Weiwei Lin | Profiles RNS

Weiwei Lin, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmcology, Physiology & Biophysics

PhD, Peking University
MMed, Guangzhou Medical College
BS, Guangdong Medical & Pharmaceutical

Websites

ORCID : 0009-0008-4909-9204

My research aims to use the power of precision mass spectrometry towards functional multi-omics-based systems biology to uncover the molecular networks altered in Alzheimer’s disease and other brain pathologies.
A) Mapping protein-protein interactions linked to AD progression and other neurodegenerative diseases.
B) High-resolution LC-MS-based integrative metabolomic and proteomic platform development and application.
C) Brain disease-associated native protein complexes.

Other Research

Title

Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.
12/15/2022 - 11/30/2025 (Co-Investigator)
PI: Wendy Wei Qiao Qiu, MD, PhD
NIH NIH
1 RF1 AG075832-01A1

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Le NTT, Mercer RCC, Fang C, Sundaravadivelu A, Labadorf AT, Lin W, Kwan J, Blum B, Emili A, Harris DA. Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs. bioRxiv. 2026 Jan 31.View Related Profiles.

Labadorf, Adam
Blum, Benjamin
Harris, David
Lin, Weiwei

PMID: 41659520; PMCID: PMC12873866; DOI: 10.64898/2026.01.28.702331;

Guangxin Sun,1† WeiWei Lin,2†, Ruixi Chen,1 Lulu Jiang, 3 Michael J. DeMott,1 Abigail McShane,1 Chi Kong Chan,1 Dylan Ehrbar,4 Xiaoling Zhang,5 Thomas J. Begley,4 Andrew Emili,6 Benjamin Wolozin,3* Peter C. Dedon1,. Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model. BioRxiv. 2025. View Publication

Lin W, Phanse S, van der Spek SJF, Lampl N, Stephens MC, Ortiz AR, Taylor A, Hekman R, Roberts R, Jiang L, Havugimana P, Botas J, Emili A, Wolozin B. Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy. bioRxiv. 2025 Jul 06.View Related Profiles.

Wolozin, Benjamin
Van Der Spek, Sophie
Lin, Weiwei

PMID: 40631216; PMCID: PMC12236515; DOI: 10.1101/2025.07.05.663296;

Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, McComb M, Emili A. Protocol for dual metabolomics and proteomics using nanoflow liquid chromatography-tandem mass spectrometry. STAR Protoc. 2025 Jun 20; 6(2):103745.View Related Profiles.

Blum, Benjamin
Lin, Weiwei

PMID: 40188434; PMCID: PMC12001105; DOI: 10.1016/j.xpro.2025.103745;

Lawton ML, Inge MM, Blum BC, Smith-Mahoney EL, Bolzan D, Lin W, McConney C, Porter J, Moore J, Youssef A, Tharani Y, Varelas X, Denis GV, Wong WW, Padhorny D, Kozakov D, Siggers T, Wuchty S, Snyder-Cappione J, Emili A. Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming. PLoS Biol. 2024 Dec; 22(12):e3002943.View Related Profiles.

Blum, Benjamin
Denis, Gerald
Moore, Jarrod
Snyder-Cappione , Jennifer
Lin, Weiwei
Wong, Wilson
Varelas, Xaralabos

PMID: 39689157; PMCID: PMC11703073; DOI: 10.1371/journal.pbio.3002943;

Lagani GD, Sha M, Lin W, Natarajan S, Kankkunen M, Kistler SA, Lampl N, Waxman H, Harper ER, Emili A, Beffert U, Ho A. Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development. J Neurosci. 2024 Oct 16; 44(42).View Related Profiles.

Ho, Angela
Kankkunen, Marcus
Beffert, Uwe
Lin, Weiwei

PMID: 39227156; PMCID: PMC11484552; DOI: 10.1523/JNEUROSCI.0072-24.2024;

Zhang Z, Lin W, Gan Q, Lei M, Gong B, Zhang C, Henrique JS, Han J, Tian H, Tao Q, Potempa LA, Stein TD, Emili A, Qiu WQ. The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP. Angiogenesis. 2024 Nov; 27(4):861-881.View Related Profiles.

