William Paul Duprex, PhD
Professor
Boston University School of Medicine
Dept of Microbiology

PhD, Queen's University Belfast



The overarching goal of my research program is to understand the molecular basis of paramyxovirus pathogenesis and attenuation with a view to translating this knowledge into the development and delivery of safe and efficacious vectored vaccines. I have over fifteen years experience as a molecular virologist and I and my laboratory have developed reverse genetics systems for both positive and negative strand RNA viruses. Currently my group focuses on respiratory paramyxoviruses.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences



2013 European Society for Clinical Virology: Gardner Prize Lectureship
2006 Wellcome Trust: Special Prize in Bioimaging


Shifting a Paradigm in Vaccine Safety: From Empirical to Rational Attenuation
06/01/2016 - 05/31/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI099100-05

DIVA: vanquishing acute viral infections by finding the TIPping point
03/01/2017 - 11/30/2018 (PI)
Department of Defense/DARPA


Dissecting the pathogenesis of feline morbillivirus
03/11/2016 - 11/30/2018 (PI)
Zoetis, LLC


Generation of Predictive Models of Viral Pathogenesis
11/06/2015 - 09/30/2017 (PI)
Battelle Memorial Institute/Pacific Northwest National Laboratory Department of Energy


Investigating feline morbillivirus molecular epidemiology in cats in the North Eastern United States
08/26/2014 - 06/30/2016 (PI)
Zoetis, LLC


Shifting a Paradigm in Vaccine Safety: From Empirical to Rational Attenuation
06/01/2013 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI099100-03

Mapping the Adaption of Animal Morbilliviruses to Human Cells: Evolution, Structural Modelling and Prediction
09/30/2013 - 03/31/2016 (PI)
Department of Defense/DARPA


Illuminating the Cellular Tropism of measles Vaccine Viruses in Macaques: What is the Effect of Vaccination Route on Immunogenicity and Protection?
04/01/2010 - 08/31/2014 (PI)
Foundation for NIH


Multimodal Imaging of Antibody-Mediated Therapy During Acute Viral Encephalitides
06/06/2012 - 06/30/2013 (Co-PI)
PI: Katharine N. Bossart, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R21AI101442-02



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Allen IV, McQuaid S, Penalva R, Ludlow M, Duprex WP, Rima BK. Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans. mSphere. 2018 May-Jun; 3(3).View Related Profiles. PMID: 29743202.
     
  2. Harris M, Duprex WP. Whether you are a virus or a learned society-based virology journal, evolution is critical for success! J Gen Virol. 2018 Jan; 99(1):1-2. PMID: 29347999.
     
  3. de Swart RL, de Vries RD, Rennick LJ, van Amerongen G, McQuaid S, Verburgh RJ, Yüksel S, de Jong A, Lemon K, Nguyen DT, Ludlow M, Osterhaus ADME, Duprex WP. Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection. NPJ Vaccines. 2017; 2:22.View Related Profiles. PMID: 29263877.
     
  4. Rissanen I, Ahmed AA, Azarm K, Beaty S, Hong P, Nambulli S, Duprex WP, Lee B, Bowden TA. Idiosyncratic Mòjiang virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses. Nat Commun. 2017 Jul 12; 8:16060.View Related Profiles. PMID: 28699636.
     
  5. de Vries RD, Ludlow M, de Jong A, Rennick LJ, Verburgh RJ, van Amerongen G, van Riel D, van Run PRWA, Herfst S, Kuiken T, Fouchier RAM, Osterhaus ADME, de Swart RL, Duprex WP. Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets. PLoS Pathog. 2017 May; 13(5):e1006371.View Related Profiles. PMID: 28481926.
     
  6. Beaty SM, Park A, Won ST, Hong P, Lyons M, Vigant F, Freiberg AN, tenOever BR, Duprex WP, Lee B. Efficient and Robust Paramyxoviridae Reverse Genetics Systems. mSphere. 2017 Mar-Apr; 2(2). PMID: 28405630; DOI: 10.1128/mSphere.00376-16;.
     
  7. Beaty SM, Nachbagauer R, Hirsh A, Vigant F, Duehr J, Azarm KD, Stelfox AJ, Bowden TA, Duprex WP, Krammer F, Lee B. Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats. J Infect Dis. 2017 Jan 15; 215(2):209-213. PMID: 27811320; DOI: 10.1093/infdis/jiw534;.
     
  8. Morfopoulou S, Mee ET, Connaughton SM, Brown JR, Gilmour K, Chong WK, Duprex WP, Ferguson D, Hubank M, Hutchinson C, Kaliakatsos M, McQuaid S, Paine S, Plagnol V, Ruis C, Virasami A, Zhan H, Jacques TS, Schepelmann S, Qasim W, Breuer J. Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis. Acta Neuropathol. 2017 Jan; 133(1):139-147. PMID: 27770235; DOI: 10.1007/s00401-016-1629-y;.
     
  9. Laksono BM, de Vries RD, McQuaid S, Duprex WP, de Swart RL. Measles Virus Host Invasion and Pathogenesis. Viruses. 2016 Jul 28; 8(8). PMID: 27483301; PMCID: PMC4997572; DOI: 10.3390/v8080210;.
     
  10. Hume AJ, Ames J, Rennick LJ, Duprex WP, Marzi A, Tonkiss J, Mühlberger E. Inactivation of RNA Viruses by Gamma Irradiation: A Study on Mitigating Factors. Viruses. 2016 Jul 22; 8(7).View Related Profiles. PMID: 27455307; PMCID: PMC4974539; DOI: 10.3390/v8070204;.
     
Showing 10 of 108 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 108 publications over 21 distinct years, with a maximum of 11 publications in 2011 and 2012

YearPublications
19952
19992
20004
20012
20029
20031
20042
20055
20065
20079
20082
20096
20102
201111
201211
20136
20149
20157
20166
20175
20182
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Disease
Respiratory
Vaccine
Virology
Contact for Mentoring:

620 Albany St
Boston MA 02118
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