Nina Lin | Profiles RNS

Nina Lin, MD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Infectious Diseases

MD, Harvard Medical School
BS, Stanford University

Websites

	Infectious Diseases Faculty
	Boston Medical Center Provider Profile
	LinkedIn
	ResearchGate

ORCID : 0000-0002-4913-0442

Dr. Nina Lin is a physician scientist who is engaged in HIV translational research. Her research is focused on understanding the effect of chronic HIV infection on aging of the immune system and chronic inflammation. She is the PI on several clinical trials, including being a co-Chair of ACTG A5325 and A5220s, to evaluate interventions which may improve or alter the clinical course of chronic HIV infection. Her research while at MGH/BWH had been on understanding HIV-1 coreceptor usage in subtype C infection and the factors associated with its switching. She is the Director of the BU Infectious Disease Clinical Research Unit (CRU) where several HIV and/or infectious diseases clinical studies are being conducted.

Impact of smoking and its cessation on systemic and airway immune activation
08/15/2016 - 06/30/2018 (Co-Investigator)
Boston Medical Center Corporation NIH NIDA
5R01DA042685-02

The Effects of Opiod Use on HIV-1 Reservoir Dynamics
08/15/2018 - 05/31/2024 (PI)
Brigham and Womens Hospital National Institute o
5R61DA047038-03

Tocilizumab to Prevent the Progression of Hypoxemic Respiratory Failure in Hospitalized…
04/30/2020 - 04/30/2024 (PI)
Massachusetts General Hospital Genentech, Inc.

Impact of smoking and its cessation on systemic and airway immune activation
07/01/2019 - 12/31/2023 (PI)
National Institute on Drug Abuse/NIH/DHHS National Heart, Lung
5R01DA042685-03

Rapid Bacterial Identification (RABIT) Study
08/01/2019 - 10/31/2023 (PI)
Day Zero Diagnostics, Inc.

Intensified antiretroviral therapy with raltegravir in acute HIV infection to limit establishment…
01/01/2020 - 06/30/2023 (PI)
Merck

Providence Boston Center for AIDS Research (CFAR)
07/01/2019 - 06/30/2023 (Multi-PI)
PI: Nina Lin, MD
The Miriam Hospital National Institute o
5P30AI042853-24

A PHASE III, RANDOMIZED, DOUBLE-BLIND,MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF REMDESIVIR PLUS TOCILIZUMAB COMPARED WITH REMDESIVIR PLUS PLACEBO IN HOSPITALIZED PATIENTS WITH SEVERE COVID-19 PNEUMONIA
06/28/2020 - 06/28/2023 (PI)
Genentech, Inc.

SALSA 208090 A Phase III, randomized, multicenter, open-label, non-inferiority study evaluating…
03/06/2020 - 10/17/2022 (PI)
ViiV Healthcare

GS-US-380-4580 A Phase 3b, Multicenter, Open-Label Study to Evaluate Switching From a Regimen of…
01/01/2019 - 03/31/2022 (PI)
Gilead Sciences

PILOT STUDY - EFFECTS OF BICTEGRAVIR-EMTRICITABINE-TENOFOVIR ALAFENAMIDE ON CORONARY FLOW RESERVE…
01/01/2019 - 03/31/2022 (PI)
Brigham and Womens Hospital

Showing 10 of 28 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2022	Persistent HIV expression induced type I IFN responses and inflammaging	5R01AG060890-05
2021	Persistent HIV expression induced type I IFN responses and inflammaging	5R01AG060890-04	2
2021	Impact of smoking and its cessation on systemic and airway immune activation	5R01DA042685-05
2020	The effects of opioid use on HIV-1 reservoir dynamics	5R61DA047038-03
2020	Persistent HIV expression induced type I IFN responses and inflammaging	5R01AG060890-03	2
2020	Impact of smoking and its cessation on systemic and airway immune activation	5R01DA042685-04
2019	The effects of opioid use on HIV-1 reservoir dynamics	5R61DA047038-02
2019	Persistent HIV expression induced type I IFN responses and inflammaging	5R01AG060890-02	2
2019	Impact of smoking and its cessation on systemic and airway immune activation	5R01DA042685-03
2018	The effects of opioid use on HIV-1 reservoir dynamics	1R61DA047038-01

Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

McLaughlin A, Lin N, Jiang W, Lodi S, Lioznov D, Patts G, Gnatienko N, Blokhina E, Bendiks S, Freiberg MS, Tindle HA, Krupitsky E, Hahn JA, Samet JH, So-Armah K. Association of Alcohol Consumption With CD4 Recovery After Antiretroviral Therapy Initiation in St. Petersburg, Russia. J Acquir Immune Defic Syndr. 2023 Nov 01; 94(3):244-252.View Related Profiles.

