Steven Craig Borkan, MD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Nephrology

MD, University of Cincinnati
BS, University of Michigan at Ann Arbor



Steven C. Borkan, M.D. is an Associate Professor of Medicine at Boston University and an attending physician in the Renal Section at Boston Medical Center. His interests include education of medical students and house staff, basic research on the cellular mechanisms of ischemic acute renal failure and the care of patients with both general medical and renal diseases. Dr. Borkan is the senior author of almost 40 peer reviewed publications in the area of the cellular stress response to acute ischemia and has been a Principal Investigator for the NIH for about 20 years. Dr. Borkan has also received several awards for excellence in teaching from medical students, house staff and colleagues at Boston Medical Center. Most recently, he was a finalist for the Metcalf Teaching Award at Boston University for full-time faculty and received the Grant V. Rodkey award from the Massachusetts Medical Society for significant contributions to medical student education and mentoring. As a teacher, Dr. Borkan is known for his ability to link challenging clinical problems with physiologic principals in manner that is memorable and enjoyable.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Rapid Point-of-Care Diagnostic Test for Acute Kidney Injury
01/02/2019 - 04/02/2019 (PI)
Comm. of Mass./Massachusetts Technology Transfer Center



Nucleophosmin Centered Diagnostics and Treatment of Ischemic Acute Kidney Injury
04/01/2023 - 03/31/2025 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2R01DK118267-04

Nucleophosmin Centered Diagnostics and Treatment of Ischemic Acute Kidney Injury
06/01/2020 - 03/31/2024 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
5R01DK118267-03

NPM-Based Peptide Therapeutic for Acute Kidney Injury (AKI)
05/20/2021 - 10/01/2021 (PI)
MassVentures

Cytoprotective Role of HSP72 in Renal Cell Injury
06/01/2013 - 05/31/2018 (PI)
NIH-NIDDK
4R01DK053387-16

Cytoprotective Role of HSP72 in Renal Cell Injury
06/01/2013 - 05/31/2018 (PI)
NIH-NIDDK
5R01DK053387-14

Cytoprotective Role of HSP72 in Renal Cell Injury
06/01/2010 - 05/31/2013 (PI)
NIH-NIDDK
5R01 DK053387-12

Bridge Funding - role of Hsp72
07/01/2008 - 06/30/2009 (PI)
Amer Soc Nephrology

Cytoprotective Role of HSP72 in Renal Cell Injury
07/01/2003 - 06/30/2009 (PI)
NIH-NIDDK
5R01DK053387-09 (B)

Cytoprotective Role Of Hspt2 I
07/01/1999 - 06/30/2003 (PI)
NIH-NIDDK
5 R01 DK53387-04 (A)

Retrograde Protein Transport I
04/21/1997 - 01/31/2000 (PI)
NIH-NIDDK
5 R29 DK47994-05


Title


Yr Title Project-Sub Proj Pubs
2023 Nucleophosmin Centered Diagnostics and Treatment of Ischemic Acute Kidney Injury 2R01DK118267-04
2021 Nucleophosmin Centered Diagnostics and Treatment of Ischemic Acute Kidney Injury 5R01DK118267-03
2020 Nucleophosmin Centered Diagnostics and Treatment of Ischemic Acute Kidney Injury 5R01DK118267-02
2019 Nucleophosmin Centered Diagnostics and Treatment of Ischemic Acute Kidney Injury 1R01DK118267-01A1
2016 Cytoprotective Role of HSP72 in Renal Cell Injury 4R01DK053387-16 22
2015 Cytoprotective Role of HSP72 in Renal Cell Injury 5R01DK053387-15 22
2014 Cytoprotective Role of HSP72 in Renal Cell Injury 5R01DK053387-14 22
2013 Cytoprotective Role of HSP72 in Renal Cell Injury 2R01DK053387-13A1 22
2012 Cytoprotective Role of HSP72 in Renal Cell Injury 5R01DK053387-12 22
2011 Cytoprotective Role of HSP72 in Renal Cell Injury 5R01DK053387-11 22
Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kamel MH, Upadhyay A, Borkan SC. Intractable hyponatremia complicated by a reset osmostat: a case report. J Med Case Rep. 2023 Jan 14; 17(1):13.View Related Profiles. PMID: 36639685; PMCID: PMC9840259; DOI: 10.1186/s13256-022-03732-w;
     
