Reiko Matsui, MD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Vascular Biology

MD, Kanazawa University



I have been working on oxidative stress and redox signaling in Vascular Biology Section in Chobanian and Avedisian School of Medicine. My current and previous projects are as follows.
- Glutaredoxin and ischemic limb vascularization. In recent years my focus is the roles of glutaredoxin-1 (Glrx) in cardiovascular disease. Glrx regulates cellular signaling and transcription by reversing protein-glutathione adducts. This relatively unexplored enzyme and its targets and function have just emerged as a significant redox signaling mechanism. We identified Glrx as an anti-angiogenic molecule which may suppress hypoxia inducible factor (HIF)-1a activation. We aim to to develop therapeutic strategy to improve poor ischemic limb vascularization in diabetes and aged individuals.
- Tumor angiogenesis: we found mouse melanoma implants growth does not correlate with endothelial angiogenesis in endothelial-specific Glrx transgenic mice. We are developing a new area of Glrx and tumor angiogenesis.
- We also explore Glrx role in liver fibrosis with my collaborators. Glrx-deficient mice develop fatty liver and diet-induced liver fibrosis. Glrx inhibits angiogenesis as well as fibrotic process. Our collaborative paper shows Glrx attenuates lung fibrosis. We aim to examine the Glrx effects on liver fibrosis models.
- In the past, I worked on vascular complications in glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD is a key enzyme of the pentose phosphate pathway which contributes to NADPH generation. G6PD deficiency is the most prevalent enzymopathy in humans, and was thought to worsen cardiovascular disease due to oxidative stress and hemolytic anemia. However, we found that angiotensin II –induced cardiovascular hypertrophy was attenuated in G6PD-deficient mice. There are many enzymes that depend on NADPH including the oxidant source, NADPH oxidase, and enzymes in the cholesterol synthesis pathway. We also demonstrated higher blood pressure, less atherosclerosis, lower oxidants and plasma cholesterol in G6PD-deficient mice with apoE-/- background. These studies are actually consistent with clinical reports on G6PD-deficient people, and confirmed a contribution of NADPH oxidase to vascular hypertrophy and atherosclerosis.
Overall, based on my broad clinical experiences in internal medicine, I would like to develop my research to bring benefit to patients.

Member
Boston University
Whitaker Cardiovascular Institute


Boston Medical Center




Regulation of ischemic limb vascularization by glutaredoxin-1
07/01/2016 - 06/30/2024 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL133013-04

SUMO2-p66Shc axis in vascular endothelial dysfunction and atherosclerosis
04/01/2020 - 03/31/2022 (Subcontract PI)
The University of Iowa NIH NHLBI
5R01HL152132-02

Regulation of Hypoxia-incucable factor-1 and angiogenesis by glutaredoxin-1
08/01/2016 - 04/30/2018 (PI)
NIH/National Institute on Aging
3R03AG051857-02S1

Hindlimb Ischemia Model
02/02/2017 - 02/02/2018 (PI)
VL39, Inc.



Protein Modification By Nitrat
07/01/2001 - 06/30/2002 (PI)
NIH
1RO3 AG19078-01 (A)


Title


Yr Title Project-Sub Proj Pubs
2019 Regulation of ischemic limb vascularization by glutaredoxin-1 5R01HL133013-04 11
2018 Regulation of ischemic limb vascularization by glutaredoxin-1 5R01HL133013-03 11
2017 Regulation of ischemic vascularization by glutaredoxin-1 by aging 5R03AG051857-02 5
2017 Regulation of ischemic vascularization by glutaredoxin-1 by aging 3R03AG051857-02S1 5
2017 Regulation of ischemic limb vascularization by glutaredoxin-1 5R01HL133013-02 11
2016 Regulation of ischemic vascularization by glutaredoxin-1 by aging 1R03AG051857-01 5
2016 Regulation of ischemic limb vascularization by glutaredoxin-1 1R01HL133013-01 11
2001 PROTEIN MODIFICATION BY NITRATION IN AGING RATS 1R03AG019078-01 3

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Minetti ET, Hamburg NM, Matsui R. Drivers of cardiovascular disease in metabolic dysfunction-associated steatotic liver disease: the threats of oxidative stress. Front Cardiovasc Med. 2024; 11:1469492.View Related Profiles. PMID: 39411175; PMCID: PMC11473390; DOI: 10.3389/fcvm.2024.1469492;
     
