Shuaiying Cui, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, University of Science and Technology of China

Dr. Cui's research has focused on the development of novel agents that can elicit developmental stage-specific gene silencing or reprogramming in hematopoietic stem cells and progenitors through a series of epigenetic chromatin modifications by nucleosome remodeling, histone deacetylation and demethylation. Such agents can be applied to the treatment of the patients with hematologic disorders such as sickle cell disease and beta-thalassemia, as well as acute myeloid leukemia (Blood cancer), which arise from congenital defects in genome. The findings from these preclinical studies could also help to establish therapeutic indications in other hematological malignancies.

American Society of Hematology (ASH) Junior Faculty Award in Basic/Translational research
07/01/2017 - 06/30/2019 (PI)
American Society of Hematology

Regulating transcriptional co-activator PGC-1a for the treatment of sickle cell disease
05/12/2017 - 06/30/2018 (PI)
Pfizer, Inc

LSD1 Inhibition for the treatment of beta-globin disorders
07/01/2016 - 06/30/2018 (PI)
American Heart Assoc

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Morrison TA, Wilcox I, Luo HY, Farrell JJ, Kurita R, Nakamura Y, Murphy GJ, Cui S, Steinberg MH, Chui DHK. A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression. Blood Cells Mol Dis. 2018 Mar; 69:1-9.View Related Profiles. PMID: 29227829.
  2. Ibanez V, Vaitkus K, Rivers A, Molokie R, Cui S, Engel JD, DeSimone J, Lavelle D. Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons. Blood. 2017 01 12; 129(2):260-263. PMID: 27908882; DOI: 10.1182/blood-2016-10-746727;.
  3. Dai Y, Sangerman J, Nouraie M, Faller AD, Oneal P, Rock A, Owoyemi O, Niu X, Nekhai S, Maharaj D, Cui S, Taylor R, Steinberg M, Perrine S. Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer. Am J Hematol. 2017 Jan; 92(1):E10-E11.View Related Profiles. PMID: 27766663; DOI: 10.1002/ajh.24590;.
  4. Rivers A, Vaitkus K, Ibanez V, Ruiz MA, Jagadeeswaran R, Saunthararajah Y, Cui S, Engel JD, DeSimone J, Lavelle D. The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis). Haematologica. 2016 Jun; 101(6):688-97. PMID: 26858356; PMCID: PMC5013966; DOI: 10.3324/haematol.2015.140749;.
  5. Cui S, Engel JD. Gene and Cell Therapies for Beta-Globinopathies, edited by Punam Malik and John Tisdale. Genetic reactivation of fetal hemoglobin for beta-thalassemia and SCD. 2016.
  6. White JC, Pawar A, Fu G, Cui S, Tavernier F, Hamid M, Harro D, Giacherio D, Campbell AD, Hines PC. TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1. Blood Cells Mol Dis. 2015 Dec; 55(4):316-7. PMID: 26460253; DOI: 10.1016/j.bcmd.2015.07.003;.
  7. Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16; 126(3):386-96. PMID: 26031919; PMCID: PMC4504950; DOI: 10.1182/blood-2015-02-626259;.
  8. Cui S, Tanabe O, Sierant M, Shi L, Campbell A, Lim KC, Engel JD. Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic ß-type globin genes. Blood. 2015 Feb 26; 125(9):1477-87. PMID: 25561507; PMCID: PMC4342359; DOI: 10.1182/blood-2014-10-605022;.
  9. Shi L, Sierant MC, Gurdziel K, Zhu F, Cui S, Kolodziej KE, Strouboulis J, Guan Y, Tanabe O, Lim KC, Engel JD. Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells. PLoS Genet. 2014 May; 10(5):e1004339. PMID: 24811540; PMCID: PMC4014424; DOI: 10.1371/journal.pgen.1004339;.
  10. Shi L, Lin YH, Sierant MC, Zhu F, Cui S, Guan Y, Sartor MA, Tanabe O, Lim KC, Engel JD. Developmental transcriptome analysis of human erythropoiesis. Hum Mol Genet. 2014 Sep 01; 23(17):4528-42. PMID: 24781209; PMCID: PMC4119405; DOI: 10.1093/hmg/ddu167;.
Showing 10 of 18 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 18 publications over 9 distinct years, with a maximum of 4 publications in 2016

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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(617) 638-7530 (fax)

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