Richard Fine | Profiles RNS

Richard E. Fine, PhD

Emeritus Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Brandeis University
BS, University of California, Berkeley

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Bedford VA - Edith Nourse Rogers Memorial VA Hosp

BU Research
NIH RePORTER Research

Library Screen for Drugs that Increase IDE in Cerebrovasculature
10/01/2004 - 04/30/2006 (PI)
Harvard Center for Neurodegeneration and Repair (HCNR)

A Beta Degradation by Cultured Human Cerebrovascular Endothelial Cells
10/01/2002 - 09/30/2005 (PI)
Alzheimer's Association

Isolation of Peptide Containing Vesicles from the Brain
01/01/2001 - 12/31/2004 (PI)
Atiantis Biopharmaceuticals Inc

Neuronal Ca++ Sequestering Compartments: Protective Role
05/01/1998 - 04/30/2004 (PI)
NIH/National Institute on Aging
5 R37 AG05894 30

Title

Yr	Title	Project-Sub Proj	Pubs
2014	The role of retromer in Parkinson's Disease	5I21BX001620-02
2013	The role of retromer in Parkinson's Disease	1I21BX001620-01A1
2006	PROTEINS &PEPTIDES ASSOCIATED W/ NEURONAL DENSE CORE VESICLES	5P41RR010888-10-7086	259
2006	CHARACTERIZATION OF THE SYNAPTIC PROTEIN SV2	5P41RR010888-10-7165	259
2005	PROTEINS &PEPTIDES ASSOCIATED W/ NEURONAL DENSE CORE VESICLES	5P41RR010888-09-118	259
2005	CHARACTERIZATION OF THE SYNAPTIC PROTEIN SV2	5P41RR010888-09-211	259
2004	PROTEINS &PEPTIDES ASSOCIATED W/ NEURONAL DENSE CORE VESICLES	5P41RR010888-08-118	259
2004	CHARACTERIZATION OF THE SYNAPTIC PROTEIN SV2	5P41RR010888-08-211	259
2002	NEURONAL CA++ SEQUESTERING COMPARTMENTS--PROTECTIVE ROLE	5R37AG005894-30	22
2001	NEURONAL CA++ SEQUESTERING COMPARTMENTS--PROTECTIVE ROLE	5R37AG005894-29	22

Showing 10 of 36 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Zhu H, Wang X, Wallack M, Li H, Carreras I, Dedeoglu A, Hur JY, Zheng H, Li H, Fine R, Mwamburi M, Sun X, Kowall N, Stern RA, Qiu WQ. Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease. Mol Psychiatry. 2015 Feb; 20(2):252-62.View Related Profiles.

Dedeoglu, Alpaslan
Zhu, Haihao
Carreras, Isabel
Kowall, Neil
Fine, Richard
Stern, Robert
Qiu, Wendy

PMID: 24614496; PMCID: PMC4161670; DOI: 10.1038/mp.2014.17;

Sullivan CP, Berg EA, Elliott-Bryant R, Fishman JB, McKee AC, Morin PJ, Shia MA, Fine RE. Pyroglutamate-Aß 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aß 11 forming the central core. Neurosci Lett. 2011 Nov 14; 505(2):109-12.View Related Profiles.

McKee, Ann
Morin, Peter
Fine, Richard

PMID: 22001577; PMCID: PMC3253715; DOI: 10.1016/j.neulet.2011.09.071;

Sullivan CP, Jay AG, Stack EC, Pakaluk M, Wadlinger E, Fine RE, Wells JM, Morin PJ. Retromer disruption promotes amyloidogenic APP processing. Neurobiol Dis. 2011 Aug; 43(2):338-45.View Related Profiles.

Jay, Anthony
Morin, Peter
Fine, Richard

PMID: 21515373; PMCID: PMC3114192; DOI: 10.1016/j.nbd.2011.04.002;

Yaar M, Zhai S, Panova I, Fine RE, Eisenhauer PB, Blusztajn JK, Lopez-Coviella I, Gilchrest BA. A cyclic peptide that binds p75(NTR) protects neurones from beta amyloid (1-40)-induced cell death. Neuropathol Appl Neurobiol. 2007 Oct; 33(5):533-43.View Related Profiles.

Gilchrest, Barbara
Blusztajn, Jan
Yaar, Mina
Fine, Richard

PMID: 17596181

Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures. J Neurosci Res. 2006 May 15; 83(7):1262-70.View Related Profiles.

