Sharmila Masli, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Ophthalmology

PhD, Northeastern University
MS, Northeastern University
BSc, University of Bombay



The major focus of research in the laboratory is the study of molecular mechanisms utilized by ocular antigen presenting cells (APCs) to regulate inflammatory ocular immune responses. Particular focus is on elucidating the role of thrombospondin-1 (TSP-1) in regulating ocular inflammation.

Resident ocular APCs in the posterior and anterior segment of the eye depend on TSP-1 for maintaining an anti-inflammatory phenotype. In the absence of TSP-1 these APCs acquire more immunogenic phenotype. These observations are examined further to determine their role in ocular inflammation.

Induction of regulatory T cells (Treg) subset by ocular APCs is known to be a key component of ocular immune privilege. The ability of ocular APCs to induce Treg and its correlation with their expression of TSP-1 is examined in the laboratory at the level of molecular mechanisms.

The laboratory has identified spontaneous development of autoimmune Sjögren’s syndrome and related ocular inflammation in TSP-1 deficient mice that closely resembles clinical symptoms in human Sjögren’s patients. Different projects in the laboratory address immunologic mechanisms underlying disease development in these mice.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




STTR Phase I: Clusterin Targeting of Ocular Surface Disease
09/30/2023 - 08/31/2024 (Subcontract PI)
Proteris Biotech, Inc. NIH NEI
1R41EY034396-01A1

Mechanisms underlying mustard gas-induced conjunctival injury and use of lipid mediators as medical countermeasures
09/01/2023 - 08/31/2024 (Subcontract PI)
Schepens Eye Research Institute NIH NEI
1R56EY035213-01

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 08/31/2024 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.


Determining the efficacy of Platelet Like Cells (PLC) in resolving Sjogren’s syndrome-associated chronic dry eye in a pre-clinical mouse model (TSP-1-/- mice).
12/22/2022 - 04/30/2024 (PI)
Stellular Bio, Inc.


Tear biomarkers for differential diagnosis of Sjogren's vs. non-Sjogren's dry eye
09/01/2020 - 07/01/2022 (PI)
Sjogren's Foundation


Determining the effect of natriuretic peptides and sGC peptide on mucin secretion by conjunctival goblet cells
07/01/2017 - 04/30/2018 (PI)
Ironwood Pharmaceuticals, Inc.


Determining efficacy of IL-17 antagonist in resolving Sjogren's syndrome associated chronic dry eye
08/08/2016 - 12/31/2017 (PI)
Allergan Sales Inc


Molecular Mechanisms Underlying Immune Regulation of Ocular Inflammation
04/15/2013 - 08/31/2015 (PI)
NIH/National Eye Institute
5R01EY015472-11



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Gordon RA, Nguyen Y, Foulquier N, Beydon M, Gheita TA, Hajji R, Sahbudin I, Hoi A, Ng WF, Mendonça JA, Wallace DJ, Shea B, Bruyn GA, Goodman SM, Fisher BA, Baldini C, Torralba KD, Bootsma H, Akpek EK, Karakus S, Baer AN, Chakravarty SD, Terslev L, D'Agostino MA, Mariette X, DiRenzo D, Rasmussen A, Papas A, Montoya C, Arends S, Yusof MYM, Pintilie I, Warner BM, Hammitt KM, Strand V, Bouillot C, Tugwell P, Inanc N, Andreu JL, Wahren-Herlenius M, Devauchelle-Pensec V, Shiboski CH, Benyoussef A, Masli S, Lee AYS, Cornec D, Bowman S, Rischmueller M, McCoy SS, Seror R. The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation. Semin Arthritis Rheum. 2024 Apr; 65:152378. PMID: 38310657; PMCID: PMC10954392; DOI: 10.1016/j.semarthrit.2024.152378;
     
  2. Masli S, Akpek EK. Reduced tear thrombospondin-1/matrix metalloproteinase-9 ratio can aid in detecting Sjögren's syndrome etiology in patients with dry eye. Clin Transl Sci. 2022 Aug; 15(8):1999-2009. PMID: 35610740; PMCID: PMC9372415; DOI: 10.1111/cts.13316;
     
  3. Soriano-Romaní L, Mir FA, Singh N, Chin I, Hafezi-Moghadam A, Masli S. CD47 Binding on Vascular Endothelial Cells Inhibits IL-17-Mediated Leukocyte Adhesion. Int J Mol Sci. 2022 May 20; 23(10). PMID: 35628515; PMCID: PMC9146020; DOI: 10.3390/ijms23105705;
     
  4. Logeswaran A, Contreras-Ruiz L, Masli S. Conjunctival Goblet Cell Responses to TLR5 Engagement Promote Activation of Local Antigen-Presenting Cells. Front Immunol. 2021; 12:716939. PMID: 34434198; PMCID: PMC8380822; DOI: 10.3389/fimmu.2021.716939;
     
  5. Simon LS, Keshav V, Baharozian C, Masli S, Lee HJ. Thrombospondin 1 polymorphism associated with decreased expression and increased risk of pterygium. Graefes Arch Clin Exp Ophthalmol. 2021 Aug; 259(8):2301-2307.View Related Profiles. PMID: 33661363
     
  6. Ramos MF, Brassard J, Masli S. Immunology and Pathology in Ocular Drug Development. Toxicol Pathol. 2021 04; 49(3):483-504. PMID: 33468035
     
  7. Masli S, Dartt DA. Mouse Models of Sjögren's Syndrome with Ocular Surface Disease. Int J Mol Sci. 2020 Nov 30; 21(23). PMID: 33266081; PMCID: PMC7730359; DOI: 10.3390/ijms21239112;
     
  8. Akpek EK, Wu HY, Karakus S, Zhang Q, Masli S. Differential Diagnosis of Sjögren Versus Non-Sjögren Dry Eye Through Tear Film Biomarkers. Cornea. 2020 Aug; 39(8):991-997. PMID: 32195754
     
  9. Foulsham W, Dohlman TH, Mittal SK, Taketani Y, Singh RB, Masli S, Dana R. Thrombospondin-1 in ocular surface health and disease. Ocul Surf. 2019 07; 17(3):374-383. PMID: 31173926; PMCID: PMC6708501; DOI: 10.1016/j.jtos.2019.06.001;
     
  10. Soriano-Romaní L, Contreras-Ruiz L, López-García A, Diebold Y, Masli S. Topical Application of TGF-ß-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation. Int J Mol Sci. 2018 Dec 20; 20(1). PMID: 30577496; PMCID: PMC6337581; DOI: 10.3390/ijms20010009;
     
Showing 10 of 63 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 63 publications over 25 distinct years, with a maximum of 8 publications in 2015

YearPublications
19941
19961
19971
19992
20001
20022
20041
20052
20063
20072
20084
20096
20103
20113
20132
20144
20158
20162
20172
20184
20191
20202
20213
20222
20241


1996 Northeastern University: Phi Beta Delta
1995 Northeastern University: Rho Chi
1987 Student of the Year

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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