Paul Pilch | Profiles RNS

Paul Pilch, PhD

Emeritus Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Purdue University
BA, Temple University

Websites

	Biochemistry Faculty
	LinkedIn

ORCID : 0000-0003-1997-0499

Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Endocrinology, Diabetes, Nutrition & Weight Management

Research Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston Medical Center

Ribosome biogenesis regulates adipocyte function
07/01/2017 - 06/30/2022 (PI of Sub-Project / SP)
PI: Libin Liu, PhD
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK112945-04

Caveolae and Adipocyte Lipid Metabolism
05/01/2016 - 04/30/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK097708-05

Adiporedoxin, a Novel Player in Adipokine Secretion
04/16/2012 - 03/31/2017 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK092942-04

Caveolae and Adipocyte Lipid Metabolism
07/05/2013 - 04/30/2016 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK097708-03

Activation of Hexose Transport by Insulin
04/01/2008 - 02/28/2014 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK030425-30

Regulation of Glut4 Expression and Translocation in Skeletal Muscle
07/01/2007 - 06/30/2010 (PI)
American Diabetes Association

Metabolism, Endocrinology and Obesity Training Grant
05/15/1998 - 04/30/2008 (Co-PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2 T32 DK07201 27

Exercise, Denervation, and Insulin Resistance in Muscle
08/01/1996 - 03/31/2007 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R01 DK49147 09

Mentor-based Postdoctoral Fellowship Program Application
07/01/1997 - 12/31/2004 (PI)
American Diabetes Association

Postdoctoral Training
12/01/1999 - 11/30/2002 (PI)
Adipogenix Inc

Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity
09/25/2014 - 07/01/2016 (Activity-level PI)
PI: Susan Fried, PhD
NIH-NIDDK
1R56DK104369-02

Title

Yr	Title	Project-Sub Proj	Pubs
2018	Ribosome biogenesis regulates adipocyte function	5R01DK112945-02	1
2017	Ribosome biogenesis regulates adipocyte function	1R01DK112945-01	1
2017	Caveolae and adipocyte lipid metabolism	5R01DK097708-05	6
2016	Caveolae and adipocyte lipid metabolism	4R01DK097708-04	6
2016	Metabolism, Endocrinology and Obesity Training Grant	5T32DK007201-39	75
2015	Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity	3R56DK104369-02S1	1
2015	Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity	5R56DK104369-02	1
2015	Caveolae and adipocyte lipid metabolism	5R01DK097708-03	6
2015	Adiporedoxin, a Novel Player in Adipokine Secretion	5R01DK092942-04	3
2014	Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity	1R56DK104369-01	1

Showing 10 of 80 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Wang H, Wan X, Pilch PF, Ellisen LW, Fried SK, Liu L. An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming. Elife. 2020 12 15; 9.View Related Profiles.

Liu, Libin
Pilch, Paul
Fried, Susan

PMID: 33320092; PMCID: PMC7758072; DOI: 10.7554/eLife.63665;

Wang H, Pilch PF, Liu L. Cavin-1/PTRF mediates insulin-dependent focal adhesion remodeling and ameliorates high-fat diet-induced inflammatory responses in mice. J Biol Chem. 2019 07 05; 294(27):10544-10552.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 31126986; PMCID: PMC6615684; DOI: 10.1074/jbc.RA119.008824;

Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM. Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nat Commun. 2018 01 12; 9(1):168.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 29330478; PMCID: PMC5766592; DOI: 10.1038/s41467-017-02585-y;

Ding SY, Liu L, Pilch PF. Muscular dystrophy in PTFR/cavin-1 null mice. JCI Insight. 2017 03 09; 2(5):e91023.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 28289716; PMCID: PMC5333963; DOI: 10.1172/jci.insight.91023;

Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Corrigendum: Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2016 12 08; 7:13775. PMID: 27929114; PMCID: PMC5155156; DOI: 10.1038/ncomms13775;

Liu L, Pilch PF. PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges. Elife. 2016 Aug 16; 5.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 27528195; PMCID: PMC4987143; DOI: 10.7554/eLife.17508;

Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70.View Related Profiles.

Laflamme, Collette
Karastergiou, Kalypso
Liu, Libin
Pilch, Paul
Ding, Shiying
Fried, Susan
Meshulam, Tova
Wu, Yuanyuan

PMID: 26629401; PMCID: PMC4632174; DOI: 10.1016/j.molmet.2015.09.002;

Lo HP, Nixon SJ, Hall TE, Cowling BS, Ferguson C, Morgan GP, Schieber NL, Fernandez-Rojo MA, Bastiani M, Floetenmeyer M, Martel N, Laporte J, Pilch PF, Parton RG. The caveolin-cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle. J Cell Biol. 2015 Aug 31; 210(5):833-49. PMID: 26323694; PMCID: PMC4555827; DOI: 10.1083/jcb.201501046;

Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2015; 6:7808. PMID: 26245716; PMCID: PMC4530473; DOI: 10.1038/ncomms8808;

Liu L, Hansen CG, Honeyman BJ, Nichols BJ, Pilch PF. Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. PLoS One. 2014; 9(7):e102935.View Related Profiles.

