Rebecca Kusko | Profiles RNS

Rebecca Kusko, PhD

Predoctoral Trainee (previously held)

Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Genetics & Genomics

Websites

	LinkedIn
	MIT
	Immuneering

Rebecca Kusko, PhD is the SVP and Head of R&D at Immuneering Corporation. She completing her undergraduate degree at MIT in Biological Engineering and earning a PhD in Genetics and Genomics from BU before joining Immuneering in 2014. At Immuneering she has been accelerating pharma R&D using AI and other advanced algorithms. Additionally she is a board member of the MAQC Society, an FDA-led initiative around moving toward best practices for big data analysis. Her published areas of experience include: drug mechanism of action (MOA), drug repositioning, target identification, big data reproducibility, oncology, neurodegeneration, transcriptomics, and computational toxicology.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Kim J, Zhang J, Cha Y, Kolitz S, Funt J, Escalante Chong R, Barrett S, Kusko R, Zeskind B, Kaufman H. Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19). J Transl Med. 2020 06 25; 18(1):257. PMID: 32586380; PMCID: PMC7315012; DOI: 10.1186/s12967-020-02430-9;

Pan B, Kusko R, Xiao W, Zheng Y, Liu Z, Xiao C, Sakkiah S, Guo W, Gong P, Zhang C, Ge W, Shi L, Tong W, Hong H. Correction to: Similarities and differences between variants called with human reference genome HG19 or HG38. BMC Bioinformatics. 2019 May 15; 20(1):252. PMID: 31092200; PMCID: PMC6521484; DOI: 10.1186/s12859-019-2776-7;

Pan B, Kusko R, Xiao W, Zheng Y, Liu Z, Xiao C, Sakkiah S, Guo W, Gong P, Zhang C, Ge W, Shi L, Tong W, Hong H. Similarities and differences between variants called with human reference genome HG19 or HG38. BMC Bioinformatics. 2019 Mar 14; 20(Suppl 2):101. PMID: 30871461; PMCID: PMC6419332; DOI: 10.1186/s12859-019-2620-0;

Sakkiah S, Guo W, Pan B, Kusko R, Tong W, Hong H. Computational prediction models for assessing endocrine disrupting potential of chemicals. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2018; 36(4):192-218. PMID: 30633647

Kusko R, Dreymann J, Ross J, Cha Y, Escalante-Chong R, Garcia-Miralles M, Tan LJ, Burczynski ME, Zeskind B, Laifenfeld D, Pouladi M, Geva M, Grossman I, Hayden MR. Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse. Mol Neurodegener. 2018 05 21; 13(1):25. PMID: 29783994; PMCID: PMC5963017; DOI: 10.1186/s13024-018-0259-3;

Sakkiah S, Kusko R, Pan B, Guo W, Ge W, Tong W, Hong H. Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated Through Molecular Dynamics Simulations. Front Pharmacol. 2018; 9:492. PMID: 29867496; PMCID: PMC5962723; DOI: 10.3389/fphar.2018.00492;

Brothers JF, Ung M, Escalante-Chong R, Ross J, Zhang J, Cha Y, Lysaght A, Funt J, Kusko R. Integrity, standards, and QC-related issues with big data in pre-clinical drug discovery. Biochem Pharmacol. 2018 06; 152:84-93. PMID: 29551586

Shi L, Kusko R, Wolfinger RD, Haibe-Kains B, Fischer M, Sansone SA, Mason CE, Furlanello C, Jones WD, Ning B, Tong W. The international MAQC Society launches to enhance reproducibility of high-throughput technologies. Nat Biotechnol. 2017 12 08; 35(12):1127-1128. PMID: 29220036

Garcia-Miralles M, Geva M, Tan JY, Yusof NABM, Cha Y, Kusko R, Tan LJ, Xu X, Grossman I, Orbach A, Hayden MR, Pouladi MA. Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice. JCI Insight. 2017 12 07; 2(23). PMID: 29212949; PMCID: PMC5752291; DOI: 10.1172/jci.insight.95665;

Ross CJ, Towfic F, Shankar J, Laifenfeld D, Thoma M, Davis M, Weiner B, Kusko R, Zeskind B, Knappertz V, Grossman I, Hayden MR. A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis. Genome Med. 2017 May 31; 9(1):50. PMID: 28569182; PMCID: PMC5450152; DOI: 10.1186/s13073-017-0436-y;

