Simon C. Body, MBChB, MPH, FAHA
Professor
Boston University Chobanian & Avedisian School of Medicine
Anesthesiology

MBBChB, Univ of Auckland
MPH, Harvard School of Public Health
MS, Univ of Auckland
BS, Univ of Auckland



Dr. Body completed his residency and fellowship training in New Zealand. After nearly 30 years of experience at Brigham and Women’s and Beth Israel Hospitals, Dr. Body joined BU School of Medicine in 2020. His clinical expertise is in adult cardiac and thoracic anesthesia.

In 2000, Dr. Body initiated and led a program of examining the genetic influences upon adverse clinical outcomes after coronary artery bypass graft (CABG) surgery. Along with his co-investigators at BWH (Dr. J. Daniel Muehlschlegel), he collected over 2200 patients who had undergone primary CABG as the substrate for this research. Dr. Body and his colleagues are examining the role of variation in candidate genes and their phenotypic expression on adverse postoperative outcomes, specifically atrial fibrillation.

The other major focus of Dr. Body's research is the genetic causes of bicuspid aortic valve (BAV) disease and its and its consequences - calcific aortic valve disease and aortic aneurysm. Along with his colleagues at US, Canadian and European institutions he has led the International BAV Consortium which has collected over 2,500 patients with a bicuspid aortic valve. His own cohort has over 1,700 BAV patients. These cohorts along with those of the GenTAC program and others from collaborating Investigators are currently being used to determine these genetic causes of BAV. Dr. Body is a member of the GenTAC Alliance and Vice Chair of its Basic Science Working Group.

Dr. Body has published more 220 papers, several book chapter and has been almost continuously funded by the NIH, AHA and other organizations since 2001. He has extensive experience mentoring clinical and research residents, fellows and staff.


Genomics of Post-Operative Atrial Fibrillation after Cardiac Surgery
03/15/2021 - 08/31/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL149998-02

Using GenTAC Resources in BioLINCC to discover BAV-specific Aortic Phenotypes
09/01/2020 - 11/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
7R21HL150373-02



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. DiGregorio H, Mansoorshahi S, Carlisle SG, Tovar Pensa C, Watts A, McNeely C, Sabate-Rotes A, Yetman A, Michelena HI, De Backer JFA, Mosquera LM, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Citro R, De Marco M, Tretter JT, McBride KL, Body SC, Milewicz DM, Prakash SK. Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve. Heart. 2025 Feb 12; 111(5):221-229. PMID: 39658198; PMCID: PMC11821425; DOI: 10.1136/heartjnl-2024-324669;
     
  2. Carlisle SG, Albasha H, Michelena HI, Sabate-Rotes A, Bianco L, De Backer J, Mosquera LM, Yetman AT, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Guo D, Citro R, De Marco M, Tretter JT, McBride KL, Milewicz DM, Body SC, Prakash SK. Rare genomic copy number variants implicate new candidate genes for bicuspid aortic valve. PLoS One. 2024; 19(9):e0304514. PMID: 39240962; PMCID: PMC11379187; DOI: 10.1371/journal.pone.0304514;
     
  3. Mansoorshahi S, Yetman AT, Bissell MM, Kim YY, Michelena HI, De Backer J, Mosquera LM, Hui DS, Caffarelli A, Andreassi MG, Foffa I, Guo D, Citro R, De Marco M, Tretter JT, Morris SA, Body SC, Chong JX, Bamshad MJ, Milewicz DM, Prakash SK. Whole-exome sequencing uncovers the genetic complexity of bicuspid aortic valve in families with early-onset complications. Am J Hum Genet. 2024 Oct 03; 111(10):2219-2231. PMID: 39226896; PMCID: PMC11480851; DOI: 10.1016/j.ajhg.2024.08.001;
     
  4. Karamnov S, Sarkisian N, Wollborn J, Justice S, Fields K, Kovacheva VP, Osho AA, Sabe A, Body SC, Muehlschlegel JD. Sex, Atrial Fibrillation, and Long-Term Mortality After Cardiac Surgery. JAMA Netw Open. 2024 Aug 01; 7(8):e2426865. PMID: 39167408; PMCID: PMC11339658; DOI: 10.1001/jamanetworkopen.2024.26865;
     