Honeyman, Brian
Liu, Libin
Pilch, Paul

PMID: 25036884; PMCID: PMC4103889; DOI: 10.1371/journal.pone.0102935;

Showing 10 of 152 results. Show More

Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF. Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J Biol Chem. 2014 Mar 21; 289(12):8473-83.View Related Profiles.

Liu, Libin
Pilch, Paul
Ding, Shiying
Fried, Susan

PMID: 24509860; PMCID: PMC3961672; DOI: 10.1074/jbc.M113.546242;

Fernández-Rojo MA, Gongora M, Fitzsimmons RL, Martel N, Martin SD, Nixon SJ, Brooks AJ, Ikonomopoulou MP, Martin S, Lo HP, Myers SA, Restall C, Ferguson C, Pilch PF, McGee SL, Anderson RL, Waters MJ, Hancock JF, Grimmond SM, Muscat GE, Parton RG. Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Rep. 2013 Jul 25; 4(2):238-47. PMID: 23850288; DOI: 10.1016/j.celrep.2013.06.017;

Govender P, Romero F, Shah D, Paez J, Ding SY, Liu L, Gower A, Baez E, Aly SS, Pilch P, Summer R. Cavin1; a regulator of lung function and macrophage phenotype. PLoS One. 2013; 8(4):e62045.View Related Profiles.

Gower, Adam
Liu, Libin
Pilch, Paul
Govender, Praveen
Aly, Sherif
Ding, Shiying

PMID: 23634221; PMCID: PMC3636273; DOI: 10.1371/journal.pone.0062045;

Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol. 2013 Apr; 33(8):1503-14. PMID: 23382078; PMCID: PMC3624246; DOI: 10.1128/MCB.01716-12;

Hill MM, Daud NH, Aung CS, Loo D, Martin S, Murphy S, Black DM, Barry R, Simpson F, Liu L, Pilch PF, Hancock JF, Parat MO, Parton RG. Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1. PLoS One. 2012; 7(8):e43041.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 22912783; PMCID: PMC3418245; DOI: 10.1371/journal.pone.0043041;

Breen MR, Camps M, Carvalho-Simoes F, Zorzano A, Pilch PF. Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion. PLoS One. 2012; 7(4):e34516. PMID: 22493697; PMCID: PMC3321009; DOI: 10.1371/journal.pone.0034516;

Tkachenko E, Tse D, Sideleva O, Deharvengt SJ, Luciano MR, Xu Y, McGarry CL, Chidlow J, Pilch PF, Sessa WC, Toomre DK, Stan RV. Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells. PLoS One. 2012; 7(3):e32655. PMID: 22403691; PMCID: PMC3293851; DOI: 10.1371/journal.pone.0032655;

Meshulam T, Breen MR, Liu L, Parton RG, Pilch PF. Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity. J Lipid Res. 2011 Aug; 52(8):1526-32.View Related Profiles.

Liu, Libin
Pilch, Paul
Meshulam, Tova

PMID: 21652731; PMCID: PMC3137018; DOI: 10.1194/jlr.M015628;

Pilch PF, Liu L. Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes. Trends Endocrinol Metab. 2011 Aug; 22(8):318-24.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 21592817; PMCID: PMC3149783; DOI: 10.1016/j.tem.2011.04.001;

Kandror KV, Pilch PF. The sugar is sIRVed: sorting Glut4 and its fellow travelers. Traffic. 2011 Jun; 12(6):665-71.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 21306486; DOI: 10.1111/j.1600-0854.2011.01175.x;

Pilch PF, Meshulam T, Ding S, Liu L. Caveolae and lipid trafficking in adipocytes. Clin Lipidol. 2011; 6(1):49-58.View Related Profiles.

Liu, Libin
Pilch, Paul
Ding, Shiying
Meshulam, Tova

PMID: 21625349; PMCID: PMC3103140; DOI: 10.2217/clp.10.80;

Howes MT, Kirkham M, Riches J, Cortese K, Walser PJ, Simpson F, Hill MM, Jones A, Lundmark R, Lindsay MR, Hernandez-Deviez DJ, Hadzic G, McCluskey A, Bashir R, Liu L, Pilch P, McMahon H, Robinson PJ, Hancock JF, Mayor S, Parton RG. Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. J Cell Biol. 2010 Aug 23; 190(4):675-91.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 20713605; PMCID: PMC2928008; DOI: 10.1083/jcb.201002119;

Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May; 51(5):914-22.View Related Profiles.

Hamilton, James
Kirber, Michael
Pilch, Paul
Meshulam, Tova

PMID: 20388923; PMCID: PMC2853459; DOI: 10.1194/jlr.M900251;

Jedrychowski MP, Gartner CA, Gygi SP, Zhou L, Herz J, Kandror KV, Pilch PF. Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem. 2010 Jan 1; 285(1):104-14.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 19864425; PMCID: PMC2804154; DOI: 10.1074/jbc.M109.040428;

Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P. Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 2009 Dec; 58(12):2788-96.View Related Profiles.

