Raphael Zoeller | Profiles RNS

Raphael A. Zoeller Jr, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Texas A&M University
BS, University of Maine

Websites

Graduate Medical Sciences Faculty

ORCID : 0000-0002-6560-0993

My expertise is in the area of lipid biosynthesis and metabolism and how they relate to human disease. My laboratory uses molecular biology, lipid chemistry & analysis, protein chemistry and forward genetics (mutant isolation).
We have recently developed a cell-based, high-throughput protocol to screen small molecule libraries for inhibitors of animal cell phospholipid biosynthesis. We have identified several candidate compounds and are now characterizing their efficacy and mode(s) of action.

Research Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Biomedical Genetics

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Member
Boston University
Boston Nutrition Obesity Research Center

BU Research
NIH RePORTER Research

A High Throughput Screen for Inhibitors of Mammalian Glycerolipid Biosynthesis
04/01/2015 - 03/31/2019 (PI)
NIH/National Institute of General Medical Sciences
5R01GM107675-03

Endothelial Cell Hypoxia Tolerance: Role of Plasmalogens
07/01/2003 - 06/30/2008 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL68232 04

Regulation of Plasmalogen Levels in Animal Cells
07/01/2004 - 06/30/2007 (PI)
American Heart Association - Northeast Affliate

Biosynthesis and Function of Animal Cell Plasmalogens
12/01/1993 - 06/30/2004 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM50571 08

Title

Yr	Title	Project-Sub Proj	Pubs
2017	A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis	5R01GM107675-03	2
2016	A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis	5R01GM107675-02	2
2015	A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis	1R01GM107675-01A1	2
2001	BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS	5R01GM050571-08	12
2000	BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS	5R01GM050571-07	12
1999	BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS	5R01GM050571-06	12
1998	BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS	2R01GM050571-05A1	12
1997	BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS	5R01GM050571-04	12
1996	BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS	5R01GM050571-03	12
1995	BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS	5R01GM050571-02	12

Showing 10 of 16 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Shakya S, Herr RA, Carlson HL, Zoeller RA, Albert CJ, Ford DA. Endothelial Cell Protein Targeting by Myeloperoxidase-Derived 2-Chlorofatty Aldehyde. Antioxidants (Basel). 2022 May 10; 11(5). PMID: 35624804; PMCID: PMC9138145; DOI: 10.3390/antiox11050940;

Honsho M, Tanaka M, Zoeller RA, Fujiki Y. Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum. Front Cell Dev Biol. 2020; 8:855. PMID: 33042986; PMCID: PMC7517302; DOI: 10.3389/fcell.2020.00855;

Werner ER, Keller MA, Sailer S, Lackner K, Koch J, Hermann M, Coassin S, Golderer G, Werner-Felmayer G, Zoeller RA, Hulo N, Berger J, Watschinger K. The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7792-7798. PMID: 32209662; PMCID: PMC7149458; DOI: 10.1073/pnas.1917461117;

Park H, Haller J, Smith F, Parkin N, Lythe T, Zoeller RA, Chakravorty S. Attenuation of Hemolysis Due to Glucose-6-Phosphate Isomerase Deficiency With Ketogenic Diet - A Case Report. Hemasphere. 2020 Feb; 4(1):e328. PMID: 32072144; PMCID: PMC7000473; DOI: 10.1097/HS9.0000000000000328;

Zoeller RA, Geoghegan-Barek K. A cell-based high-throughput screen identifies tyrphostin AG 879 as an inhibitor of animal cell phospholipid and fatty acid biosynthesis. Biochem Biophys Rep. 2019 Jul; 18:100621. PMID: 30899803; PMCID: PMC6406593; DOI: 10.1016/j.bbrep.2019.100621;

Jarugumilli GK, Choi JR, Chan P, Yu M, Sun Y, Chen B, Niu J, DeRan M, Zheng B, Zoeller R, Lin C, Wu X. Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2- trans-Hexadecenal. ACS Chem Biol. 2018 05 18; 13(5):1130-1136. PMID: 29608264; PMCID: PMC5959771; DOI: 10.1021/acschembio.7b01063;

Werner ER, Keller MA, Sailer S, Seppi D, Golderer G, Werner-Felmayer G, Zoeller RA, Watschinger K. A novel assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates. J Lipid Res. 2018 05; 59(5):901-909. PMID: 29540573; PMCID: PMC5928432; DOI: 10.1194/jlr.D080283;

Nakahara K, Ohkuni A, Kitamura T, Abe K, Naganuma T, Ohno Y, Zoeller RA, Kihara A. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell. 2012 May 25; 46(4):461-71. PMID: 22633490; DOI: 10.1016/j.molcel.2012.04.033;

Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE. Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes. PLoS One. 2012; 7(4):e34904.View Related Profiles.

