Ruben Dries, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, Erasmus Universiteit Rotterdam
PhD, Katholieke Univ Leuven
MS, Katholieke Univ Leuven
BS, Katholieke Univ Leuven



Ruben Dries, PhD combines computational data analysis with novel experimental approaches and technologies to understand basic biological concepts in health and disease. These insights could then be leveraged to target tumor specific processes or inhibit the development of treatment resistance. These interests grew dynamically throughout his research career. In his early studies Dr. Dries developed a systems biology approach to dissect the regulatory network of neural differentiating embryonic stem cells and used this knowledge at a later stage to understand how cancer cells transcriptionally respond to targeted therapies and other stress factors. More recently, he expanded this area by focusing on how cells can spatially communicate within their microenvironment and build tools to facilitate these type of analyses.


As a young and dynamic group his lab works together as a team in the following areas:

1) Establishing multi-cellular breast cancer models that better reflect spatial tumor heterogeneity

2) Building tools to explore and quantify cellular cross-talk

3) Assess the contribution of supporting cells to cancer cells within the breast tumor microenvironment

4) Document the gradual response to targeted therapy at the transcriptional and chromatin level in breast cancer cells

Diversity, Equity, Inclusion and Accessibility

I believe that diversity and inclusion (D&I) is a core part of science and I am fully committed to serving as an advocate for D&I in my lab and academic scientific ecosystem. From a social justice perspective, D&I is critical for eliminating barriers to higher education like inequality and prejudice, and evening the playing field for the next generation of scientists from diverse backgrounds. Diverse research teams have been shown to lead to more impactful research. In my lab, I openly welcome scientists from a variety of backgrounds and at all stages of their careers to foster an inclusive and interdisciplinary research environment. It is clear to me that D&I provide major benefits to science and is absolutely necessary for upholding rigorous science. Without D&I in science, it is impossible to grasp human biology that varies from people with diverse ethnic and socioeconomic backgrounds.
In August 2020, I launched my lab with the goal of creating an inclusive culture for people from diverse backgrounds. I remind myself of the importance of D&I in my interactions with students, coworkers, and leadership, and I actively encourage others to take part in activities that will advance D&I initiatives. My desire to contribute to D&I is also reflected in the types of research problems I pursue. My lab recently established a research collaboration with Massachusetts General Hospital, the Boston University Medical Center (BUMC) Cancer Center, and other researchers in my lab to investigate therapies for predominantly Black women with late-stage breast cancer.
In short, I consider promoting D&I to be one of the most important aspects of my role as a research professor and mentor. In the future, I will continue to promote D&I efforts in my scientific community. My goal is to serve as an advocate for D&I in my scientific ecosystem at BUMC. I will continue to work closely with other labs and leadership who are also dedicated to this goal and improving D&I in my scientific academic ecosystem.

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Computational Biomedicine

Associate Member
Boston University
Center for Regenerative Medicine


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Ikonomou L, Magnusson M, Dries R, Herzog EL, Hynds RE, Borok Z, Park JA, Skolasinski S, Burgess JK, Turner L, Mojarad SM, Mahoney JE, Lynch T, Lehmann M, Thannickal VJ, Hook JL, Vaughan AE, Hoffman ET, Weiss DJ, Ryan AL. Stem cells, cell therapies, and bioengineering in lung biology and disease 2021. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 01; 323(3):L341-L354. PMID: 35762622; PMCID: PMC9484991; DOI: 10.1152/ajplung.00113.2022;
     
  2. Del Rossi N, Chen JG, Yuan GC, Dries R. Analyzing Spatial Transcriptomics Data Using Giotto. Curr Protoc. 2022 Apr; 2(4):e405. PMID: 35384407; PMCID: PMC9009248; DOI: 10.1002/cpz1.405;
     
  3. Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, Dries R, Campbell JD, Belkina AC, Balazs AB, Murphy GJ. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022 03 01; 13(1):1103.View Related Profiles. PMID: 35232959; PMCID: PMC8888592; DOI: 10.1038/s41467-022-28616-x;
     