Pilch, Paul
Ding, Shiying

PMID: 19741162; PMCID: PMC2780886; DOI: 10.2337/db09-0763;

Bastiani M, Liu L, Hill MM, Jedrychowski MP, Nixon SJ, Lo HP, Abankwa D, Luetterforst R, Fernandez-Rojo M, Breen MR, Gygi SP, Vinten J, Walser PJ, North KN, Hancock JF, Pilch PF, Parton RG. MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. J Cell Biol. 2009 Jun 29; 185(7):1259-73.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 19546242; PMCID: PMC2712963; DOI: 10.1083/jcb.200903053;

Liu L, Brown D, McKee M, Lebrasseur NK, Yang D, Albrecht KH, Ravid K, Pilch PF. Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab. 2008 Oct; 8(4):310-7.View Related Profiles.

Ravid, Katya
Albrecht, Kenneth
Liu, Libin
Pilch, Paul

PMID: 18840361; PMCID: PMC2581738; DOI: 10.1016/j.cmet.2008.07.008;

Pilch PF. The mass action hypothesis: formation of Glut4 storage vesicles, a tissue-specific, regulated exocytic compartment. Acta Physiol (Oxf). 2008 Jan; 192(1):89-101. PMID: 18171432; DOI: 10.1111/j.1748-1716.2007.01788.x;

Liu L, Pilch PF. A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization. J Biol Chem. 2008 Feb 15; 283(7):4314-22.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 18056712

Saito T, Jones CC, Huang S, Czech MP, Pilch PF. The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J Biol Chem. 2007 Nov 2; 282(44):32280-7. PMID: 17848569

Chao LC, Zhang Z, Pei L, Saito T, Tontonoz P, Pilch PF. Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle. Mol Endocrinol. 2007 Sep; 21(9):2152-63. PMID: 17550977; PMCID: PMC2602962; DOI: 10.1210/me.2007-0169;

Pilch PF, Souto RP, Liu L, Jedrychowski MP, Berg EA, Costello CE, Gygi SP. Cellular spelunking: exploring adipocyte caveolae. J Lipid Res. 2007 Oct; 48(10):2103-11.View Related Profiles.

Costello, Catherine
Liu, Libin
Pilch, Paul

PMID: 17496267

Coderre L, Vallega GA, Pilch PF, Chipkin SR. Regulation of glycogen concentration and glycogen synthase activity in skeletal muscle of insulin-resistant rats. Arch Biochem Biophys. 2007 Aug 1; 464(1):144-50. PMID: 17509520

Liu L, Jedrychowski MP, Gygi SP, Pilch PF. Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes. Mol Biol Cell. 2006 Oct; 17(10):4249-56.View Related Profiles.

Liu, Libin
Pilch, Paul

PMID: 16870704; PMCID: PMC1635356; DOI: 10.1091/mbc.E06-04-0278;

Pilch PF, Bergenhem N. Pharmacological targeting of adipocytes/fat metabolism for treatment of obesity and diabetes. Mol Pharmacol. 2006 Sep; 70(3):779-85. PMID: 16760360

Kandror KV, Pilch PF. Isolation of GLUT4 storage vesicles. Curr Protoc Cell Biol. 2006 Apr; Chapter 3:Unit 3.20.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 18228488; DOI: 10.1002/0471143030.cb0320s30;

Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF. Role of caveolin-1 and cholesterol in transmembrane fatty acid movement. Biochemistry. 2006 Mar 7; 45(9):2882-93.View Related Profiles.

Hamilton, James
Pilch, Paul
Meshulam, Tova

PMID: 16503643

Gross DN, Miyoshi H, Hosaka T, Zhang HH, Pino EC, Souza S, Obin M, Greenberg AS, Pilch PF. Dynamics of lipid droplet-associated proteins during hormonally stimulated lipolysis in engineered adipocytes: stabilization and lipid droplet binding of adipocyte differentiation-related protein/adipophilin. Mol Endocrinol. 2006 Feb; 20(2):459-66.View Related Profiles.

Pino, Elizabeth
Pilch, Paul

PMID: 16239256

Hosaka T, Brooks CC, Presman E, Kim SK, Zhang Z, Breen M, Gross DN, Sztul E, Pilch PF. p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation. Mol Biol Cell. 2005 Jun; 16(6):2882-90. PMID: 15800058; PMCID: PMC1142432; DOI: 10.1091/mbc.E05-01-0072;

Wharton J, Meshulam T, Vallega G, Pilch P. Dissociation of insulin receptor expression and signaling from caveolin-1 expression. J Biol Chem. 2005 Apr 8; 280(14):13483-6.View Related Profiles.

Pilch, Paul
Meshulam, Tova

PMID: 15699039

Wang YL, Guo W, Zang Y, Yaney GC, Vallega G, Getty-Kaushik L, Pilch P, Kandror K, Corkey BE. Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning. Obes Res. 2004 Nov; 12(11):1781-8.View Related Profiles.

Corkey, Barbara
Kandror, Konstantin
Pilch, Paul
Guo, Wen

PMID: 15601973

Gross DN, Farmer SR, Pilch PF. Glut4 storage vesicles without Glut4: transcriptional regulation of insulin-dependent vesicular traffic. Mol Cell Biol. 2004 Aug; 24(16):7151-62.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 15282314; PMCID: PMC479711

Tortorella LL, Lin CB, Pilch PF. ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle. Biochem Biophys Res Commun. 2003 Jun 20; 306(1):163-8. PMID: 12788083

Tojo H, Kaieda I, Hattori H, Katayama N, Yoshimura K, Kakimoto S, Fujisawa Y, Presman E, Brooks CC, Pilch PF. The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa. Mol Endocrinol. 2003 Jul; 17(7):1216-29. PMID: 12677009

Souto RP, Vallega G, Wharton J, Vinten J, Tranum-Jensen J, Pilch PF. Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. J Biol Chem. 2003 May 16; 278(20):18321-9. PMID: 12637562

Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA. Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J Biol Chem. 2003 Mar 7; 278(10):7988-95.View Related Profiles.

