Tho Pham | Profiles RNS

Tho X. Pham, PhD

Postdoctoral Associate (previously held)

Boston University Chobanian & Avedisian School of Medicine

Rheumatology

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Hu S, Kang H, Bae M, Kim MB, Jang H, Corvino O, Pham TX, Lee Y, Smyth JA, Park YK, Lee JY. Histone Deacetylase 9 Deletion Inhibits Hepatic Steatosis and Adipose Tissue Inflammation in Male Diet-Induced Obese Mice. J Gastroenterol Hepatol. 2024 Dec 27. PMID: 39730208

Raslan AA, Pham TX, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis. Nat Commun. 2024 Jun 27; 15(1):5449.View Related Profiles.

Raslan, Ahmed
Bujor, Andreea
Tilston-Lunel, Andrew
Ligresti, Giovanni
Hong, Jeongmin
Trojanowska, Maria
Pham, Tho
Varelas, Xaralabos

PMID: 38937456; PMCID: PMC11211333; DOI: 10.1038/s41467-024-49545-x;

Raslan AA, Pham TX, Lee J, Hong J, Schmottlach J, Nicolas K, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration. bioRxiv. 2023 Jan 20.View Related Profiles.

Raslan, Ahmed
Bujor, Andreea
Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho
Varelas, Xaralabos

PMID: 36712020; PMCID: PMC9882122; DOI: 10.1101/2023.01.17.523179;

Gao AY, Diaz Espinosa AM, Gianì F, Pham TX, Carver CM, Aravamudhan A, Bartman CM, Ligresti G, Caporarello N, Schafer MJ, Haak AJ. Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome. Am J Physiol Lung Cell Mol Physiol. 2022 Dec 01; 323(6):L685-L697.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 36223640; PMCID: PMC9744654; DOI: 10.1152/ajplung.00023.2022;

Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Author Correction: Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Sep 28; 13(1):5687.View Related Profiles.

Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho

PMID: 36171208; PMCID: PMC9519969; DOI: 10.1038/s41467-022-33197-w;

Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Jul 25; 13(1):4170.View Related Profiles.

Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho

PMID: 35879310; PMCID: PMC9314350; DOI: 10.1038/s41467-022-31890-4;

Kim MB, Bae M, Lee Y, Kang H, Hu S, Pham TX, Park YK, Lee JY. Consumption of Low Dose Fucoxanthin Does Not Prevent Hepatic and Adipose Inflammation and Fibrosis in Mouse Models of Diet-Induced Obesity. Nutrients. 2022 May 29; 14(11). PMID: 35684079; PMCID: PMC9183127; DOI: 10.3390/nu14112280;

Kim MB, Pham TX, vanLuling M, Kostour V, Kang H, Corvino O, Jang H, Odell W, Bae M, Park YK, Lee JY. Nicotinamide riboside supplementation exerts an anti-obesity effect and prevents inflammation and fibrosis in white adipose tissue of female diet-induced obesity mice. J Nutr Biochem. 2022 Sep; 107:109058. PMID: 35643283

Ligresti G, Pham TX, Sanders YY. Circular RNA Methylation: A New Twist in Lung Fibrosis. Am J Respir Cell Mol Biol. 2022 May; 66(5):471-472.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 35238732; PMCID: PMC9116359; DOI: 10.1165/rcmb.2022-0044ED;

Pham TX, Lee J, Guan J, Caporarello N, Meridew JA, Jones DL, Tan Q, Huang SK, Tschumperlin DJ, Ligresti G. Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis. JCI Insight. 2022 Mar 22; 7(6).View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 35167499; PMCID: PMC8986080; DOI: 10.1172/jci.insight.153672;

Showing 10 of 39 results. Show More

Ring NAR, Volpe MC, Stepišnik T, Mamolo MG, Panov P, Kocev D, Vodret S, Fortuna S, Calabretti A, Rehman M, Colliva A, Marchesan P, Camparini L, Marcuzzo T, Bussani R, Scarabellotto S, Confalonieri M, Pham TX, Ligresti G, Caporarello N, Loffredo FS, Zampieri D, Džeroski S, Zacchigna S. Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation. Cell Death Dis. 2021 12 17; 13(1):2.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 34916483; PMCID: PMC8677786; DOI: 10.1038/s41419-021-04439-4;

