Philip Stashenko | Profiles RNS

Philip Stashenko, DMD, PhD, CAGS

Professor

Boston University Henry M. Goldman School of Dental Medicine

Translational Dental Medicine

PhD, Harvard University
BA, New York University
CAGS, Harvard University
DMD, Harvard School of Dental Medicine

Websites

ORCID : 0000-0002-0334-5982

Adjunct Associate Professor
Harvard School of Dental Medicine
Oral Medicine, Infection and Immunity

Director
Boston University Henry M. Goldman School of Dental Medicine
Endodontics

BU Research

Inhibiting inflammation and bone erosion in periodontal disease by targeting cell endogenous negative signaling
05/14/2021 - 01/31/2024 (Subcontract PI)
Tulane University NIH NIDCR
5R01DE023813-10

Role of the Oral Microbiome in Oral Squamous Cell Carcinoma Progression
07/10/2019 - 06/30/2023 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R21DE028063-02

Ga13 signaling attenuates periodontal inflammation and alveolar bone loss in the mouse model of age-associated periodontitis
06/01/2021 - 05/31/2023 (Subcontract PI)
Tulane University NIH NIDCR
7R01DE028264-05

Hormonal Modulation of Disseminating Endodontic Infections
10/01/2019 - 12/31/2021 (PI)
Foundation for Endodontics

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Chaaban M, AlSulaiman A, Kantarci A, Stashenko P, Will LA, Motro M. Longitudinal changes in the dental arch width and symmetry in identical and fraternal twins. Am J Orthod Dentofacial Orthop. 2022 Sep 19.View Related Profiles.

Alsulaiman, Ahmed
Motro, Melih
Stashenko, Philip

PMID: 36137854

Tazawa K, Azuma Presse MM, Furusho H, Stashenko P, Sasaki H. Revisiting the role of IL-1 signaling in the development of apical periodontitis. Front Dent Med. 2022; 3. PMID: 36938490; PMCID: PMC10021022; DOI: 10.3389/fdmed.2022.985558;

Stashenko P, Yost S, Choi Y, Danciu T, Chen T, Yoganathan S, Kressirer C, Ruiz-Tourrella M, Das B, Kokaras A, Frias-Lopez J. The Oral Mouse Microbiome Promotes Tumorigenesis in Oral Squamous Cell Carcinoma. mSystems. 2019 Aug 06; 4(4). PMID: 31387932; PMCID: PMC6687944; DOI: 10.1128/mSystems.00323-19;

Sasaki H, Furusho H, Rider DB, Dobeck JM, Kuo WP, Fujimura A, Yoganathan S, Hirai K, Xu S, Sasaki K, Stashenko P. Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice. J Endod. 2019 Feb; 45(2):181-188. PMID: 30711175; PMCID: PMC6364571; DOI: 10.1016/j.joen.2018.10.007;

Yost S, Stashenko P, Choi Y, Kukuruzinska M, Genco CA, Salama A, Weinberg EO, Kramer CD, Frias-Lopez J. Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses. Int J Oral Sci. 2018 11 12; 10(4):32.View Related Profiles.

Salama, Andrew
Kramer, Carolyn
Kukuruzinska, Maria
Stashenko, Philip

PMID: 30420594; PMCID: PMC6232154; DOI: 10.1038/s41368-018-0037-7;

Hirai K, Furusho H, Kawashima N, Xu S, de Beer MC, Battaglino R, Van Dyke T, Stashenko P, Sasaki H. Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4. J Dent Res. 2019 01; 98(1):117-125.View Related Profiles.

Stashenko, Philip
Van Dyke, Thomas

PMID: 30189157; PMCID: PMC6304714; DOI: 10.1177/0022034518796456;

Movila A, Kajiya M, Wisitrasameewong W, Stashenko P, Vardar-Sengul S, Hernandez M, Thomas Temple H, Kawai T. Intravital endoscopic technology for real-time monitoring of inflammation caused in experimental periodontitis. J Immunol Methods. 2018 06; 457:26-29. PMID: 29567043; PMCID: PMC5924649; DOI: 10.1016/j.jim.2018.03.006;

Colombo APV, Paster BJ, Grimaldi G, Lourenço TGB, Teva A, Campos-Neto A, McCluskey J, Kleanthous H, Van Dyke TE, Stashenko P. Clinical and microbiological parameters of naturally occurring periodontitis in the non-human primate Macaca mulatta. J Oral Microbiol. 2017; 9(1):1403843.View Related Profiles.

