, Chi NF, Chiou HY, Hu CJ, Jeng JS, Tang SC, Lin HJ, Hsieh YC. Application of hyperglycemia/diabetes-derived polygenic risk scores on the risk of poor outcomes after an ischemic stroke. J Chin Med Assoc. 2022 01 01; 85(1):81-87. PMID: 35006127

Chung HH, Hsieh MJ, Hsieh YS, Chen PN, Ko CP, Yu NY, Lin CW, Yang SF. The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells. Pharmaceuticals (Basel). 2021 Nov 19; 14(11). PMID: 34832965

Wu MH, Wu C, Lin JH, Chen LY, Lee CY, Huang TJ, Hsieh YC, Chien LN. Risk Factors for Spine Reoperation and Joint Replacement Surgeries after Short-Segment Lumbar Spinal Surgeries for Lumbar Degenerative Disc Disease: A Population-Based Cohort Study. J Clin Med. 2021 Oct 31; 10(21). PMID: 34768658

Chang CY, Luo DZ, Pei JC, Kuo MC, Hsieh YC, Lai WS. Not Just a Bystander: The Emerging Role of Astrocytes and Research Tools in Studying Cognitive Dysfunctions in Schizophrenia. Int J Mol Sci. 2021 May 19; 22(10). PMID: 34069523

Yeh JS, Hsu CY, Huang CY, Chen WT, Hsieh YC, Chien LN. The effect of de-escalation of P2Y12 receptor inhibitor therapy after acute myocardial infarction in patients undergoing percutaneous coronary intervention: A nationwide cohort study. PLoS One. 2021; 16(1):e0246029. PMID: 33493236

Hsieh YS, Chu SC, Huang SC, Kao SH, Lin MS, Chen PN. Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer. Am J Chin Med. 2021; 49(1):181-198. PMID: 33371817

Chou SY, Chan L, Chung CC, Chiu JY, Hsieh YC, Hong CT. Altered Insulin Receptor Substrate 1 Phosphorylation in Blood Neuron-Derived Extracellular Vesicles From Patients With Parkinson's Disease. Front Cell Dev Biol. 2020; 8:564641. PMID: 33344443

Chen CW, Hsieh YC, Hsieh MH, Lin YK, Huang CY, Yeh JS. Predictive Power of In-Hospital and Long-Term Mortality of the GRACE, TIMI, Revised CADILLAC and PAMI Score in NSTEMI Patients with Diabetes - Data from TSOC ACS-DM Registry. Acta Cardiol Sin. 2020 Nov; 36(6):595-602. PMID: 33235415

Sui Y, Hong CT, Chien LN, Liu HY, Chiou HY, Hsieh YC. Association between Anemia and Stroke in Females: A Nationwide, Population-Based Cohort Study in Taiwan. Int J Environ Res Public Health. 2020 Oct 13; 17(20). PMID: 33066053

Chiou HY, Bai CH, Lien LM, Hu CJ, Jeng JS, Tang SC, Lin HJ, Hsieh YC. Interactive Effects of a Combination of the HDAC3 and HDAC9 Genes with Diabetes Mellitus on the Risk of Ischemic Stroke. Thromb Haemost. 2021 Mar; 121(3):396-404. PMID: 32961570

Chen KY, Liu YT, Hsieh YC, Tzou YM. Organic fragments newly released from heat-treated peat soils create synergies with dissolved organic carbon to enhance Cr(VI) removal. Ecotoxicol Environ Saf. 2020 Sep 15; 201:110800. PMID: 32540617

Wu D, Yang CC, Chen KY, Lin YC, Wu PJ, Hsieh PH, Nakao Y, Ow MYL, Hsieh YC, Hu CJ. Hydrolyzed Chicken Extract (ProBeptigen®) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial. Nutrients. 2020 May 10; 12(5). PMID: 32397609

Wang CA, Hsieh YC, Huang CY, Liu JC, Hsieh MH, Lin YK, Yeh JS. Comparison between ticagrelor versus clopidogrel in long term outcomes of Taiwanese diabetic subjects with acute coronary syndrome undergoing successful revascularization: From TSOC ACS-DM registry. Medicine (Baltimore). 2020 May; 99(19):e19969. PMID: 32384446

