Simon C. Body, MBChB, MPH, FAHA
Boston University School of Medicine
Dept of Anesthesiology

MBBChB, Univ of Auckland
MPH, Harvard School of Public Health
MS, Univ of Auckland

Dr. Body completed his residency and fellowship training in New Zealand. After nearly 30 years of experience at Brigham and Women’s and Beth Israel Hospitals, Dr. Body joined BU School of Medicine in 2020. His clinical expertise is in adult cardiac and thoracic anesthesia.

In 2000, Dr. Body initiated and led a program of examining the genetic influences upon adverse clinical outcomes after coronary artery bypass graft (CABG) surgery. Along with his co-investigators at BWH (Dr. J. Daniel Muehlschlegel), he collected over 2200 patients who had undergone primary CABG as the substrate for this research. Dr. Body and his colleagues are examining the role of variation in candidate genes and their phenotypic expression on adverse postoperative outcomes, specifically atrial fibrillation.

The other major focus of Dr. Body's research is the genetic causes of bicuspid aortic valve (BAV) disease and its and its consequences - calcific aortic valve disease and aortic aneurysm. Along with his colleagues at US, Canadian and European institutions he has led the International BAV Consortium which has collected over 2,500 patients with a bicuspid aortic valve. His own cohort has over 1,700 BAV patients. These cohorts along with those of the GenTAC program and others from collaborating Investigators are currently being used to determine these genetic causes of BAV. Dr. Body is a member of the GenTAC Alliance and Vice Chair of its Basic Science Working Group.

Dr. Body has published more 220 papers, several book chapter and has been almost continuously funded by the NIH, AHA and other organizations since 2001. He has extensive experience mentoring clinical and research residents, fellows and staff.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E. Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Sci Adv. 2020 Sep; 6(38). PMID: 32938681
  2. Mahmoodi BK, Tragante V, Kleber ME, Holmes MV, Schmidt AF, McCubrey RO, Howe LJ, Direk K, Allayee H, Baranova EV, Braund PS, Delgado GE, Eriksson N, Gijsberts CM, Gong Y, Hartiala J, Heydarpour M, Pasterkamp G, Kotti S, Kuukasjärvi P, Lenzini PA, Levin D, Lyytikäinen LP, Muehlschlegel JD, Nelson CP, Nikus K, Pilbrow AP, Wilson Tang WH, van der Laan SW, van Setten J, Vilmundarson RO, Deanfield J, Deloukas P, Dudbridge F, James S, Mordi IR, Teren A, Bergmeijer TO, Body SC, Bots M, Burkhardt R, Cooper-DeHoff RM, Cresci S, Danchin N, Doughty RN, Grobbee DE, Hagström E, Hazen SL, Held C, Hoefer IE, Hovingh GK, Johnson JA, Kaczor MP, Kähönen M, Klungel OH, Laurikka JO, Lehtimäki T, Maitland-van der Zee AH, McPherson R, Palmer CN, Kraaijeveld AO, Pepine CJ, Sanak M, Sattar N, Scholz M, Simon T, Spertus JA, Stewart AFR, Szczeklik W, Thiery J, Visseren FLJ, Waltenberger J, Richards AM, Lang CC, Cameron VA, Åkerblom A, Pare G, März W, Samani NJ, Hingorani AD, Ten Berg JM, Wallentin L, Asselbergs FW, Patel RS. Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data. Circulation. 2020 Aug 11; 142(6):546-555. PMID: 32654539
  3. Maleki S, Poujade FA, Bergman O, Gådin JR, Simon N, Lång K, Franco-Cereceda A, Body SC, Björck HM, Eriksson P. Endothelial/Epithelial Mesenchymal Transition in Ascending Aortas of Patients With Bicuspid Aortic Valve. Front Cardiovasc Med. 2019; 6:182. PMID: 31921896
  4. Faggion Vinholo T, Brownstein AJ, Ziganshin BA, Zafar MA, Kuivaniemi H, Body SC, Bale AE, Elefteriades JA. Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2019 Update and Clinical Implications. Aorta (Stamford). 2019 Jun; 7(4):99-107. PMID: 31842235
  5. Nissen AP, Truong VTT, Alhafez BA, Puthumana JJ, Estrera AL, Body SC, Prakash SK. Surgical repair of bicuspid aortopathy at small diameters: Clinical and institutional factors. J Thorac Cardiovasc Surg. 2020 06; 159(6):2216-2226.e2. PMID: 31543305
  6. Fulmer D, Toomer K, Guo L, Moore K, Glover J, Moore R, Stairley R, Lobo G, Zuo X, Dang Y, Su Y, Fogelgren B, Gerard P, Chung D, Heydarpour M, Mukherjee R, Body SC, Norris RA, Lipschutz JH. Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis. Circulation. 2019 10 15; 140(16):1331-1341. PMID: 31387361
  7. Kaneko T, Hirji S, Percy E, Aranki S, McGurk S, Body S, Heydarpour M, Mallidi H, Singh S, Pelletier M, Rawn J, Shekar P. Characterizing Risks Associated With Mitral Annular Calcification in Mitral Valve Replacement. Ann Thorac Surg. 2019 12; 108(6):1761-1767. PMID: 31207248
  8. Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 05 22; 11(493). PMID: 31118289
  9. Stone G, Choi A, Meritxell O, Gorham J, Heydarpour M, Seidman CE, Seidman JG, Aranki SF, Body SC, Carey VJ, Raby BA, Stranger BE, Muehlschlegel JD. Sex differences in gene expression in response to ischemia in the human left ventricular myocardium. Hum Mol Genet. 2019 05 15; 28(10):1682-1693. PMID: 30649309
  10. Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E. Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. Front Cardiovasc Med. 2019; 6:49. PMID: 31041314
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This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 202 publications over 32 distinct years, with a maximum of 15 publications in 2016 and 2019


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