Stephen Farmer | Profiles RNS

Stephen Farmer, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, National Institute for Medical Research (NIMR)
BSc, University of Liverpool

Websites

Biochemistry Faculty

ORCID : 0000-0003-2483-2795

Obesity has now reached pandemic proportions, resulting in dramatic increases in the occurrence of its associated disorders including diabetes and cardiovascular disease. Understanding the processes and metabolic perturbations that contribute to the expansion of adipose depots accompanying obesity is critical for the development of appropriate therapeutics. Expansion of white adipose (WAT) tissue depots particularly the intra-abdominal depots contribute to insulin resistance and inflammation that lead to type 2 diabetes, whereas brown adipose (BAT) resists expansion because it oxidizes lipids and, consequently, it is associated with an healthier phenotype. Our studies are focused on identifying the mechanisms regulating the formation and function of white and brown adipocytes (fat cells) using a variety of experimental approaches including overexpression and knock down of specific nuclear factors that we consider to be likely regulators of these processes in cells in culture as well as in mice. At present our focus is on nuclear factors that modulate the activity of the two principal regulators of adipogenesis (fat cell differentiation) peroxisome proliferator-activated receptor gamma (PPARg) and CCAAT/enhancer binding proteins alpha, beta and delta (C/EBPs). We are particularly interested in identifying the factors regulating commitment of mesenchymal progenitors to the adipogenic lineage and are adopting a variety of approaches to achieve this goal, which includes gene profiling to discover novel regulators as well as investigating the role of selected candidate genes.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston Medical Center

Member
Boston University
Genome Science Institute

BU Research
NIH RePORTER Research

Deconstructing the diet-induced remodeling of adipose tissue
03/01/2023 - 02/28/2027 (Multi-PI)
PI: Stephen Farmer, PhD
NIH/National Diabetes & Digestive & Kidney Diseases
1R01DK134534-01

Elucidating ACLP-dependent signaling pathways in the adipose tissue stromal-vascular niche
04/15/2022 - 03/31/2026 (Key Person)
PI: Matthew D. Layne, PhD
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK132080-02

Boston Nutrition Obesity Research Center - Administrative Supplement
06/01/2019 - 05/31/2023 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
3P30DK046200-27S1

Boston Nutrition Obesity Research Center - ABM Core
11/01/2018 - 05/31/2023 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
3P30DK046200-29

Therapeutic strategies to induce browning of white adipose tissue
07/19/2019 - 04/30/2023 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK117163-03

Healthy Remodeling of Obese Adipose Tissue
03/01/2018 - 03/31/2022 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK117161-04

Healthier White Adipose by recruitment of Beige/Brite Adipocytes
04/16/2014 - 02/28/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK102199-04

The Role of MRTFA in Adipose Tissue Remodeling
03/01/2017 - 02/28/2018 (Key Person / Mentor)
NIH/National Diabetes & Digestive & Kidney Diseases
3F32DK109635-01A1S1

Study of the molecular mechanisms of white adipose tissue browning after treatment with the cyclin dependent kinases (CDK's) inhibitor the Seliciclib
06/01/2016 - 05/31/2017 (Key Person / Mentor)
PI: Nabil Rabhi, PhD
Societe Francophone du Diabete

Enhancing Energy Expending Adipocytes in White Adipose Tissue
04/01/2016 - 03/31/2017 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
4R01DK098830-04

Showing 10 of 12 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Deconstructing the diet-induced remodeling of adipose tissue	5R01DK134534-02
2023	Deconstructing the diet-induced remodeling of adipose tissue	1R01DK134534-01
2021	Therapeutic strategies to induce browning of white adipose tissue	5R01DK117163-03
2021	Healthy Remodeling of Obese Adipose Tissue	5R01DK117161-04
2020	Therapeutic strategies to induce browning of white adipose tissue	5R01DK117163-02
2020	Healthy Remodeling of Obese Adipose Tissue	5R01DK117161-03
2019	Therapeutic strategies to induce browning of white adipose tissue	1R01DK117163-01A1
2019	Healthy Remodeling of Obese Adipose Tissue	5R01DK117161-02
2018	Healthy Remodeling of Obese Adipose Tissue	1R01DK117161-01
2017	Healthier White Adipose by Recruitment of Beige/Brite Adipocytes	5R01DK102199-04	5

Showing 10 of 51 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Hu AJ, Li W, Dinh C, Zhang Y, Hu JK, Daniele SG, Hou X, Yang Z, Asara JM, Hu GF, Farmer SR, Hu MG. CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver. Nat Commun. 2024 Feb 05; 15(1):1091. PMID: 38316780; PMCID: PMC10844593; DOI: 10.1038/s41467-024-45294-z;

Santos KBNH, Knobl P, Henriques F, Lopes MA, Franco FO, Bueno LL, Farmer SR, Batista ML. Pathological beige remodeling induced by cancer cachexia depends on the disease severity and involves mainly the trans-differentiation of mature white adipocytes. bioRxiv. 2023 Sep 18. PMID: 37781595; PMCID: PMC10541144; DOI: 10.1101/2023.09.18.558327;

Desevin K, Cortez BN, Lin JZ, Lama D, Layne MD, Farmer SR, Rabhi N. Adrenergic Reprogramming of Preexisting Adipogenic Trajectories Steer Naïve Mural Cells Toward Beige Differentiation. bioRxiv. 2023 Aug 26.View Related Profiles.