Kao YT, Hsieh YC, Hsu CY, Huang CY, Hsieh MH, Lin YK, Yeh JS. Comparison of the TIMI, GRACE, PAMI and CADILLAC risk scores for prediction of long-term cardiovascular outcomes in Taiwanese diabetic patients with ST-segment elevation myocardial infarction: From the registry of the Taiwan Society of Cardiology. PLoS One. 2020; 15(2):e0229186. PMID: 32053694

Chen CH, Hsieh YC, Yang PM, Liu YR, Cho EC. Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochem Biophys Res Commun. 2020 Apr 16; 524(4):1003-1009. PMID: 32063361

Hong CT, Hsieh YC, Liu HY, Chiou HY, Chien LN. Association Between Anemia and Dementia: A Nationwide, Populationbased Cohort Study in Taiwan. Curr Alzheimer Res. 2020; 17(2):196-204. PMID: 32183675

Chu SC, Chen PN, Yu CH, Hsieh YS, Kuo DY. Double immunofluorescent evidence that oxidative stress-associated activation of JNK/AP-1 signaling participates in neuropeptide-mediated appetite control. Eur Neuropsychopharmacol. 2019 Nov; 29(11):1235-1249. PMID: 31519469

Liou YF, Chen PN, Chu SC, Kao SH, Chang YZ, Hsieh YS, Chang HR. Thymoquinone suppresses the proliferation of renal cell carcinoma cells via reactive oxygen species-induced apoptosis and reduces cell stemness. Environ Toxicol. 2019 Nov; 34(11):1208-1220. PMID: 31298468

Chu SC, Chen PN, Yu CH, Hsieh YS, Kuo DY. Role of hypoxia-inducible factor-1a in regulating oxidative stress and hypothalamic neuropeptides-mediated appetite control. Brain Res. 2019 Oct 15; 1721:146329. PMID: 31295466

Yang WE, Ho YC, Tang CM, Hsieh YS, Chen PN, Lai CT, Yang SF, Lin CW. Duchesnea indica extract attenuates oral cancer cells metastatic potential through the inhibition of the matrix metalloproteinase-2 activity by down-regulating the MEK/ERK pathway. Phytomedicine. 2019 Oct; 63:152960. PMID: 31280137

Liou YF, Hsieh YS, Hung TW, Chen PN, Chang YZ, Kao SH, Lin SW, Chang HR. Thymoquinone inhibits metastasis of renal cell carcinoma cell 786-O-SI3 associating with downregulation of MMP-2 and u-PA and suppression of PI3K/Src signaling. Int J Med Sci. 2019; 16(5):686-695. PMID: 31217736

Tang SC, Chen YR, Chi NF, Chen CH, Cheng YW, Hsieh FI, Hsieh YC, Yeh HL, Sung PS, Hu CJ, Chern CM, Lin HJ, Lien LM, Peng GS, Chiou HY, Jeng JS. Prevalence and clinical characteristics of stroke patients with p.R544C NOTCH3 mutation in Taiwan. Ann Clin Transl Neurol. 2019 Jan; 6(1):121-128. PMID: 30656190

Yu CH, Chu SC, Yang SF, Hsieh YS, Lee CY, Chen PN. Induction of apoptotic but not autophagic cell death by Cinnamomum cassia extracts on human oral cancer cells. J Cell Physiol. 2019 Apr; 234(4):5289-5303. PMID: 30317581

Guan HH, Hsieh YC, Lin PJ, Huang YC, Yoshimura M, Chen LY, Chen SK, Chuankhayan P, Lin CC, Chen NC, Nakagawa A, Chan SI, Chen CJ. Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas. Sci Rep. 2018 Oct 08; 8(1):14935. PMID: 30297797

Lin CY, Yang ST, Shen SC, Hsieh YC, Hsu FT, Chen CY, Chiang YH, Chuang JY, Chen KY, Hsu TI, Leong WC, Su YK, Lo WL, Yeh YS, Patria YN, Shih HM, Chang CC, Chou SY. Serum amyloid A1 in combination with integrin aVß3 increases glioblastoma cells mobility and progression. Mol Oncol. 2018 May; 12(5):756-771. PMID: 29603594

Huang SF, Chu SC, Hsieh YH, Chen PN, Hsieh YS. Viola Yedoensis Suppresses Cell Invasion by Targeting the Protease and NF-?B Activities in A549 and Lewis Lung Carcinoma Cells. Int J Med Sci. 2018; 15(4):280-290. PMID: 29511364