Stashenko, Philip
Van Dyke, Thomas

PMID: 29805776; PMCID: PMC5963701; DOI: 10.1080/20002297.2017.1403843;

Youssef H, Stashenko P. Interleukin-1 and estrogen protect against disseminating dentoalveolar infections. Int J Oral Sci. 2017 03; 9(1):16-23. PMID: 28358036; PMCID: PMC5379163; DOI: 10.1038/ijos.2016.61;

Showing 10 of 132 results. Show More

Rider D, Furusho H, Xu S, Trachtenberg AJ, Kuo WP, Hirai K, Susa M, Bahammam L, Stashenko P, Fujimura A, Sasaki H. Elevated CD14 (Cluster of Differentiation 14) and Toll-Like Receptor (TLR) 4 Signaling Deteriorate Periapical Inflammation in TLR2 Deficient Mice. Anat Rec (Hoboken). 2016 09; 299(9):1281-92. PMID: 27314637; PMCID: PMC4982827; DOI: 10.1002/ar.23383;

Xie E, Kotha A, Biaco T, Sedani N, Zou J, Stashenko P, Duncan MJ, Campos-Neto A, Cayabyab MJ. Correction: Oral Delivery of a Novel Recombinant Streptococcus mitis Vector Elicits Robust Vaccine Antigen-Specific Oral Mucosal and Systemic Antibody Responses and T Cell Tolerance. PLoS One. 2016; 11(1):e0147781. PMID: 26800455; PMCID: PMC4723311; DOI: 10.1371/journal.pone.0147781;

Daifalla N, Cayabyab MJ, Xie E, Kim HB, Tzipori S, Stashenko P, Duncan M, Campos-Neto A. Commensal Streptococcus mitis is a unique vector for oral mucosal vaccination. Microbes Infect. 2015 Mar; 17(3):237-42. PMID: 25522856; PMCID: PMC4346494; DOI: 10.1016/j.micinf.2014.11.002;

AlShwaimi E, Berggreen E, Furusho H, Rossall JC, Dobeck J, Yoganathan S, Stashenko P, Sasaki H. IL-17 receptor A signaling is protective in infection-stimulated periapical bone destruction. J Immunol. 2013 Aug 15; 191(4):1785-91. PMID: 23863904; PMCID: PMC3767040; DOI: 10.4049/jimmunol.1202194;

Jiang H, Chen W, Zhu G, Zhang L, Tucker B, Hao L, Feng S, Ci H, Ma J, Wang L, Stashenko P, Li YP. RNAi-mediated silencing of Atp6i and Atp6i haploinsufficiency prevents both bone loss and inflammation in a mouse model of periodontal disease. PLoS One. 2013; 8(4):e58599. PMID: 23577057; PMCID: PMC3618217; DOI: 10.1371/journal.pone.0058599;

Ma J, Chen W, Zhang L, Tucker B, Zhu G, Sasaki H, Hao L, Wang L, Ci H, Jiang H, Stashenko P, Li YP. RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease. Infect Immun. 2013 Apr; 81(4):1021-30. PMID: 23166162; PMCID: PMC3639609; DOI: 10.1128/IAI.00756-12;

Gao B, Chen W, Hao L, Zhu G, Feng S, Ci H, Zhou X, Stashenko P, Li YP. Inhibiting periapical lesions through AAV-RNAi silencing of cathepsin K. J Dent Res. 2013 Feb; 92(2):180-6. PMID: 23166044; PMCID: PMC3545691; DOI: 10.1177/0022034512468757;

Silva MJ, Kajiya M, AlShwaimi E, Sasaki H, Hong J, Ok P, Rezende TM, Pagonis TC, White RR, Paster BJ, Stashenko P, Kawai T. Bacteria-reactive immune response may induce RANKL-expressing T cells in the mouse periapical bone loss lesion. J Endod. 2012 Mar; 38(3):346-50. PMID: 22341072; PMCID: PMC3291477; DOI: 10.1016/j.joen.2011.12.029;

Sasaki H, Stashenko P. Interrelationship of the pulp and apical periodontitis. Seltzer and Bender's Dental Pulp. 2012; 277-299. View Publication

Morse LR, Xu Y, Solomon B, Boyle L, Yoganathan S, Stashenko P, Battaglino RA. Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction. Transl Stroke Res. 2011 Dec 01; 2(4):643-50. PMID: 22368723; PMCID: PMC3285243; DOI: 10.1007/s12975-011-0118-9;

Ohta K, Laborde NJ, Kajiya M, Shin J, Zhu T, Thondukolam AK, Min C, Kamata N, Karimbux NY, Stashenko P, Kawai T. Expression and possible immune-regulatory function of ghrelin in oral epithelium. J Dent Res. 2011 Nov; 90(11):1286-92. PMID: 21865591; PMCID: PMC3188459; DOI: 10.1177/0022034511420431;

Franco GC, Kajiya M, Nakanishi T, Ohta K, Rosalen PL, Groppo FC, Ernst CW, Boyesen JL, Bartlett JD, Stashenko P, Taubman MA, Kawai T. Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo. Exp Cell Res. 2011 Jun 10; 317(10):1454-64. PMID: 21420951; PMCID: PMC3115670; DOI: 10.1016/j.yexcr.2011.03.014;