McKee, Ann
Carreras, Isabel
Ullman, M.
Fine, Richard

PMID: 16511862

Carreras I, Garrett-Young R, Ullman MD, Eisenhauer PB, Fine RE, Wells JM, Conn KJ. Upregulation of clusterin/apolipoprotein J in lactacystin-treated SH-SY5Y cells. J Neurosci Res. 2005 Feb 15; 79(4):495-502.View Related Profiles.

Carreras, Isabel
Ullman, M.
Fine, Richard

PMID: 15635600

Gao W, Eisenhauer PB, Conn K, Lynch JA, Wells JM, Ullman MD, McKee A, Thatte HS, Fine RE. Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells. Neurosci Lett. 2004 Nov 16; 371(1):6-11.View Related Profiles.

Ullman, M.
Fine, Richard

PMID: 15500957

Conn KJ, Gao W, McKee A, Lan MS, Ullman MD, Eisenhauer PB, Fine RE, Wells JM. Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology. Brain Res. 2004 Oct 1; 1022(1-2):164-72.View Related Profiles.

McKee, Ann
Ullman, M.
Fine, Richard

PMID: 15353226

Eisenhauer PB, Jacewicz MS, Conn KJ, Koul O, Wells JM, Fine RE, Newburg DS. Escherichia coli Shiga toxin 1 and TNF-alpha induce cytokine release by human cerebral microvascular endothelial cells. Microb Pathog. 2004 Apr; 36(4):189-96. PMID: 15001224

Conn KJ, Ullman MD, Larned MJ, Eisenhauer PB, Fine RE, Wells JM. cDNA microarray analysis of changes in gene expression associated with MPP+ toxicity in SH-SY5Y cells. Neurochem Res. 2003 Dec; 28(12):1873-81.View Related Profiles.

Ullman, M.
Fine, Richard

PMID: 14649730

Showing 10 of 56 results. Show More

Conn KJ, Gao WW, Ullman MD, McKeon-O'Malley C, Eisenhauer PB, Fine RE, Wells JM. Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells. J Neurosci Res. 2002 Jun 15; 68(6):755-60.View Related Profiles.

Ullman, M.
Fine, Richard

PMID: 12111836

Yaar M, Zhai S, Fine RE, Eisenhauer PB, Arble BL, Stewart KB, Gilchrest BA. Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling. J Biol Chem. 2002 Mar 8; 277(10):7720-5.View Related Profiles.

Gilchrest, Barbara
Yaar, Mina
Fine, Richard

PMID: 11756426

Conn KJ, Ullman MD, Eisenhauer PB, Fine RE, Wells JM. Decreased expression of the NADH:ubiquinone oxidoreductase (complex I) subunit 4 in 1-methyl-4-phenylpyridinium -treated human neuroblastoma SH-SY5Y cells. Neurosci Lett. 2001 Jun 29; 306(3):145-8.View Related Profiles.

Ullman, M.
Fine, Richard

PMID: 11406316

Johnson RJ, Xiao G, Shanmugaratnam J, Fine RE. Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein. Neurobiol Aging. 2001 May-Jun; 22(3):387-95. PMID: 11378243

Eisenhauer PB, Chaturvedi P, Fine RE, Ritchie AJ, Pober JS, Cleary TG, Newburg DS. Tumor necrosis factor alpha increases human cerebral endothelial cell Gb3 and sensitivity to Shiga toxin. Infect Immun. 2001 Mar; 69(3):1889-94. PMID: 11179369; PMCID: PMC98098; DOI: 10.1128/IAI.69.3.1889-1894.2001;

Berg EA, Johnson RJ, Leeman SE, Boyd N, Kimerer L, Fine RE. Isolation and characterization of substance P-containing dense core vesicles from rabbit optic nerve and termini. J Neurosci Res. 2000 Dec 15; 62(6):830-9.View Related Profiles.

Fine, Richard
Leeman, Susan

PMID: 11107168

Davies TA, Long HJ, Eisenhauer PB, Hastey R, Cribbs DH, Fine RE, Simons ER. Beta amyloid fragments derived from activated platelets deposit in cerebrovascular endothelium: usage of a novel blood brain barrier endothelial cell model system. Amyloid. 2000 Sep; 7(3):153-65.View Related Profiles.

