Richard I. Near, PhD
Research Assistant Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, University of Washington
MS, University of Washington

Expertise includes: Molecular biology in general including cloning, genomics, RTPCR, geneomic PCR, vector construction including Lentiviral vectors, RNA and DNA isolation animal work, creation of mouse IPSC cells and infection with Lentiviral vectors, transgenic mice, teratoma creation and mouse tumors. Antibody background and antibody genomic families. Previously have worked on breast cancer involving the gene BCAR3 and related family members as related to estrogen treatment resistance, differentiation patterns, cell migration, cell matrix interactions and Cancer Stem cells and metastases. I also created a BCAR KO mouse strain with unusual characteristics. Previous studied also were applied to signal transduction in cancer; Had interest in Zinc finger proteins and RNA zipcodes.

More recently in conjunction with the company ANTIGEN, we have interests in AIDs with a SBIR grant. Further we have interests in immunology related to Antibody Dependent Cell Cytotoxicity ADCC. We have further interests in Antibody FCR (receptors) and have recent research in COVID. We have created unusual cloning vectors and cell strains that do not fucosilate proteins which may
allow antibodies greater stability (as well as other proteins). We also work with single-chain antibodies and express high amounts of proteins in variants of CHO cell lines.

Boston University
BU-BMC Cancer Center

Boston Medical Center

Boston University
Genome Science Institute

Cell Line Engineering with Genomics Tools
07/01/2015 - 06/30/2020 (PI)
Antagen Institute for Biomed Research


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Changchuin Mao, Richard Near and Wenda Gao. Identification of a Guinea Pig Fc?Receptor that Exhibits Enhanced Binding to Afucosylated Human and Mouse IgG. . J Infect Dis Med1: 102-105. . 2016; 102-105. .
  2. Makkinje A, Vanden Borre P, Near RI, Patel PS, Lerner A. Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas). J Biol Chem. 2012 Aug 10; 287(33):27703-14.View Related Profiles. PMID: 22711540; PMCID: PMC3431688; DOI: 10.1074/jbc.M112.389981;
  3. Vanden Borre P, Near RI, Makkinje A, Mostoslavsky G, Lerner A. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal. 2011 Jun; 23(6):1030-40.View Related Profiles. PMID: 21262352; PMCID: PMC3062698; DOI: 10.1016/j.cellsig.2011.01.018;
  4. Makkinje A, Near RI, Infusini G, Vanden Borre P, Bloom A, Cai D, Costello CE, Lerner A. AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal. 2009 Sep; 21(9):1423-35.View Related Profiles. PMID: 19454314; PMCID: PMC2740797; DOI: 10.1016/j.cellsig.2009.05.006;
  5. Near RI, Smith RS, Toselli PA, Freddo TF, Bloom AB, Vanden Borre P, Seldin DC, Lerner A. Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 2009; 15:685-99.View Related Profiles. PMID: 19365570; PMCID: PMC2666772
  6. Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. J Cell Physiol. 2007 Sep; 212(3):655-65.View Related Profiles. PMID: 17427198; PMCID: PMC2640322
  7. Felekkis KN, Narsimhan RP, Near R, Castro AF, Zheng Y, Quilliam LA, Lerner A. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res. 2005 Jan; 3(1):32-41.View Related Profiles. PMID: 15671247
  8. Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A. AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res. 2003 Oct 15; 63(20):6802-8.View Related Profiles. PMID: 14583477
  9. Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol. 2003 Jan 15; 170(2):969-78.View Related Profiles. PMID: 12517963
  10. Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A. Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia. Clin Cancer Res. 2002 Feb; 8(2):589-95.View Related Profiles. PMID: 11839681
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 34 publications over 23 distinct years, with a maximum of 4 publications in 1993


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Breast Cancer
Knock-out Mice
Prostate Cancer

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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