Layne, Matthew
Rabhi, Nabil
Farmer, Stephen

PMID: 37662295; PMCID: PMC10473761; DOI: 10.1101/2023.08.26.554950;

Hu AJ, Li W, Pathak A, Hu GF, Hou X, Farmer SR, Hu MG. CDK6 is essential for mesenchymal stem cell proliferation and adipocyte differentiation. Front Mol Biosci. 2023; 10:1146047. PMID: 37664186; PMCID: PMC10469316; DOI: 10.3389/fmolb.2023.1146047;

Lotfollahzadeh S, Xia C, Amraei R, Hua N, Kandror KV, Farmer SR, Wei W, Costello CE, Chitalia V, Rahimi N. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Mol Metab. 2023 Jul; 73:101744.View Related Profiles.

Costello, Catherine
Kandror, Konstantin
Rahimi, Nader
Hua, Ning
Farmer, Stephen
Chitalia, Vipul

PMID: 37245847; PMCID: PMC10267597; DOI: 10.1016/j.molmet.2023.101744;

Dance YW, Obenreder MC, Seibel AJ, Meshulam T, Ogony JW, Lahiri N, Pacheco-Spann L, Radisky DC, Layne MD, Farmer SR, Nelson CM, Tien J. Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status. Cell Mol Bioeng. 2023 Feb; 16(1):23-39.View Related Profiles.

Tien, Joe
Layne, Matthew
Farmer, Stephen
Meshulam, Tova

PMID: 36660589; PMCID: PMC9842842; DOI: 10.1007/s12195-022-00750-y;

Rabhi N, Desevin K, Belkina AC, Tilston-Lunel A, Varelas X, Layne MD, Farmer SR. Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Sci Alliance. 2022 05; 5(5).View Related Profiles.

Tilston-Lunel, Andrew
Belkina, Anna
Layne, Matthew
Rabhi, Nabil
Farmer, Stephen
Varelas, Xaralabos

PMID: 35181634; PMCID: PMC8860101; DOI: 10.26508/lsa.202101286;

Jafari N, Kolla M, Meshulam T, Shafran JS, Qiu Y, Casey AN, Pompa IR, Ennis CS, Mazzeo CS, Rabhi N, Farmer SR, Denis GV. Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes. Sci Signal. 2021 11 23; 14(710):eabj2807.View Related Profiles.

Denis, Gerald
Rabhi, Nabil
Jafari, Naser
Farmer, Stephen
Meshulam, Tova

PMID: 34813359; PMCID: PMC8765301; DOI: 10.1126/scisignal.abj2807;

Biagi CAO, Cury SS, Alves CP, Rabhi N, Silva WA, Farmer SR, Carvalho RF, Batista ML. Multidimensional Single-Nuclei RNA-Seq Reconstruction of Adipose Tissue Reveals Adipocyte Plasticity Underlying Thermogenic Response. Cells. 2021 11 08; 10(11).View Related Profiles.

Rabhi, Nabil
Farmer, Stephen

PMID: 34831295; PMCID: PMC8618495; DOI: 10.3390/cells10113073;

Rabhi N, Farmer SR. Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies. Genes Dev. 2021 11 01; 35(21-22):1395-1397.View Related Profiles.

Rabhi, Nabil
Farmer, Stephen

PMID: 34725126; PMCID: PMC8559673; DOI: 10.1101/gad.349053.121;

Showing 10 of 113 results. Show More

Rabhi N, Desevin K, Cortez BN, Hekman R, Lin JZ, Emili A, Farmer SR. The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice. Sci Rep. 2021 10 13; 11(1):20365.View Related Profiles.

Emili, Andrew
Rabhi, Nabil
Farmer, Stephen

PMID: 34645915; PMCID: PMC8514475; DOI: 10.1038/s41598-021-99871-z;

Wang D, Rabhi N, Yet SF, Farmer SR, Layne MD. Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A. Sci Rep. 2021 02 17; 11(1):3948.View Related Profiles.