Ng R, Singh F, Papamanou DA, Song X, Patel C, Holewa C, Patel N, Klepac-Ceraj V, Fontana CR, Kent R, Pagonis TC, Stashenko PP, Soukos NS. Endodontic photodynamic therapy ex vivo. J Endod. 2011 Feb; 37(2):217-22. PMID: 21238805; PMCID: PMC3034089; DOI: 10.1016/j.joen.2010.10.008;

Sasaki H, Suzuki N, Alshwaimi E, Xu Y, Battaglino R, Morse L, Stashenko P. 18ß-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-?B inactivation in interleukin-10-deficient mice. J Periodontal Res. 2010 Dec; 45(6):757-63. PMID: 20682015; PMCID: PMC3075584; DOI: 10.1111/j.1600-0765.2010.01296.x;

Stashenko P, Van Dyke T, Tully P, Kent R, Sonis S, Tanner AC. Inflammation and genetic risk indicators for early periodontitis in adults. J Periodontol. 2011 Apr; 82(4):588-96.View Related Profiles.

Stashenko, Philip
Van Dyke, Thomas

PMID: 21054222; PMCID: PMC3299480; DOI: 10.1902/jop.2010.100443;

Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino RA. Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae. Biochim Biophys Acta. 2010 Dec; 1800(12):1241-7. PMID: 20713131; PMCID: PMC2967667; DOI: 10.1016/j.bbagen.2010.08.001;

Xu Y, Morse LR, da Silva RA, Odgren PR, Sasaki H, Stashenko P, Battaglino RA. PAMM: a redox regulatory protein that modulates osteoclast differentiation. Antioxid Redox Signal. 2010 Jul 01; 13(1):27-37. PMID: 19951071; PMCID: PMC2877117; DOI: 10.1089/ars.2009.2886;

AlShwaimi E, Purcell P, Kawai T, Sasaki H, Oukka M, Campos-Neto A, Stashenko P. Regulatory T cells in mouse periapical lesions. J Endod. 2009 Sep; 35(9):1229-33. PMID: 19720221; PMCID: PMC2778286; DOI: 10.1016/j.joen.2009.06.006;

Hillman JD, Andrews SW, Painter S, Stashenko P. Adaptive Changes in a Strain of Streptococcus mutans during Colonisation of the Human Oral Cavity. Adaptive Changes in a Strain of Streptococcus mutans during Colonisation of the Human Oral Cavity. 2009; 2(4):231-239. View Publication
Jha PK, Stashenko P. In silico identification of tandem inter/intra-generic genetic elements (TIGE) using a random nucleotide generating Perl program: A potential approach for locating structure-function regions of recently sequenced genomes. Online Journal of Bioinformatics. 2009; 10(1):40-50. View Publication

Sasaki H, Suzuki N, Kent R, Kawashima N, Takeda J, Stashenko P. T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10-deficient mice. J Immunol. 2008 May 01; 180(9):6193-8. PMID: 18424741

Fimple JL, Fontana CR, Foschi F, Ruggiero K, Song X, Pagonis TC, Tanner AC, Kent R, Doukas AG, Stashenko PP, Soukos NS. Photodynamic treatment of endodontic polymicrobial infection in vitro. J Endod. 2008 Jun; 34(6):728-34. PMID: 18498901; PMCID: PMC2596687; DOI: 10.1016/j.joen.2008.03.011;

Leshem O, Kashino SS, Gonçalves RB, Suzuki N, Onodera M, Fujimura A, Sasaki H, Stashenko P, Campos-Neto A. Th1 biased response to a novel Porphyromonas gingivalis protein aggravates bone resorption caused by this oral pathogen. Microbes Infect. 2008 May; 10(6):664-72. PMID: 18457976; PMCID: PMC3607305; DOI: 10.1016/j.micinf.2008.03.003;

Morse LR, Nguyen HP, Jain N, Williams S, Tun CG, Battaglino RA, Stashenko P, Garshick E. Age and motor score predict osteoprotegerin level in chronic spinal cord injury. J Musculoskelet Neuronal Interact. 2008 Jan-Mar; 8(1):50-7.View Related Profiles.