Chu SC, Chen PN, Chen JR, Yu CH, Hsieh YS, Kuo DY. Role of hypothalamic leptin-LepRb signaling in NPY-CART-mediated appetite suppression in amphetamine-treated rats. Horm Behav. 2018 Feb; 98:173-182. PMID: 29307696

Chen LY, Huang YC, Huang ST, Hsieh YC, Guan HH, Chen NC, Chuankhayan P, Yoshimura M, Tai MH, Chen CJ. Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor. Sci Rep. 2018 Jan 10; 8(1):287. PMID: 29321480

Wu HC, Horng CT, Lee YL, Chen PN, Lin CY, Liao CY, Hsieh YS, Chu SC. Cinnamomum Cassia Extracts Suppress Human Lung Cancer Cells Invasion by Reducing u-PA/MMP Expression through the FAK to ERK Pathways. Int J Med Sci. 2018; 15(2):115-123. PMID: 29333095

Hsieh MJ, Yang SF, Hsieh YS, Chen TY, Chiou HL. Corrigendum to "Autophagy Inhibition Enhances Apoptosis Induced by Dioscin in Huh7 Cells". Evid Based Complement Alternat Med. 2017; 2017:7143563. PMID: 29358967

Lin JH, Hsieh YC, Chen YC, Wang Y, Chen CC, Chiang YH. Diagnostic accuracy of standardised qualitative sensory test in the detection of lumbar lateral stenosis involving the L5 nerve root. Sci Rep. 2017 09 06; 7(1):10598. PMID: 28878316

Hung TW, Chen PN, Wu HC, Wu SW, Tsai PY, Hsieh YS, Chang HR. Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways. Int J Med Sci. 2017; 14(10):984-993. PMID: 28924370

Chen YY, Hsieh MJ, Hsieh YS, Chang YC, Chen PN, Yang SF, Ho HY, Chou YE, Lin CW. Antimetastatic effects of Rheum palmatum L. extract on oral cancer cells. Environ Toxicol. 2017 Oct; 32(10):2287-2294. PMID: 28678381

Tu SH, Hsieh YC, Huang LC, Lin CY, Hsu KW, Hsieh WS, Chi WM, Lee CH. A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model. BMC Cancer. 2017 Jun 23; 17(1):440. PMID: 28645267

Hsieh MJ, Tsai TL, Hsieh YS, Wang CJ, Chiou HL. Erratum to: Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines. Arch Toxicol. 2017 06; 91(6):2495-2496. PMID: 28451738

Lin JH, Chien LN, Tsai WL, Chen LY, Chiang YH, Hsieh YC. Early vertebroplasty associated with a lower risk of mortality and respiratory failure in aged patients with painful vertebral compression fractures: a population-based cohort study in Taiwan. Spine J. 2017 Sep; 17(9):1310-1318. PMID: 28483705

Chen PN, Yang SF, Yu CC, Lin CY, Huang SH, Chu SC, Hsieh YS. Duchesnea indica extract suppresses the migration of human lung adenocarcinoma cells by inhibiting epithelial-mesenchymal transition. Environ Toxicol. 2017 Aug; 32(8):2053-2063. PMID: 28371048

Lin CY, Hsieh YH, Yang SF, Chu SC, Chen PN, Hsieh YS. Cinnamomum cassia extracts reverses TGF-ß1-induced epithelial-mesenchymal transition in human lung adenocarcinoma cells and suppresses tumor growth in vivo. Environ Toxicol. 2017 Jul; 32(7):1878-1887. PMID: 28258635

Wu SW, Chen PN, Lin CY, Hsieh YS, Chang HR. Everolimus suppresses invasion and migration of renal cell carcinoma by inhibiting FAK activity and reversing epithelial to mesenchymal transition in vitro and in vivo. Environ Toxicol. 2017 Jul; 32(7):1888-1898. PMID: 28258630

Hsieh YC, Tu SH, Su CT, Cho EC, Wu CH, Hsieh MC, Lin SY, Liu YR, Hung CS, Chiou HY. A polygenic risk score for breast cancer risk in a Taiwanese population. Breast Cancer Res Treat. 2017 May; 163(1):131-138. PMID: 28205043

Yu CH, Chu SC, Chen PN, Hsieh YS, Kuo DY. Participation of ghrelin signalling in the reciprocal regulation of hypothalamic NPY/POMC-mediated appetite control in amphetamine-treated rats. Appetite. 2017 Jun 01; 113:30-40. PMID: 28229938