Simons, Elizabeth
Fine, Richard
Davies-Heerema, Theresa

PMID: 11019856

Bartolák-Suki E, Sipe JD, Fine RE, Rosene DL, Moss MB. Serum amyloid A is present in the capillaries and microinfarcts of hypertensive monkey brain: an immunohistochemical study. Amyloid. 2000 Jun; 7(2):111-7.View Related Profiles.

Rosene, Douglas
Bartolak-Suki, Erzsebet
Moss, Mark
Fine, Richard

PMID: 10842713

Chung TF, Sipe JD, McKee A, Fine RE, Schreiber BM, Liang JS, Johnson RJ. Serum amyloid A in Alzheimer's disease brain is predominantly localized to myelin sheaths and axonal membrane. Amyloid. 2000 Jun; 7(2):105-10.View Related Profiles.

McKee, Ann
Schreiber, Barbara
Fine, Richard

PMID: 10842712

Hara M, Yaar M, Byers HR, Goukassian D, Fine RE, Gonsalves J, Gilchrest BA. Kinesin participates in melanosomal movement along melanocyte dendrites. J Invest Dermatol. 2000 Mar; 114(3):438-43.View Related Profiles.

Gilchrest, Barbara
Goukassian, David
Yaar, Mina
Fine, Richard

PMID: 10692101

Xiao G, Chung TF, Fine RE, Johnson RJ. Calreticulin is transported to the surface of NG108-15 cells where it forms surface patches and is partially degraded in an acidic compartment. J Neurosci Res. 1999 Dec 1; 58(5):652-62. PMID: 10561693

Schreiber BM, Veverbrants M, Fine RE, Blusztajn JK, Salmona M, Patel A, Sipe JD. Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis. Biochem J. 1999 Nov 15; 344 Pt 1:7-13.View Related Profiles.

Schreiber, Barbara
Blusztajn, Jan
Fine, Richard

PMID: 10548527; PMCID: PMC1220607

Xiao G, Chung TF, Pyun HY, Fine RE, Johnson RJ. KDEL proteins are found on the surface of NG108-15 cells. Brain Res Mol Brain Res. 1999 Oct 1; 72(2):121-8. PMID: 10529470

Thoidis G, Kupriyanova T, Cunningham JM, Chen P, Cadel S, Foulon T, Cohen P, Fine RE, Kandror KV. Glucose transporter Glut3 is targeted to secretory vesicles in neurons and PC12 cells. J Biol Chem. 1999 May 14; 274(20):14062-6.View Related Profiles.

Kandror, Konstantin
Fine, Richard

PMID: 10318820

Abraham CR, Marshall DC, Tibbles HE, Otto K, Long HJ, Billingslea AM, Hastey R, Johnson R, Fine RE, Smith SJ, Simons ER, Davies TA. Platelets and DAMI megakaryocytes possess beta-secretase-like activity. J Lab Clin Med. 1999 May; 133(5):507-15.View Related Profiles.

Abraham, Carmela
Simons, Elizabeth
Fine, Richard
Davies-Heerema, Theresa

PMID: 10235134

Fine RE. The biochemistry of Alzheimer disease. Alzheimer Dis Assoc Disord. 1999 Apr-Jun; 13 Suppl 1:S82-7. PMID: 10369525

Davies TA, Billingslea AM, Long HJ, Tibbles H, Wells JM, Eisenhauer PB, Smith SJ, Cribbs DH, Fine RE, Simons ER. Brain endothelial cell enzymes cleave platelet-retained amyloid precursor protein. J Lab Clin Med. 1998 Oct; 132(4):341-50.View Related Profiles.

Simons, Elizabeth
Fine, Richard
Davies-Heerema, Theresa

PMID: 9794706

Simons ER, Marshall DC, Long HJ, Otto K, Billingslea A, Tibbles H, Wells J, Eisenhauer P, Fine RE, Cribbs DH, Davies TA, Abraham CR. Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases. Amyloid. 1998 Sep; 5(3):153-62.View Related Profiles.

Abraham, Carmela
Simons, Elizabeth
Fine, Richard
Davies-Heerema, Theresa

PMID: 9818052

Thoidis G, Chen P, Pushkin AV, Vallega G, Leeman SE, Fine RE, Kandror KV. Two distinct populations of synaptic-like vesicles from rat brain. Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1):183-8.View Related Profiles.

