Nina Lin | Profiles RNS

Nina Lin, MD

Assistant Professor

Boston University School of Medicine

Dept of Medicine

Infectious Diseases

MD, Harvard Medical School

Websites

	Infectious Diseases Faculty
	Boston Medical Center Provider Profile

Dr. Nina Lin is a physician scientist who is engaged in HIV translational research. Her research is focused on understanding the effect of chronic HIV infection on aging of the immune system and chronic inflammation. She is the PI on several clinical trials, including being a co-Chair of ACTG A5325 and A5220s, to evaluate interventions which may improve or alter the clinical course of chronic HIV infection. Her research while at MGH/BWH had been on understanding HIV-1 coreceptor usage in subtype C infection and the factors associated with its switching. She is the Director of the BU Infectious Disease Clinical Research Unit (CRU) where several HIV and/or infectious diseases clinical studies are being conducted.

Impact of smoking and its cessation on systemic and airway immune activation
08/15/2016 - 06/30/2018 (Subcontract Co-PI)
Boston Medical Center Corporation NIH NIDA
5R01DA042685-02

Providence/Boston Center for AIDS Research(CFAR): Core E-Biobehavioral Sciences
07/01/2018 - 06/30/2023 (PI)
Miriam Hospital NIH-NIAID

Persistent HIV expression induced type 1 IFN responses and inflammaging
08/01/2018 - 04/30/2023 (PI)
Trustees of Boston University NIH-NIAID

Rapid Bacterial Identification (RABIT) Study
08/01/2019 - 08/31/2022 (PI)
Day Zero Diagnostics, Inc.

Impact of smoking and its cessation on systemic and airway immune activation
08/15/2016 - 06/30/2022 (PI)
NIH-NIDA
5R01DA042685-03

PILOT STUDY - EFFECTS OF BICTEGRAVIR-EMTRICITABINE-TENOFOVIR ALAFENAMIDE ON CORONARY FLOW RESERVE…
01/01/2019 - 01/31/2022 (PI)
Brigham & Women's

The Effects of Opiod Use on HIV-1 Reservoir Dynamics
08/15/2018 - 05/31/2021 (PI)
Brigham & Women's NIH-NIDA
1R61DA047038-01

REPRIEVE A5332 Cardiac MRI (substudy): Mechanisms of Cardiac Dysfunction in HIV and the Effect of..
06/16/2017 - 03/31/2021 (PI)
Mass General Hosp NIH-NHLBI

MK-00036400001
01/10/2018 - 01/09/2021 (PI)
Merck

GS-US-380-4030: A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy
06/19/2017 - 06/19/2020 (PI)
Gilead Sciences

REPRIEVE A5332 (main study)
05/01/2015 - 04/30/2020 (PI)
Mass General Hosp NIH-NHLBI
5U01HL123336-05

Showing 10 of 23 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2020	The effects of opioid use on HIV-1 reservoir dynamics	5R61DA047038-03
2020	Persistent HIV expression induced type I IFN responses and inflammaging	5R01AG060890-03	2
2020	Impact of smoking and its cessation on systemic and airway immune activation	5R01DA042685-04
2019	The effects of opioid use on HIV-1 reservoir dynamics	5R61DA047038-02
2019	Persistent HIV expression induced type I IFN responses and inflammaging	5R01AG060890-02	2
2019	Impact of smoking and its cessation on systemic and airway immune activation	5R01DA042685-03
2018	The effects of opioid use on HIV-1 reservoir dynamics	1R61DA047038-01
2018	Persistent HIV expression induced type I IFN responses and inflammaging	1R01AG060890-01	2
2017	Impact of smoking and its cessation on systemic and airway immune activation	5R01DA042685-02
2016	Impact of smoking and its cessation on systemic and airway immune activation	1R01DA042685-01

Showing 10 of 16 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Stone JH, Frigault MJ, Serling-Boyd NJ, Fernandes AD, Harvey L, Foulkes AS, Horick NK, Healy BC, Shah R, Bensaci AM, Woolley AE, Nikiforow S, Lin N, Sagar M, Schrager H, Huckins DS, Axelrod M, Pincus MD, Fleisher J, Sacks CA, Dougan M, North CM, Halvorsen YD, Thurber TK, Dagher Z, Scherer A, Wallwork RS, Kim AY, Schoenfeld S, Sen P, Neilan TG, Perugino CA, Unizony SH, Collier DS, Matza MA, Yinh JM, Bowman KA, Meyerowitz E, Zafar A, Drobni ZD, Bolster MB, Kohler M, D'Silva KM, Dau J, Lockwood MM, Cubbison C, Weber BN, Mansour MK. Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. N Engl J Med. 2020 10 21.View Related Profiles.