Corkey, Barbara
Hamilton, James
Pilch, Paul
Guo, Wen

PMID: 12499383

Tortorella LL, Pilch PF. C2C12 myocytes lack an insulin-responsive vesicular compartment despite dexamethasone-induced GLUT4 expression. Am J Physiol Endocrinol Metab. 2002 Sep; 283(3):E514-24. PMID: 12169445

Tortorella LL, Milasincic DJ, Pilch PF. Critical proliferation-independent window for basic fibroblast growth factor repression of myogenesis via the p42/p44 MAPK signaling pathway. J Biol Chem. 2001 Apr 27; 276(17):13709-17. PMID: 11279003

Martinez C, Vallega G, Pilch PF. Insulin-dependent phosphorylation of a 70-kDa protein in light microsomes from rat adipocytes. Biochem Biophys Res Commun. 2000 Oct 5; 276(3):1302-5. PMID: 11027626

Zhou M, Lin BZ, Coughlin S, Vallega G, Pilch PF. UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase. Am J Physiol Endocrinol Metab. 2000 Sep; 279(3):E622-9. PMID: 10950831

Liu H, Kublaoui B, Pilch PF, Lee J. Insulin activation of mitogen-activated protein (MAP) kinase and Akt is phosphatidylinositol 3-kinase-dependent in rat adipocytes. Biochem Biophys Res Commun. 2000 Aug 11; 274(3):845-51. PMID: 10924365

Zhou M, Vallega G, Kandror KV, Pilch PF. Insulin-mediated translocation of GLUT-4-containing vesicles is preserved in denervated muscles. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E1019-26.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 10827003

Calera MR, Vallega G, Pilch PF. Dynamics of protein-tyrosine phosphatases in rat adipocytes. J Biol Chem. 2000 Mar 3; 275(9):6308-12. PMID: 10692429

Lee W, Ryu J, Souto RP, Pilch PF, Jung CY. Separation and partial characterization of three distinct intracellular GLUT4 compartments in rat adipocytes. Subcellular fractionation without homogenization. J Biol Chem. 1999 Dec 31; 274(53):37755-62. PMID: 10608836

Woldin CN, Hing FS, Lee J, Pilch PF, Shipley GG. Structural studies of the detergent-solubilized and vesicle-reconstituted insulin receptor. J Biol Chem. 1999 Dec 3; 274(49):34981-92.View Related Profiles.

Shipley, G.
Pilch, Paul

PMID: 10574975

Hamm JK, el Jack AK, Pilch PF, Farmer SR. Role of PPAR gamma in regulating adipocyte differentiation and insulin-responsive glucose uptake. Ann N Y Acad Sci. 1999 Nov 18; 892:134-45.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 10842659

El-Jack AK, Kandror KV, Pilch PF. The formation of an insulin-responsive vesicular cargo compartment is an early event in 3T3-L1 adipocyte differentiation. Mol Biol Cell. 1999 May; 10(5):1581-94.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 10233164; PMCID: PMC25345

El-Jack AK, Hamm JK, Pilch PF, Farmer SR. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha. J Biol Chem. 1999 Mar 19; 274(12):7946-51.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 10075691

Calera MR, Pilch PF. Induction of Akt-2 correlates with differentiation in Sol8 muscle cells. Biochem Biophys Res Commun. 1998 Oct 29; 251(3):835-41. PMID: 9790996

Lin B, Coughlin S, Pilch PF. Bidirectional regulation of uncoupling protein-3 and GLUT-4 mRNA in skeletal muscle by cold. Am J Physiol. 1998 Sep; 275(3 Pt 1):E386-91. PMID: 9725803

Zhou M, Sevilla L, Vallega G, Chen P, Palacin M, Zorzano A, Pilch PF, Kandror KV. Insulin-dependent protein trafficking in skeletal muscle cells. Am J Physiol. 1998 Aug; 275(2 Pt 1):E187-96.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 9688618

Kummer JL, Calera MR, Pilch PF. Separation of IRS-1 and PI3-kinase from GLUT4 vesicles in rat skeletal muscle. Biochem Biophys Res Commun. 1998 May 8; 246(1):282-6. PMID: 9600107

Kandror KV, Pilch PF. Multiple endosomal recycling pathways in rat adipose cells. Biochem J. 1998 May 1; 331 ( Pt 3):829-35.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 9560311; PMCID: PMC1219424

Calera MR, Martinez C, Liu H, Jack AK, Birnbaum MJ, Pilch PF. Insulin increases the association of Akt-2 with Glut4-containing vesicles. J Biol Chem. 1998 Mar 27; 273(13):7201-4. PMID: 9516411

Cushman SW, Goodyear LJ, Pilch PF, Ralston E, Galbo H, Ploug T, Kristiansen S, Klip A. Molecular mechanisms involved in GLUT4 translocation in muscle during insulin and contraction stimulation. Adv Exp Med Biol. 1998; 441:63-71. PMID: 9781314

Yaar M, Zhai S, Pilch PF, Doyle SM, Eisenhauer PB, Fine RE, Gilchrest BA. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J Clin Invest. 1997 Nov 1; 100(9):2333-40.View Related Profiles.