Layne, Matthew
Rabhi, Nabil
Farmer, Stephen

PMID: 33597582; PMCID: PMC7889889; DOI: 10.1038/s41598-021-82941-7;

Batista ML, Meshulam T, Desevin K, Rabhi N, Farmer SR. Three-Dimensional Adipocyte Culture as a Model to Study Cachexia-Induced White Adipose Tissue Remodeling. J Vis Exp. 2021 01 18; (167).View Related Profiles.

Rabhi, Nabil
Farmer, Stephen
Meshulam, Tova

PMID: 33522508

Rabhi N, Belkina AC, Desevin K, Cortez BN, Farmer SR. Shifts of Immune Cell Populations Differ in Response to Different Effectors of Beige Remodeling of Adipose Tissue. iScience. 2020 Dec 18; 23(12):101765.View Related Profiles.

Belkina, Anna
Rabhi, Nabil
Farmer, Stephen

PMID: 33294778; PMCID: PMC7683338; DOI: 10.1016/j.isci.2020.101765;

Kim S, Rabhi N, Blum BC, Hekman R, Wynne K, Emili A, Farmer S, Schlezinger JJ. Triphenyl phosphate is a selective PPAR? modulator that does not induce brite adipogenesis in vitro and in vivo. Arch Toxicol. 2020 09; 94(9):3087-3103.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Schlezinger, Jennifer
Rabhi, Nabil
Farmer, Stephen

PMID: 32683515; PMCID: PMC7443879; DOI: 10.1007/s00204-020-02815-1;

Jones JEC, Rabhi N, Orofino J, Gamini R, Perissi V, Vernochet C, Farmer SR. The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet. Sci Rep. 2020 02 11; 10(1):2380.View Related Profiles.

Jones, Jessica
Rabhi, Nabil
Farmer, Stephen
Perissi, Valentina

PMID: 32047213; PMCID: PMC7012923; DOI: 10.1038/s41598-020-59284-w;

Jash S, Banerjee S, Lee MJ, Farmer SR, Puri V. CIDEA Transcriptionally Regulates UCP1 for Britening and Thermogenesis in Human Fat Cells. iScience. 2019 Oct 25; 20:73-89. PMID: 31563853; PMCID: PMC6817690; DOI: 10.1016/j.isci.2019.09.011;

Rabhi N, Farmer SR. Adipose Progenitor Cells Contribute to Lipid Spillover during Obesity. Trends Endocrinol Metab. 2019 07; 30(7):416-418.View Related Profiles.

Rabhi, Nabil
Farmer, Stephen

PMID: 31153731

Farmer SR. Boning Up on Irisin. N Engl J Med. 2019 04 11; 380(15):1480-1482. PMID: 30970196

Henriques F, Lopes MA, Franco FO, Knobl P, Santos KB, Bueno LL, Correa VA, Bedard AH, Guilherme A, Birbrair A, Peres SB, Farmer SR, Batista ML. Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome. Sci Rep. 2018 12 21; 8(1):18024. PMID: 30575787; PMCID: PMC6303407; DOI: 10.1038/s41598-018-36626-3;

Jager M, Lee MJ, Li C, Farmer SR, Fried SK, Layne MD. Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue. PLoS One. 2018; 13(5):e0197777.View Related Profiles.

Li, Chendi
Layne, Matthew
Jager, Mike
Farmer, Stephen
Fried, Susan

PMID: 29799877; PMCID: PMC5969754; DOI: 10.1371/journal.pone.0197777;

Lin JZ, Rabhi N, Farmer SR. Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis. Cell Rep. 2018 05 15; 23(7):1977-1987.View Related Profiles.

Rabhi, Nabil
Farmer, Stephen

PMID: 29768198; PMCID: PMC6675460; DOI: 10.1016/j.celrep.2018.04.057;

Hou X, Zhang Y, Li W, Hu AJ, Luo C, Zhou W, Hu JK, Daniele SG, Wang J, Sheng J, Fan Y, Greenberg AS, Farmer SR, Hu MG. CDK6 inhibits white to beige fat transition by suppressing RUNX1. Nat Commun. 2018 03 09; 9(1):1023. PMID: 29523786; PMCID: PMC5845007; DOI: 10.1038/s41467-018-03451-1;

Wang H, Liu L, Lin JZ, Aprahamian TR, Farmer SR. Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes. Cell Metab. 2016 Dec 13; 24(6):835-847.View Related Profiles.

Liu, Libin
Farmer, Stephen
Aprahamian, Tamar

PMID: 27974179; PMCID: PMC6674884; DOI: 10.1016/j.cmet.2016.10.005;

Bian H, Lin JZ, Li C, Farmer SR. Myocardin-related transcription factor A (MRTFA) regulates the fate of bone marrow mesenchymal stem cells and its absence in mice leads to osteopenia. Mol Metab. 2016 Oct; 5(10):970-9.View Related Profiles.