Sagar, Manish
Lin, Nina

PMID: 33085857

Olson A, Coote C, Snyder-Cappione JE, Lin N, Sagar M. HIV-1 transcription but not intact provirus levels are associated with systemic inflammation. J Infect Dis. 2020 Oct 19.View Related Profiles.

Snyder-Cappione , Jennifer
Sagar, Manish
Lin, Nina

PMID: 33075121

Sinha P, Mostaghim A, Bielick CG, McLaughlin A, Hamer DH, Wetzler LM, Bhadelia N, Fagan MA, Linas BP, Assoumou SA, Ieong MH, Lin NH, Cooper ER, Brade KD, White LF, Barlam TF, Sagar M. Early administration of interleukin-6 inhibitors for patients with severe COVID-19 disease is associated with decreased intubation, reduced mortality, and increased discharge. Int J Infect Dis. 2020 Oct; 99:28-33.View Related Profiles.

Linas, Benjamin
Hamer, Davidson
Cooper, Ellen
White, Laura
Wetzler, Lee
Sagar, Manish
Fagan, Maura
Ieong, Michael
Bhadelia, Nahid
Lin, Nina
Sinha, Pranay
Assoumou, Sabrina
Barlam, Tamar

PMID: 32721528

Registre L, Moreau Y, Ataca ST, Pulukuri S, Henrich TJ, Lin N, Sagar M. HIV-1 Coreceptor Usage and Variable Loop Contact Impact V3 Loop Broadly Neutralizing Antibody Susceptibility. J Virol. 2020 01 06; 94(2).View Related Profiles.

Registre, Ludy
Sagar, Manish
Lin, Nina
Ataca, Sila

PMID: 31694950

Asundi A, Cervantes-Arslanian AM, Lin NH, Barbosa F. Infectious Myelitis. Semin Neurol. 2019 08; 39(4):472-481.View Related Profiles.

Cervantes-Arslanian, Anna
Asundi, Archana
Lin, Nina

PMID: 31533188

Asundi A, Robles Y, Starr T, Landay A, Kinslow J, Ladner J, White L, Plank RM, Melbourne K, Weisholtz D, Bennett M, Pan H, Stern E, Lin A, Kuritzkes DR, Lin NH. Immunological and Neurometabolite Changes Associated With Switch From Efavirenz to an Integrase Inhibitor. J Acquir Immune Defic Syndr. 2019 08 15; 81(5):585-593.View Related Profiles.

Asundi, Archana
White, Laura
Lin, Nina

PMID: 31045650

Belkina AC, Starchenko A, Drake KA, Proctor EA, Pihl RMF, Olson A, Lauffenburger DA, Lin N, Snyder-Cappione JE. Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging. Front Immunol. 2018; 9:2783.View Related Profiles.

Belkina, Anna
Snyder-Cappione , Jennifer
Lin, Nina
Pihl, Riley

PMID: 30568654

Olson A, Ragan EJ, Nakiyingi L, Lin N, Jacobson KR, Ellner JJ, Manabe YC, Sagar M. Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans. J Acquir Immune Defic Syndr. 2018 11 01; 79(3):407-411.View Related Profiles.

Ellner, Jerrold
Jacobson, Karen
Sagar, Manish
Lin, Nina

PMID: 30063648

Lin N, Gonzalez OA, Registre L, Becerril C, Etemad B, Lu H, Wu X, Lockman S, Essex M, Moyo S, Kuritzkes DR, Sagar M. Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants. EBioMedicine. 2016 Jun; 8:237-47.View Related Profiles.

Etemad, Behzad
Registre, Ludy
Sagar, Manish
Lin, Nina

PMID: 27428434; PMCID: PMC4919596; DOI: 10.1016/j.ebiom.2016.04.040;

Scully E, Lockhart A, Huang L, Robles Y, Becerril C, Romero-Tejeda M, Albrecht MA, Palmer CD, Bosch RJ, Altfeld M, Kuritzkes DR, Lin NH. Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men. J Infect Dis. 2016 Mar 01; 213(5):771-5. PMID: 26494772; DOI: 10.1093/infdis/jiv501;

Showing 10 of 25 results. Show More

Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013 Jun 1; 207(11):1694-702.View Related Profiles.

Sagar, Manish
Lin, Nina

PMID: 23460751; PMCID: PMC3636784; DOI: 10.1093/infdis/jit086;

Lin NH, Becerril C, Giguel F, Novitsky V, Moyo S, Makhema J, Essex M, Lockman S, Kuritzkes DR, Sagar M. Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C. Virology. 2012 Nov 25; 433(2):296-307.View Related Profiles.

