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PhD, Harvard University

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Pharmacology & Experimental Therapeutics Faculty

ORCID : 0000-0001-5022-6049

Research
Publications

NIH RePORTER Research

Title

Yr	Title	Project-Sub Proj	Pubs
1998	PARTIAL AGONISM AND MODULATION OF GABA RECEPTOR FUNCTION	5R01NS035700-03	1
1997	PARTIAL AGONISM AND MODULATION OF GABA RECEPTOR FUNCTION	5R01NS035700-02	1
1996	PARTIAL AGONISM AND MODULATION OF GABA RECEPTOR FUNCTION	1R01NS035700-01	1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Oblak A, Gibbs TT, Blatt GJ. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism Res. 2013 Dec; 6(6):571-83.View Related Profiles.

Oblak, Adrian
Blatt, Gene
Gibbs, Terrell

PMID: 23894004; PMCID: PMC3859849; DOI: 10.1002/aur.1317;

Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH. The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol. 2013 Aug; 84(2):261-74.View Related Profiles.

Farb, David
Russek, Shelley
Martin, Stella
Gibbs, Terrell

PMID: 23716622; PMCID: PMC3716320; DOI: 10.1124/mol.113.085696;

Kostakis E, Jang MK, Russek SJ, Gibbs TT, Farb DH. A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons. J Neurochem. 2011 Nov; 119(3):486-96.View Related Profiles.

Farb, David
Russek, Shelley
Gibbs, Terrell

PMID: 21883211; PMCID: PMC3360518; DOI: 10.1111/j.1471-4159.2011.07442.x;

Oblak AL, Gibbs TT, Blatt GJ. Reduced GABAA receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2011 Mar 22; 1380:218-28.View Related Profiles.

Oblak, Adrian
Blatt, Gene
Gibbs, Terrell

PMID: 20858465; PMCID: PMC3020259; DOI: 10.1016/j.brainres.2010.09.021;

Oblak AL, Gibbs TT, Blatt GJ. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. J Neurochem. 2010 Sep 1; 114(5):1414-23.View Related Profiles.

Oblak, Adrian
Blatt, Gene
Gibbs, Terrell

PMID: 20557420; PMCID: PMC2923229; DOI: 10.1111/j.1471-4159.2010.06858.x;

Oblak A, Gibbs TT, Blatt GJ. Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Res. 2009 Aug; 2(4):205-19.View Related Profiles.

Oblak, Adrian
Blatt, Gene
Gibbs, Terrell

PMID: 19650112; PMCID: PMC2762426; DOI: 10.1002/aur.88;

Berezhnoy D, Gibbs TT, Farb DH. Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site. Mol Pharmacol. 2009 Aug; 76(2):440-50.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 19483108; PMCID: PMC2713131; DOI: 10.1124/mol.109.054650;

Sadri-Vakili G, Janis GC, Pierce RC, Gibbs TT, Farb DH. Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo. J Pharmacol Exp Ther. 2008 Dec; 327(3):840-5.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 18772319; PMCID: PMC2864155; DOI: 10.1124/jpet.108.143958;

Whittaker MT, Gibbs TT, Farb DH. Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum. J Neurochem. 2008 Oct; 107(2):510-21.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 18710414; PMCID: PMC2752276; DOI: 10.1111/j.1471-4159.2008.05627.x;

Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Pharmacological Properties of DOV 315,090, an ocinaplon metabolite. BMC Pharmacol. 2008; 8:11.View Related Profiles.

Farb, David
Downing, Scott
Gibbs, Terrell

PMID: 18554397; PMCID: PMC2529273; DOI: 10.1186/1471-2210-8-11;

Showing 10 of 45 results. Show More

Guptill JT, Booker AB, Gibbs TT, Kemper TL, Bauman ML, Blatt GJ. [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. J Autism Dev Disord. 2007 May; 37(5):911-20.View Related Profiles.