Li, Chendi
Bian, Hejiao
Farmer, Stephen

PMID: 27689009; PMCID: PMC5034694; DOI: 10.1016/j.molmet.2016.08.012;

Lin JZ, Farmer SR. LSD1-a pivotal epigenetic regulator of brown and beige fat differentiation and homeostasis. Genes Dev. 2016 Aug 15; 30(16):1793-5. PMID: 27601528; PMCID: PMC5024678; DOI: 10.1101/gad.288720.116;

Lin JZ, Farmer SR. Morphogenetics in brown, beige and white fat development. Adipocyte. 2016 Apr-Jun; 5(2):130-5. PMID: 27386157; PMCID: PMC4916862; DOI: 10.1080/21623945.2016.1140708;

Beluzi M, Peres SB, Henriques FS, Sertié RA, Franco FO, Santos KB, Knobl P, Andreotti S, Shida CS, Neves RX, Farmer SR, Seelaender M, Lima FB, Batista ML. Pioglitazone treatment increases survival and prevents body weight loss in tumor-bearing animals: possible anti-cachectic effect. PLoS One. 2015; 10(3):e0122660. PMID: 25807446; PMCID: PMC4373945; DOI: 10.1371/journal.pone.0122660;

McDonald ME, Li C, Bian H, Smith BD, Layne MD, Farmer SR. Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes. Cell. 2015 Jan 15; 160(1-2):105-18.View Related Profiles.

Smith, Barbara
Li, Chendi
Bian, Hejiao
Layne, Matthew
Farmer, Stephen

PMID: 25579684; PMCID: PMC4384505; DOI: 10.1016/j.cell.2014.12.005;

Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26. PMID: 23291629; PMCID: PMC3567215; DOI: 10.1038/nm.3056;

Batista ML, Neves RX, Peres SB, Yamashita AS, Shida CS, Farmer SR, Seelaender M. Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia. J Endocrinol. 2012 Dec; 215(3):363-73. PMID: 23033362; DOI: 10.1530/JOE-12-0307;

Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer SR, Accili D. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppar?. Cell. 2012 Aug 3; 150(3):620-32. PMID: 22863012; PMCID: PMC3413172; DOI: 10.1016/j.cell.2012.06.027;

Pino E, Wang H, McDonald ME, Qiang L, Farmer SR. Roles for peroxisome proliferator-activated receptor ? (PPAR?) and PPAR? coactivators 1a and 1ß in regulating response of white and brown adipocytes to hypoxia. J Biol Chem. 2012 May 25; 287(22):18351-8.View Related Profiles.

Pino, Elizabeth
Farmer, Stephen

PMID: 22493496; PMCID: PMC3365780; DOI: 10.1074/jbc.M112.350918;

Boss O, Farmer SR. Recruitment of brown adipose tissue as a therapy for obesity-associated diseases. Front Endocrinol (Lausanne). 2012; 3:14. PMID: 22654854; PMCID: PMC3356088; DOI: 10.3389/fendo.2012.00014;

Karki S, Chakrabarti P, Huang G, Wang H, Farmer SR, Kandror KV. The multi-level action of fatty acids on adiponectin production by fat cells. PLoS One. 2011; 6(11):e28146.View Related Profiles.

Kandror, Konstantin
Chakrabarti, Partha
Karki, Shakun
Farmer, Stephen

PMID: 22140527; PMCID: PMC3226650; DOI: 10.1371/journal.pone.0028146;

Batista ML, Peres SB, McDonald ME, Alcantara PS, Olivan M, Otoch JP, Farmer SR, Seelaender M. Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors. Cytokine. 2012 Jan; 57(1):9-16. PMID: 22099872; DOI: 10.1016/j.cyto.2011.10.008;

Chakrabarti P, English T, Karki S, Qiang L, Tao R, Kim J, Luo Z, Farmer SR, Kandror KV. SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL. J Lipid Res. 2011 Sep; 52(9):1693-701.View Related Profiles.

Kandror, Konstantin
Chakrabarti, Partha
Karki, Shakun
Farmer, Stephen
Luo, Zhijun

PMID: 21743036; PMCID: PMC3151689; DOI: 10.1194/jlr.M014647;

Vernochet C, McDonald ME, Farmer SR. Brown adipose tissue: a promising target to combat obesity. Drug News Perspect. 2010 Sep; 23(7):409-17. PMID: 20862392; DOI: 10.1358/dnp.2010.23.7.1487083;

Vernochet C, Davis KE, Scherer PE, Farmer SR. Mechanisms regulating repression of haptoglobin production by peroxisome proliferator-activated receptor-gamma ligands in adipocytes. Endocrinology. 2010 Feb; 151(2):586-94. PMID: 19952271; PMCID: PMC2817616; DOI: 10.1210/en.2009-1057;