Garshick, Eric
Stashenko, Philip
Williams, Steve

PMID: 18398265; PMCID: PMC2365904

Foschi F, Fontana CR, Ruggiero K, Riahi R, Vera A, Doukas AG, Pagonis TC, Kent R, Stashenko PP, Soukos NS. Photodynamic inactivation of Enterococcus faecalis in dental root canals in vitro. Lasers Surg Med. 2007 Dec; 39(10):782-7. PMID: 18081066

Morse L, Teng YD, Pham L, Newton K, Yu D, Liao WL, Kohler T, Müller R, Graves D, Stashenko P, Battaglino R. Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats (SCI-induced bone loss in growing rats). Osteoporos Int. 2008 May; 19(5):645-52. PMID: 17987335; PMCID: PMC4370281; DOI: 10.1007/s00198-007-0494-x;

Yang S, Chen W, Stashenko P, Li YP. Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation. J Cell Sci. 2007 Oct 01; 120(Pt 19):3362-71. PMID: 17881498; PMCID: PMC3587975; DOI: 10.1242/jcs.008300;

Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P. NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts. Bone. 2008 Jan; 42(1):180-92. PMID: 17988971; PMCID: PMC3593247; DOI: 10.1016/j.bone.2007.09.046;

Schulze-Späte U, Battaglino R, Fu J, Sharma A, Vokes M, Stashenko P. Brn3 transcription factors control terminal osteoclastogenesis. J Cell Biochem. 2007 Sep 01; 102(1):1-12. PMID: 17668438

Pham L, Purcell P, Morse L, Stashenko P, Battaglino RA. Expression analysis of nha-oc/NHA2: a novel gene selectively expressed in osteoclasts. Gene Expr Patterns. 2007 Oct; 7(8):846-51. PMID: 17698421; PMCID: PMC2271150; DOI: 10.1016/j.modgep.2007.07.002;

Kawai T, Paster BJ, Komatsuzawa H, Ernst CW, Goncalves RB, Sasaki H, Ouhara K, Stashenko PP, Sugai M, Taubman MA. Cross-reactive adaptive immune response to oral commensal bacteria results in an induction of receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent periodontal bone resorption in a mouse model. Oral Microbiol Immunol. 2007 Jun; 22(3):208-15. PMID: 17488448

Battaglino R, Vokes M, Schulze-Späte U, Sharma A, Graves D, Kohler T, Müller R, Yoganathan S, Stashenko P. Fluoxetine treatment increases trabecular bone formation in mice. J Cell Biochem. 2007 Apr 15; 100(6):1387-94. PMID: 17041947

Keles A, Grunes B, Difuria C, Gagari E, Srinivasan V, Darendeliler MA, Muller R, Kent R, Stashenko P. Inhibition of tooth movement by osteoprotegerin vs. pamidronate under conditions of constant orthodontic force. Eur J Oral Sci. 2007 Apr; 115(2):131-6. PMID: 17451503

Ernst CW, Lee JE, Nakanishi T, Karimbux NY, Rezende TM, Stashenko P, Seki M, Taubman MA, Kawai T. Diminished forkhead box P3/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kappaB ligand (RANKL+) T cells in bone resorption lesion of periodontal disease. Clin Exp Immunol. 2007 May; 148(2):271-80. PMID: 17355249; PMCID: PMC1868884; DOI: 10.1111/j.1365-2249.2006.03318.x;

Stashenko P, Gonçalves RB, Lipkin B, Ficarelli A, Sasaki H, Campos-Neto A. Th1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis. Am J Pathol. 2007 Jan; 170(1):203-13. PMID: 17200194; PMCID: PMC1762702; DOI: 10.2353/ajpath.2007.060597;

Foschi F, Izard J, Sasaki H, Sambri V, Prati C, Müller R, Stashenko P. Treponema denticola in disseminating endodontic infections. J Dent Res. 2006 Aug; 85(8):761-5. PMID: 16861296; PMCID: PMC3579618; DOI: 10.1177/154405910608500814;

Soukos NS, Chen PS, Morris JT, Ruggiero K, Abernethy AD, Som S, Foschi F, Doucette S, Bammann LL, Fontana CR, Doukas AG, Stashenko PP. Photodynamic therapy for endodontic disinfection. J Endod. 2006 Oct; 32(10):979-84. PMID: 16982278

Gonçalves RB, Leshem O, Bernards K, Webb JR, Stashenko PP, Campos-Neto A. T-cell expression cloning of Porphyromonas gingivalis genes coding for T helper-biased immune responses during infection. Infect Immun. 2006 Jul; 74(7):3958-66. PMID: 16790769; PMCID: PMC1489718; DOI: 10.1128/IAI.02029-05;

Foschi F, Cavrini F, Montebugnoli L, Stashenko P, Sambri V, Prati C. Detection of bacteria in endodontic samples by polymerase chain reaction assays and association with defined clinical signs in Italian patients. Oral Microbiol Immunol. 2005 Oct; 20(5):289-95. PMID: 16101964

Gyurko R, Shoji H, Battaglino RA, Boustany G, Gibson FC, Genco CA, Stashenko P, Van Dyke TE. Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone. 2005 Mar; 36(3):472-9.View Related Profiles.