Gilchrest, Barbara
Yaar, Mina
Pilch, Paul
Fine, Richard

PMID: 9410912; PMCID: PMC508430

Lin BZ, Pilch PF, Kandror KV. Sortilin is a major protein component of Glut4-containing vesicles. J Biol Chem. 1997 Sep 26; 272(39):24145-7.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 9305862

Lee J, Pilch PF, Shoelson SE, Scarlata SF. Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. Biochemistry. 1997 Mar 4; 36(9):2701-8. PMID: 9054578

Stephens JM, Lee J, Pilch PF. Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem. 1997 Jan 10; 272(2):971-6. PMID: 8995390

Milasincic DJ, Calera MR, Farmer SR, Pilch PF. Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways. Mol Cell Biol. 1996 Nov; 16(11):5964-73.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 8887626; PMCID: PMC231599

Coderre L, Vallega GA, Pilch PF, Chipkin SR. In vivo effects of dexamethasone and sucrose on glucose transport (GLUT-4) protein tissue distribution. Am J Physiol. 1996 Oct; 271(4 Pt 1):E643-8. PMID: 8897851

Kandror KV, Pilch PF. The insulin-like growth factor II/mannose 6-phosphate receptor utilizes the same membrane compartments as GLUT4 for insulin-dependent trafficking to and from the rat adipocyte cell surface. J Biol Chem. 1996 Sep 6; 271(36):21703-8.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 8702963

Kandror KV, Pilch PF. Compartmentalization of protein traffic in insulin-sensitive cells. Am J Physiol. 1996 Jul; 271(1 Pt 1):E1-14.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 8760075

Stephens JM, Morrison RF, Pilch PF. The expression and regulation of STATs during 3T3-L1 adipocyte differentiation. J Biol Chem. 1996 May 3; 271(18):10441-4. PMID: 8631837

Tozzo E, Kahn BB, Pilch PF, Kandror KV. Glut4 is targeted to specific vesicles in adipocytes of transgenic mice overexpressing Glut4 selectively in adipose tissue. J Biol Chem. 1996 May 3; 271(18):10490-4.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 8631845

Lee J, Shoelson SE, Pilch PF. Intermolecular phosphorylation between insulin holoreceptors does not stimulate substrate kinase activity. J Biol Chem. 1995 Dec 29; 270(52):31136-40. PMID: 8537376

Muñoz P, Rosemblatt M, Testar X, Palacín M, Thoidis G, Pilch PF, Zorzano A. The T-tubule is a cell-surface target for insulin-regulated recycling of membrane proteins in skeletal muscle. Biochem J. 1995 Dec 1; 312 ( Pt 2):393-400. PMID: 8526847; PMCID: PMC1136275

Coderre L, Kandror KV, Vallega G, Pilch PF. Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle. J Biol Chem. 1995 Nov 17; 270(46):27584-8.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 7499220

Stephens JM, Pilch PF. The metabolic regulation and vesicular transport of GLUT4, the major insulin-responsive glucose transporter. Endocr Rev. 1995 Aug; 16(4):529-46. PMID: 8521793

Kandror KV, Stephens JM, Pilch PF. Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and structural segregation from GLUT4. J Cell Biol. 1995 May; 129(4):999-1006.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 7744970; PMCID: PMC2120482

Kandror KV, Coderre L, Pushkin AV, Pilch PF. Comparison of glucose-transporter-containing vesicles from rat fat and muscle tissues: evidence for a unique endosomal compartment. Biochem J. 1995 Apr 15; 307 ( Pt 2):383-90.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 7733873; PMCID: PMC1136660

Kublaoui B, Lee J, Pilch PF. Dynamics of signaling during insulin-stimulated endocytosis of its receptor in adipocytes. J Biol Chem. 1995 Jan 6; 270(1):59-65. PMID: 7814420

Kandror KV, Yu L, Pilch PF. The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity. J Biol Chem. 1994 Dec 9; 269(49):30777-80.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 7983006

Kandror KV, Pilch PF. gp160, a tissue-specific marker for insulin-activated glucose transport. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):8017-21.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 8058750; PMCID: PMC44536

Lee J, Pilch PF. The insulin receptor: structure, function, and signaling. Am J Physiol. 1994 Feb; 266(2 Pt 1):C319-34. PMID: 8141246

Kandror K, Pilch PF. Identification and isolation of glycoproteins that translocate to the cell surface from GLUT4-enriched vesicles in an insulin-dependent fashion. J Biol Chem. 1994 Jan 7; 269(1):138-42.View Related Profiles.