Kandror, Konstantin
Fine, Richard
Leeman, Susan

PMID: 9419350; PMCID: PMC18168

Johnson RJ, Liu N, Shanmugaratnam J, Fine RE. Increased calreticulin stability in differentiated NG-108-15 cells correlates with resistance to apoptosis induced by antisense treatment. Brain Res Mol Brain Res. 1998 Jan; 53(1-2):104-11. PMID: 9473613

Yaar M, Zhai S, Pilch PF, Doyle SM, Eisenhauer PB, Fine RE, Gilchrest BA. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J Clin Invest. 1997 Nov 1; 100(9):2333-40.View Related Profiles.

Gilchrest, Barbara
Yaar, Mina
Pilch, Paul
Fine, Richard

PMID: 9410912; PMCID: PMC508430

Shanmugaratnam J, Berg E, Kimerer L, Johnson RJ, Amaratunga A, Schreiber BM, Fine RE. Retinal Muller glia secrete apolipoproteins E and J which are efficiently assembled into lipoprotein particles. Brain Res Mol Brain Res. 1997 Oct 15; 50(1-2):113-20.View Related Profiles.

Schreiber, Barbara
Fine, Richard

PMID: 9406925

Liang JS, Sloane JA, Wells JM, Abraham CR, Fine RE, Sipe JD. Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain. Neurosci Lett. 1997 Apr 4; 225(2):73-6.View Related Profiles.

Abraham, Carmela
Fine, Richard

PMID: 9147377

Davies TA, Long HJ, Tibbles HE, Sgro KR, Wells JM, Rathbun WH, Seetoo KF, McMenamin ME, Smith SJ, Feldman RG, Levesque CA, Fine RE, Simons ER. Moderate and advanced Alzheimer's patients exhibit platelet activation differences. Neurobiol Aging. 1997 Mar-Apr; 18(2):155-62.View Related Profiles.

Simons, Elizabeth
Fine, Richard
Davies-Heerema, Theresa

PMID: 9258892

Davies TA, Long HJ, Sgro K, Rathbun WH, McMenamin ME, Seetoo K, Tibbles H, Billingslea AM, Fine RE, Fishman JB, Levesque CA, Smith SJ, Wells JM, Simons ER. Activated Alzheimer disease platelets retain more beta amyloid precursor protein. Neurobiol Aging. 1997 Mar-Apr; 18(2):147-53.View Related Profiles.

Simons, Elizabeth
Fine, Richard
Davies-Heerema, Theresa

PMID: 9258891

Amaratunga A, Abraham CR, Edwards RB, Sandell JH, Schreiber BM, Fine RE. Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells. J Biol Chem. 1996 Mar 8; 271(10):5628-32.View Related Profiles.

Schreiber, Barbara
Abraham, Carmela
Sandell, Julie
Fine, Richard

PMID: 8621425

Liang JS, Fine RE, Abraham CR, Sipe JD. The fibril forming region of the beta-amyloid precursor differs from that of the amyloid A precursor in its interaction with lipids. Biochem Biophys Res Commun. 1996 Feb 27; 219(3):962-7.View Related Profiles.

Abraham, Carmela
Fine, Richard

PMID: 8645287

Amaratunga AP, Kosik KS, Rittenhouse PA, Leeman SE, Fine RE. Antisense inhibition of protein synthesis and function : rabbit retinal protein. Methods Mol Med. 1996; 1:109-19.View Related Profiles.

Fine, Richard
Leeman, Susan

PMID: 21359719; DOI: 10.1385/0-89603-305-8:109;

Amaratunga A, Fine RE. Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve. J Biol Chem. 1995 Jul 21; 270(29):17268-72. PMID: 7542234

Amaratunga A, Leeman SE, Kosik KS, Fine RE. Inhibition of kinesin synthesis in vivo inhibits the rapid transport of representative proteins for three transport vesicle classes into the axon. J Neurochem. 1995 May; 64(5):2374-6.View Related Profiles.

Fine, Richard
Leeman, Susan

PMID: 7536813

Liu N, Fine RE, Simons E, Johnson RJ. Decreasing calreticulin expression lowers the Ca2+ response to bradykinin and increases sensitivity to ionomycin in NG-108-15 cells. J Biol Chem. 1994 Nov 18; 269(46):28635-9.View Related Profiles.

