William Paul Duprex, PhD
Professor
Boston University School of Medicine
Dept of Microbiology

PhD, Queen's University Belfast




The overarching goal of my research program is to understand the molecular basis of paramyxovirus pathogenesis and attenuation with a view to translating this knowledge into the development and delivery of safe and efficacious vectored vaccines. I have over fifteen years experience as a molecular virologist and I and my laboratory have developed reverse genetics systems for both positive and negative strand RNA viruses. Currently my group focuses on respiratory paramyxoviruses.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2013 European Society for Clinical Virology: Gardner Prize Lectureship
2006 Wellcome Trust: Special Prize in Bioimaging


DIVA: vanquishing acute viral infections by finding the TIPping point
03/01/2017 - 11/30/2018 (PI)
Department of Defense/DARPA


Shifting a Paradigm in Vaccine Safety: From Empirical to Rational Attenuation
06/01/2016 - 11/30/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI099100-05

Dissecting the pathogenesis of feline morbillivirus
03/11/2016 - 11/30/2018 (PI)
Zoetis, LLC


Generation of Predictive Models of Viral Pathogenesis
11/06/2015 - 09/30/2017 (Subcontract PI)
Battelle Memorial Institute/Pacific Northwest National Laboratory Department of Energy


Investigating feline morbillivirus molecular epidemiology in cats in the North Eastern United States
08/26/2014 - 06/30/2016 (PI)
Zoetis, LLC


Shifting a Paradigm in Vaccine Safety: From Empirical to Rational Attenuation
06/01/2013 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI099100-03

Mapping the Adaption of Animal Morbilliviruses to Human Cells: Evolution, Structural Modelling and Prediction
09/30/2013 - 03/31/2016 (PI)
Department of Defense/DARPA


Illuminating the Cellular Tropism of measles Vaccine Viruses in Macaques: What is the Effect of Vaccination Route on Immunogenicity and Protection?
04/01/2010 - 08/31/2014 (PI)
Foundation for NIH


Multimodal Imaging of Antibody-Mediated Therapy During Acute Viral Encephalitides
06/06/2012 - 06/30/2013 (Co-PI)
PI: Katharine N. Bossart, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R21AI101442-02



Title

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kuhn JH, Adkins S, Alioto D, Alkhovsky SV, Amarasinghe GK, Anthony SJ, Avšic-Županc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Bartonicka T, Basler C, Bavari S, Beer M, Bente DA, Bergeron É, Bird BH, Blair C, Blasdell KR, Bradfute SB, Breyta R, Briese T, Brown PA, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Buzkan N, Calisher CH, Cao M, Casas I, Chamberlain J, Chandran K, Charrel RN, Chen B, Chiumenti M, Choi IR, Clegg JCS, Crozier I, da Graça JV, Dal Bó E, Dávila AMR, de la Torre JC, de Lamballerie X, de Swart RL, Di Bello PL, Di Paola N, Di Serio F, Dietzgen RG, Digiaro M, Dolja VV, Dolnik O, Drebot MA, Drexler JF, Dürrwald R, Dufkova L, Dundon WG, Duprex WP, Dye JM, Easton AJ, Ebihara H, Elbeaino T, Ergünay K, Fernandes J, Fooks AR, Formenty PBH, Forth LF, Fouchier RAM, Freitas-Astúa J, Gago-Zachert S, Gao GF, García ML, García-Sastre A, Garrison AR, Gbakima A, Goldstein T, Gonzalez JJ, Griffiths A, Groschup MH, Günther S, Guterres A, Hall RA, Hammond J, Hassan M, Hepojoki J, Hepojoki S, Hetzel U, Hewson R, Hoffmann B, Hongo S, Höper D, Horie M, Hughes HR, Hyndman TH, Jambai A, Jardim R, Jiang D, Jin Q, Jonson GB, Junglen S, Karadag S, Keller KE, Klempa B, Klingström J, Kobinger G, Kondo H, Koonin EV, Krupovic M, Kurath G, Kuzmin IV, Laenen L, Lamb RA, Lambert AJ, Langevin SL, Lee B, Lemos ERS, Leroy EM, Li D, Li J, Liang M, Liú W, Liú Y, Lukashevich IS, Maes P, Marciel de Souza W, Marklewitz M, Marshall SH, Martelli GP, Martin RR, Marzano SL, Massart S, McCauley JW, Mielke-Ehret N, Minafra A, Minutolo M, Mirazimi A, Mühlbach HP, Mühlberger E, Naidu R, Natsuaki T, Navarro B, Navarro JA, Netesov SV, Neumann G, Nowotny N, Nunes MRT, Nylund A, Økland AL, Oliveira RC, Palacios G, Pallas V, Pályi B, Papa A, Parrish CR, Pauvolid-Corrêa A, Paweska JT, Payne S, Pérez DR, Pfaff F, Radoshitzky SR, Rahman AU, Ramos-González PL, Resende RO, Reyes CA, Rima BK, Romanowski V, Robles Luna G, Rota P, Rubbenstroth D, Runstadler JA, Ruzek D, Sabanadzovic S, Salát J, Sall AA, Salvato MS, Sarpkaya K, Sasaya T, Schwemmle M, Shabbir MZ, Shí X, Shí Z, Shirako Y, Simmonds P, Širmarová J, Sironi M, Smither S, Smura T, Song JW, Spann KM, Spengler JR, Stenglein MD, Stone DM, Straková P, Takada A, Tesh RB, Thornburg NJ, Tomonaga K, Tordo N, Towner JS, Turina M, Tzanetakis I, Ulrich RG, Vaira AM, van den Hoogen B, Varsani A, Vasilakis N, Verbeek M, Wahl V, Walker PJ, Wang H, Wang J, Wang X, Wang LF, Wèi T, Wells H, Whitfield AE, Williams JV, Wolf YI, Wú Z, Yang X, Yáng X, Yu X, Yutin N, Zerbini FM, Zhang T, Zhang YZ, Zhou G, Zhou X. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol. 2020 Sep 04.View Related Profiles. PMID: 32888050
     