Blatt, Gene
Bauman, Margaret
Gibbs, Terrell
Kemper, Thomas

PMID: 17019626

Gibbs TT, Russek SJ, Farb DH. Sulfated steroids as endogenous neuromodulators. Pharmacol Biochem Behav. 2006 Aug; 84(4):555-67.View Related Profiles.

Farb, David
Russek, Shelley
Gibbs, Terrell

PMID: 17023038

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors. J Pharmacol Exp Ther. 2006 Dec; 319(3):1244-52.View Related Profiles.

Farb, David
Russek, Shelley
Gibbs, Terrell

PMID: 16971504

Downing SS, Lee YT, Farb DH, Gibbs TT. Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation. Br J Pharmacol. 2005 Aug; 145(7):894-906.View Related Profiles.

Farb, David
Downing, Scott
Gibbs, Terrell

PMID: 15912137; PMCID: PMC1576208; DOI: 10.1038/sj.bjp.0706251;

Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7380-5.View Related Profiles.

Farb, David
Russek, Shelley
Gibbs, Terrell

PMID: 15870187; PMCID: PMC1129138; DOI: 10.1073/pnas.0502579102;

Sadri-Vakili G, Johnson DW, Janis GC, Gibbs TT, Pierce RC, Farb DH. Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate. J Neurochem. 2003 Jul; 86(1):92-101.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 12807429

Malayev A, Gibbs TT, Farb DH. Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids. Br J Pharmacol. 2002 Feb; 135(4):901-9.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 11861317; PMCID: PMC1573207

Lyons HR, Land MB, Gibbs TT, Farb DH. Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels. J Neurochem. 2001 Sep; 78(5):1114-26.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 11553685

Gibbs TT, Farb DH. Dueling enigmas: neurosteroids and sigma receptors in the limelight. Sci STKE. 2000 Nov 28; 2000(60):pe1.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 11752623

Weaver CE, Land MB, Purdy RH, Richards KG, Gibbs TT, Farb DH. Geometry and charge determine pharmacological effects of steroids on N-methyl-D-aspartate receptor-induced Ca(2+) accumulation and cell death. J Pharmacol Exp Ther. 2000 Jun; 293(3):747-54.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 10869372

Lyons HR, Gibbs TT, Farb DH. Turnover and down-regulation of GABA(A) receptor alpha1, beta2S, and gamma1 subunit mRNAs by neurons in culture. J Neurochem. 2000 Mar; 74(3):1041-8.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 10693935

Park-Chung M, Malayev A, Purdy RH, Gibbs TT, Farb DH. Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites. Brain Res. 1999 May 29; 830(1):72-87.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 10350561

Weaver CE, Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons. Brain Res. 1998 Aug 24; 803(1-2):129-36.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 9729331

Yaghoubi N, Malayev A, Russek SJ, Gibbs TT, Farb DH. Neurosteroid modulation of recombinant ionotropic glutamate receptors. Brain Res. 1998 Aug 24; 803(1-2):153-60.View Related Profiles.

Farb, David
Russek, Shelley
Gibbs, Terrell

PMID: 9729352

Park-Chung M, Wu FS, Purdy RH, Malayev AA, Gibbs TT, Farb DH. Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids. Mol Pharmacol. 1997 Dec; 52(6):1113-23.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 9396781

Weaver CE, Park-Chung M, Gibbs TT, Farb DH. 17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors. Brain Res. 1997 Jul 4; 761(2):338-41.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 9252035

Friedman LK, Gibbs TT, Farb DH. gamma-aminobutyric acidA receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture. Brain Res. 1996 Jan 22; 707(1):100-9.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 8866718

Gyenes M, Wang Q, Gibbs TT, Farb DH. Phosphorylation factors control neurotransmitter and neuromodulator actions at the gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1994 Sep; 46(3):542-9.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 7935336

