Weiwei Lin, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmcology, Physiology & Biophysics

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My research aims to use the power of precision mass spectrometry towards functional multi-omics-based systems biology to uncover the molecular networks altered in Alzheimer’s disease and other brain pathologies.
A) Mapping protein-protein interactions linked to AD progression and other neurodegenerative diseases.
B) High-resolution LC-MS-based integrative metabolomic and proteomic platform development and application.
C) Brain disease-associated native protein complexes.


Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.
12/15/2022 - 11/30/2025 (Co-Investigator)
PI: Wendy Wei Qiao Qiu, MD, PhD
1 RF1 AG075832-01A1

Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, Guo H, McComb M, Emili A. PANAMA-enabled high-sensitivity dual nanoflow LC-MS metabolomics and proteomics analysis. Cell Rep Methods. 2024 Jul 15; 4(7):100803.View Related Profiles. PMID: 38959888; DOI: 10.1016/j.crmeth.2024.100803;
  2. Lagani GD, Lin W, Natarajan S, Lampl N, Harper ER, Emili A, Beffert U, Ho A. Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development. bioRxiv. 2024 Jan 12.View Related Profiles. PMID: 38260505; PMCID: PMC10802565; DOI: 10.1101/2024.01.12.575269;
  3. Lin W, Mousavi F, Blum BC, Heckendorf CF, Moore J, Lampl N, McComb M, Kotelnikov S, Yin W, Rabhi N, Layne MD, Kozakov D, Chitalia VC, Emili A. Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease. Front Pharmacol. 2023; 14:1243505.View Related Profiles. PMID: 38089059; PMCID: PMC10715419; DOI: 10.3389/fphar.2023.1243505;
  4. Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling. Int J Mol Sci. 2023 Mar 01; 24(5).View Related Profiles. PMID: 36902152; PMCID: PMC10002553; DOI: 10.3390/ijms24054724;
  5. Paul I, Bolzan D, Youssef A, Gagnon KA, Hook H, Karemore G, Oliphant MUJ, Lin W, Liu Q, Phanse S, White C, Padhorny D, Kotelnikov S, Chen CS, Hu P, Denis GV, Kozakov D, Raught B, Siggers T, Wuchty S, Muthuswamy SK, Emili A. Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Nat Commun. 2023 Feb 08; 14(1):688.View Related Profiles. PMID: 36755019; PMCID: PMC9908882; DOI: 10.1038/s41467-023-36122-x;
  6. Heckendorf C, Blum BC, Lin W, Lawton ML, Emili A. Integration of Metabolomic and Proteomic Data to Uncover Actionable Metabolic Pathways. Methods Mol Biol. 2023; 2660:137-148.View Related Profiles. PMID: 37191795
  7. Liu Y, Zhang X, Lin W, Kehriman N, Kuang W, Ling X. Multi-factor combined biomarker screening strategy to rapidly diagnose Alzheimer's disease and evaluate drug effect based on a rat model. J Pharm Anal. 2022 Aug; 12(4):627-636. PMID: 36105160; PMCID: PMC9463486; DOI: 10.1016/j.jpha.2022.04.003;
  8. Blum BC, Lin W, Lawton ML, Liu Q, Kwan J, Turcinovic I, Hekman R, Hu P, Emili A. Multiomic Metabolic Enrichment Network Analysis Reveals Metabolite-Protein Physical Interaction Subnetworks Altered in Cancer. Mol Cell Proteomics. 2022 01; 21(1):100189.View Related Profiles. PMID: 34933084; PMCID: PMC8761777; DOI: 10.1016/j.mcpro.2021.100189;
  9. Muraoka S, Lin W, Takamatsu-Yukawa K, Hu J, Ikezu S, DeTure MA, Dickson DW, Emili A, Ikezu T. Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles. Aging Dis. 2021 Sep; 12(6):1376-1388.View Related Profiles. PMID: 34527416; PMCID: PMC8407888; DOI: 10.14336/AD.2020.1007;
  10. Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S, Maziuk BF, Lei S, Song J, Alvarez VE, Hovde S, Abisambra JF, Kuo MH, Kanaan N, Murray ME, Crary JF, Zhao J, Cheng JX, Petrucelli L, Li H, Emili A, Wolozin B. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell. 2021 10 21; 81(20):4209-4227.e12.View Related Profiles. PMID: 34453888; PMCID: PMC8541906; DOI: 10.1016/j.molcel.2021.07.038;
Showing 10 of 18 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 18 publications over 10 distinct years, with a maximum of 4 publications in 2021 and 2023


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71 East Concord St.
Boston MA 02118
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