Vernochet C, Peres SB, Farmer SR. Mechanisms of obesity and related pathologies: transcriptional control of adipose tissue development. FEBS J. 2009 Oct; 276(20):5729-37. PMID: 19754874; DOI: 10.1111/j.1742-4658.2009.07302.x;

Alonso-Vale MI, Peres SB, Vernochet C, Farmer SR, Lima FB. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity. J Pineal Res. 2009 Oct; 47(3):221-7. PMID: 19663997; DOI: 10.1111/j.1600-079X.2009.00705.x;

Vernochet C, Peres SB, Davis KE, McDonald ME, Qiang L, Wang H, Scherer PE, Farmer SR. C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists. Mol Cell Biol. 2009 Sep; 29(17):4714-28. PMID: 19564408; PMCID: PMC2725706; DOI: 10.1128/MCB.01899-08;

Farmer SR. Obesity: Be cool, lose weight. Nature. 2009 Apr 16; 458(7240):839-40. PMID: 19370020; DOI: 10.1038/458839a;

Farmer SR. Brown fat and skeletal muscle: unlikely cousins? Cell. 2008 Sep 5; 134(5):726-7. PMID: 18775306; DOI: 10.1016/j.cell.2008.08.018;

Farmer SR. Molecular determinants of brown adipocyte formation and function. Genes Dev. 2008 May 15; 22(10):1269-75. PMID: 18483216; PMCID: PMC2732411; DOI: 10.1101/gad.1681308;

Farmer SR, Spiegelman BM. Cell Differentiation. Curr Opin Cell Biol. 2007 Dec; 19(6):603-604. PMID: 19050740; DOI: 10.1016/j.ceb.2007.11.002;

Wang H, Qiang L, Farmer SR. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol. 2008 Jan; 28(1):188-200. PMID: 17954559; PMCID: PMC2223282; DOI: 10.1128/MCB.00992-07;

Bezy O, Vernochet C, Gesta S, Farmer SR, Kahn CR. TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity. Mol Cell Biol. 2007 Oct; 27(19):6818-31. PMID: 17646392; PMCID: PMC2099230; DOI: 10.1128/MCB.00375-07;

Xu Y, Farmer SR, Smith BD. Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression. J Biol Chem. 2007 Sep 7; 282(36):26046-56.View Related Profiles.

Smith, Barbara
Farmer, Stephen

PMID: 17611194

Qiang L, Wang H, Farmer SR. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol. 2007 Jul; 27(13):4698-707. PMID: 17452443; PMCID: PMC1951471; DOI: 10.1128/MCB.02279-06;

Farmer SR. Transcriptional control of adipocyte formation. Cell Metab. 2006 Oct; 4(4):263-73. PMID: 17011499; PMCID: PMC1958996; DOI: 10.1016/j.cmet.2006.07.001;

Liu J, Wang H, Zuo Y, Farmer SR. Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin. Mol Cell Biol. 2006 Aug; 26(15):5827-37. PMID: 16847334; PMCID: PMC1592783; DOI: 10.1128/MCB.00441-06;

Karagiannides I, Thomou T, Tchkonia T, Pirtskhalava T, Kypreos KE, Cartwright A, Dalagiorgou G, Lash TL, Farmer SR, Timchenko NA, Kirkland JL. Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging. J Biol Chem. 2006 Aug 11; 281(32):23025-33. PMID: 16754681

LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E175-81.View Related Profiles.

Saha, Asish
Ruderman, Neil
Farmer, Stephen

PMID: 16464908

Zuo Y, Qiang L, Farmer SR. Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta during adipogenesis requires a peroxisome proliferator-activated receptor-gamma-associated repression of HDAC1 at the C/ebp alpha gene promoter. J Biol Chem. 2006 Mar 24; 281(12):7960-7. PMID: 16431920

Qiang L, Farmer SR. C/EBPalpha-dependent induction of glutathione S-transferase zeta/maleylacetoacetate isomerase (GSTzeta/MAAI) expression during the differentiation of mouse fibroblasts into adipocytes. Biochem Biophys Res Commun. 2006 Feb 17; 340(3):845-51. PMID: 16376852

Farmer SR. Regulation of PPARgamma activity during adipogenesis. Int J Obes (Lond). 2005 Mar; 29 Suppl 1:S13-6. PMID: 15711576

Schadinger SE, Bucher NL, Schreiber BM, Farmer SR. PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. Am J Physiol Endocrinol Metab. 2005 Jun; 288(6):E1195-205.View Related Profiles.