Tan KC, Pham TX, Lee Y, Lee JY, Balunas MJ. Identification of Apocarotenoids as Chemical Markers of In Vitro Anti-Inflammatory Activity for Spirulina Supplements. J Agric Food Chem. 2021 Nov 03; 69(43):12674-12685. PMID: 34672564; PMCID: PMC11290940; DOI: 10.1021/acs.jafc.1c03015;

Kim MB, Lee Y, Bae M, Kang H, Hu S, Pham TX, Lee JY, Park YK. Sugar kelp (Saccharina latissima) inhibits hepatic inflammation and fibrosis in a mouse model of diet-induced nonalcoholic steatohepatitis. J Nutr Biochem. 2021 11; 97:108799. PMID: 34119629

Kim MB, Lee Y, Bae M, Kang H, Pham TX, Hu S, Lee JY, Park YK. Erratum to "Comprehensive characterization of metabolic, inflammatory and fibrotic changes in a mouse model of diet-derived nonalcoholic steatohepatitis" [The Journal of Nutritional Biochemistry Volume 85 (2020) 108463]. J Nutr Biochem. 2021 Jul; 93:108636. PMID: 33962092

Tan Q, Link PA, Meridew JA, Pham TX, Caporarello N, Ligresti G, Tschumperlin DJ. Spontaneous Lung Fibrosis Resolution Reveals Novel Antifibrotic Regulators. Am J Respir Cell Mol Biol. 2021 04; 64(4):453-464.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 33493091; PMCID: PMC8008802; DOI: 10.1165/rcmb.2020-0396OC;

Fortier SM, Penke LR, King D, Pham TX, Ligresti G, Peters-Golden M. Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions. JCI Insight. 2021 03 22; 6(6).View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 33561015; PMCID: PMC8026183; DOI: 10.1172/jci.insight.144799;

Yu SY, Kim MB, Park YK, Bae M, Kang H, Hu S, Pham TX, Carpenter R, Lee J, Lee OH, Lee JY, Kim YC. Anthocyanin-Rich Aronia Berry Extract Mitigates High-Fat and High-Sucrose Diet-Induced Adipose Tissue Inflammation by Inhibiting Nuclear Factor-?B Activation. J Med Food. 2021 Jun; 24(6):586-594. PMID: 33751905

Caceres C, Kim MB, Bae M, Pham TX, Lee Y, Hu S, O'Neill EN, Kim B, Park YK, Lee JY. The effect of cranberry consumption on lipid metabolism and inflammation in human apo A-I transgenic mice fed a high-fat and high-cholesterol diet. Br J Nutr. 2021 07 28; 126(2):183-190. PMID: 33059793

Caporarello N, Meridew JA, Aravamudhan A, Jones DL, Austin SA, Pham TX, Haak AJ, Moo Choi K, Tan Q, Haresi A, Huang SK, Katusic ZS, Tschumperlin DJ, Ligresti G. Vascular dysfunction in aged mice contributes to persistent lung fibrosis. Aging Cell. 2020 08; 19(8):e13196.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 32691484; PMCID: PMC7431829; DOI: 10.1111/acel.13196;

Kim MB, Lee Y, Bae M, Kang H, Pham TX, Hu S, Lee JY, Park YK. Comprehensive characterization of metabolic, inflammatory and fibrotic changes in a mouse model of diet-derived nonalcoholic steatohepatitis. J Nutr Biochem. 2020 11; 85:108463. PMID: 32891893

Bae M, Lee Y, Pham TX, Hu S, Park YK, Lee JY. Astaxanthin inhibits the reduction of glycolysis during the activation of hepatic stellate cells. Life Sci. 2020 Sep 01; 256:117926. PMID: 32535081; PMCID: PMC7442723; DOI: 10.1016/j.lfs.2020.117926;

Pham TX, Bae M, Kim MB, Lee Y, Hu S, Kang H, Park YK, Lee JY. Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2019 09 01; 1865(9):2451-2463. PMID: 31195117; PMCID: PMC6614025; DOI: 10.1016/j.bbadis.2019.06.009;

Pham TX, Lee Y, Bae M, Hu S, Kang H, Kim MB, Park YK, Lee JY. Spirulina supplementation in a mouse model of diet-induced liver fibrosis reduced the pro-inflammatory response of splenocytes. Br J Nutr. 2019 04; 121(7):748-755. PMID: 30806344

Lee Y, Pham TX, Bae M, Hu S, O'Neill E, Chun OK, Han MJ, Koo SI, Park YK, Lee JY. Blackcurrant (Ribes nigrum) Prevents Obesity-Induced Nonalcoholic Steatohepatitis in Mice. Obesity (Silver Spring). 2019 01; 27(1):112-120. PMID: 30569636