Sung JY, Chen CI, Hsieh YC, Chen YR, Wu HC, Chan L, Hu CJ, Hu HH, Chiou HY, Chi NF. Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective study. PeerJ. 2017; 5:e2948. PMID: 28168113

Hsieh YS, Yang SF, Hsieh YH, Hung CH, Chu SC, Yang SH, Chen PN. Erratum: "The Inhibitory Effect of Abietic Acid on Melanoma Cancer Metastasis and Invasiveness In Vitro and In Vivo". Am J Chin Med. 2017; 45(2):403. PMID: 28423939

Horng CT, Wu YJ, Chen PN, Chu SC, Tsai CM, Hsieh YS. Koelreuteria Formosana Extract Induces Growth Inhibition and Cell Death in Human Colon Carcinoma Cells via G2/M Arrest and LC3-II Activation-Dependent Autophagy. Nutr Cancer. 2017 Jan; 69(1):44-55. PMID: 27880045

Chang PY, Hsieh MJ, Hsieh YS, Chen PN, Yang JS, Lo FC, Yang SF, Lu KH. Tricetin inhibits human osteosarcoma cells metastasis by transcriptionally repressing MMP-9 via p38 and Akt pathways. Environ Toxicol. 2017 Aug; 32(8):2032-2040. PMID: 27860196

Lu KH, Chen PN, Hsieh YH, Lin CY, Cheng FY, Chiu PC, Chu SC, Hsieh YS. 3-Hydroxyflavone inhibits human osteosarcoma U2OS and 143B cells metastasis by affecting EMT and repressing u-PA/MMP-2 via FAK-Src to MEK/ERK and RhoA/MLC2 pathways and reduces 143B tumor growth in vivo. Food Chem Toxicol. 2016 Nov; 97:177-186. PMID: 27600294

Lin JH, Chien LN, Tsai WL, Chen LY, Hsieh YC, Chiang YH. Reoperation rates of anterior cervical discectomy and fusion versus posterior laminoplasty for multilevel cervical degenerative diseases: a population-based cohort study in Taiwan. Spine J. 2016 Dec; 16(12):1428-1436. PMID: 27520080

Huang YW, Chuang CY, Hsieh YS, Chen PN, Yang SF, Shih-Hsuan-Lin, Chen YY, Lin CW, Chang YC. Rubus idaeus extract suppresses migration and invasion of human oral cancer by inhibiting MMP-2 through modulation of the Erk1/2 signaling pathway. Environ Toxicol. 2017 Mar; 32(3):1037-1046. PMID: 27322511

Chiu HH, Hsieh YC, Chen YH, Wang HY, Lu CY, Chen CJ, Li YK. Three important amino acids control the regioselectivity of flavonoid glucosidation in glycosyltransferase-1 from Bacillus cereus. Appl Microbiol Biotechnol. 2016 Oct; 100(19):8411-24. PMID: 27198725

Huang SF, Horng CT, Hsieh YS, Hsieh YH, Chu SC, Chen PN. Epicatechin-3-gallate reverses TGF-ß1-induced epithelial-to-mesenchymal transition and inhibits cell invasion and protease activities in human lung cancer cells. Food Chem Toxicol. 2016 Aug; 94:1-10. PMID: 27224248

Chu SC, Yu CH, Chen PN, Hsieh YS, Kuo DY. Role of oxidative stress in disrupting the function of negative glucocorticoid response element in daily amphetamine-treated rats. Psychoneuroendocrinology. 2016 Sep; 71:1-11. PMID: 27235634

Chan L, Wang HM, Chen KY, Lin YC, Wu PJ, Hsieh WL, Chen YR, Liu CP, Tsai HY, Chen YR, Chang HH, Hsieh YC, Hu CJ. Effectiveness of Essence of Chicken in Improving Cognitive Function in Young People Under Work-Related Stress: A Randomized Double-Blind Trial. Medicine (Baltimore). 2016 May; 95(19):e3640. PMID: 27175681; PMCID: PMC4902523

Collum TD, Padmanabhan MS, Hsieh YC, Culver JN. Tobacco mosaic virus-directed reprogramming of auxin/indole acetic acid protein transcriptional responses enhances virus phloem loading. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):E2740-9. PMID: 27118842; PMCID: PMC4868455

Hsieh YC, Cho EC, Tu SH, Wu CH, Hung CS, Hsieh MC, Su CT, Liu YR, Lee CH, Ho YS, Chiou HY. MSH2 rs2303425 Polymorphism is Associated with Early-Onset Breast Cancer in Taiwan. Ann Surg Oncol. 2017 Feb; 24(2):603-610. PMID: 26975740