Zhang, Chao
Henrique, Jessica
Han, Jingyan
Tao, Qiushan
Stein, Thor
Lin, Weiwei
Qiu, Wendy

PMID: 39276310; PMCID: PMC11564276; DOI: 10.1007/s10456-024-09946-4;

Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, Guo H, McComb M, Emili A. PANAMA-enabled high-sensitivity dual nanoflow LC-MS metabolomics and proteomics analysis. Cell Rep Methods. 2024 Jul 15; 4(7):100803.View Related Profiles.

Blum, Benjamin
Lin, Weiwei

PMID: 38959888; PMCID: PMC11294829; DOI: 10.1016/j.crmeth.2024.100803;

Lagani GD, Lin W, Natarajan S, Lampl N, Harper ER, Emili A, Beffert U, Ho A. Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development. bioRxiv. 2024 Jan 12.View Related Profiles.

Ho, Angela
Beffert, Uwe
Lin, Weiwei

PMID: 38260505; PMCID: PMC10802565; DOI: 10.1101/2024.01.12.575269;

Lin W, Mousavi F, Blum BC, Heckendorf CF, Moore J, Lampl N, McComb M, Kotelnikov S, Yin W, Rabhi N, Layne MD, Kozakov D, Chitalia VC, Emili A. Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease. Front Pharmacol. 2023; 14:1243505.View Related Profiles.

Blum, Benjamin
Layne, Matthew
Rabhi, Nabil
Chitalia, Vipul
Lin, Weiwei

PMID: 38089059; PMCID: PMC10715419; DOI: 10.3389/fphar.2023.1243505;

Showing 10 of 25 results. Show More

Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling. Int J Mol Sci. 2023 Mar 01; 24(5).View Related Profiles.

Luptak, Ivan
Moore, Jarrod
Goel, Raghuveera
Perissi, Valentina
Lin, Weiwei

PMID: 36902152; PMCID: PMC10002553; DOI: 10.3390/ijms24054724;

Paul I, Bolzan D, Youssef A, Gagnon KA, Hook H, Karemore G, Oliphant MUJ, Lin W, Liu Q, Phanse S, White C, Padhorny D, Kotelnikov S, Chen CS, Hu P, Denis GV, Kozakov D, Raught B, Siggers T, Wuchty S, Muthuswamy SK, Emili A. Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Nat Commun. 2023 Feb 08; 14(1):688.View Related Profiles.

Chen, Christopher
Denis, Gerald
Lin, Weiwei

PMID: 36755019; PMCID: PMC9908882; DOI: 10.1038/s41467-023-36122-x;

Heckendorf C, Blum BC, Lin W, Lawton ML, Emili A. Integration of Metabolomic and Proteomic Data to Uncover Actionable Metabolic Pathways. Methods Mol Biol. 2023; 2660:137-148.View Related Profiles.

Blum, Benjamin
Lin, Weiwei

PMID: 37191795

Liu Y, Zhang X, Lin W, Kehriman N, Kuang W, Ling X. Multi-factor combined biomarker screening strategy to rapidly diagnose Alzheimer's disease and evaluate drug effect based on a rat model. J Pharm Anal. 2022 Aug; 12(4):627-636. PMID: 36105160; PMCID: PMC9463486; DOI: 10.1016/j.jpha.2022.04.003;

Blum BC, Lin W, Lawton ML, Liu Q, Kwan J, Turcinovic I, Hekman R, Hu P, Emili A. Multiomic Metabolic Enrichment Network Analysis Reveals Metabolite-Protein Physical Interaction Subnetworks Altered in Cancer. Mol Cell Proteomics. 2022 01; 21(1):100189.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Lin, Weiwei

PMID: 34933084; PMCID: PMC8761777; DOI: 10.1016/j.mcpro.2021.100189;

Muraoka S, Lin W, Takamatsu-Yukawa K, Hu J, Ikezu S, DeTure MA, Dickson DW, Emili A, Ikezu T. Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles. Aging Dis. 2021 Sep; 12(6):1376-1388.View Related Profiles.

Emili, Andrew
Ikezu, Seiko
Ikezu, Tsuneya
Lin, Weiwei

PMID: 34527416; PMCID: PMC8407888; DOI: 10.14336/AD.2020.1007;

Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S, Maziuk BF, Lei S, Song J, Alvarez VE, Hovde S, Abisambra JF, Kuo MH, Kanaan N, Murray ME, Crary JF, Zhao J, Cheng JX, Petrucelli L, Li H, Emili A, Wolozin B. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell. 2021 10 21; 81(20):4209-4227.e12.View Related Profiles.

