Robert Walker

Clinical Instructor

Boston University Chobanian & Avedisian School of Medicine

Neurosurgery

MD, Howard University
MSc, University of Utah
BS, La Sierra University

Websites

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	Research Gate

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Matsukawa T, Yin M, Nigam N, Negi V, Li L, Small D, Zhu YJ, Walker RL, Meltzer PS, Aplan PD. NUP98::Nsd1 and FLT3-ITD collaborate to generate acute myeloid leukemia. Leukemia. 2023 Jul; 37(7):1545-1548. PMID: 37147424; PMCID: PMC10317830; DOI: 10.1038/s41375-023-01913-0;

Matsukawa T, Yin M, Baslan T, Chung YJ, Cao D, Bertoli R, Zhu YJ, Walker RL, Freeland A, Knudsen E, Lowe SW, Meltzer PS, Aplan PD. Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context. FASEB J. 2022 Sep; 36(9):e22430. PMID: 35920299; PMCID: PMC9377154; DOI: 10.1096/fj.202200061RR;

Li XL, Pongor L, Tang W, Das S, Muys BR, Jones MF, Lazar SB, Dangelmaier EA, Hartford CC, Grammatikakis I, Hao Q, Sun Q, Schetter A, Martindale JL, Tang B, Jenkins LM, Robles AI, Walker RL, Ambs S, Chari R, Shabalina SA, Gorospe M, Hussain SP, Harris CC, Meltzer PS, Prasanth KV, Aladjem MI, Andresson T, Lal A. A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells. Elife. 2020 Oct 28; 9. PMID: 33112233; PMCID: PMC7673786; DOI: 10.7554/eLife.53734;

Lazar SB, Pongor L, Li XL, Grammatikakis I, Muys BR, Dangelmaier EA, Redon CE, Jang SM, Walker RL, Tang W, Ambs S, Harris CC, Meltzer PS, Aladjem MI, Lal A. Genome-Wide Analysis of the FOXA1 Transcriptional Network Identifies Novel Protein-Coding and Long Noncoding RNA Targets in Colorectal Cancer Cells. Mol Cell Biol. 2020 10 13; 40(21). PMID: 32839292; PMCID: PMC7556848; DOI: 10.1128/MCB.00224-20;

van Wietmarschen N, Sridharan S, Nathan WJ, Tubbs A, Chan EM, Callen E, Wu W, Belinky F, Tripathi V, Wong N, Foster K, Noorbakhsh J, Garimella K, Cruz-Migoni A, Sommers JA, Huang Y, Borah AA, Smith JT, Kalfon J, Kesten N, Fugger K, Walker RL, Dolzhenko E, Eberle MA, Hayward BE, Usdin K, Freudenreich CH, Brosh RM, West SC, McHugh PJ, Meltzer PS, Bass AJ, Nussenzweig A. Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature. 2020 Oct; 586(7828):292-298. PMID: 32999459; PMCID: PMC8916167; DOI: 10.1038/s41586-020-2769-8;

McGlinchey RP, Lacy SM, Walker RL, Lee JC. Cathepsin K is a potent disaggregase of a-synuclein fibrils. Biochem Biophys Res Commun. 2020 09 03; 529(4):1106-1111. PMID: 32819572; PMCID: PMC7478362; DOI: 10.1016/j.bbrc.2020.06.155;

Ohkuni K, Suva E, Au WC, Walker RL, Levy-Myers R, Meltzer PS, Baker RE, Basrai MA. Deposition of Centromeric Histone H3 Variant CENP-A/Cse4 into Chromatin Is Facilitated by Its C-Terminal Sumoylation. Genetics. 2020 04; 214(4):839-854. PMID: 32111629; PMCID: PMC7153950; DOI: 10.1534/genetics.120.303090;

Au WC, Zhang T, Mishra PK, Eisenstatt JR, Walker RL, Ocampo J, Dawson A, Warren J, Costanzo M, Baryshnikova A, Flick K, Clark DJ, Meltzer PS, Baker RE, Myers C, Boone C, Kaiser P, Basrai MA. Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast. PLoS Genet. 2020 02; 16(2):e1008597. PMID: 32032354; PMCID: PMC7032732; DOI: 10.1371/journal.pgen.1008597;

Yin M, Chung YJ, Lindsley RC, Walker RL, Zhu YJ, Ebert BL, Meltzer PS, Aplan PD. Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background. Blood. 2019 06 13; 133(24):2610-2614. PMID: 30992267; PMCID: PMC6566592; DOI: 10.1182/blood.2018864173;