Schreiber, Barbara
Bucher, Nancy
Farmer, Stephen

PMID: 15644454

Farmer SR, Auwerx J. Adipose tissue: new therapeutic targets from molecular and genetic studies--IASO Stock Conference 2003 report. Obes Rev. 2004 Nov; 5(4):189-96. PMID: 15458394

Park BH, Qiang L, Farmer SR. Phosphorylation of C/EBPbeta at a consensus extracellular signal-regulated kinase/glycogen synthase kinase 3 site is required for the induction of adiponectin gene expression during the differentiation of mouse fibroblasts into adipocytes. Mol Cell Biol. 2004 Oct; 24(19):8671-80. PMID: 15367685; PMCID: PMC516726

Liu J, Farmer SR. Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J Biol Chem. 2004 Oct 22; 279(43):45020-7. PMID: 15308623

Gross DN, Farmer SR, Pilch PF. Glut4 storage vesicles without Glut4: transcriptional regulation of insulin-dependent vesicular traffic. Mol Cell Biol. 2004 Aug; 24(16):7151-62.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 15282314; PMCID: PMC479711

Davis KE, Moldes M, Farmer SR. The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation. J Biol Chem. 2004 Oct 8; 279(41):42453-61. PMID: 15277530

Moldes M, Zuo Y, Morrison RF, Silva D, Park BH, Liu J, Farmer SR. Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis. Biochem J. 2003 Dec 15; 376(Pt 3):607-13. PMID: 12954078; PMCID: PMC1223802

Farmer SR. The forkhead transcription factor Foxo1: a possible link between obesity and insulin resistance. Mol Cell. 2003 Jan; 11(1):6-8. PMID: 12535515

Prusty D, Park BH, Davis KE, Farmer SR. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes. J Biol Chem. 2002 Nov 29; 277(48):46226-32. PMID: 12270934

Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W. Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr. 2002 May; 132(5):904-10.View Related Profiles.

Corkey, Barbara
Farmer, Stephen
Guo, Wen
Ido, Yasuo

PMID: 11983812

Hamm JK, Park BH, Farmer SR. A role for C/EBPbeta in regulating peroxisome proliferator-activated receptor gamma activity during adipogenesis in 3T3-L1 preadipocytes. J Biol Chem. 2001 May 25; 276(21):18464-71. PMID: 11279134

Dixon TM, Daniel KW, Farmer SR, Collins S. CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis. J Biol Chem. 2001 Jan 5; 276(1):722-8. PMID: 11024036

Morrison RF, Farmer SR. Hormonal signaling and transcriptional control of adipocyte differentiation. J Nutr. 2000 Dec; 130(12):3116S-3121S. PMID: 11110883

Roh C, Thoidis G, Farmer SR, Kandror KV. Identification and characterization of leptin-containing intracellular compartment in rat adipose cells. Am J Physiol Endocrinol Metab. 2000 Oct; 279(4):E893-9.View Related Profiles.

Kandror, Konstantin
Farmer, Stephen

PMID: 11001773

Hamm JK, el Jack AK, Pilch PF, Farmer SR. Role of PPAR gamma in regulating adipocyte differentiation and insulin-responsive glucose uptake. Ann N Y Acad Sci. 1999 Nov 18; 892:134-45.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 10842659

Stephens JM, Morrison RF, Wu Z, Farmer SR. PPARgamma ligand-dependent induction of STAT1, STAT5A, and STAT5B during adipogenesis. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):216-22. PMID: 10448095

Morrison RF, Farmer SR. Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J Biol Chem. 1999 Jun 11; 274(24):17088-97. PMID: 10358062

Layne MD, Farmer SR. Tumor necrosis factor-alpha and basic fibroblast growth factor differentially inhibit the insulin-like growth factor-I induced expression of myogenin in C2C12 myoblasts. Exp Cell Res. 1999 May 25; 249(1):177-87.View Related Profiles.

Layne, Matthew
Farmer, Stephen

PMID: 10328964

El-Jack AK, Hamm JK, Pilch PF, Farmer SR. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha. J Biol Chem. 1999 Mar 19; 274(12):7946-51.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 10075691

Morrison RF, Farmer SR. Insights into the transcriptional control of adipocyte differentiation. J Cell Biochem. 1999; Suppl 32-33:59-67. PMID: 10629104

Fine A, Miranda K, Farmer SR, Anderson NL. Effect of insoluble extracellular matrix molecules on Fas expression in epithelial cells. J Cell Physiol. 1998 Mar; 174(3):285-92.View Related Profiles.

Fine, Alan
Farmer, Stephen

PMID: 9462690

Wu Z, Xie Y, Morrison RF, Bucher NL, Farmer SR. PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes. J Clin Invest. 1998 Jan 1; 101(1):22-32.View Related Profiles.

Bucher, Nancy
Farmer, Stephen

PMID: 9421462; PMCID: PMC508536

Milasincic DJ, Calera MR, Farmer SR, Pilch PF. Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways. Mol Cell Biol. 1996 Nov; 16(11):5964-73.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 8887626; PMCID: PMC231599

Wu Z, Bucher NL, Farmer SR. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids. Mol Cell Biol. 1996 Aug; 16(8):4128-36.View Related Profiles.