  4. Dries R, Chen J, Del Rossi N, Khan MM, Sistig A, Yuan GC. Advances in spatial transcriptomic data analysis. Genome Res. 2021 10; 31(10):1706-1718. PMID: 34599004; PMCID: PMC8494229; DOI: 10.1101/gr.275224.121;
     
  5. Cao KL, Abadi AJ, Davis-Marcisak EF, Hsu L, Arora A, Coullomb A, Deshpande A, Feng Y, Jeganathan P, Loth M, Meng C, Mu W, Pancaldi V, Sankaran K, Righelli D, Singh A, Sodicoff JS, Stein-O'Brien GL, Subramanian A, Welch JD, You Y, Argelaguet R, Carey VJ, Dries R, Greene CS, Holmes S, Love MI, Ritchie ME, Yuan GC, Culhane AC, Fertig E. Author Correction: Community-wide hackathons to identify central themes in single-cell multi-omics. Genome Biol. 2021 Aug 25; 22(1):246. PMID: 34433496; PMCID: PMC8385897; DOI: 10.1186/s13059-021-02468-y;
     
  6. Lê Cao KA, Abadi AJ, Davis-Marcisak EF, Hsu L, Arora A, Coullomb A, Deshpande A, Feng Y, Jeganathan P, Loth M, Meng C, Mu W, Pancaldi V, Sankaran K, Righelli D, Singh A, Sodicoff JS, Stein-O'Brien GL, Subramanian A, Welch JD, You Y, Argelaguet R, Carey VJ, Dries R, Greene CS, Holmes S, Love MI, Ritchie ME, Yuan GC, Culhane AC, Fertig E. Community-wide hackathons to identify central themes in single-cell multi-omics. Genome Biol. 2021 08 05; 22(1):220. PMID: 34353350; PMCID: PMC8340473; DOI: 10.1186/s13059-021-02433-9;
     
  7. Huang H, Gont A, Kee L, Dries R, Pfeifer K, Sharma B, Debruyne DN, Harlow M, Sengupta S, Guan J, Yeung CM, Wang W, Hallberg B, Palmer RH, Irwin MS, George RE. Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration. Cell Rep. 2021 07 13; 36(2):109363. PMID: 34260934; PMCID: PMC8328392; DOI: 10.1016/j.celrep.2021.109363;
     
  8. Jiang B, Gao Y, Che J, Lu W, Kaltheuner IH, Dries R, Kalocsay M, Berberich MJ, Jiang J, You I, Kwiatkowski N, Riching KM, Daniels DL, Sorger PK, Geyer M, Zhang T, Gray NS. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol. 2021 06; 17(6):675-683. PMID: 33753926; PMCID: PMC8590456; DOI: 10.1038/s41589-021-00765-y;
     
  9. Dries R, Zhu Q, Dong R, Eng CL, Li H, Liu K, Fu Y, Zhao T, Sarkar A, Bao F, George RE, Pierson N, Cai L, Yuan GC. Giotto: a toolbox for integrative analysis and visualization of spatial expression data. Genome Biol. 2021 03 08; 22(1):78. PMID: 33685491; PMCID: PMC7938609; DOI: 10.1186/s13059-021-02286-2;
     
  10. Deryckere A, Stappers E, Dries R, Peyre E, van den Berghe V, Conidi A, Zampeta FI, Francis A, Bresseleers M, Stryjewska A, Vanlaer R, Maas E, Smal IV, van IJcken WFJ, Grosveld FG, Nguyen L, Huylebroeck D, Seuntjens E. Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb. Development. 2020 05 26; 147(10). PMID: 32253238
     
Showing 10 of 28 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 28 publications over 10 distinct years, with a maximum of 6 publications in 2019 and 2021

YearPublications
20111
20131
20151
20162
20173
20183
20196
20202
20216
20223

2018 Abstract selected for oral talk at the Keystone meeting
2015 Abstract selected for oral talk at the Syboss meeting
2014 Abstract selected for oral talk at the BSCDB meeting
2010 IWT Fellowship: Strategic Basic Research Fund
2009 Ioannina University: International summer internship
2008 Tsinghua University: Travel and study fellowship
Contact for Mentoring:

670 Albany Street
Boston MA 02118
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