Genco, Caroline
Gibson, Frank
Stashenko, Philip
Gyurko, Robert
Van Dyke, Thomas

PMID: 15777672

Sasaki H, Okamatsu Y, Kawai T, Kent R, Taubman M, Stashenko P. The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J Periodontal Res. 2004 Dec; 39(6):432-41. PMID: 15491348

Dayan S, Stashenko P, Niederman R, Kupper TS. Oral epithelial overexpression of IL-1alpha causes periodontal disease. J Dent Res. 2004 Oct; 83(10):786-90. PMID: 15381720

Okamatsu Y, Kim D, Battaglino R, Sasaki H, Späte U, Stashenko P. MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival. J Immunol. 2004 Aug 01; 173(3):2084-90. PMID: 15265944

Battaglino R, Fu J, Späte U, Ersoy U, Joe M, Sedaghat L, Stashenko P. Serotonin regulates osteoclast differentiation through its transporter. J Bone Miner Res. 2004 Sep; 19(9):1420-31. PMID: 15312242

Sasaki H, Balto K, Kawashima N, Eastcott J, Hoshino K, Akira S, Stashenko P. Gamma interferon (IFN-gamma) and IFN-gamma-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resorption in vivo. Clin Diagn Lab Immunol. 2004 Jan; 11(1):106-10. PMID: 14715554

von Stechow D, Balto K, Stashenko P, Müller R. Three-dimensional quantitation of periradicular bone destruction by micro-computed tomography. J Endod. 2003 Apr; 29(4):252-6. PMID: 12701773

Niederman R, Kelderman H, Socransky S, Ostroff G, Genco C, Kent R, Stashenko P. Enhanced neutrophil emigration and Porphyromonas gingivalis reduction following PGG-glucan treatment of mice. Arch Oral Biol. 2002 Aug; 47(8):613-8.View Related Profiles.

Genco, Caroline
Stashenko, Philip

PMID: 12221019

Stashenko P, Niederman R, DePaola D. Basic and clinical research: issues of cost, manpower needs, and infrastructure. J Dent Educ. 2002 Aug; 66(8):927-38; discussion 939-41. PMID: 12214841

Battaglino R, Kim D, Fu J, Vaage B, Fu XY, Stashenko P. c-myc is required for osteoclast differentiation. J Bone Miner Res. 2002 May; 17(5):763-73. PMID: 12009006

Balto K, White R, Mueller R, Stashenko P. A mouse model of inflammatory root resorption induced by pulpal infection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Apr; 93(4):461-8. PMID: 12029286

Niederman R, Westernoff T, Lee C, Mark LL, Kawashima N, Ullman-Culler M, Dewhirst FE, Paster BJ, Wagner DD, Mayadas T, Hynes RO, Stashenko P. Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. J Clin Periodontol. 2001 Jun; 28(6):569-75. PMID: 11350525

Deng W, Stashenko P, Chen W, Liang Y, Shimizu K, Li YP. Characterization of mouse Atp6i gene, the gene promoter, and the gene expression. J Bone Miner Res. 2001 Jun; 16(6):1136-46. PMID: 11393791

Balto K, Sasaki H, Stashenko P. Interleukin-6 deficiency increases inflammatory bone destruction. Infect Immun. 2001 Feb; 69(2):744-50. PMID: 11159963

Hou L, Sasakj H, Stashenko P. B-Cell deficiency predisposes mice to disseminating anaerobic infections: protection by passive antibody transfer. Infect Immun. 2000 Oct; 68(10):5645-51. PMID: 10992465

Sasaki H, Hou L, Belani A, Wang CY, Uchiyama T, Müller R, Stashenko P. IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo. J Immunol. 2000 Oct 01; 165(7):3626-30. PMID: 11034365

Hou L, Sasaki H, Stashenko P. Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection. Infect Immun. 2000 Aug; 68(8):4681-7. PMID: 10899873

Mark LL, Haffajee AD, Socransky SS, Kent RL, Guerrero D, Kornman K, Newman M, Stashenko P. Effect of the interleukin-1 genotype on monocyte IL-1beta expression in subjects with adult periodontitis. J Periodontal Res. 2000 Jun; 35(3):172-7. PMID: 10929872

Balto K, Müller R, Carrington DC, Dobeck J, Stashenko P. Quantification of periapical bone destruction in mice by micro-computed tomography. J Dent Res. 2000 Jan; 79(1):35-40. PMID: 10690658

Li YP, Chen W, Liang Y, Li E, Stashenko P. Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet. 1999 Dec; 23(4):447-51. PMID: 10581033

Gilad JZ, Teles R, Goodson M, White RR, Stashenko P. Development of a clindamycin-impregnated fiber as an intracanal medication in endodontic therapy. J Endod. 1999 Nov; 25(11):722-7. PMID: 10726537

Kawashima N, Niederman R, Hynes RO, Ullmann-Cullere M, Stashenko P. Infection-stimulated infraosseus inflammation and bone destruction is increased in P-/E-selectin knockout mice. Immunology. 1999 May; 97(1):117-23. PMID: 10447722