Yost KE, Clatterbuck Soper SF, Walker RL, Pineda MA, Zhu YJ, Ester CD, Showman S, Roschke AV, Waterfall JJ, Meltzer PS. Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Sci Rep. 2019 03 14; 9(1):4544. PMID: 30872698; PMCID: PMC6418139; DOI: 10.1038/s41598-019-41058-8;

Showing 10 of 35 results. Show More

Kouprina N, Liskovykh M, Lee NCO, Noskov VN, Waterfall JJ, Walker RL, Meltzer PS, Topol EJ, Larionov V. Analysis of the 9p21.3 sequence associated with coronary artery disease reveals a tendency for duplication in a CAD patient. Oncotarget. 2018 Mar 16; 9(20):15275-15291. PMID: 29632643; PMCID: PMC5880603; DOI: 10.18632/oncotarget.24567;

Flynn JD, McGlinchey RP, Walker RL, and Lee JC. Structural features of a-synuclein amyloid fibrils revealed by Raman spectroscopy. J. Biol Chem. 2018.
DeTorres AT, Brewer C, Zalewski C, King K, Walker RL, Asthagiri A, Chittiboina P, Kim J. . Audiologic Natural History of Small Volume Cochleovestibular Schwannomas in Neurofibromatosis Type 2. Otol & Neurotol. 2018.

Flynn JD, McGlinchey RP, Walker RL, Lee JC. Structural features of a-synuclein amyloid fibrils revealed by Raman spectroscopy. J Biol Chem. 2018 01 19; 293(3):767-776. PMID: 29191831; PMCID: PMC5777252; DOI: 10.1074/jbc.M117.812388;

Walker RL, Mehta G, Brewer C, Asthagiri A, Kim J, Butman J, Chittiboina P. MRI FLAIR hyperintensity in labyrinth is a predictive biomarker for hearing loss in neurofibromatosis type 2 patients with small vestibular schwannoma. J. Neurosurg. 2017.

Pfefferkorn CM, Walker RL, He Y, Gruschus JM, Lee JC. Tryptophan probes reveal residue-specific phospholipid interactions of apolipoprotein C-III. Biochim Biophys Acta. 2015 Nov; 1848(11 Pt A):2821-8. PMID: 26301570; PMCID: PMC4598292; DOI: 10.1016/j.bbamem.2015.08.018;

Gindin Y, Jiang Y, Francis P, Walker RL, Abaan OD, Zhu YJ, Meltzer PS. miR-23a impairs bone differentiation in osteosarcoma via down-regulation of GJA1. Front Genet. 2015; 6:233. PMID: 26191074; PMCID: PMC4488756; DOI: 10.3389/fgene.2015.00233;

Grøntved L, Waterfall JJ, Kim DW, Baek S, Sung MH, Zhao L, Park JW, Nielsen R, Walker RL, Zhu YJ, Meltzer PS, Hager GL, Cheng SY. Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling. Nat Commun. 2015 Apr 28; 6:7048. PMID: 25916672; PMCID: PMC6309829; DOI: 10.1038/ncomms8048;

Pfefferkorn CM, Walker RL, He Y, Gruschus JM, Lee J. Tryptophan probes reveal residue-specific phospholipid interactions of apolipoprotein C-III. Biochimica et Biophysica Acta-Biomembranes. 2015; 2821-2828.

Killian JK, Miettinen M, Walker RL, Wang Y, Zhu YJ, Waterfall JJ, Noyes N, Retnakumar P, Yang Z, Smith WI, Killian MS, Lau CC, Pineda M, Walling J, Stevenson H, Smith C, Wang Z, Lasota J, Kim SY, Boikos SA, Helman LJ, Meltzer PS. Recurrent epimutation of SDHC in gastrointestinal stromal tumors. Sci Transl Med. 2014 Dec 24; 6(268):268ra177. PMID: 25540324; PMCID: PMC7670881; DOI: 10.1126/scitranslmed.3009961;

Li XL, Hara T, Choi Y, Subramanian M, Francis P, Bilke S, Walker RL, Pineda M, Zhu Y, Yang Y, Luo J, Wakefield LM, Brabletz T, Park BH, Sharma S, Chowdhury D, Meltzer PS, Lal A. A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster. Mol Cell Biol. 2014 Feb; 34(3):533-50. PMID: 24277930

Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ, Meltzer PS. High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet. 2014 Jan; 46(1):8-10. PMID: 24241536

Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS. The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology. Cancer Res. 2013 Jul 15; 73(14):4372-82. PMID: 23856246; PMCID: PMC4893961; DOI: 10.1158/0008-5472.CAN-12-3342;

Klorin G, Rozenblum E, Glebov O, Walker RL, Park Y, Meltzer PS, Kirsch IR, Kaye FJ, Roschke AV. Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines. Cancer Genet. 2013 May; 206(5):191-205. PMID: 23830731; PMCID: PMC4030604; DOI: 10.1016/j.cancergen.2013.04.006;

Beachy SH, Onozawa M, Chung YJ, Slape C, Bilke S, Francis P, Pineda M, Walker RL, Meltzer P, Aplan PD. Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. Blood. 2012 Aug 02; 120(5):1048-59. PMID: 22723554; PMCID: PMC3412328; DOI: 10.1182/blood-2012-01-401760;

O'Shea PJ, Kim DW, Logan JG, Davis S, Walker RL, Meltzer PS, Cheng SY, Williams GR. Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor ß gene due to activation of Wnt/ß-catenin protein signaling. J Biol Chem. 2012 May 18; 287(21):17812-17822. PMID: 22442145; PMCID: PMC3366792; DOI: 10.1074/jbc.M111.311464;

Figueroa JD, Cordero K, Baldeosingh K, Torrado AI, Walker RL, Miranda JD, and De Leon M. Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury. . J. Neurotrauma. 2012.

Killian JK, Walker RL, Bilke S, Chen Y, Davis S, Cornelison R, Smith WI, Meltzer PS. Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples. Methods Mol Biol. 2012; 823:107-18. PMID: 22081342

Killian JK, Bilke S, Davis S, Walker RL, Jaeger E, Killian MS, Waterfall JJ, Bibikova M, Fan JB, Smith WI, Meltzer PS. A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology. Am J Pathol. 2011 Jul; 179(1):55-65. PMID: 21641572; PMCID: PMC3123808; DOI: 10.1016/j.ajpath.2011.03.022;

Zaidi MR, Davis S, Noonan FP, Graff-Cherry C, Hawley TS, Walker RL, Feigenbaum L, Fuchs E, Lyakh L, Young HA, Hornyak TJ, Arnheiter H, Trinchieri G, Meltzer PS, De Fabo EC, Merlino G. Interferon-? links ultraviolet radiation to melanomagenesis in mice. Nature. 2011 Jan 27; 469(7331):548-53. PMID: 21248750; PMCID: PMC3140101; DOI: 10.1038/nature09666;

Walker RL, Lee JC. Membrane interactions of apolipoprotein C-III probed by tryptophan fluorescence. Society Meeting Abstracts. Biophysical Journal,. 2011; 508.

Furumoto H, Ying H, Chandramouli GV, Zhao L, Walker RL, Meltzer PS, Willingham MC, Cheng SY. An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis. Mol Cell Biol. 2005 Jan; 25(1):124-35. PMID: 15601836; PMCID: PMC538780; DOI: 10.1128/MCB.25.1.124-135.2005;

Cunliffe HE, Ringnér M, Bilke S, Walker RL, Cheung JM, Chen Y, Meltzer PS. The gene expression response of breast cancer to growth regulators: patterns and correlation with tumor expression profiles. Cancer Res. 2003 Nov 01; 63(21):7158-66. PMID: 14612509

Kees UR, Ford J, Watson M, Murch A, Ringner M, Walker RL, Meltzer P. Gene expression profiles in a panel of childhood leukemia cell lines mirror critical features of the disease. . 2003 Jul; 2(7):671-7. PMID: 12883040

Yen PM, Feng X, Flamant F, Chen Y, Walker RL, Weiss RE, Chassande O, Samarut J, Refetoff S, Meltzer PS. Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. . 2003 Jun; 4(6):581-7. PMID: 12776178

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 13 distinct years, with a maximum of 6 publications in 2020

Bar chart showing 35 publications over 13 distinct years, with a maximum of 6 publications in 2020

Year	Publications
2003	3
2005	1
2011	3
2012	4
2013	4
2014	1
2015	4
2017	2
2018	3
2019	2
2020	6
2022	1
2023	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biophysical Spectroscopy
Protein Structure
Protein Purification
Membrane Biophysics

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