  2. Tsukahara Y, Ferran B, Minetti ET, Chong BSH, Gower AC, Bachschmid MM, Matsui R. Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis. Antioxidants (Basel). 2022 Apr 28; 11(5).View Related Profiles. PMID: 35624731; PMCID: PMC9138033; DOI: 10.3390/antiox11050867;
     
  3. Mustafa Rizvi SH, Shao D, Tsukahara Y, Pimentel DR, Weisbrod RM, Hamburg NM, McComb ME, Matsui R, Bachschmid MM. Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis. Free Radic Biol Med. 2021 10; 174:73-83.View Related Profiles. PMID: 34332079; PMCID: PMC8432375; DOI: 10.1016/j.freeradbiomed.2021.07.037;
     
  4. Burns M, Rizvi SHM, Tsukahara Y, Pimentel DR, Luptak I, Hamburg NM, Matsui R, Bachschmid MM. Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases. Int J Mol Sci. 2020 Sep 16; 21(18).View Related Profiles. PMID: 32948023; PMCID: PMC7555996; DOI: 10.3390/ijms21186803;
     
  5. Watanabe Y, Watanabe K, Fujioka D, Nakamura K, Nakamura T, Uematsu M, Bachschmid MM, Matsui R, Kugiyama K. Protein S-glutathionylation stimulate adipogenesis by stabilizing C/EBPß in 3T3L1 cells. FASEB J. 2020 04; 34(4):5827-5837.View Related Profiles. PMID: 32141127; PMCID: PMC8491561; DOI: 10.1096/fj.201902575R;
     
  6. Matsui R, Hamburg NM. Eating Chocolate to Improve Muscle Health and Walking Ability in Patients With Peripheral Artery Disease. Circ Res. 2020 02 28; 126(5):600-602.View Related Profiles. PMID: 32078440
     
  7. Matsui R, Ferran B, Oh A, Croteau D, Shao D, Han J, Pimentel DR, Bachschmid MM. Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. Antioxid Redox Signal. 2020 04 01; 32(10):677-700.View Related Profiles. PMID: 31813265; PMCID: PMC7047114; DOI: 10.1089/ars.2019.7963;
     
  8. Yura Y, Chong BSH, Johnson RD, Watanabe Y, Tsukahara Y, Ferran B, Murdoch CE, Behring JB, McComb ME, Costello CE, Janssen-Heininger YMW, Cohen RA, Bachschmid MM, Matsui R. Endothelial cell-specific redox gene modulation inhibits angiogenesis but promotes B16F0 tumor growth in mice. FASEB J. 2019 12; 33(12):14147-14158.View Related Profiles. PMID: 31647879; PMCID: PMC6894059; DOI: 10.1096/fj.201900786R;
     
  9. Kimura T, Ferran B, Tsukahara Y, Shang Q, Desai S, Fedoce A, Pimentel DR, Luptak I, Adachi T, Ido Y, Matsui R, Bachschmid MM. Production of adeno-associated virus vectors for in vitro and in vivo applications. Sci Rep. 2019 09 19; 9(1):13601.View Related Profiles. PMID: 31537820; PMCID: PMC6753157; DOI: 10.1038/s41598-019-49624-w;
     
  10. Shao D, Yao C, Kim MH, Fry J, Cohen RA, Costello CE, Matsui R, Seta F, McComb ME, Bachschmid MM. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators. Redox Biol. 2019 04; 22:101150.View Related Profiles. PMID: 30877853; PMCID: PMC6423473; DOI: 10.1016/j.redox.2019.101150;
     
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 20 distinct years, with a maximum of 5 publications in 2016

YearPublications
19921
19941
19991
20011
20021
20031
20051
20061
20101
20122
20143
20151
20165
20173
20181
20194
20204
20211
20221
20241


Scientists Develop New Method to Produce High Quantities of Viral Vectors for Gene Therapy

SMA News Today 10/2/2019
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

angiogenesis
G6PD
glutaredoxin
redox signaling
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Google Map

617.358.7813
Download vCard

Matsui's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
See all (226) concept(s)
_
Media Mentions
_
Co-Authors
See all (28) people
_
Similar People
See all (60) people
_
Same Department
Search Department