Bucher, Nancy
Farmer, Stephen

PMID: 8754811; PMCID: PMC231409

Milasincic DJ, Dhawan J, Farmer SR. Anchorage-dependent control of muscle-specific gene expression in C2C12 mouse myoblasts. In Vitro Cell Dev Biol Anim. 1996 Feb; 32(2):90-9. PMID: 8907122

Wu Z, Xie Y, Bucher NL, Farmer SR. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev. 1995 Oct 1; 9(19):2350-63.View Related Profiles.

Bucher, Nancy
Farmer, Stephen

PMID: 7557387

Rana B, Xie Y, Mischoulon D, Bucher NL, Farmer SR. The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycle. J Biol Chem. 1995 Jul 28; 270(30):18123-32.View Related Profiles.

Bucher, Nancy
Farmer, Stephen

PMID: 7629124

Jensen DE, Rich CB, Terpstra AJ, Farmer SR, Foster JA. Transcriptional regulation of the elastin gene by insulin-like growth factor-I involves disruption of Sp1 binding. Evidence for the role of Rb in mediating Sp1 binding in aortic smooth muscle cells. J Biol Chem. 1995 Mar 24; 270(12):6555-63. PMID: 7896792

Rana B, Mischoulon D, Xie Y, Bucher NL, Farmer SR. Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors. Mol Cell Biol. 1994 Sep; 14(9):5858-69.View Related Profiles.

Bucher, Nancy
Farmer, Stephen

PMID: 8065319; PMCID: PMC359112

Dhawan J, Farmer SR. Induction of collagen synthesis in response to adhesion and TGF beta is dependent on the actin-containing cytoskeleton. Adv Exp Med Biol. 1994; 358:159-68. PMID: 7801802

Mischoulon D, Rana B, Kotliar N, Pilch PF, Bucher NL, Farmer SR. Differential regulation of glucose transporter 1 and 2 mRNA expression by epidermal growth factor and transforming growth factor-beta in rat hepatocytes. J Cell Physiol. 1992 Nov; 153(2):288-96.View Related Profiles.

Bucher, Nancy
Pilch, Paul
Farmer, Stephen

PMID: 1429849

Mooney D, Hansen L, Vacanti J, Langer R, Farmer S, Ingber D. Switching from differentiation to growth in hepatocytes: control by extracellular matrix. J Cell Physiol. 1992 Jun; 151(3):497-505. PMID: 1295898

Mischoulon D, Rana B, Bucher NL, Farmer SR. Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture. Mol Cell Biol. 1992 Jun; 12(6):2553-60.View Related Profiles.

Bucher, Nancy
Farmer, Stephen

PMID: 1588957; PMCID: PMC364448

Bellas RE, Bendori R, Farmer SR. Epidermal growth factor activation of vinculin and beta 1-integrin gene transcription in quiescent Swiss 3T3 cells. Regulation through a protein kinase C-independent pathway. J Biol Chem. 1991 Jun 25; 266(18):12008-14. PMID: 1711046

Dhawan J, Lichtler AC, Rowe DW, Farmer SR. Cell adhesion regulates pro-alpha 1(I) collagen mRNA stability and transcription in mouse fibroblasts. J Biol Chem. 1991 May 5; 266(13):8470-5. PMID: 2022661

Rogers LC, Junier MP, Farmer SR, Ojeda SR. A sex-related difference in the developmental expression of class II beta-tubulin messenger RNA in rat hypothalamus. Mol Cell Neurosci. 1991 Apr; 2(2):130-8. PMID: 19912791

Dhawan J, Farmer SR. Regulation of alpha 1 (I)-collagen gene expression in response to cell adhesion in Swiss 3T3 fibroblasts. J Biol Chem. 1990 Jun 5; 265(16):9015-21. PMID: 2188970

Goldstein B, Rogelj S, Siegel S, Farmer SR, Niles RM. Cyclic adenosine monophosphate-mediated induction of F9 teratocarcinoma differentiation in the absence of retinoic acid. J Cell Physiol. 1990 May; 143(2):205-12. PMID: 1692026

Bucher NL, Robinson GS, Farmer SR. Effects of extracellular matrix on hepatocyte growth and gene expression: implications for hepatic regeneration and the repair of liver injury. Semin Liver Dis. 1990 Feb; 10(1):11-9.View Related Profiles.

Bucher, Nancy
Farmer, Stephen

PMID: 2336565

Clement A, Campisi J, Farmer SR, Brody JS. Constitutive expression of growth-related mRNAs in proliferating and nonproliferating lung epithelial cells in primary culture: evidence for growth-dependent translational control. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):318-22.View Related Profiles.