Kawashima N, Stashenko P. Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation. Arch Oral Biol. 1999 Jan; 44(1):55-66. PMID: 10075151

Yelick PC, Abduljabbar TS, Stashenko P. zALK-8, a novel type I serine/threonine kinase receptor, is expressed throughout early zebrafish development. Dev Dyn. 1998 Apr; 211(4):352-61. PMID: 9566954

Stashenko P, Teles R, D'Souza R. Periapical inflammatory responses and their modulation. Crit Rev Oral Biol Med. 1998; 9(4):498-521. PMID: 9825224

Stashenko P. Alumni Day '98 Symposium. The "M" in D.M.D.: new horizons in oral medicine in the 21st century. Harv Dent Bull. 1998; 7(2):15. PMID: 11820125

Teles R, Wang CY, Stashenko P. Increased susceptibility of RAG-2 SCID mice to dissemination of endodontic infections. Infect Immun. 1997 Sep; 65(9):3781-7. PMID: 9284152

Wang CY, Tani-Ishii N, Stashenko P. Bone-resorptive cytokine gene expression in periapical lesions in the rat. Oral Microbiol Immunol. 1997 Apr; 12(2):65-71. PMID: 9227128

Petit MD, Stashenko P. Extracts of periodontopathic microorganisms lack functional superantigenic activity for murine T cells. J Periodontal Res. 1996 Nov; 31(8):517-24. PMID: 8971649

Yelick PC, Driever W, Neuhauss S, Stashenko P. Craniofacial cartilage development in zebrafish. Ann N Y Acad Sci. 1996 Jun 08; 785:360-1. PMID: 8702181

Li YP, Chen W, Stashenko P. Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit. Biochem Biophys Res Commun. 1996 Jan 26; 218(3):813-21. PMID: 8579597

Li YP, Chen W, Stashenko P. Characterization of a silencer element in the first exon of the human osteocalcin gene. Nucleic Acids Res. 1995 Dec 25; 23(24):5064-72. PMID: 8559666

Tani-Ishii N, Wang CY, Stashenko P. Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure. Oral Microbiol Immunol. 1995 Aug; 10(4):213-9. PMID: 8602333

Li YP, Alexander M, Wucherpfennig AL, Yelick P, Chen W, Stashenko P. Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas. J Bone Miner Res. 1995 Aug; 10(8):1197-202. PMID: 8585423

Rahimi P, Wang CY, Stashenko P, Lee SK, Lorenzo JA, Graves DT. Monocyte chemoattractant protein-1 expression and monocyte recruitment in osseous inflammation in the mouse. Endocrinology. 1995 Jun; 136(6):2752-9. PMID: 7750500

Campos-Neto A, Mengel JO, Oliveira-Silva DA, Bonini PV, Taketomi E, Stashenko PP. Potent stimulation of murine B cells to proliferate and to secrete immunoglobulins by a lipoteichoic acid-like molecule produced by Clostridium botulinum C and D. Braz J Med Biol Res. 1995 May; 28(5):575-84. PMID: 8555978

Stashenko P, Wang CY, Riley E, Wu Y, Ostroff G, Niederman R. Reduction of infection-stimulated periapical bone resorption by the biological response modifier PGG glucan. J Dent Res. 1995 Jan; 74(1):323-30. PMID: 7876425

Stashenko P, Wang CY, Tani-Ishii N, Yu SM. Pathogenesis of induced rat periapical lesions. Oral Surg Oral Med Oral Pathol. 1994 Oct; 78(4):494-502. PMID: 7800381

Tani-Ishii N, Wang CY, Tanner A, Stashenko P. Changes in root canal microbiota during the development of rat periapical lesions. Oral Microbiol Immunol. 1994 Jun; 9(3):129-35. PMID: 7936717

Wucherpfennig AL, Li YP, Stetler-Stevenson WG, Rosenberg AE, Stashenko P. Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts. J Bone Miner Res. 1994 Apr; 9(4):549-56. PMID: 8030443

Li YP, Stashenko P. Characterization of a tumor necrosis factor-responsive element which down-regulates the human osteocalcin gene. Mol Cell Biol. 1993 Jun; 13(6):3714-21. PMID: 8388544

Wang CY, Stashenko P. Characterization of bone-resorbing activity in human periapical lesions. J Endod. 1993 Mar; 19(3):107-11. PMID: 8509747

Wang CY, Stashenko P. The role of interleukin-1 alpha in the pathogenesis of periapical bone destruction in a rat model system. Oral Microbiol Immunol. 1993 Feb; 8(1):50-6. PMID: 8510985

Wucherpfennig AL, Dewhirst FE, Stashenko P. Platelet activating factor increases intracellular calcium in isolated osteoclasts but does not modify bone resorption. Bone. 1993; 14(1):13-8. PMID: 8442997