Corkey, Barbara
Zoeller, Raphael

PMID: 22493722; PMCID: PMC3321042; DOI: 10.1371/journal.pone.0034904;

Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA. Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1a to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease. Biochim Biophys Acta. 2011 Nov; 1812(11):1393-402.View Related Profiles.

Corkey, Barbara
Zoeller, Raphael

PMID: 21787864; PMCID: PMC3185221; DOI: 10.1016/j.bbadis.2011.07.007;

Showing 10 of 42 results. Show More

Anbukumar DS, Shornick LP, Albert CJ, Steward MM, Zoeller RA, Neumann WL, Ford DA. Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal. J Lipid Res. 2010 May; 51(5):1085-92. PMID: 20019386; PMCID: PMC2853435; DOI: 10.1194/jlr.M003673;

Haller JF, Smith C, Liu D, Zheng H, Tornheim K, Han GS, Carman GM, Zoeller RA. Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase. J Biol Chem. 2010 Jan 8; 285(2):866-77.View Related Profiles.

Tornheim, Keith
Zoeller, Raphael

PMID: 19903819; PMCID: PMC2801288; DOI: 10.1074/jbc.M109.068213;

Gaposchkin DP, Farber HW, Zoeller RA. On the importance of plasmalogen status in stimulated arachidonic acid release in the macrophage cell line RAW 264.7. Biochim Biophys Acta. 2008 Apr; 1781(4):213-9.View Related Profiles.

Farber, Harrison
Zoeller, Raphael

PMID: 18328831; DOI: 10.1016/j.bbalip.2008.01.007;

Zheng H, Duclos RI, Smith CC, Farber HW, Zoeller RA. Synthesis and biological properties of the fluorescent ether lipid precursor 1-O-[9'-(1'-pyrenyl)]nonyl-sn-glycerol. J Lipid Res. 2006 Mar; 47(3):633-42.View Related Profiles.

Farber, Harrison
Zoeller, Raphael

PMID: 16369049

Liu D, Nagan N, Just WW, Rodemer C, Thai TP, Zoeller RA. Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids. J Lipid Res. 2005 Apr; 46(4):727-35. PMID: 15687349

Munn NJ, Arnio E, Liu D, Zoeller RA, Liscum L. Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport. J Lipid Res. 2003 Jan; 44(1):182-92. PMID: 12518037

Zoeller RA, Grazia TJ, LaCamera P, Park J, Gaposchkin DP, Farber HW. Increasing plasmalogen levels protects human endothelial cells during hypoxia. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H671-9.View Related Profiles.

Farber, Harrison
Lacamera, Peter
Zoeller, Raphael

PMID: 12124215

Nagan N, Zoeller RA. Plasmalogens: biosynthesis and functions. Prog Lipid Res. 2001 May; 40(3):199-229. PMID: 11275267

Gaposchkin DP, Zoeller RA, Broitman SA. Incorporation of polyunsaturated fatty acids into CT-26, a transplantable murine colonic adenocarcinoma. Lipids. 2000 Feb; 35(2):181-6.View Related Profiles.

Zoeller, Raphael
Broitman, Selwyn

PMID: 10757549

Zoeller RA, Lake AC, Nagan N, Gaposchkin DP, Legner MA, Lieberthal W. Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether. Biochem J. 1999 Mar 15; 338 ( Pt 3):769-76. PMID: 10051451; PMCID: PMC1220115

Gaposchkin DP, Zoeller RA. Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants. J Lipid Res. 1999 Mar; 40(3):495-503. PMID: 10064738

Nagan N, Hajra AK, Larkins LK, Lazarow P, Purdue PE, Rizzo WB, Zoeller RA. Isolation of a Chinese hamster fibroblast variant defective in dihydroxyacetonephosphate acyltransferase activity and plasmalogen biosynthesis: use of a novel two-step selection protocol. Biochem J. 1998 May 15; 332 ( Pt 1):273-9. PMID: 9576878; PMCID: PMC1219478

James PF, Lake AC, Hajra AK, Larkins LK, Robinson M, Buchanan FG, Zoeller RA. An animal cell mutant with a deficiency in acyl/alkyl-dihydroxyacetone-phosphate reductase activity. Effects on the biosynthesis of ether-linked and diacyl glycerolipids. J Biol Chem. 1997 Sep 19; 272(38):23540-6.View Related Profiles.

Robinson, Meghan
Zoeller, Raphael

PMID: 9295290

James PF, Zoeller RA. Isolation of animal cell mutants defective in long-chain fatty aldehyde dehydrogenase. Sensitivity to fatty aldehydes and Schiff's base modification of phospholipids: implications for Sj-ogren-Larsson syndrome. J Biol Chem. 1997 Sep 19; 272(38):23532-9. PMID: 9295289

Nagan N, Hajra AK, Das AK, Moser HW, Moser A, Lazarow P, Purdue PE, Zoeller RA. A fibroblast cell line defective in alkyl-dihydroxyacetone phosphate synthase: a novel defect in plasmalogen biosynthesis. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4475-80. PMID: 9114014; PMCID: PMC20747

Zoeller RA, Layne MD, Modest EJ. Animal cell mutants unable to take up biologically active glycerophospholipids. J Lipid Res. 1995 Sep; 36(9):1866-75.View Related Profiles.