Wu FS, Gibbs TT, Farb DH. Dual activation of GABAA and glycine receptors by beta-alanine: inverse modulation by progesterone and 5 alpha-pregnan-3 alpha-ol-20-one. Eur J Pharmacol. 1993 Aug 15; 246(3):239-46.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 8223947

Friedman L, Gibbs TT, Farb DH. Gamma-aminobutyric acidA receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. Mol Pharmacol. 1993 Jul; 44(1):191-7.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 8393520

Farb DH, Gibbs TT, Wu FS, Gyenes M, Friedman L, Russek SJ. Steroid modulation of amino acid neurotransmitter receptors. Adv Biochem Psychopharmacol. 1992; 47:119-31.View Related Profiles.

Farb, David
Russek, Shelley
Gibbs, Terrell

PMID: 1324566

Celentano JJ, Gyenes M, Gibbs TT, Farb DH. Negative modulation of the gamma-aminobutyric acid response by extracellular zinc. Mol Pharmacol. 1991 Nov; 40(5):766-73.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 1658609

Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol. 1991 Sep; 40(3):333-6.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 1654510

Borden LA, Gibbs TT. Flunitrazepam photoaffinity labeling of the GABA(A) receptor reduces inhibition of [3H]Ro15-4513 binding by GABA. Eur J Pharmacol. 1990 Jun 12; 188(6):391-7. PMID: 2164940

Roca DJ, Schiller GD, Friedman L, Rozenberg I, Gibbs TT, Farb DH. gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines. Mol Pharmacol. 1990 May; 37(5):710-9.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 1692607

Wu FS, Gibbs TT, Farb DH. Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone. Mol Pharmacol. 1990 May; 37(5):597-602.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 2338942

Farrant M, Gibbs TT, Farb DH. Molecular and cellular mechanisms of GABA/benzodiazepine-receptor regulation: electrophysiological and biochemical studies. Neurochem Res. 1990 Feb; 15(2):175-91.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 2159123

Czajkowski C, Gibbs TT, Farb DH. Transmembrane topology of the gamma-aminobutyric acidA/benzodiazepine receptor: subcellular distribution and allosteric coupling determined in situ. Mol Pharmacol. 1989 Jan; 35(1):75-84.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 2536471

Celentano JJ, Gibbs TT, Farb DH. Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons. Brain Res. 1988 Jul 12; 455(2):377-80.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 2900060

Gibbs TT, Mierlak D, Gyenes M, Celentano JJ, Farb DH. Functional and structural correlates of GABA receptor modulation. Adv Biochem Psychopharmacol. 1988; 45:95-107.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 2845741

Borden LA, Gibbs TT, Farb DH. Identification, characterization, and developmental regulation of embryonic benzodiazepine binding sites. J Neurosci. 1987 Jun; 7(6):1902-10.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 3598653

Farb DH, Czajkowski CM, Borden LA, Schiller GD, Gibbs TT. Turnover of the benzodiazepine/gamma-aminobutyric acid receptor complex determined in situ. Adv Biochem Psychopharmacol. 1986; 41:51-66.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 3017074

Gibbs TT, Chan CY, Czajkowski CM, Farb DH. Benzodiazepine receptor photoaffinity labeling: correlation of function with binding. Eur J Pharmacol. 1985 Apr 2; 110(2):171-80.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 2985408

Farb DH, Borden LA, Chan CY, Czajkowski CM, Gibbs TT, Schiller GD. Modulation of neuronal function through benzodiazepine receptors: biochemical and electrophysiological studies of neurons in primary monolayer cell culture. Ann N Y Acad Sci. 1984; 435:1-31.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 6099704

Chan CY, Gibbs TT, Borden LA, Farb DH. Multiple embryonic benzodiazepine binding sites: evidence for functionality. Life Sci. 1983 Nov 21; 33(21):2061-9.View Related Profiles.

Farb, David
Gibbs, Terrell

PMID: 6316055

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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