McLaughlin, Angela
Samet, Jeffrey
So-Armah, Kaku
Lin, Nina
Lodi, Sara

PMID: 37850982; PMCID: PMC10593489; DOI: 10.1097/QAI.0000000000003250;

Asundi A, Olson A, Jiang W, Varshney SP, White LF, Sagar M, Lin NH. Integrase Inhibitor Use Associated with Weight Gain in Women and Incident Diabetes Mellitus. AIDS Res Hum Retroviruses. 2022 03; 38(3):208-215.View Related Profiles.

Olson, Alex
Asundi, Archana
White, Laura
Sagar, Manish
Lin, Nina

PMID: 34877881; PMCID: PMC8968841; DOI: 10.1089/aid.2021.0091;

Kuniholm J, Armstrong E, Bernabe B, Coote C, Berenson A, Patalano SD, Olson A, He X, Lin NH, Fuxman Bass JI, Henderson AJ. Intragenic proviral elements support transcription of defective HIV-1 proviruses. PLoS Pathog. 2021 12; 17(12):e1009982.View Related Profiles.

Olson, Alex
Henderson, Andrew
Lin, Nina

PMID: 34962974; PMCID: PMC8746790; DOI: 10.1371/journal.ppat.1009982;

Ragan EJ, McCallum C, Marathe J, Cole M, Hofman M, Henderson AJ, Flack T, Miller NS, Burks EJ, Zhao GQ, Denis R, Lin NH, Jacobson KR, Andry CD, Pelton SI, Duffy ER, Bhadelia N. Pandemic Response Requires Research Samples: A U.S. Safety-Net Hospital's Experience and Call for National Action. Ann Intern Med. 2021 12; 174(12):1727-1732.View Related Profiles.

Henderson, Andrew
Duffy, Elizabeth
Burks, Eric
Marathe, Jai
Jacobson, Karen
Bhadelia, Nahid
Miller, Nancy
Lin, Nina
Pelton, Stephen

PMID: 34724402; DOI: 10.7326/M21-2857;

Olson A, Coote C, Snyder-Cappione JE, Lin N, Sagar M. HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation. J Infect Dis. 2021 06 04; 223(11):1934-1942.View Related Profiles.

Olson, Alex
Snyder-Cappione , Jennifer
Sagar, Manish
Lin, Nina

PMID: 33075121; PMCID: PMC8176637; DOI: 10.1093/infdis/jiaa657;

Kamel MH, Mahmoud H, Zhen A, Liu J, Bielick CG, Mostaghim A, Lin N, Chitalia V, Ilori T, Waikar SS, Upadhyay A. End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts. PLoS One. 2021; 16(6):e0252679.View Related Profiles.

Zhen, Aileen
Upadhyay, Ashish
Bielick, Catherine
Kamel, Mohamed
Lin, Nina
Waikar, Sushrut
Ilori, Titilayo
Chitalia, Vipul

PMID: 34086775; PMCID: PMC8177422; DOI: 10.1371/journal.pone.0252679;

Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676.View Related Profiles.

Olson, Alex
Belkina, Anna
Korkmaz, Filiz
Mostoslavsky, Gustavo
Rifkin, Ian
Snyder-Cappione , Jennifer
Quillen, Karen
Sagar, Manish
Bhadelia, Nahid
Lin, Nina
Pihl, Riley
Corley, Ronald
Gummuluru, Suryaram
Kataria, Yachana

PMID: 33897682; PMCID: PMC8062931; DOI: 10.3389/fimmu.2021.614676;

Stone JH, Frigault MJ, Serling-Boyd NJ, Fernandes AD, Harvey L, Foulkes AS, Horick NK, Healy BC, Shah R, Bensaci AM, Woolley AE, Nikiforow S, Lin N, Sagar M, Schrager H, Huckins DS, Axelrod M, Pincus MD, Fleisher J, Sacks CA, Dougan M, North CM, Halvorsen YD, Thurber TK, Dagher Z, Scherer A, Wallwork RS, Kim AY, Schoenfeld S, Sen P, Neilan TG, Perugino CA, Unizony SH, Collier DS, Matza MA, Yinh JM, Bowman KA, Meyerowitz E, Zafar A, Drobni ZD, Bolster MB, Kohler M, D'Silva KM, Dau J, Lockwood MM, Cubbison C, Weber BN, Mansour MK. Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. N Engl J Med. 2020 12 10; 383(24):2333-2344.View Related Profiles.

