Simon C. Body, MBChB, MPH, FAHA
Boston University Chobanian & Avedisian School of Medicine

MBBChB, Univ of Auckland
MPH, Harvard School of Public Health
MS, Univ of Auckland
BS, Univ of Auckland

Dr. Body completed his residency and fellowship training in New Zealand. After nearly 30 years of experience at Brigham and Women’s and Beth Israel Hospitals, Dr. Body joined BU School of Medicine in 2020. His clinical expertise is in adult cardiac and thoracic anesthesia.

In 2000, Dr. Body initiated and led a program of examining the genetic influences upon adverse clinical outcomes after coronary artery bypass graft (CABG) surgery. Along with his co-investigators at BWH (Dr. J. Daniel Muehlschlegel), he collected over 2200 patients who had undergone primary CABG as the substrate for this research. Dr. Body and his colleagues are examining the role of variation in candidate genes and their phenotypic expression on adverse postoperative outcomes, specifically atrial fibrillation.

The other major focus of Dr. Body's research is the genetic causes of bicuspid aortic valve (BAV) disease and its and its consequences - calcific aortic valve disease and aortic aneurysm. Along with his colleagues at US, Canadian and European institutions he has led the International BAV Consortium which has collected over 2,500 patients with a bicuspid aortic valve. His own cohort has over 1,700 BAV patients. These cohorts along with those of the GenTAC program and others from collaborating Investigators are currently being used to determine these genetic causes of BAV. Dr. Body is a member of the GenTAC Alliance and Vice Chair of its Basic Science Working Group.

Dr. Body has published more 220 papers, several book chapter and has been almost continuously funded by the NIH, AHA and other organizations since 2001. He has extensive experience mentoring clinical and research residents, fellows and staff.

Genomics of Post-Operative Atrial Fibrillation after Cardiac Surgery
03/15/2021 - 08/31/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI

Using GenTAC Resources in BioLINCC to discover BAV-specific Aortic Phenotypes
09/01/2020 - 11/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Selbst MA, Laughlin MK, Ward CR, Michelena H, Sabate-Rotes A, Bianco L, De Backer J, Mosquera LM, Yetman AT, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Guo D, Citro R, De Marco M, Tretter JT, Morris SA, McBride KL, Body SC, Prakash SK. Bicuspid Aortic Valve Disease With Early Onset Complications: Characteristics And Aortic Outcomes. medRxiv. 2024 Mar 13. PMID: 38559132; PMCID: PMC10980111; DOI: 10.1101/2024.03.11.24304079;
  2. Mansoorshahi S, Yetman AT, Bissell MM, Kim YY, Michelena H, Hui DS, Caffarelli A, Andreassi MG, Foffa I, Guo D, Citro R, De Marco M, Tretter JT, Morris SA, Body SC, Chong JX, Bamshad MJ, Milewicz DM, Prakash SK. Whole Exome Sequencing Uncovers the Genetic Complexity of Bicuspid Aortic Valve in Families with Early Onset Complications. medRxiv. 2024 Feb 08. PMID: 38370698; PMCID: PMC10871469; DOI: 10.1101/2024.02.07.24302406;
  3. Carlisle SG, Albasha H, Michelena H, Sabate-Rotes A, Bianco L, De Backer J, Mosquera LM, Yetman AT, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Guo DC, Citro R, De Marco M, Tretter JT, McBride KL, Milewicz DM, Body SC, Prakash SK. Rare Genomic Copy Number Variants Implicate New Candidate Genes for Bicuspid Aortic Valve. medRxiv. 2023 Oct 24. PMID: 37961530; PMCID: PMC10635161; DOI: 10.1101/2023.10.23.23297397;
  4. Asher SR, Ong CS, Malapero RJ, Heydarpour M, Malzberg GW, Shahram JT, Nguyen TB, Shook DC, Shernan SK, Shekar P, Kaneko T, Citro R, Muehlschlegel JD, Body SC. Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery. Front Cardiovasc Med. 2023; 10:1202174. PMID: 37840960; PMCID: PMC10570832; DOI: 10.3389/fcvm.2023.1202174;
  5. Tessler I, Albuisson J, Piñeiro-Sabarís R, Verstraeten A, Kamber Kaya HE, Siguero-Álvarez M, Goudot G, MacGrogan D, Luyckx I, Shpitzen S, Levin G, Kelman G, Reshef N, Mananet H, Holdcraft J, Muehlschlegel JD, Peloso GM, Oppenheim O, Cheng C, Mazzella JM, Andelfinger G, Mital S, Eriksson P, Billon C, Heydarpour M, Dietz HC, Jeunemaitre X, Leitersdorf E, Sprinzak D, Blacklow SC, Body SC, Carmi S, Loeys B, de la Pompa JL, Gilon D, Messas E, Durst R. Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve. JAMA Cardiol. 2023 Aug 01; 8(8):721-731.View Related Profiles. PMID: 37405741; PMCID: PMC10323766; DOI: 10.1001/jamacardio.2023.1469;
  6. Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E. Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. Circulation. 2023 Aug 22; 148(8):661-678. PMID: 37427430; PMCID: PMC10527599; DOI: 10.1161/CIRCULATIONAHA.122.063402;
  7. Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E. Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity. Eur Heart J. 2023 Mar 07; 44(10):885-898. PMID: 36660854; PMCID: PMC9991042; DOI: 10.1093/eurheartj/ehac818;
  8. Kelly I, Fields K, Sarin P, Pang A, Sigurdsson MI, Shernan SK, Fox AA, Body SC, Muehlschlegel JD. Identifying Patients Vulnerable to Inadequate Pain Resolution After Cardiac Surgery. Semin Thorac Cardiovasc Surg. 2022 Sep 07. PMID: 36084862
  9. Roselli C, Yu M, Nauffal V, Georges A, Yang Q, Love K, Weng LC, Delling FN, Maurya SR, Schrölkamp M, Tfelt-Hansen J, Hagège A, Jeunemaitre X, Debette S, Amouyel P, Guan W, Muehlschlegel JD, Body SC, Shah S, Samad Z, Kyryachenko S, Haynes C, Rienstra M, Le Tourneau T, Probst V, Roussel R, Wijdh-Den Hamer IJ, Siland JE, Knowlton KU, Jacques Schott J, Levine RA, Benjamin EJ, Vasan RS, Horne BD, Muhlestein JB, Benfari G, Enriquez-Sarano M, Natale A, Mohanty S, Trivedi C, Shoemaker MB, Yoneda ZT, Wells QS, Baker MT, Farber-Eger E, Michelena HI, Lundby A, Norris RA, Slaugenhaupt SA, Dina C, Lubitz SA, Bouatia-Naji N, Ellinor PT, Milan DJ. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. Eur Heart J. 2022 May 01; 43(17):1668-1680.View Related Profiles. PMID: 35245370; PMCID: PMC9649914; DOI: 10.1093/eurheartj/ehac049;
  10. Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E. A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling. Cell Rep. 2022 Apr 12; 39(2):110685.View Related Profiles. PMID: 35417712
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This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 218 publications over 36 distinct years, with a maximum of 15 publications in 2016 and 2019


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