Brody, Jerome
Farmer, Stephen

PMID: 1688657; PMCID: PMC53254

Paine R, Ben-Ze'ev A, Farmer SR, Brody JS. The pattern of cytokeratin synthesis is a marker of type 2 cell differentiation in adult and maturing fetal lung alveolar cells. Dev Biol. 1988 Oct; 129(2):505-15.View Related Profiles.

Brody, Jerome
Farmer, Stephen

PMID: 2458290

Dike LE, Farmer SR. Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6792-6. PMID: 3045824; PMCID: PMC282064

Ben-Ze'ev A, Robinson GS, Bucher NL, Farmer SR. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2161-5.View Related Profiles.

Bucher, Nancy
Farmer, Stephen

PMID: 3353374; PMCID: PMC279949

Aiello LP, Shia MA, Robinson GS, Pilch PF, Farmer SR. Characterization and hepatic expression of rat alpha 1-inhibitor III mRNA. J Biol Chem. 1988 Mar 15; 263(8):4013-22.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 2450089

Farmer SR, Robinson GS, Mbangkollo D, Bond JF, Knight GB, Fenton MJ, Berkowitz EM. Differential expression of the beta-tubulin multigene family during rat brain development. Ann N Y Acad Sci. 1986; 466:41-50. PMID: 3460418

Bond JF, Robinson GS, Farmer SR. Differential expression of two neural cell-specific beta-tubulin mRNAs during rat brain development. Mol Cell Biol. 1984 Jul; 4(7):1313-9. PMID: 6095061; PMCID: PMC368913

Bond JF, Farmer SR. Regulation of tubulin and actin mRNA production in rat brain: expression of a new beta-tubulin mRNA with development. Mol Cell Biol. 1983 Aug; 3(8):1333-42. PMID: 6621528; PMCID: PMC369979

Farmer SR, Wan KM, Ben-Ze'ev A, Penman S. Regulation of actin mRNA levels and translation responds to changes in cell configuration. Mol Cell Biol. 1983 Feb; 3(2):182-9. PMID: 6835208; PMCID: PMC368520

Spiegelman BM, Farmer SR. Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes. Cell. 1982 May; 29(1):53-60. PMID: 7105184

Fulton AB, Prives J, Farmer SR, Penman S. Developmental reorganization of the skeletal framework and its surface lamina in fusing muscle cells. J Cell Biol. 1981 Oct; 91(1):103-12. PMID: 7197679; PMCID: PMC2111955

Lemischka IR, Farmer S, Racaniello VR, Sharp PA. Nucleotide sequence and evolution of a mammalian alpha-tubulin messenger RNA. J Mol Biol. 1981 Sep 5; 151(1):101-20. PMID: 7328649

Ben-Ze'ev A, Farmer SR, Penman S. Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage-dependent fibroblasts. Cell. 1980 Sep; 21(2):365-72. PMID: 6157481

Ben-Ze'ev A, Farmer SR, Penman S. Mechanisms of regulating tubulin synthesis in cultured mammalian cells. Cell. 1979 Jun; 17(2):319-25. PMID: 455467

Farmer SR, Ben-Ze'av A, Benecke BJ, Penman S. Altered translatability of messenger RNA from suspended anchorage-dependent fibroblasts: reversal upon cell attachment to a surface. Cell. 1978 Oct; 15(2):627-37. PMID: 719755

Farmer SR, Henshaw EC, Berridge MV, Tata JR. Translation of Xenopus vitellogenin mRNA during primary and secondary induction. Nature. 1978 Jun 1; 273(5661):401-3. PMID: 661953

Berridge MV, Farmer SR, Green CD, Henshaw EC, Tata JR. Characterization of polysomes from Xenopus liver synthesizing vitellogenin and translation of vitellogenin and albumin messenger RNA's in vitro. Eur J Biochem. 1976 Feb 2; 62(1):161-71. PMID: 1248478

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 109 publications over 38 distinct years, with a maximum of 6 publications in 1999 and 2021

Bar chart showing 109 publications over 38 distinct years, with a maximum of 6 publications in 1999 and 2021

Year	Publications
1980	1
1981	2
1982	1
1983	2
1984	1
1986	1
1988	4
1990	4
1991	3
1992	3
1994	2
1995	3
1996	3
1998	2
1999	6
2000	2
2001	2
2002	2
2003	2
2004	5
2005	3
2006	5
2007	5
2008	2
2009	5
2010	1
2011	3
2012	4
2013	1
2015	2
2016	4
2018	4
2019	3
2020	3
2021	6
2022	2
2023	4
2024	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

fat cells
fat cell differentiation
PPARg
CCAAT Enhancer Binding Protein
C/EBPs

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