Kandror, Konstantin
Pilch, Paul

PMID: 8276787

Pilch PF, Wilkinson W, Garvey WT, Ciaraldi TP, Hueckstaedt TP, Olefsky JM. Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles. J Clin Endocrinol Metab. 1993 Jul; 77(1):286-9. PMID: 8325954

Thoidis G, Kotliar N, Pilch PF. Immunological analysis of GLUT4-enriched vesicles. Identification of novel proteins regulated by insulin and diabetes. J Biol Chem. 1993 Jun 5; 268(16):11691-6. PMID: 8505298

Shoelson SE, Lee J, Lynch CS, Backer JM, Pilch PF. BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor. J Biol Chem. 1993 Feb 25; 268(6):4085-91. PMID: 8382690

Lee J, O'Hare T, Pilch PF, Shoelson SE. Insulin receptor autophosphorylation occurs asymmetrically. J Biol Chem. 1993 Feb 25; 268(6):4092-8. PMID: 8440700

Mischoulon D, Rana B, Kotliar N, Pilch PF, Bucher NL, Farmer SR. Differential regulation of glucose transporter 1 and 2 mRNA expression by epidermal growth factor and transforming growth factor-beta in rat hepatocytes. J Cell Physiol. 1992 Nov; 153(2):288-96.View Related Profiles.

Bucher, Nancy
Pilch, Paul
Farmer, Stephen

PMID: 1429849

Coderre L, Monfar MM, Chen KS, Heydrick SJ, Kurowski TG, Ruderman NB, Pilch PF. Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles. Endocrinology. 1992 Oct; 131(4):1821-5.View Related Profiles.

Ruderman, Neil
Pilch, Paul
Heydrick, Stanley

PMID: 1396328

Kotliar N, Pilch PF. Expression of the glucose transporter isoform GLUT 4 is insufficient to confer insulin-regulatable hexose uptake to cultured muscle cells. Mol Endocrinol. 1992 Mar; 6(3):337-45. PMID: 1584210

Goldfine ID, Pilch P. Insulin secretion and action and diabetes mellitus. J Cell Biochem. 1992 Jan; 48(1):1-2. PMID: 1583071

Shoelson SE, Boni-Schnetzler M, Pilch PF, Kahn CR. Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process. Biochemistry. 1991 Aug 6; 30(31):7740-6. PMID: 1651107

Del Vecchio RL, Pilch PF. Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT 4)-containing vesicles. J Biol Chem. 1991 Jul 15; 266(20):13278-83. PMID: 1649187

Sinha MK, Raineri-Maldonado C, Buchanan C, Pories WJ, Carter-Su C, Pilch PF, Caro JF. Adipose tissue glucose transporters in NIDDM. Decreased levels of muscle/fat isoform. Diabetes. 1991 Apr; 40(4):472-7. PMID: 2010047

Dohm GL, Elton CW, Friedman JE, Pilch PF, Pories WJ, Atkinson SM, Caro JF. Decreased expression of glucose transporter in muscle from insulin-resistant patients. Am J Physiol. 1991 Mar; 260(3 Pt 1):E459-63. PMID: 2003599

Treadway JL, Morrison BD, Wemmie JA, Frias I, O'Hare T, Pilch PF, Pessin JE. The endogenous functional turkey erythrocyte and rat liver insulin receptor is an alpha 2 beta 2 heterotetrameric complex. Biochem J. 1990 Oct 1; 271(1):99-105. PMID: 2222423; PMCID: PMC1149518

Strout HV, Vicario PP, Biswas C, Saperstein R, Brady EJ, Pilch PF, Berger J. Vanadate treatment of streptozotocin diabetic rats restores expression of the insulin-responsive glucose transporter in skeletal muscle. Endocrinology. 1990 May; 126(5):2728-32. PMID: 2184022

Kasanicki MA, Pilch PF. Regulation of glucose-transporter function. Diabetes Care. 1990 Mar; 13(3):219-27. PMID: 2407477

Pilch PF. Glucose transporters: what's in a name? Endocrinology. 1990 Jan; 126(1):3-5. PMID: 2403520

O'Hare T, Pilch PF. Intrinsic kinase activity of the insulin receptor. Int J Biochem. 1990; 22(4):315-24. PMID: 2159922

Vilaró S, Palacín M, Pilch PF, Testar X, Zorzano A. Expression of an insulin-regulatable glucose carrier in muscle and fat endothelial cells. Nature. 1989 Dec 14; 342(6251):798-800. PMID: 2689883

Del Vecchio RL, Pilch PF. Insulin stimulates the tyrosine phosphorylation of a 165 kDa protein that is associated with microsomal membranes of rat adipocytes. Biochim Biophys Acta. 1989 Nov 17; 986(1):41-6. PMID: 2479417

Zorzano A, Wilkinson W, Kotliar N, Thoidis G, Wadzinkski BE, Ruoho AE, Pilch PF. Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations. J Biol Chem. 1989 Jul 25; 264(21):12358-63. PMID: 2545707

Berger J, Biswas C, Vicario PP, Strout HV, Saperstein R, Pilch PF. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature. 1989 Jul 6; 340(6228):70-2. PMID: 2739728

Fukumoto H, Kayano T, Buse JB, Edwards Y, Pilch PF, Bell GI, Seino S. Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. J Biol Chem. 1989 May 15; 264(14):7776-9. PMID: 2656669

Waugh SM, DiBella EE, Pilch PF. Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding. Biochemistry. 1989 Apr 18; 28(8):3448-55. PMID: 2742847

Waugh SM, Pilch PF. Insulin binding changes the interface region between alpha subunits of the insulin receptor. Biochemistry. 1989 Mar 21; 28(6):2722-7. PMID: 2659079

Goldstein RH, Poliks CF, Pilch PF, Smith BD, Fine A. Stimulation of collagen formation by insulin and insulin-like growth factor I in cultures of human lung fibroblasts. Endocrinology. 1989 Feb; 124(2):964-70.View Related Profiles.