  5. Karamnov S, Dimentberg R, Cornella L, Shook DC, Nyman C, Shernan SK, Body SC, Muehlschlegel JD. Fostering a New Generation of Cardiothoracic Anesthesiology Clinician-Scientists: A Systematic Approach. J Cardiothorac Vasc Anesth. 2024 Oct; 38(10):2169-2172. PMID: 38955618
     
  6. Selbst MA, Laughlin MK, Ward CR, Michelena H, Sabate-Rotes A, Bianco L, De Backer J, Mosquera LM, Yetman AT, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Guo D, Citro R, De Marco M, Tretter JT, Morris SA, McBride KL, Body SC, Prakash SK. Bicuspid Aortic Valve Disease With Early Onset Complications: Characteristics And Aortic Outcomes. medRxiv. 2024 Mar 13. PMID: 38559132; PMCID: PMC10980111; DOI: 10.1101/2024.03.11.24304079;
     
  7. Mansoorshahi S, Yetman AT, Bissell MM, Kim YY, Michelena H, Hui DS, Caffarelli A, Andreassi MG, Foffa I, Guo D, Citro R, De Marco M, Tretter JT, Morris SA, Body SC, Chong JX, Bamshad MJ, Milewicz DM, Prakash SK. Whole Exome Sequencing Uncovers the Genetic Complexity of Bicuspid Aortic Valve in Families with Early Onset Complications. medRxiv. 2024 Feb 08. PMID: 38370698; PMCID: PMC10871469; DOI: 10.1101/2024.02.07.24302406;
     
  8. Carlisle SG, Albasha H, Michelena H, Sabate-Rotes A, Bianco L, De Backer J, Mosquera LM, Yetman AT, Bissell MM, Andreassi MG, Foffa I, Hui DS, Caffarelli A, Kim YY, Guo DC, Citro R, De Marco M, Tretter JT, McBride KL, Milewicz DM, Body SC, Prakash SK. Rare Genomic Copy Number Variants Implicate New Candidate Genes for Bicuspid Aortic Valve. medRxiv. 2023 Oct 24. PMID: 37961530; PMCID: PMC10635161; DOI: 10.1101/2023.10.23.23297397;
     
  9. Asher SR, Ong CS, Malapero RJ, Heydarpour M, Malzberg GW, Shahram JT, Nguyen TB, Shook DC, Shernan SK, Shekar P, Kaneko T, Citro R, Muehlschlegel JD, Body SC. Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery. Front Cardiovasc Med. 2023; 10:1202174. PMID: 37840960; PMCID: PMC10570832; DOI: 10.3389/fcvm.2023.1202174;
     
  10. Tessler I, Albuisson J, Piñeiro-Sabarís R, Verstraeten A, Kamber Kaya HE, Siguero-Álvarez M, Goudot G, MacGrogan D, Luyckx I, Shpitzen S, Levin G, Kelman G, Reshef N, Mananet H, Holdcraft J, Muehlschlegel JD, Peloso GM, Oppenheim O, Cheng C, Mazzella JM, Andelfinger G, Mital S, Eriksson P, Billon C, Heydarpour M, Dietz HC, Jeunemaitre X, Leitersdorf E, Sprinzak D, Blacklow SC, Body SC, Carmi S, Loeys B, de la Pompa JL, Gilon D, Messas E, Durst R. Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve. JAMA Cardiol. 2023 Aug 01; 8(8):721-731.View Related Profiles. PMID: 37405741; PMCID: PMC10323766; DOI: 10.1001/jamacardio.2023.1469;
     
Showing 10 of 225 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 223 publications over 37 distinct years, with a maximum of 15 publications in 2016 and 2019

YearPublications
19861
19872
19881
19921
19931
19942
19952
19965
19972
19984
19994
20007
20015
20025
20034
20046
200510
20066
20077
20089
200913
201013
201110
20127
20134
201410
20157
201615
201714
20189
201915
20202
20215
20223
20235
20246
20251

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