Farruggia C, Kim MB, Bae M, Lee Y, Pham TX, Yang Y, Han MJ, Park YK, Lee JY. Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners. J Nutr Biochem. 2018 12; 62:202-209. PMID: 30308382

Pham TX, Bae M, Lee Y, Park YK, Lee JY. Transcriptional and posttranscriptional repression of histone deacetylases by docosahexaenoic acid in macrophages. J Nutr Biochem. 2018 07; 57:162-169. PMID: 29734115

Pham TX, Lee JY. Epigenetic Regulation of Adipokines. Int J Mol Sci. 2017 Aug 10; 18(8). PMID: 28796178; PMCID: PMC5578130; DOI: 10.3390/ijms18081740;

Pham TX, Park YK, Bae M, Lee JY. The Potential Role of an Endotoxin Tolerance-Like Mechanism for the Anti-Inflammatory Effect of Spirulina platensis Organic Extract in Macrophages. J Med Food. 2017 Mar; 20(3):201-210. PMID: 28121488

Yang Y, Bae M, Park YK, Lee Y, Pham TX, Rudraiah S, Manautou J, Koo SI, Lee JY. Histone deacetylase 9 plays a role in the antifibrogenic effect of astaxanthin in hepatic stellate cells. J Nutr Biochem. 2017 02; 40:172-177. PMID: 27915160

Kim B, Lee SG, Park YK, Ku CS, Pham TX, Wegner CJ, Yang Y, Koo SI, Chun OK, Lee JY. Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice. Nutr Res Pract. 2016 Oct; 10(5):494-500. PMID: 27698956

Pham TX, Park YK, Lee JY. Anti-Inflammatory Effects of Spirulina platensis Extract via the Modulation of Histone Deacetylases. Nutrients. 2016 Jun 21; 8(6). PMID: 27338466

Pham TX, Lee JY. Anti-Inflammatory Effect of Spirulina platensis in Macrophages Is Beneficial for Adipocyte Differentiation and Maturation by Inhibiting Nuclear Factor-?B Pathway in 3T3-L1 Adipocytes. J Med Food. 2016 Jun; 19(6):535-42. PMID: 27206252

Kim B, Farruggia C, Ku CS, Pham TX, Yang Y, Bae M, Wegner CJ, Farrell NJ, Harness E, Park YK, Koo SI, Lee JY. Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis. J Nutr Biochem. 2017 05; 43:27-35. PMID: 28193580

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 2016 Apr; 63(4):1190-204. PMID: 26404765

Ku CS, Kim B, Pham TX, Yang Y, Wegner CJ, Park YK, Balunas M, Lee JY. Blue-Green Algae Inhibit the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice. J Med Food. 2015 Dec; 18(12):1299-306. PMID: 26566121

Ku CS, Kim B, Pham TX, Yang Y, Weller CL, Carr TP, Park YK, Lee JY. Hypolipidemic Effect of a Blue-Green Alga (Nostoc commune) Is Attributed to Its Nonlipid Fraction by Decreasing Intestinal Cholesterol Absorption in C57BL/6J Mice. J Med Food. 2015 Nov; 18(11):1214-22. PMID: 26161942

Benn T, Kim B, Park YK, Yang Y, Pham TX, Ku CS, Farruggia C, Harness E, Smyth JA, Lee JY. Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol. Br J Nutr. 2015 Jun 14; 113(11):1697-703. PMID: 25899149

Yang Y, Pham TX, Wegner CJ, Kim B, Ku CS, Park YK, Lee JY. Astaxanthin lowers plasma TAG concentrations and increases hepatic antioxidant gene expression in diet-induced obesity mice. Br J Nutr. 2014 Dec 14; 112(11):1797-804. PMID: 25328157

Lee SG, Kim B, Yang Y, Pham TX, Park YK, Manatou J, Koo SI, Chun OK, Lee JY. Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-?B independent of NRF2-mediated mechanism. J Nutr Biochem. 2014 Apr; 25(4):404-11. PMID: 24565673

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 39 publications over 12 distinct years, with a maximum of 7 publications in 2021 and 2022

Bar chart showing 39 publications over 12 distinct years, with a maximum of 7 publications in 2021 and 2022

Year	Publications
2013	1
2014	1
2015	4
2016	5
2017	2
2018	2
2019	3
2020	4
2021	7
2022	7
2023	1
2024	2

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