Fine, Alan
Smith, Barbara
Pilch, Paul
Goldstein, Ronald

PMID: 2463909

O'Hare T, Pilch PF. Intrinsic kinase activity of the insulin receptor. The intact (alpha 2 beta 2) insulin receptor from rat liver contains a kinase domain with greater intrinsic activity than the intact insulin receptor from human placenta. J Biol Chem. 1989 Jan 5; 264(1):602-10. PMID: 2535848

James DE, Pilch PF. Fractionation of endocytic vesicles and glucose-transporter-containing vesicles in rat adipocytes. Biochem J. 1988 Dec 15; 256(3):725-32. PMID: 3066353; PMCID: PMC1135476

Roome J, O'Hare T, Pilch PF, Brautigan DL. Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors. Biochem J. 1988 Dec 1; 256(2):493-500. PMID: 2851993; PMCID: PMC1135437

Tapson VF, Boni-Schnetzler M, Pilch PF, Center DM, Berman JS. Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor I in vitro. J Clin Invest. 1988 Sep; 82(3):950-7.View Related Profiles.

Center, David
Berman, Jeffrey
Pilch, Paul

PMID: 3262126; PMCID: PMC303607

O'Hare T, Pilch PF. Separation and characterization of three insulin receptor species that differ in subunit composition. Biochemistry. 1988 Jul 26; 27(15):5693-700. PMID: 3052583

Zorzano A, James DE, Ruderman NB, Pilch PF. Insulin-like growth factor I binding and receptor kinase in red and white muscle. FEBS Lett. 1988 Jul 18; 234(2):257-62.View Related Profiles.

Ruderman, Neil
Pilch, Paul

PMID: 2968920

Böni-Schnetzler M, Kaligian A, DelVecchio R, Pilch PF. Ligand-dependent intersubunit association within the insulin receptor complex activates its intrinsic kinase activity. J Biol Chem. 1988 May 15; 263(14):6822-8.View Related Profiles.

Kaligian, Aram
Pilch, Paul

PMID: 2834392

James DE, Brown R, Navarro J, Pilch PF. Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature. 1988 May 12; 333(6169):183-5. PMID: 3285221

Aiello LP, Shia MA, Robinson GS, Pilch PF, Farmer SR. Characterization and hepatic expression of rat alpha 1-inhibitor III mRNA. J Biol Chem. 1988 Mar 15; 263(8):4013-22.View Related Profiles.

Pilch, Paul
Farmer, Stephen

PMID: 2450089

Böni-Schnetzler M, Pilch PF. Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):7832-6. PMID: 3500470; PMCID: PMC299411

James DE, Lederman L, Pilch PF. Purification of insulin-dependent exocytic vesicles containing the glucose transporter. J Biol Chem. 1987 Aug 25; 262(24):11817-24. PMID: 2957373

Böni-Schnetzler M, Scott W, Waugh SM, DiBella E, Pilch PF. The insulin receptor. Structural basis for high affinity ligand binding. J Biol Chem. 1987 Jun 15; 262(17):8395-401. PMID: 3597378

Cousin JL, Samson M, Pilch PF, Fehlmann M. Internalization of insulin receptors and HLA antigens in human hepatoma cells. Biochem J. 1987 Mar 1; 242(2):403-10. PMID: 3036089; PMCID: PMC1147719

James DE, Zorzano A, Böni-Schnetzler M, Nemenoff RA, Powers A, Pilch PF, Ruderman NB. Intrinsic differences of insulin receptor kinase activity in red and white muscle. J Biol Chem. 1986 Nov 15; 261(32):14939-44.View Related Profiles.

Ruderman, Neil
Pilch, Paul

PMID: 3021758

Böni-Schnetzler M, Rubin JB, Pilch PF. Structural requirements for the transmembrane activation of the insulin receptor kinase. J Biol Chem. 1986 Nov 15; 261(32):15281-7. PMID: 3021769

Aiello LP, Wessling-Resnick M, Pilch PF. Dipeptide metalloendoprotease substrates are glucose transport inhibitors and membrane structure perturbants. Biochemistry. 1986 Jul 1; 25(13):3944-50. PMID: 3527260

Pilch PF, O'Hare T, Rubin J, Boni-Schnetzler M. The ligand binding subunit of the insulin-like growth factor 1 receptor has properties of a peripheral membrane protein. Biochem Biophys Res Commun. 1986 Apr 14; 136(1):45-50. PMID: 3010976

Helmy S, Porter-Jordan K, Dawidowicz EA, Pilch P, Schwartz AL, Fine RE. Separation of endocytic from exocytic coated vesicles using a novel cholinesterase mediated density shift technique. Cell. 1986 Feb 14; 44(3):497-506. PMID: 2867830

Wessling M, Pilch PF. Characterization and solubilization of the cytochalasin B binding component from human placental microsomes. Biochim Biophys Acta. 1984 Oct 17; 777(1):123-32. PMID: 6541505