  2. Xiang Y, Nambulli S, Xiao Z, Liu H, Sang Z, Duprex WP, Schneidman-Duhovny D, Zhang C, Shi Y. Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2. bioRxiv. 2020 Aug 25.View Related Profiles. PMID: 32869034
     
  3. Klimstra WB, Tilston-Lunel NL, Nambulli S, Boslett J, McMillen CM, Gilliland T, Dunn MD, Sun C, Wheeler SE, Wells A, Hartman AL, McElroy AK, Reed DS, Rennick LJ, Duprex WP. SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients. J Gen Virol. 2020 Aug 21.View Related Profiles. PMID: 32821033
     
  4. Rennick LJ, Nambulli S, Lemon K, Olinger GY, Crossland NA, Millar EL, Duprex WP. Recombinant subtype A and B human respiratory syncytial virus clinical isolates co-infect the respiratory tract of cotton rats. J Gen Virol. 2020 Jul 29.View Related Profiles. PMID: 32723429
     
  5. Rijsbergen LC, Rennick LJ, Laksono BM, van Run PRWA, Kuiken T, Duprex WP, de Swart RL, de Vries RD. In vivo comparison of a laboratory-adapted and clinical-isolate-based recombinant human respiratory syncytial virus. J Gen Virol. 2020 Jul 21.View Related Profiles. PMID: 32692644
     
  6. Klimstra WB, Tilston-Lunel NL, Nambulli S, Boslett J, McMillen CM, Gilliland T, Dunn MD, Sun C, Wheeler SE, Wells A, Hartman AL, McElroy AK, Reed DS, Rennick LJ, Duprex WP. SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients. bioRxiv. 2020 Jun 22.View Related Profiles. PMID: 32607507
     
  7. Welch SR, Tilston NL, Lo MK, Whitmer SLM, Harmon JR, Scholte FEM, Spengler JR, Duprex WP, Nichol ST, Spiropoulou CF. Inhibition of Nipah Virus by Defective Interfering Particles. J Infect Dis. 2020 May 11; 221(Supplement_4):S460-S470. PMID: 32108876
     
  8. Laksono BM, de Vries RD, Duprex WP, de Swart RL. Measles pathogenesis, immune suppression and animal models. Curr Opin Virol. 2020 Apr; 41:31-37. PMID: 32339942
     
  9. Blockus S, Sake SM, Wetzke M, Grethe C, Graalmann T, Pils M, Le Goffic R, Galloux M, Prochnow H, Rox K, Hüttel S, Rupcic Z, Wiegmann B, Dijkman R, Rameix-Welti MA, Eléouët JF, Duprex WP, Thiel V, Hansen G, Brönstrup M, Haid S, Pietschmann T. Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry. Antiviral Res. 2020 05; 177:104774. PMID: 32197980
     
  10. Amarasinghe GK, Ayllón MA, Bào Y, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chabi-Jesus C, Chandran K, Chiapponi C, Crozier I, de Swart RL, Dietzgen RG, Dolnik O, Drexler JF, Dürrwald R, Dundon WG, Duprex WP, Dye JM, Easton AJ, Fooks AR, Formenty PBH, Fouchier RAM, Freitas-Astúa J, Griffiths A, Hewson R, Horie M, Hyndman TH, Jiang D, Kitajima EW, Kobinger GP, Kondo H, Kurath G, Kuzmin IV, Lamb RA, Lavazza A, Lee B, Lelli D, Leroy EM, Li J, Maes P, Marzano SL, Moreno A, Mühlberger E, Netesov SV, Nowotny N, Nylund A, Økland AL, Palacios G, Pályi B, Paweska JT, Payne SL, Prosperi A, Ramos-González PL, Rima BK, Rota P, Rubbenstroth D, Shi M, Simmonds P, Smither SJ, Sozzi E, Spann K, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, van den Hoogen B, Vasilakis N, Wahl V, Walker PJ, Wang LF, Whitfield AE, Williams JV, Zerbini FM, Zhang T, Zhang YZ, Kuhn JH. Taxonomy of the order Mononegavirales: update 2019. Arch Virol. 2019 Jul; 164(7):1967-1980.View Related Profiles. PMID: 31089958
     
Showing 10 of 124 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 124 publications over 23 distinct years, with a maximum of 11 publications in 2011 and 2012

YearPublications
19952
19992
20004
20012
20029
20031
20042
20055
20065
20079
20082
20096
20102
201111
201211
20136
20149
20157
20166
20175
20185
20194
20209
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Disease
Respiratory
Vaccine
Virology
Contact for Mentoring:

620 Albany St
Boston MA 02118
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