Simons, Elizabeth
Fine, Richard

PMID: 7961812

Bielinski DF, Pyun HY, Linko-Stentz K, Macara IG, Fine RE. Ral and Rab3a are major GTP-binding proteins of axonal rapid transport and synaptic vesicles and do not redistribute following depolarization stimulated synaptosomal exocytosis. Biochim Biophys Acta. 1993 Sep 19; 1151(2):246-56. PMID: 8373799

Liu N, Fine RE, Johnson RJ. Comparison of cDNAs from bovine brain coding for two isoforms of calreticulin. Biochim Biophys Acta. 1993 Sep 3; 1202(1):70-6. PMID: 8373827

Amaratunga A, Morin PJ, Kosik KS, Fine RE. Inhibition of kinesin synthesis and rapid anterograde axonal transport in vivo by an antisense oligonucleotide. J Biol Chem. 1993 Aug 15; 268(23):17427-30.View Related Profiles.

Morin, Peter
Fine, Richard

PMID: 7688725

Morin PJ, Abraham CR, Amaratunga A, Johnson RJ, Huber G, Sandell JH, Fine RE. Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized. J Neurochem. 1993 Aug; 61(2):464-73.View Related Profiles.

Abraham, Carmela
Sandell, Julie
Morin, Peter
Fine, Richard

PMID: 7687653

Davies TA, Fine RE, Johnson RJ, Levesque CA, Rathbun WH, Seetoo KF, Smith SJ, Strohmeier G, Volicer L, Delva L, et al. Non-age related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease. Biochem Biophys Res Commun. 1993 Jul 15; 194(1):537-43.View Related Profiles.

Fine, Richard
Davies-Heerema, Theresa

PMID: 8333868

Morin PJ, Johnson RJ, Fine RE. Kinesin is rapidly transported in the optic nerve as a membrane associated protein. Biochim Biophys Acta. 1993 Mar 14; 1146(2):275-81.View Related Profiles.

Morin, Peter
Fine, Richard

PMID: 8452861

Johnson RJ, Pyun HY, Lytton J, Fine RE. Differences in the subcellular localization of calreticulin and organellar Ca(2+)-ATPase in neurons. Brain Res Mol Brain Res. 1993 Jan; 17(1-2):9-16. PMID: 8381914

Johnson RJ, Liu NG, Fishman JB, Dixon JD, Fine RE. Isolation of a calreticulin-like calcium binding protein from bovine brain. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):69-76. PMID: 1312207

Morin PJ, Liu NG, Johnson RJ, Leeman SE, Fine RE. Isolation and characterization of rapid transport vesicle subtypes from rabbit optic nerve. J Neurochem. 1991 Feb; 56(2):415-27.View Related Profiles.

Morin, Peter
Fine, Richard
Leeman, Susan

PMID: 1824859

Morin PJ, Johnson RJ, Shachar I, Fine RE, Leeman SE. Characteristics of tachykinin transport vesicles in the optic nerve. Ann N Y Acad Sci. 1991; 632:442-3.View Related Profiles.

Morin, Peter
Fine, Richard
Leeman, Susan

PMID: 1952634

Bielinski DF, Morin PJ, Dickey BF, Fine RE. Low molecular weight GTP-binding proteins are associated with neuronal organelles involved in rapid axonal transport and exocytosis. J Biol Chem. 1989 Nov 5; 264(31):18363-7.View Related Profiles.

Morin, Peter
Fine, Richard

PMID: 2478544

Fine RE. Vesicles without clathrin: intermediates in bulk flow exocytosis. Cell. 1989 Aug 25; 58(4):609-10. PMID: 2670245

Thomas K, Navarro J, Benson RJ, Campbell KP, Rotundo RL, Fine RE. Newly synthesized calsequestrin, destined for the sarcoplasmic reticulum, is contained in early/intermediate Golgi-derived clathrin-coated vesicles. J Biol Chem. 1989 Feb 25; 264(6):3140-5. PMID: 2563378

Fishman JB, Dickey BF, Fine RE. Purification and characterization of the rat liver vasopressin (V1) receptor. J Biol Chem. 1987 Oct 15; 262(29):14049-55. PMID: 2958456

Fishman JB, Rubin JB, Handrahan JV, Connor JR, Fine RE. Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res. 1987; 18(2):299-304. PMID: 3694713

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 56 publications over 21 distinct years, with a maximum of 7 publications in 1993

Bar chart showing 56 publications over 21 distinct years, with a maximum of 7 publications in 1993

Year	Publications
1987	2
1989	3
1991	2
1992	1
1993	7
1994	1
1995	2
1996	3
1997	5
1998	4
1999	6
2000	5
2001	4
2002	1
2003	1
2004	3
2005	1
2006	1
2007	1
2011	2
2014	1

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