Emili, Andrew
Wolozin, Benjamin
Cheng, Ji-Xin
Jiang, Lulu
Verma, Mamta
Ash, Peter
Alvarez, Victor
Lin, Weiwei
Yang, Zhuo

PMID: 34453888; PMCID: PMC8541906; DOI: 10.1016/j.molcel.2021.07.038;

Deehan M, Lin W, Blum B, Emili A, Frydman H. Intracellular Density of Wolbachia Is Mediated by Host Autophagy and the Bacterial Cytoplasmic Incompatibility Gene cifB in a Cell Type-Dependent Manner in Drosophila melanogaster. mBio. 2021 01 12; 12(1).View Related Profiles.

Emili, Andrew
Blum, Benjamin
Frydman, Horacio
Lin, Weiwei

PMID: 33436431; PMCID: PMC7844536; DOI: 10.1128/mBio.02205-20;

Muraoka S, Lin W, Chen M, Hersh SW, Emili A, Xia W, Ikezu T. Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids. Methods. 2020 05 01; 177:35-49.View Related Profiles.

Emili, Andrew
Ikezu, Tsuneya
Xia, Weiming
Lin, Weiwei

PMID: 32035230; PMCID: PMC7667497; DOI: 10.1016/j.ymeth.2020.02.002;

Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ, Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK, Bryant CD. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. J Neurosci. 2020 01 02; 40(1):107-130.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Wolozin, Benjamin
Bryant, Camron
Apicco, Daniel
Rosene, Douglas
Mortazavi, Farzad
Beierle, Jacob
Yazdani, Neema
Ash, Peter
Lin, Weiwei

PMID: 31704785; PMCID: PMC6939476; DOI: 10.1523/JNEUROSCI.1808-19.2019;

Zhang J, Lin W, Wu R, Liu Y, Zhu K, Ren J, Zhang S, Ling X. Mechanisms of the active components from Korean pine nut preventing and treating d-galactose-induced aging rats. Biomed Pharmacother. 2018 Jul; 103:680-690. PMID: 29679909; DOI: 10.1016/j.biopha.2018.04.063;

Lin W, Zhang J, Liu Y, Wu R, Yang H, Hu X, Ling X. Studies on diagnostic biomarkers and therapeutic mechanism of Alzheimer's disease through metabolomics and hippocampal proteomics. Eur J Pharm Sci. 2017 Jul 15; 105:119-126. PMID: 28495476; DOI: 10.1016/j.ejps.2017.05.003;

Li Z, Zhao Y, Lin W, Ye M, Ling X. Rapid screening and identification of active ingredients in licorice extract interacting with V3 loop region of HIV-1 gp120 using ACE and CE-MS. J Pharm Biomed Anal. 2015; 111:28-35. PMID: 25854854; DOI: 10.1016/j.jpba.2015.02.021;

Li J, Lin W, Lin W, Xu P, Zhang J, Yang H, Ling X. Metabolic profiling study on potential toxicity and immunotoxicity-biomarker discovery in rats treated with cyclophosphamide using HPLC-ESI-IT-TOF-MS. Biomed Chromatogr. 2015 May; 29(5):768-76. PMID: 25322901; DOI: 10.1002/bmc.3355;

Yang H, Lin W, Zhang J, Lin W, Xu P, Li J, Ling X. Metabonomic analysis of the toxic effects of TM208 in rat urine by HPLC-ESI-IT-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 15; 959:49-54. PMID: 24747524; DOI: 10.1016/j.jchromb.2014.03.036;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 25 publications over 12 distinct years, with a maximum of 5 publications in 2024

Bar chart showing 25 publications over 12 distinct years, with a maximum of 5 publications in 2024

Year	Publications
2014	2
2015	1
2017	1
2018	1
2019	1
2020	1
2021	4
2022	1
2023	4
2024	5
2025	3
2026	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

LC-MS/MS
Proteomics
Phosphoproteomics
Metabolomics
Mass Spectrometry
Protein Protein Interaction
Protein-metabolite interaction
Protein Complexes
Alzheimer Disease
Tauopathies
ApoE

Contact for Mentoring:

71 East Concord St.
Boston MA 02118
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617.358.0565

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