  2. Wang Z, Havasi A, Beeler AA, Borkan SC. Mechanisms of nucleophosmin (NPM)-mediated regulated cell death elucidated by Hsp70 during renal ischemia. Apoptosis. 2022 02; 27(1-2):22-33.View Related Profiles. PMID: 34762220
     
  3. Lowe RC, Borkan SC. Effective Medical Lecturing: Practice Becomes Theory: A Narrative Review. Med Sci Educ. 2021 Apr; 31(2):935-943.View Related Profiles. PMID: 33457070; PMCID: PMC7800837; DOI: 10.1007/s40670-020-01172-z;
     
  4. Wang Z, Belghasem M, Salih E, Henderson J, Igwebuike C, Havasi A, Borkan SC. T95 nucleophosmin phosphorylation as a novel mediator and marker of regulated cell death in acute kidney injury. Am J Physiol Renal Physiol. 2020 09 01; 319(3):F552-F561.View Related Profiles. PMID: 32686519; PMCID: PMC7509286; DOI: 10.1152/ajprenal.00230.2020;
     
  5. Igwebuike C, Yaglom J, Huiting L, Feng H, Campbell JD, Wang Z, Havasi A, Pimentel D, Sherman MY, Borkan SC. Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity. Cell Death Dis. 2020 04 03; 11(4):217.View Related Profiles. PMID: 32245975; PMCID: PMC7125232; DOI: 10.1038/s41419-020-2382-7;
     
  6. Wang Z, Salih E, Igwebuike C, Mulhern R, Bonegio RG, Havasi A, Borkan SC. Nucleophosmin Phosphorylation as a Diagnostic and Therapeutic Target for Ischemic AKI. J Am Soc Nephrol. 2019 01; 30(1):50-62.View Related Profiles. PMID: 30573638; PMCID: PMC6317607; DOI: 10.1681/ASN.2018040401;
     
  7. Wang Z, Gall JM, Bonegio R, Havasi A, Illanes K, Schwartz JH, Borkan SC. Correction for Wang et al., "Nucleophosmin, a Critical Bax Cofactor in Ischemia-Induced Cell Death". Mol Cell Biol. 2017 10 01; 37(19).View Related Profiles. PMID: 28899998; PMCID: PMC5599719; DOI: 10.1128/MCB.00258-17;
     
  8. Jaberi A, Seth B, Steenkamp D, Alexanian S, Borkan SC. Sodium-Glucose Cotransporter 2 Inhibitors and Euglycemic Diabetic Ketoacidosis: Metabolic Acidosis With a Twist. Clin Diabetes. 2016 Oct; 34(4):214-216.View Related Profiles. PMID: 27766015; PMCID: PMC5070590; DOI: 10.2337/cd16-0001;
     
  9. Havasi A, Lu W, Cohen HT, Beck L, Wang Z, Igwebuike C, Borkan SC. Blocking peptides and molecular mimicry as treatment for kidney disease. Am J Physiol Renal Physiol. 2017 Jun 01; 312(6):F1016-F1025.View Related Profiles. PMID: 27654896; PMCID: PMC5495884; DOI: 10.1152/ajprenal.00601.2015;
     
  10. Nolin AC, Mulhern RM, Panchenko MV, Pisarek-Horowitz A, Wang Z, Shirihai O, Borkan SC, Havasi A. Proteinuria causes dysfunctional autophagy in the proximal tubule. Am J Physiol Renal Physiol. 2016 Dec 01; 311(6):F1271-F1279.View Related Profiles. PMID: 27582098; PMCID: PMC5210197; DOI: 10.1152/ajprenal.00125.2016;
     
Showing 10 of 56 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 55 publications over 31 distinct years, with a maximum of 4 publications in 2002 and 2016

YearPublications
19861
19871
19881
19891
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19911
19931
19962
19971
19981
19992
20002
20011
20024
20032
20042
20052
20063
20083
20092
20102
20113
20122
20131
20142
20164
20171
20191
20202
20212
20231
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

apoptosis
BCL proteins
cell biology
ischemia
kidney
mitochondria
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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