Layne, Matthew
Zoeller, Raphael

PMID: 8558075

Rangaswamy S, Zoeller RA. Fatty acid desaturation in an animal cell mutant defective in plasmanylethanolamine desaturase. Biochim Biophys Acta. 1994 Feb 10; 1211(1):79-84. PMID: 8123685

Singh N, Zoeller RA, Tykocinski ML, Lazarow PB, Tartakoff AM. Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors. Mol Cell Biol. 1994 Jan; 14(1):21-31. PMID: 8264589; PMCID: PMC358352

Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA. Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J Biol Chem. 1993 Oct 15; 268(29):22055-9. PMID: 7691822

Zoeller RA, Rangaswamy S, Herscovitz H, Rizzo WB, Hajra AK, Das AK, Moser HW, Moser A, Lazarow PB, Santos MJ. Mutants in a macrophage-like cell line are defective in plasmalogen biosynthesis, but contain functional peroxisomes. J Biol Chem. 1992 Apr 25; 267(12):8299-306.View Related Profiles.

Herscovitz, Haya
Zoeller, Raphael

PMID: 1569085

Zoeller RA, Raetz CR. Strategies for isolating somatic cell mutants defective in lipid biosynthesis. Methods Enzymol. 1992; 209:34-51. PMID: 1495413

Gordon JA, Zoeller RA, Spector AA. Hydroxyeicosatetraenoic acid oxidation in Chinese hamster ovary cells: a peroxisomal metabolic pathway. Biochim Biophys Acta. 1991 Aug 20; 1085(1):21-8. PMID: 1892874

James PF, Rizzo WB, Lee J, Zoeller RA. Isolation and characterization of a Chinese hamster ovary cell line deficient in fatty alcohol:NAD+ oxidoreductase activity. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6102-6. PMID: 2201021; PMCID: PMC54480

Morand OH, Allen LA, Zoeller RA, Raetz CR. A rapid selection for animal cell mutants with defective peroxisomes. Biochim Biophys Acta. 1990 May 16; 1034(2):132-41. PMID: 2354189

Zoeller RA, Allen LA, Santos MJ, Lazarow PB, Hashimoto T, Tartakoff AM, Raetz CR. Chinese hamster ovary cell mutants defective in peroxisome biogenesis. Comparison to Zellweger syndrome. J Biol Chem. 1989 Dec 25; 264(36):21872-8. PMID: 2689450

Morand OH, Zoeller RA, Raetz CR. Disappearance of plasmalogens from membranes of animal cells subjected to photosensitized oxidation. J Biol Chem. 1988 Aug 15; 263(23):11597-606. PMID: 3403548

Zoeller RA, Morand OH, Raetz CR. A possible role for plasmalogens in protecting animal cells against photosensitized killing. J Biol Chem. 1988 Aug 15; 263(23):11590-6. PMID: 3403547

Zoeller RA, Wightman PD, Anderson MS, Raetz CR. Accumulation of lysophosphatidylinositol in RAW 264.7 macrophage tumor cells stimulated by lipid A precursors. J Biol Chem. 1987 Dec 15; 262(35):17212-20. PMID: 3680297

Zoeller RA, Raetz CR. Isolation of animal cell mutants deficient in plasmalogen biosynthesis and peroxisome assembly. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5170-4. PMID: 3460088; PMCID: PMC323912

Zoeller RA, Wood R. The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C. Biochim Biophys Acta. 1985 Jun 30; 845(3):380-8. PMID: 2860925

Zoeller RA, Wood R. Effects of cyclopropene fatty acids on the lipid composition of the Morris hepatoma 7288C. Lipids. 1984 Jul; 19(7):529-38. PMID: 6431218

Zoeller RA, Wood R. Analysis of the stearoyl-CoA desaturase system in the Morris hepatoma 7288C and 7288CTC. Lipids. 1984 Jul; 19(7):488-91. PMID: 6146913

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 42 publications over 28 distinct years, with a maximum of 3 publications in 1997 and 2020

Bar chart showing 42 publications over 28 distinct years, with a maximum of 3 publications in 1997 and 2020

Year	Publications
1984	2
1985	1
1986	1
1987	1
1988	2
1989	1
1990	2
1991	1
1992	2
1993	1
1994	2
1995	1
1997	3
1998	1
1999	2
2000	1
2001	1
2002	1
2003	1
2005	2
2008	1
2009	2
2011	1
2012	2
2018	2
2019	1
2020	3
2022	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

glycerolipids
lipids
mutants
obesity
phospholipids
triglycerides
phospholipid biosynthesis
small molecule inhibitors

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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617.358.8752

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