Stashenko P, Yu SM, Wang CY. Kinetics of immune cell and bone resorptive responses to endodontic infections. J Endod. 1992 Sep; 18(9):422-6. PMID: 9796508

Li YP, Stashenko P. Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter. J Immunol. 1992 Feb 01; 148(3):788-94. PMID: 1309841

Stashenko P, Wang CY. Characterization of bone resorptive mediators in active periapical lesions. Proc Finn Dent Soc. 1992; 88 Suppl 1:427-32. PMID: 1508901

Wang CY, Stashenko P. Kinetics of bone-resorbing activity in developing periapical lesions. J Dent Res. 1991 Oct; 70(10):1362-6. PMID: 1939830

Stashenko P, Fujiyoshi P, Obernesser MS, Prostak L, Haffajee AD, Socransky SS. Levels of interleukin 1 beta in tissue from sites of active periodontal disease. J Clin Periodontol. 1991 Aug; 18(7):548-54. PMID: 1894750

Stashenko P, Jandinski JJ, Fujiyoshi P, Rynar J, Socransky SS. Tissue levels of bone resorptive cytokines in periodontal disease. J Periodontol. 1991 Aug; 62(8):504-9. PMID: 1920018

Nguyen L, Dewhirst FE, Hauschka PV, Stashenko P. Interleukin-1 beta stimulates bone resorption and inhibits bone formation in vivo. Lymphokine Cytokine Res. 1991 Apr; 10(1-2):15-21. PMID: 1873357

Eftimiadi C, Stashenko P, Tonetti M, Mangiante PE, Massara R, Zupo S, Ferrarini M. Divergent effect of the anaerobic bacteria by-product butyric acid on the immune response: suppression of T-lymphocyte proliferation and stimulation of interleukin-1 beta production. Oral Microbiol Immunol. 1991 Feb; 6(1):17-23. PMID: 1945479

Jandinski JJ, Stashenko P, Feder LS, Leung CC, Peros WJ, Rynar JE, Deasy MJ. Localization of interleukin-1 beta in human periodontal tissue. J Periodontol. 1991 Jan; 62(1):36-43. PMID: 2002430

Obernesser MS, Socransky SS, Stashenko P. Limit of resolution of flow cytometry for the detection of selected bacterial species. J Dent Res. 1990 Sep; 69(9):1592-8. PMID: 1697868

Dewhirst FE, Ago JM, Stashenko P. Interleukin 1 interacts synergistically with forskolin and isobutylmethylxanthine in stimulating bone resorption in organ culture. Calcif Tissue Int. 1990 Jul; 47(1):1-7. PMID: 1695117

Stashenko P. Role of immune cytokines in the pathogenesis of periapical lesions. Endod Dent Traumatol. 1990 Jun; 6(3):89-96. PMID: 2079017

Stashenko P, Yu SM. T helper and T suppressor cell reversal during the development of induced rat periapical lesions. J Dent Res. 1989 May; 68(5):830-4. PMID: 2523917

Stashenko P, Obernesser MS, Dewhirst FE. Effect of immune cytokines on bone. Immunol Invest. 1989 Jan-May; 18(1-4):239-49. PMID: 2659511

Campos-Neto A, Stashenko PP. Interleukin 1 and T-cell activation. Immunol Today. 1988 May; 9(5):131. PMID: 3267173

Stashenko P, Dewhirst FE, Rooney ML, Desjardins LA, Heeley JD. Interleukin-1 beta is a potent inhibitor of bone formation in vitro. J Bone Miner Res. 1987 Dec; 2(6):559-65. PMID: 3502684

Yu SM, Stashenko P. Identification of inflammatory cells in developing rat periapical lesions. J Endod. 1987 Nov; 13(11):535-40. PMID: 3482098

Stoufi ED, Taubman MA, Ebersole JL, Smith DJ, Stashenko PP. Phenotypic analyses of mononuclear cells recovered from healthy and diseased human periodontal tissues. J Clin Immunol. 1987 May; 7(3):235-45. PMID: 3496355

Dewhirst FE, Ago JM, Peros WJ, Stashenko P. Synergism between parathyroid hormone and interleukin 1 in stimulating bone resorption in organ culture. J Bone Miner Res. 1987 Apr; 2(2):127-34. PMID: 3502666

Stashenko P, Dewhirst FE, Peros WJ, Kent RL, Ago JM. Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption. J Immunol. 1987 Mar 01; 138(5):1464-8. PMID: 3492553

Stashenko P, Peros WJ, Gibbons RJ, Dearborn SM. Effect of monoclonal antibodies against lipoteichoic acid from the oral bacterium Streptococcus mutans on its adhesion and plaque-accumulation in vitro. Arch Oral Biol. 1986; 31(7):455-61. PMID: 3467668