Showing 10 of 19 results. Show More

Cha Y, Erez T, Reynolds IJ, Kumar D, Ross J, Koytiger G, Kusko R, Zeskind B, Risso S, Kagan E, Papapetropoulos S, Grossman I, Laifenfeld D. Drug repurposing from the perspective of pharmaceutical companies. Br J Pharmacol. 2018 01; 175(2):168-180. PMID: 28369768; PMCID: PMC5758385; DOI: 10.1111/bph.13798;

Towfic F, Kusko R, Zeskind B. Letter to the Editor response: Nygaard et al. Biostatistics. 2017 Apr 01; 18(2):197-199. PMID: 27780809; PMCID: PMC5379915; DOI: 10.1093/biostatistics/kxw031;

Huang X, Motea EA, Moore ZR, Yao J, Dong Y, Chakrabarti G, Kilgore JA, Silvers MA, Patidar PL, Cholka A, Fattah F, Cha Y, Anderson GG, Kusko R, Peyton M, Yan J, Xie XJ, Sarode V, Williams NS, Minna JD, Beg M, Gerber DE, Bey EA, Boothman DA. Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors. Cancer Cell. 2016 Dec 12; 30(6):940-952. PMID: 27960087; PMCID: PMC5161231; DOI: 10.1016/j.ccell.2016.11.006;

Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, Bezprozvanny I. The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. Neurobiol Dis. 2017 Jan; 97(Pt A):46-59. PMID: 27818324; PMCID: PMC5214572; DOI: 10.1016/j.nbd.2016.10.006;

Kusko RL, Brothers JF, Tedrow J, Pandit K, Huleihel L, Perdomo C, Liu G, Juan-Guardela B, Kass D, Zhang S, Lenburg M, Martinez F, Quackenbush J, Sciurba F, Limper A, Geraci M, Yang I, Schwartz DA, Beane J, Spira A, Kaminski N. Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 Oct 15; 194(8):948-960.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Tedrow, John
Lenburg, Marc
Kusko, Rebecca

PMID: 27104832; PMCID: PMC5067817; DOI: 10.1164/rccm.201510-2026OC;

Geva M, Kusko R, Soares H, Fowler KD, Birnberg T, Barash S, -Wagner AM, Fine T, Lysaght A, Weiner B, Cha Y, Kolitz S, Towfic F, Orbach A, Laufer R, Zeskind B, Grossman I, Hayden MR. Pridopidine activates neuroprotective pathways impaired in Huntington Disease. Hum Mol Genet. 2016 Sep 15; 25(18):3975-3987. PMID: 27466197; PMCID: PMC5291233; DOI: 10.1093/hmg/ddw238;

Krysan K, Kusko R, Grogan T, O'Hearn J, Reckamp KL, Walser TC, Garon EB, Lenburg ME, Sharma S, Spira AE, Elashoff D, Dubinett SM. PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Mol Cancer Res. 2014 May; 12(5):765-74.View Related Profiles.

Spira, Avrum
Lenburg, Marc
Kusko, Rebecca

PMID: 24469837; PMCID: PMC4020971; DOI: 10.1158/1541-7786.MCR-13-0377;

Kini LG, Herrero-Jimenez P, Kamath T, Sanghvi J, Gutierrez E, Hensle D, Kogel J, Kusko R, Rexer K, Kurzweil R, Refinetti P, Morgenthaler S, Koledova VV, Gostjeva EV, Thilly WG. Mutator/Hypermutable fetal/juvenile metakaryotic stem cells and human colorectal carcinogenesis. Front Oncol. 2013; 3:267. PMID: 24195059; PMCID: PMC3811064; DOI: 10.3389/fonc.2013.00267;

Kusko RL, Banerjee C, Long KK, Darcy A, Otis J, Sebastiani P, Melov S, Tarnopolsky M, Bhasin S, Montano M. Premature expression of a muscle fibrosis axis in chronic HIV infection. Skelet Muscle. 2012; 2(1):10.View Related Profiles.

Banerjee, Camellia
Montano, Monty
Sebastiani, Paola
Kusko, Rebecca
Bhasin, Shalender

PMID: 22676806; PMCID: PMC3407733; DOI: 10.1186/2044-5040-2-10;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 19 publications over 8 distinct years, with a maximum of 5 publications in 2017