Moraco, Andrew
Tedrow, John
Fleisher, Jorge
Sagar, Manish
Lin, Nina
Lacamera, Peter

PMID: 33085857; PMCID: PMC7646626; DOI: 10.1056/NEJMoa2028836;

Sinha P, Mostaghim A, Bielick CG, McLaughlin A, Hamer DH, Wetzler LM, Bhadelia N, Fagan MA, Linas BP, Assoumou SA, Ieong MH, Lin NH, Cooper ER, Brade KD, White LF, Barlam TF, Sagar M. Early administration of interleukin-6 inhibitors for patients with severe COVID-19 disease is associated with decreased intubation, reduced mortality, and increased discharge. Int J Infect Dis. 2020 Oct; 99:28-33.View Related Profiles.

McLaughlin, Angela
Linas, Benjamin
Bielick, Catherine
Hamer, Davidson
Cooper, Ellen
White, Laura
Wetzler, Lee
Sagar, Manish
Fagan, Maura
Ieong, Michael
Bhadelia, Nahid
Lin, Nina
Sinha, Pranay
Assoumou, Sabrina
Barlam, Tamar

PMID: 32721528; PMCID: PMC7591937; DOI: 10.1016/j.ijid.2020.07.023;

Registre L, Moreau Y, Ataca ST, Pulukuri S, Henrich TJ, Lin N, Sagar M. HIV-1 Coreceptor Usage and Variable Loop Contact Impact V3 Loop Broadly Neutralizing Antibody Susceptibility. J Virol. 2020 01 06; 94(2).View Related Profiles.

Registre, Ludy
Sagar, Manish
Lin, Nina
Ataca, Sila

PMID: 31694950; PMCID: PMC6955257; DOI: 10.1128/JVI.01604-19;

Showing 10 of 31 results. Show More

Asundi A, Cervantes-Arslanian AM, Lin NH, Barbosa F. Infectious Myelitis. Semin Neurol. 2019 08; 39(4):472-481.View Related Profiles.

Cervantes-Arslanian, Anna
Asundi, Archana
Lin, Nina

PMID: 31533188

Asundi A, Robles Y, Starr T, Landay A, Kinslow J, Ladner J, White L, Plank RM, Melbourne K, Weisholtz D, Bennett M, Pan H, Stern E, Lin A, Kuritzkes DR, Lin NH. Immunological and Neurometabolite Changes Associated With Switch From Efavirenz to an Integrase Inhibitor. J Acquir Immune Defic Syndr. 2019 08 15; 81(5):585-593.View Related Profiles.

Asundi, Archana
White, Laura
Lin, Nina

PMID: 31045650; PMCID: PMC6625862; DOI: 10.1097/QAI.0000000000002079;

Belkina AC, Starchenko A, Drake KA, Proctor EA, Pihl RMF, Olson A, Lauffenburger DA, Lin N, Snyder-Cappione JE. Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging. Front Immunol. 2018; 9:2783.View Related Profiles.

Olson, Alex
Belkina, Anna
Snyder-Cappione , Jennifer
Lin, Nina
Pihl, Riley

PMID: 30568654; PMCID: PMC6290897; DOI: 10.3389/fimmu.2018.02783;

Olson A, Ragan EJ, Nakiyingi L, Lin N, Jacobson KR, Ellner JJ, Manabe YC, Sagar M. Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans. J Acquir Immune Defic Syndr. 2018 11 01; 79(3):407-411.View Related Profiles.

Olson, Alex
Ellner, Jerrold
Jacobson, Karen
Sagar, Manish
Lin, Nina

PMID: 30063648; PMCID: PMC6506856; DOI: 10.1097/QAI.0000000000001823;

Lin N, Gonzalez OA, Registre L, Becerril C, Etemad B, Lu H, Wu X, Lockman S, Essex M, Moyo S, Kuritzkes DR, Sagar M. Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants. EBioMedicine. 2016 Jun; 8:237-47.View Related Profiles.

Etemad, Behzad
Registre, Ludy
Sagar, Manish
Lin, Nina

PMID: 27428434; PMCID: PMC4919596; DOI: 10.1016/j.ebiom.2016.04.040;

Scully E, Lockhart A, Huang L, Robles Y, Becerril C, Romero-Tejeda M, Albrecht MA, Palmer CD, Bosch RJ, Altfeld M, Kuritzkes DR, Lin NH. Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men. J Infect Dis. 2016 Mar 01; 213(5):771-5. PMID: 26494772; PMCID: PMC4747622; DOI: 10.1093/infdis/jiv501;

Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013 Jun 1; 207(11):1694-702.View Related Profiles.