Dewhirst FE, Stashenko PP, Mole JE, Tsurumachi T. Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta. J Immunol. 1985 Oct; 135(4):2562-8. PMID: 3875658

Stashenko P, Resmini LM, Haffajee AD, Socransky SS. Helper and suppressor T cells in periodontal disease. J Periodontal Res. 1985 Sep; 20(5):515-21. PMID: 2934536

Stashenko P, Resmini LM, Haffajee AD, Socransky SS. T cell responses of periodontal disease patients and healthy subjects to oral microorganisms. J Periodontal Res. 1983 Nov; 18(6):587-600. PMID: 6230432

Stashenko P. Regulatory effect of monocytes on T cell proliferative responses to oral microbial antigens. Infect Immun. 1982 Dec; 38(3):938-47. PMID: 6984019

Bhan AK, Nadler LM, Stashenko P, McCluskey RT, Schlossman SF. Stages of B cell differentiation in human lymphoid tissue. J Exp Med. 1981 Sep 01; 154(3):737-49. PMID: 7024458

Pesando JM, Nadler LM, Lazarus H, Tomaselli KJ, Stashenko P, Ritz J, Levine H, Yunis EJ, Schlossman SF. Human cell lines express multiple populations of Ia-like molecules. Hum Immunol. 1981 Aug; 3(1):67-76. PMID: 6974160; DOI: 10.1016/0198-8859(81)90044-6;

Stashenko P, Nadler LM, Hardy R, Schlossman SF. Expression of cell surface markers after human B lymphocyte activation. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3848-52. PMID: 6973760

Nadler LM, Stashenko P, Hardy R, van Agthoven A, Terhorst C, Schlossman SF. Characterization of a human B cell-specific antigen (B2) distinct from B1. J Immunol. 1981 May; 126(5):1941-7. PMID: 6163824

Nadler LM, Stashenko P, Hardy R, Tomaselli KJ, Yunis EJ, Schlossman SF, Pesando JM. Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region. Nature. 1981 Apr 16; 290(5807):591-3. PMID: 6163992

Nadler LM, Stashenko P, Hardy R, Pesando JM, Yunis EJ, Schlossman SF. Monoclonal antibodies defining serologically distinct HLA-D/DR related Ia-like antigens in man. Hum Immunol. 1981 Feb; 2(1):77-90. PMID: 6944297

Nadler LM, Ritz J, Hardy R, Pesando JM, Schlossman SF, Stashenko P. A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest. 1981 Jan; 67(1):134-40. PMID: 6969730

Stashenko P, Nadler LM, Hardy R, Schlossman SF. Characterization of a human B lymphocyte-specific antigen. J Immunol. 1980 Oct; 125(4):1678-85. PMID: 6157744

Nadler LM, Stashenko P, Hardy R, Kaplan WD, Button LN, Kufe DW, Antman KH, Schlossman SF. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res. 1980 Sep; 40(9):3147-54.View Related Profiles.

Antman, Karen
Stashenko, Philip

PMID: 7427932

Nadler LM, Stashenko P, Hardy R, Schlossman SF. A monoclonal antibody defining a lymphoma-associated antigen in man. J Immunol. 1980 Aug; 125(2):570-7. PMID: 6156208

Stashenko P, Klinman NR. Analysis of the primary anti-(4-hydroxy-3-nitrophenyl) acetyl (NP) responsive B cells in BALB/C and B10.D2 mice. J Immunol. 1980 Aug; 125(2):531-7. PMID: 6771327

Stashenko PP, Bhan AK, Schlossman SF, McCluskey RT. Local transfer of delayed hypersensitivity and cutaneous basophil hypersensitivity. J Immunol. 1977 Dec; 119(6):1987-93. PMID: 72112

Yaron A, Dunham EK, Stashenko PP, Campos-Neto A, Levine H, Schlossman SF. Immune ascites in the guinea pig: specificity of cells and antibody in an induced peritoneal exudate. J Immunol. 1977 Sep; 119(3):968-75. PMID: 70481

Stashenko PP, Schlossman SF. Antigen recognition: the specificity of an isolated T lymphocyte population. J Immunol. 1977 Feb; 118(2):544-50. PMID: 65426

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 128 publications over 39 distinct years, with a maximum of 11 publications in 2007

Bar chart showing 128 publications over 39 distinct years, with a maximum of 11 publications in 2007

Year	Publications
1980	4
1981	7
1982	1
1983	1
1985	2
1986	1
1987	5
1988	1
1989	2
1990	3
1991	6
1992	3
1993	4
1994	3
1995	6
1996	3
1997	2
1998	3
1999	4
2000	5
2001	3
2002	4
2003	1
2004	5
2005	2
2006	3
2007	11
2008	4
2009	3
2010	4
2011	4
2012	3
2013	3
2014	1
2016	2
2017	2
2018	3
2019	2
2022	2

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