Hsieh YS, Yang SF, Hsieh YH, Hung CH, Chu SC, Yang SH, Chen PN. The Inhibitory Effect of Abietic Acid on Melanoma Cancer Metastasis and Invasiveness In Vitro and In Vivo. Am J Chin Med. 2015; 43(8):1697-714. PMID: 26621449

Yeh CB, Hsieh MJ, Hsieh YS, Chien MH, Lin PY, Chiou HL, Yang SF. Corrigendum to "Terminalia catappa Exerts Antimetastatic Effects on Hepatocellular Carcinoma through Transcriptional Inhibition of Matrix Metalloproteinase-9 by Modulating NF-?B and AP-1 Activity". Evid Based Complement Alternat Med. 2015; 2015:326234. PMID: 26692372; PMCID: PMC4672127

Ho ML, Hsieh YS, Chen JY, Chen KS, Chen JJ, Kuo WH, Lin SJ, Chen PN. Corrigendum to "Antimetastatic Potentials of Dioscorea nipponica on Melanoma In Vitro and In Vivo". Evid Based Complement Alternat Med. 2015; 2015:760692. PMID: 26664455

Weng JH, Hsieh YC, Huang CC, Wei TY, Lim LH, Chen YH, Ho MR, Wang I, Huang KF, Chen CJ, Tsai MD. Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses. Biochemistry. 2015 Oct 13; 54(40):6219-29. PMID: 26389808

Cho EC, Kuo ML, Cheng JH, Cheng YC, Hsieh YC, Liu YR, Hsieh RH, Yen Y. RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress. Mediators Inflamm. 2015; 2015:287345. PMID: 26089597; PMCID: PMC4451759

Hsieh YS, Chen PN, Yu CH, Chen CH, Tsai TT, Kuo DY. Involvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats. Neurotoxicology. 2015 May; 48:131-41. PMID: 25825358

Hsieh YS, Yang SF, Sethi G, Hu DN. Natural bioactives in cancer treatment and prevention. Biomed Res Int. 2015; 2015:182835. PMID: 25883943; PMCID: PMC4391150

Horng CT, Hsieh YS, Tsai ML, Chang WK, Yang TH, Yauan CH, Wang CH, Kuo WH, Wu YC. Effects of horizontal acceleration on human visual acuity and stereopsis. Int J Environ Res Public Health. 2015 Jan 19; 12(1):910-26. PMID: 25607601; PMCID: PMC4306901

Chen KS, Chen PN, Hsieh YS, Lin CY, Lee YH, Chu SC. Capsaicin protects endothelial cells and macrophage against oxidized low-density lipoprotein-induced injury by direct antioxidant action. Chem Biol Interact. 2015 Feb 25; 228:35-45. PMID: 25603234

Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, Davies G, Wolf C, Gudnason V, Chibnik LB, Yang Q, deStefano AL, de Quervain DJ, Srikanth V, Lahti J, Grabe HJ, Smith JA, Priebe L, Yu L, Karbalai N, Hayward C, Wilson JF, Campbell H, Petrovic K, Fornage M, Chauhan G, Yeo R, Boxall R, Becker J, Stegle O, Mather KA, Chouraki V, Sun Q, Rose LM, Resnick S, Oldmeadow C, Kirin M, Wright AF, Jonsdottir MK, Au R, Becker A, Amin N, Nalls MA, Turner ST, Kardia SL, Oostra B, Windham G, Coker LH, Zhao W, Knopman DS, Heiss G, Griswold ME, Gottesman RF, Vitart V, Hastie ND, Zgaga L, Rudan I, Polasek O, Holliday EG, Schofield P, Choi SH, Tanaka T, An Y, Perry RT, Kennedy RE, Sale MM, Wang J, Wadley VG, Liewald DC, Ridker PM, Gow AJ, Pattie A, Starr JM, Porteous D, Liu X, Thomson R, Armstrong NJ, Eiriksdottir G, Assareh AA, Kochan NA, Widen E, Palotie A, Hsieh YC, Eriksson JG, Vogler C, van Swieten JC, Shulman JM, Beiser A, Rotter J, Schmidt CO, Hoffmann W, Nöthen MM, Ferrucci L, Attia J, Uitterlinden AG, Amouyel P, Dartigues JF, Amieva H, Räikkönen K, Garcia M, Wolf PA, Hofman A, Longstreth WT, Psaty BM, Boerwinkle E, DeJager PL, Sachdev PS, Schmidt R, Breteler MM, Teumer A, Lopez OL, Cichon S, Chasman DI, Grodstein F, Müller-Myhsok B, Tzourio C, Papassotiropoulos A, Bennett DA, Ikram MA, Deary IJ, van Duijn CM, Launer L, Fitzpatrick AL, Seshadri S, Mosley TH. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry. 2015 Apr 15; 77(8):749-63.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Chibnik, Lori
Wolf, Philip
Yang, Qiong
Au, Rhoda
Choi, Seung Hoan
Seshadri, Sudha
Zhao, Wei
Hsieh, Yi-Chen

