Ruben Dries, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, Erasmus Universiteit Rotterdam
PhD, Katholieke Univ Leuven
MS, Katholieke Univ Leuven

Ruben Dries, PhD combines computational data analysis with novel experimental approaches and technologies to understand basic biological concepts in health and disease. These insights could then be leveraged to target tumor specific processes or inhibit the development of treatment resistance. These interests grew dynamically throughout his research career. In his early studies Dr. Dries developed a systems biology approach to dissect the regulatory network of neural differentiating embryonic stem cells and used this knowledge at a later stage to understand how cancer cells transcriptionally respond to targeted therapies and other stress factors. More recently, he expanded this area by focusing on how cells can spatially communicate within their microenvironment and build tools to facilitate these type of analyses.

As a young and dynamic group his lab works together as a team in the following areas:

1) Establishing multi-cellular breast cancer models that better reflect spatial tumor heterogeneity

2) Building tools to explore and quantify cellular cross-talk

3) Assess the contribution of supporting cells to cancer cells within the breast tumor microenvironment

4) Document the gradual response to targeted therapy at the transcriptional and chromatin level in breast cancer cells

Assistant Professor
Boston University School of Medicine
Computational Biomedicine

Associate Member
Boston University
Center for Regenerative Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2018 Abstract selected for oral talk at the Keystone meeting
2015 Abstract selected for oral talk at the Syboss meeting
2014 Abstract selected for oral talk at the BSCDB meeting
2010 IWT Fellowship: Strategic Basic Research Fund
2009 Ioannina University: International summer internship
2008 Tsinghua University: Travel and study fellowship

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Jiang B, Gao Y, Che J, Lu W, Kaltheuner IH, Dries R, Kalocsay M, Berberich MJ, Jiang J, You I, Kwiatkowski N, Riching KM, Daniels DL, Sorger PK, Geyer M, Zhang T, Gray NS. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol. 2021 Mar 22. PMID: 33753926
  2. Dries R, Zhu Q, Dong R, Eng CL, Li H, Liu K, Fu Y, Zhao T, Sarkar A, Bao F, George RE, Pierson N, Cai L, Yuan GC. Giotto: a toolbox for integrative analysis and visualization of spatial expression data. Genome Biol. 2021 Mar 08; 22(1):78. PMID: 33685491
  3. Deryckere A, Stappers E, Dries R, Peyre E, van den Berghe V, Conidi A, Zampeta FI, Francis A, Bresseleers M, Stryjewska A, Vanlaer R, Maas E, Smal IV, van IJcken WFJ, Grosveld FG, Nguyen L, Huylebroeck D, Seuntjens E. Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb. Development. 2020 05 26; 147(10). PMID: 32253238
  4. Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2020 01 13; 37(1):37-54.e9. PMID: 31883968
  5. Dries R, Stryjewska A, Coddens K, Okawa S, Notelaers T, Birkhoff J, Dekker M, Verfaillie CM, Del Sol A, Mulugeta E, Conidi A, Grosveld FG, Huylebroeck D. Integrative and perturbation-based analysis of the transcriptional dynamics of TGFß/BMP system components in transition from embryonic stem cells to neural progenitors. Stem Cells. 2020 02; 38(2):202-217. PMID: 31675135
  6. Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, Yuan GC, Young RA, George RE. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. 2019 08; 572(7771):676-680. PMID: 31391581
  7. Tracy S, Yuan GC, Dries R. RESCUE: imputing dropout events in single-cell RNA-sequencing data. BMC Bioinformatics. 2019 Jul 12; 20(1):388. PMID: 31299886
  8. Krajewska M, Dries R, Grassetti AV, Dust S, Gao Y, Huang H, Sharma B, Day DS, Kwiatkowski N, Pomaville M, Dodd O, Chipumuro E, Zhang T, Greenleaf AL, Yuan GC, Gray NS, Young RA, Geyer M, Gerber SA, George RE. CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation. Nat Commun. 2019 04 15; 10(1):1757. PMID: 30988284
  9. Eng CL, Lawson M, Zhu Q, Dries R, Koulena N, Takei Y, Yun J, Cronin C, Karp C, Yuan GC, Cai L. Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH. Nature. 2019 04; 568(7751):235-239. PMID: 30911168
  10. Zhu Q, Shah S, Dries R, Cai L, Yuan GC. Identification of spatially associated subpopulations by combining scRNAseq and sequential fluorescence in situ hybridization data. Nat Biotechnol. 2018 Oct 29. PMID: 30371680
Showing 10 of 20 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 20 publications over 9 distinct years, with a maximum of 6 publications in 2019

Contact for Mentoring:

670 Albany Street
Boston MA 02118
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