Tien Hsu, PhD
Adjunct Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, Medical University of South Carolina




Dr. Tien Hsu was recruited to the National Central University in August 2013. Previously he was Professor of Medicine at the Boston University School of Medicine. The major research interest in Dr. Hsu’s laboratory is to understand the origin of cancer and the mechanism of its growth. In the 1990s, Dr. Hsu pioneered the study using multiple model organisms, including fruit fly, mouse, and human cells, for functional comparison of tumor-related genes in embryonic development. He has contributed greatly in the understanding of tumor suppressor genes VHL and anti-metastasis gene Nm23. He serves on the advisory board of the International VHL Disease Alliance. He was elected in 2012 as the Chair of International Congress of NDPK/Nm23/awd Gene Family. He also served as grant review panel members of NIH (USA), NSF (USA), and government agencies of other countries such as Italy, Israel, United Kingdom, Canada, Holland, etc.

Traditionally, cancer research has been focused on killing cancer cells. Such strategy has shown only limited success in the over 40 years of “War on Cancer”. Dr. Hsu believes that we need to rethink our strategy, and should focus on the role of stromal cells, which promote inflammatory reaction and support stem cell survival. It is now discovered that tumor growth and stem cell maintenance are dependent on the surrounding tissues and cells (the stroma). Controlling organ pathology by modulating the stromal function should present a gentler and more effective containment of many diseases including cancer. The concept is to contain the cancer tissue and prevent malignancy, but not to kill cancer cells. Such new direction requires a systems biology view of the interaction between the diseased tissue and the entire body. Dr. Hsu’s current research is focused on stromal biology, characterizing the function and therapeutic potential of the tumor microenvironment. His research team includes collaboration with international experts in cancer and in fibrotic diseases, which is a key aspect of tumor progression.

University Chair Professor in Biomedicine
National Central University
Program in Biomedical Sciences


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Boston Medical Center


Chair Professor
Taiwan Bio-development Foundation
Biotechnology



2013-2017 Qualcomm Tricorder XPrize: 2nd place
2012-2013 International Congress of the NDP Kinase/NM23/awd Gene Family: Chair
1989-1992 NIH Postdoctoral Research Fellowship
1987 MUSC Student Research Day: First Prize, Ph.D. Poster Section
1987 MUSC Student Research Day: Grand Prize for Best Science
1987 MUSC Student Research Day: Grand Prize for Best Presentation and Delivery



VHL tumor suppressor gene and the initiation of renal cell carcinoma
04/01/2015 - 03/31/2018 (PI)
NIH-NCI
5R01 CA109860-11

VHL and FGFR Signaling in Angiogenesis
01/20/2010 - 04/30/2011 (PI)
NIH-NCI
7R01 CA109860-06



Yr Title Project-Sub Proj Pubs
2015 VHL tumor suppressor gene and the initiation of renal cell carcinoma 5R01CA109860-11 30
2014 VHL tumor suppressor gene and the initiation of renal cell carcinoma 5R01CA109860-10 30
2013 VHL tumor suppressor gene and the initiation of renal cell carcinoma 5R01CA109860-09 30
2013 VHL tumor suppressor gene and the initiation of renal cell carcinoma 3R01CA109860-09S1 30
2012 VHL tumor suppressor gene and the initiation of renal cell carcinoma 5R01CA109860-08 30
2012 VHL tumor suppressor gene and the initiation of renal cell carcinoma 3R01CA109860-08S1 30
2011 VHL tumor suppressor gene and the initiation of renal cell carcinoma 2R01CA109860-07 30
2009 Ets1 and FGFR FUNCTIONS IN EPITHELIAL CELL MIGRATION 5P01CA078582-10-5 84
2008 VHL and FGFR signaling in angiogenesis 5R01CA109860-05 30
2008 Ets1 and FGFR FUNCTIONS IN EPITHELIAL CELL MIGRATION 5P01CA078582-09-5 84
Showing 10 of 34 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Liu SC, Hsu T, Chang YS, Chung AK, Jiang SS, OuYang CN, Yuh CH, Hsueh C, Liu YP, Tsang NM. Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling. Nat Commun. 2018 11 30; 9(1):5105. PMID: 30504771.
     
  2. Chen HY, Hsiao YT, Liu SC, Hsu T, Woon WY, I L. Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation. Phys Rev Lett. 2018 Jul 06; 121(1):018101. PMID: 30028147; DOI: 10.1103/PhysRevLett.121.018101;.
     
  3. Romani P, Ignesti M, Gargiulo G, Hsu T, Cavaliere V. Extracellular NME proteins: a player or a bystander? Lab Invest. 2018 02; 98(2):248-257. PMID: 29035383.
     
  4. Kuo CY, Lin CH, Hsu T. VHL Inactivation in Precancerous Kidney Cells Induces an Inflammatory Response via ER Stress-Activated IRE1a Signaling. Cancer Res. 2017 Jul 01; 77(13):3406-3416. PMID: 28533271.
     
  5. Bader HL, Hsu T. Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model. BMC Cancer. 2016 Oct 12; 16(1):797. PMID: 27733136.
     
  6. Romani P, Papi A, Ignesti M, Soccolini G, Hsu T, Gargiulo G, Spisni E, Cavaliere V. Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov; 389(11):1171-1182. PMID: 27449069.
     
  7. Hsu T, Steeg PS, Zollo M, Wieland T. Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified. Naunyn Schmiedebergs Arch Pharmacol. 2015 Feb; 388(2):109-17. PMID: 25585611; DOI: 10.1007/s00210-014-1079-9;.
     
  8. Kirschner R, Hsu T, Tuan NN, Chen CL, Huang SL. Characterization of fungal and bacterial components in gut/fecal microbiome. Curr Drug Metab. 2015; 16(4):272-83. PMID: 26264196.
     
  9. Pritchett TL, Bader HL, Henderson J, Hsu T. Conditional inactivation of the mouse von Hippel-Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney. Oncogene. 2015 May 14; 34(20):2631-9.View Related Profiles. PMID: 25023703; DOI: 10.1038/onc.2014.197;.
     
  10. Lin CH, Dammai V, Adryan B, Hsu T. Interaction between Nm23 and the tumor suppressor VHL. Naunyn Schmiedebergs Arch Pharmacol. 2015 Feb; 388(2):143-52. PMID: 24915993; DOI: 10.1007/s00210-014-1002-4;.
     
Showing 10 of 36 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 36 publications over 16 distinct years, with a maximum of 5 publications in 2008

YearPublications
20021
20033
20042
20054
20061
20071
20085
20092
20102
20113
20121
20143
20152
20162
20172
20182
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Cell Biology
Cancer biology
Epithelial morphogenesis
Cell migration
Tumor suppressor gene
Drosophila genetics
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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