Sagar, Manish
Lin, Nina

PMID: 22954962; PMCID: PMC3616623; DOI: 10.1016/j.virol.2012.08.013;

Wilkin TJ, Lalama CM, McKinnon J, Gandhi RT, Lin N, Landay A, Ribaudo H, Fox L, Currier JS, Mellors JW, Gulick R, Tenorio AR. A pilot trial of adding maraviroc to suppressive antiretroviral therapy for suboptimal CD4? T-cell recovery despite sustained virologic suppression: ACTG A5256. J Infect Dis. 2012 Aug 15; 206(4):534-42. PMID: 22740718; DOI: 10.1093/infdis/jis376;

Lin NH, Smeaton LM, Giguel F, Novitsky V, Moyo S, Mitchell RM, Makhema J, Essex M, Lockman S, Kuritzkes DR. Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana. J Acquir Immune Defic Syndr. 2011 May 01; 57(1):46-50. PMID: 21346588; DOI: 10.1097/QAI.0b013e318214fe27;

Henrich TJ, Li JZ, Felsenstein D, Kotton CN, Plenge RM, Pereyra F, Marty FM, Lin NH, Grazioso P, Crochiere DM, Eggers D, Kuritzkes DR, Tsibris AM. Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions. J Infect Dis. 2010 Nov 15; 202(10):1478-81. PMID: 20936980; DOI: 10.1086/657168;

Lin NH, Negusse DM, Beroukhim R, Giguel F, Lockman S, Essex M, Kuritzkes DR. The design and validation of a novel phenotypic assay to determine HIV-1 coreceptor usage of clinical isolates. J Virol Methods. 2010 Oct; 169(1):39-46. PMID: 20599562; DOI: 10.1016/j.jviromet.2010.06.012;

Tsuang MT, Lyons MJ, Meyer JM, Doyle T, Eisen SA, Goldberg J, True W, Lin N, Toomey R, Eaves L. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry. 1998 Nov; 55(11):967-72. PMID: 9819064

Lustig B, Lin NH, Smith SM, Jernigan RL, Jeang KT. A small modified hammerhead ribozyme and its conformational characteristics determined by mutagenesis and lattice calculation. Nucleic Acids Res. 1995 Sep 11; 23(17):3531-8. PMID: 7567466

Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H. In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. J Virol. 1993 Oct; 67(10):6224-33. PMID: 7690421

Dropulic B, Lin NH, Jeang KT. A method to increase the cumulative cleavage efficiency of ribozymes: thermal cycling. Nucleic Acids Res. 1993 May 11; 21(9):2273-4. PMID: 8502581

Dropulic B, Lin NH, Martin MA, Jeang KT. Functional characterization of a U5 ribozyme: intracellular suppression of human immunodeficiency virus type 1 expression. J Virol. 1992 Mar; 66(3):1432-41. PMID: 1738200

Subramanamian K, Plank RM, Lin NH, Goldman-Yassen A, Becerril C, Kemal K, Heo M, Kelley MJ, Mutimura E, Anastos K, Daily JP. Plasmodium falciparum Infection Does Not Affect Human Immunodeficiency Virus Viral Load in Coinfected Rwandan Adults.
Henrich TJ, Mclaren P, Rao S, Lin NH, Hanhauser E, Giguel F, Gulick RM, Ribaudo H, DeBakker P, Kuritzkes DR. Genome-Wide Association Study of HIV-1 Coreceptor Usage in Treatment Naive Patients from an ACTG Study.
Scully E, Lockhart A, Huang L, Robles Y, Becerril C, Romero-Tejeda M, Albrecht MA, Palmer CD, Bosch RJ, Altfeld M, Kurtizkes DR, Lin NH. Elevated levels of microbial translocation markers and CCL2 among older HIV-1 infected men.
Dong KL, Moodley A, Kwon DS, Ghebremichael MS, Dong M, Ismail N, Ndhlovu ZM, Mabuka JM, Muema DM, Pretorius K, Lin N, Madurai S, Walker BD, Ndung’u, T. Detection and Treatment of Fiebig Stage I HIV-1 Infection in Young at-risk Women in South Africa: a Prospective Cohort Study. Lancet HIV.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 21 publications over 13 distinct years, with a maximum of 4 publications in 2020

Bar chart showing 21 publications over 13 distinct years, with a maximum of 4 publications in 2020

Year	Publications
1992	1
1993	2
1995	1
1998	1
2010	2
2011	1
2012	2
2013	1
2015	1
2016	1
2018	2
2019	2
2020	4

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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617.414.5276

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