Sagar, Manish
Lin, Nina

PMID: 23460751; PMCID: PMC3636784; DOI: 10.1093/infdis/jit086;

Lin NH, Becerril C, Giguel F, Novitsky V, Moyo S, Makhema J, Essex M, Lockman S, Kuritzkes DR, Sagar M. Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C. Virology. 2012 Nov 25; 433(2):296-307.View Related Profiles.

Sagar, Manish
Lin, Nina

PMID: 22954962; PMCID: PMC3616623; DOI: 10.1016/j.virol.2012.08.013;

Wilkin TJ, Lalama CM, McKinnon J, Gandhi RT, Lin N, Landay A, Ribaudo H, Fox L, Currier JS, Mellors JW, Gulick R, Tenorio AR. A pilot trial of adding maraviroc to suppressive antiretroviral therapy for suboptimal CD4? T-cell recovery despite sustained virologic suppression: ACTG A5256. J Infect Dis. 2012 Aug 15; 206(4):534-42. PMID: 22740718; PMCID: PMC3491731; DOI: 10.1093/infdis/jis376;

Lin NH, Smeaton LM, Giguel F, Novitsky V, Moyo S, Mitchell RM, Makhema J, Essex M, Lockman S, Kuritzkes DR. Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana. J Acquir Immune Defic Syndr. 2011 May 01; 57(1):46-50. PMID: 21346588; PMCID: PMC3353541; DOI: 10.1097/QAI.0b013e318214fe27;

Henrich TJ, Li JZ, Felsenstein D, Kotton CN, Plenge RM, Pereyra F, Marty FM, Lin NH, Grazioso P, Crochiere DM, Eggers D, Kuritzkes DR, Tsibris AM. Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions. J Infect Dis. 2010 Nov 15; 202(10):1478-81. PMID: 20936980; PMCID: PMC2957553; DOI: 10.1086/657168;

Lin NH, Negusse DM, Beroukhim R, Giguel F, Lockman S, Essex M, Kuritzkes DR. The design and validation of a novel phenotypic assay to determine HIV-1 coreceptor usage of clinical isolates. J Virol Methods. 2010 Oct; 169(1):39-46. PMID: 20599562; PMCID: PMC2930119; DOI: 10.1016/j.jviromet.2010.06.012;

Tsuang MT, Lyons MJ, Meyer JM, Doyle T, Eisen SA, Goldberg J, True W, Lin N, Toomey R, Eaves L. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry. 1998 Nov; 55(11):967-72. PMID: 9819064

Lustig B, Lin NH, Smith SM, Jernigan RL, Jeang KT. A small modified hammerhead ribozyme and its conformational characteristics determined by mutagenesis and lattice calculation. Nucleic Acids Res. 1995 Sep 11; 23(17):3531-8. PMID: 7567466; PMCID: PMC307234

Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H. In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. J Virol. 1993 Oct; 67(10):6224-33. PMID: 7690421; PMCID: PMC238044

Dropulic B, Lin NH, Jeang KT. A method to increase the cumulative cleavage efficiency of ribozymes: thermal cycling. Nucleic Acids Res. 1993 May 11; 21(9):2273-4. PMID: 8502581; PMCID: PMC309510

Dropulic B, Lin NH, Martin MA, Jeang KT. Functional characterization of a U5 ribozyme: intracellular suppression of human immunodeficiency virus type 1 expression. J Virol. 1992 Mar; 66(3):1432-41. PMID: 1738200; PMCID: PMC240867

Henrich TJ, Mclaren P, Rao S, Lin NH, Hanhauser E, Giguel F, Gulick RM, Ribaudo H, DeBakker P, Kuritzkes DR. Genome-Wide Association Study of HIV-1 Coreceptor Usage in Treatment Naive Patients from an ACTG Study.
Scully E, Lockhart A, Huang L, Robles Y, Becerril C, Romero-Tejeda M, Albrecht MA, Palmer CD, Bosch RJ, Altfeld M, Kurtizkes DR, Lin NH. Elevated levels of microbial translocation markers and CCL2 among older HIV-1 infected men.
Dong KL, Moodley A, Kwon DS, Ghebremichael MS, Dong M, Ismail N, Ndhlovu ZM, Mabuka JM, Muema DM, Pretorius K, Lin N, Madurai S, Walker BD, Ndung’u, T. Detection and Treatment of Fiebig Stage I HIV-1 Infection in Young at-risk Women in South Africa: a Prospective Cohort Study. Lancet HIV.
Subramanamian K, Plank RM, Lin NH, Goldman-Yassen A, Becerril C, Kemal K, Heo M, Kelley MJ, Mutimura E, Anastos K, Daily JP. Plasmodium falciparum Infection Does Not Affect Human Immunodeficiency Virus Viral Load in Coinfected Rwandan Adults.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 16 distinct years, with a maximum of 5 publications in 2021