PMID: 25648963; PMCID: PMC4513651; DOI: 10.1016/j.biopsych.2014.08.027;

Chu SC, Chen PN, Ho YJ, Yu CH, Hsieh YS, Kuo DY. Both neuropeptide Y knockdown and Y1 receptor inhibition modulate CART-mediated appetite control. Horm Behav. 2015 Jan; 67:38-47. PMID: 25461972

Hsieh YC, Lee CH, Tu SH, Wu CH, Hung CS, Hsieh MC, Chuang CW, Ho YS, Chiou HY. CHRNA9 polymorphisms and smoking exposure synergize to increase the risk of breast cancer in Taiwan. Carcinogenesis. 2014 Nov; 35(11):2520-5. PMID: 25142973

Chu SC, Hsieh YS, Yu CC, Lai YY, Chen PN. Thymoquinone induces cell death in human squamous carcinoma cells via caspase activation-dependent apoptosis and LC3-II activation-dependent autophagy. PLoS One. 2014; 9(7):e101579. PMID: 25000169; PMCID: PMC4085014

Hsieh YS, Chu SC, Hsu LS, Chen KS, Lai MT, Yeh CH, Chen PN. Rubus idaeus L. reverses epithelial-to-mesenchymal transition and suppresses cell invasion and protease activities by targeting ERK1/2 and FAK pathways in human lung cancer cells. Food Chem Toxicol. 2013 Dec; 62:908-18. PMID: 24161487

Hsieh YC, Chen MC, Hsu CC, Chan SI, Yang YS, Chen CJ. Crystal structures of vertebrate dihydropyrimidinase and complexes from Tetraodon nigroviridis with lysine carbamylation: metal and structural requirements for post-translational modification and function. J Biol Chem. 2013 Oct 18; 288(42):30645-58. PMID: 24005677; PMCID: PMC3798535

Hsieh MJ, Tsai TL, Hsieh YS, Wang CJ, Chiou HL. Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines. Arch Toxicol. 2013 Nov; 87(11):1927-1937. PMID: 23552851; PMCID: PMC3824840

Hsieh YC, Jeng JS, Lin HJ, Hu CJ, Yu CC, Lien LM, Peng GS, Chen CI, Tang SC, Chi NF, Tseng HP, Chern CM, Hsieh FI, Bai CH, Chen YR, Chiou HY. Epistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients. PLoS One. 2012; 7(10):e47773. PMID: 23112845; PMCID: PMC3480403

Hsieh YC, Seshadri S, Chung WT, Hsieh FI, Hsu YH, Lin HJ, Tseng HP, Lien LM, Bai CH, Hu CJ, Jeng JS, Tang SC, Chen CI, Yu CC, Chiou HY. Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan. J Biomed Sci. 2012; 19:1.View Related Profiles.

Seshadri, Sudha
Hsieh, Yi-Chen

PMID: 22212150; PMCID: PMC3269363; DOI: 10.1186/1423-0127-19-1;

Lien LM, Hsieh YC, Bai CH, Chen WH, Chiu HC, Hsieh FI, Shyu KG, Chiou HY, Hsu CY. Association of blood active matrix metalloproteinase-3 with carotid plaque score from a community population in Taiwan. Atherosclerosis. 2010 Oct; 212(2):595-600. PMID: 20609440

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 120 publications over 15 distinct years, with a maximum of 14 publications in 2017 and 2024

Bar chart showing 120 publications over 15 distinct years, with a maximum of 14 publications in 2017 and 2024

Year	Publications
2010	1
2012	2
2013	3
2014	4
2015	9
2016	11
2017	14
2018	8
2019	5
2020	11
2021	4
2022	12
2023	10
2024	14
2025	12

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