Campbell C, Squicciarini J, Shia M, Pilch PF, Fine RE. Identification of a protein kinase as an intrinsic component of rat liver coated vesicles. Biochemistry. 1984 Sep 11; 23(19):4420-6. PMID: 6148963

Shia MA, Rubin JB, Pilch PF. The insulin receptor protein kinase. Physicochemical requirements for activity. J Biol Chem. 1983 Dec 10; 258(23):14450-5. PMID: 6557114

Rubin JB, Shia MA, Pilch PF. Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I. Nature. 1983 Sep 29-Oct 5; 305(5933):438-40. PMID: 6312321

Axelrod JD, Pilch PF. Unique cytochalasin B binding characteristics of the hepatic glucose carrier. Biochemistry. 1983 Apr 26; 22(9):2222-7. PMID: 6683102

Shia MA, Pilch PF. The beta subunit of the insulin receptor is an insulin-activated protein kinase. Biochemistry. 1983 Feb 15; 22(4):717-21. PMID: 6340724

Pilch PF, Shia MA, Benson RJ, Fine RE. Coated vesicles participate in the receptor-mediated endocytosis of insulin. J Cell Biol. 1983 Jan; 96(1):133-8. PMID: 6131074; PMCID: PMC2112276

Pilch PF. Modification of the insulin receptor by diethyl pyrocarbonate: effect on insulin binding and action. Biochemistry. 1982 Oct 26; 21(22):5638-44. PMID: 6756473

Massague J, Pilch PF, Czech MP. A unique proteolytic cleavage site on the beta subunit of the insulin receptor. J Biol Chem. 1981 Apr 10; 256(7):3182-90. PMID: 7009609

Pilch PF, Axelrod JD, Colello J, Czech MP. Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation. J Biol Chem. 1981 Feb 25; 256(4):1570-5. PMID: 7007367

Johnson GL, MacAndrew VI, Pilch PF. Identification of the glucagon receptor in rat liver membranes by photoaffinity crosslinking. Proc Natl Acad Sci U S A. 1981 Feb; 78(2):875-8. PMID: 6262779; PMCID: PMC319906

Carter-Su C, Pilch PF, Czech MP. Chromatographic resolution of insulin receptor from insulin-sensitive D-glucose transporter of adipocyte plasma membranes. Biochemistry. 1981 Jan 6; 20(1):216-21. PMID: 7008832

Pilch PF, Czech MP. Hormone binding alters the conformation of the insulin receptor. Science. 1980 Dec 5; 210(4474):1152-3. PMID: 7003712

Massague J, Pilch PF, Czech MP. Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7137-41. PMID: 6938960; PMCID: PMC350456

Pillion DJ, Carter-Su CA, Pilch PF, Czech MP. Isolation of adipocyte plasma membrane antigens by immunoaffinity chromatography. Insulinomimetic antibodies do not bind directly to the insulin receptor or the glucose transport system. J Biol Chem. 1980 Oct 10; 255(19):9168-76. PMID: 6773960

Czech MP, Malbon CC, Kerman K, Gitomer W, Pilch PF. Effect of thyroid status on insulin action in rat adipocytes and skeletal muscle. J Clin Invest. 1980 Sep; 66(3):574-82. PMID: 6249852; PMCID: PMC371686

Pilch PF, Czech MP. The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes. J Biol Chem. 1980 Feb 25; 255(4):1722-31. PMID: 6986378

Heinrich J, Pilch PF, Czech MP. Purification of the adipocyte insulin receptor by immunoaffinity chromatography. J Biol Chem. 1980 Feb 25; 255(4):1732-7. PMID: 6986379

Pilch PF, Thompson PA, Czech MP. Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes. Proc Natl Acad Sci U S A. 1980 Feb; 77(2):915-8. PMID: 6987672; PMCID: PMC348392

Pilch PF, Czech MP. Hexose transport in adipocytes: stimulation by insulin in the absence of intact receptor. Ann N Y Acad Sci. 1980; 358:356. PMID: 7011151

Czech MP, Massague J, Pilch PF, Carter-Su C. Structural features of the insulin effector system: relation to hexose transport activation. Ann N Y Acad Sci. 1980; 358:282-91. PMID: 7011146

Pilch PF, Czech MP. Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons. J Biol Chem. 1979 May 10; 254(9):3375-81. PMID: 429356

Pilch PF, Somerville RL. Fluorine-containing analogues of intermediates in the Shikimate pathway. Biochemistry. 1976 Nov 30; 15(24):5315-20. PMID: 11811

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 150 publications over 40 distinct years, with a maximum of 9 publications in 1980 and 1989

Bar chart showing 150 publications over 40 distinct years, with a maximum of 9 publications in 1980 and 1989

Year	Publications
1980	9
1981	4
1982	1
1983	5
1984	2
1986	5
1987	4
1988	8
1989	9
1990	5
1991	4
1992	4
1993	4
1994	4
1995	7
1996	6
1997	4
1998	7
1999	5
2000	5
2001	1
2002	2
2003	3
2004	2
2005	3
2006	4
2007	5
2008	2
2009	3
2010	2
2011	4
2012	3
2013	3
2014	2
2015	3
2016	2
2017	1
2018	1
2019	1
2020	1

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