Nabil Rabhi | Profiles RNS

Nabil Rabhi, PhD

Research Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Lille 2 University of Health and Law
MSc, Paris-Sud (University of Paris XI)
MSc, Lille 2 University of Health and Law
MSc, Lille 1 University of Science and Technology

Websites

	LinkedIn
	ResearchGate
	Google Scholar
	Loop Frontiers

ORCID : 0000-0002-7365-5951

BU Research

Analyses of expression and function of TRPV1 and Thermogenic proteins in human adipose tissues
01/01/2025 - 04/30/2026 (Subcontract PI)
Howard University NIH NIMHD
3U24MD015970-05S1

Elucidating ACLP-dependent signaling pathways in the adipose tissue stromal-vascular niche
04/15/2022 - 03/31/2026 (Key Person)
PI: Matthew D. Layne, PhD
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK132080-04

dkNET Coordinating Unit: An information network for FAIR resources and data
07/01/2023 - 06/30/2024 (Subcontract PI)
University of California, San Diego NIH NIDDK
5U24DK097771-10

dkNET Coordinating Unit: An information network for FAIR resources and data
07/01/2022 - 06/30/2023 (Subcontract PI)
University of California, San Diego NIH NIDDK
5U24DK097771-10

Boston Nutrition Obesity Research Center
02/01/2022 - 05/31/2022 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-29

Perivascular adipose tissue in cardiovascular disease
07/01/2017 - 06/30/2019 (PI)
American Heart Association

Study of the molecular mechanisms of white adipose tissue browning after treatment with the cyclin dependent kinases (CDK's) inhibitor the Seliciclib
06/01/2016 - 05/31/2017 (PI)
Societe Francophone du Diabete

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Tavares AH, Connelly SP, Maksat D, Zheng J, Rabhi N, Layne MD. TGF-ß1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype. J Biol Chem. 2025 Sep; 301(9):110563.View Related Profiles.

Layne, Matthew
Rabhi, Nabil

PMID: 40774386; PMCID: PMC12423405; DOI: 10.1016/j.jbc.2025.110563;

Sivakumar S, Lama D, Rabhi N. Childhood obesity from the genes to the epigenome. Front Endocrinol (Lausanne). 2024; 15:1393250. PMID: 39045266; PMCID: PMC11263020; DOI: 10.3389/fendo.2024.1393250;

Lin W, Mousavi F, Blum BC, Heckendorf CF, Moore J, Lampl N, McComb M, Kotelnikov S, Yin W, Rabhi N, Layne MD, Kozakov D, Chitalia VC, Emili A. Corrigendum: Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease. Front Pharmacol. 2024; 15:1376058.View Related Profiles.

Blum, Benjamin
Layne, Matthew
Rabhi, Nabil
Chitalia, Vipul

PMID: 38405670; PMCID: PMC10884821; DOI: 10.3389/fphar.2024.1376058;

Lin W, Mousavi F, Blum BC, Heckendorf CF, Moore J, Lampl N, McComb M, Kotelnikov S, Yin W, Rabhi N, Layne MD, Kozakov D, Chitalia VC, Emili A. Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease. Front Pharmacol. 2023; 14:1243505.View Related Profiles.

Blum, Benjamin
Layne, Matthew
Rabhi, Nabil
Chitalia, Vipul
Lin, Weiwei

PMID: 38089059; PMCID: PMC10715419; DOI: 10.3389/fphar.2023.1243505;

Desevin K, Cortez BN, Lin JZ, Lama D, Layne MD, Farmer SR, Rabhi N. Adrenergic Reprogramming of Preexisting Adipogenic Trajectories Steer Naïve Mural Cells Toward Beige Differentiation. bioRxiv. 2023 Aug 26.View Related Profiles.

Layne, Matthew
Rabhi, Nabil
Farmer, Stephen

PMID: 37662295; PMCID: PMC10473761; DOI: 10.1101/2023.08.26.554950;

Oger F, Bourouh C, Friano ME, Courty E, Rolland L, Gromada X, Moreno M, Carney C, Rabhi N, Durand E, Amanzougarene S, Berberian L, Derhourhi M, Blanc E, Hannou SA, Denechaud PD, Benfodda Z, Meffre P, Fajas L, Kerr-Conte J, Pattou F, Froguel P, Pourcet B, Bonnefond A, Collombat P, Annicotte JS. ß-Cell-Specific E2f1 Deficiency Impairs Glucose Homeostasis, ß-Cell Identity, and Insulin Secretion. Diabetes. 2023 Aug 01; 72(8):1112-1126. PMID: 37216637

Denechaud PD, Rabhi N. Editorial: Intra and inter organ cross-talk and cellular communication. Front Endocrinol (Lausanne). 2023; 14:1209436. PMID: 37251682; PMCID: PMC10215530; DOI: 10.3389/fendo.2023.1209436;

Bourouh C, Courty E, Rolland L, Pasquetti G, Gromada X, Rabhi N, Carney C, Moreno M, Boutry R, Caron E, Benfodda Z, Meffre P, Kerr-Conte J, Pattou F, Froguel P, Bonnefond A, Oger F, Annicotte JS. The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic ß cells. Cell Rep. 2022 Aug 09; 40(6):111170. PMID: 35947949

Rabhi N, Desevin K, Belkina AC, Tilston-Lunel A, Varelas X, Layne MD, Farmer SR. Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Sci Alliance. 2022 05; 5(5).View Related Profiles.

Tilston-Lunel, Andrew
Belkina, Anna
Layne, Matthew
Rabhi, Nabil
Farmer, Stephen
Varelas, Xaralabos

PMID: 35181634; PMCID: PMC8860101; DOI: 10.26508/lsa.202101286;

Bornaque F, Delannoy CP, Courty E, Rabhi N, Carney C, Rolland L, Moreno M, Gromada X, Bourouh C, Petit P, Durand E, Pattou F, Kerr-Conte J, Froguel P, Bonnefond A, Oger F, Annicotte JS. Glucose Regulates m6A Methylation of RNA in Pancreatic Islets. Cells. 2022 01 15; 11(2). PMID: 35053407; PMCID: PMC8773766; DOI: 10.3390/cells11020291;

Showing 10 of 30 results. Show More

Jafari N, Kolla M, Meshulam T, Shafran JS, Qiu Y, Casey AN, Pompa IR, Ennis CS, Mazzeo CS, Rabhi N, Farmer SR, Denis GV. Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes. Sci Signal. 2021 11 23; 14(710):eabj2807.View Related Profiles.

Denis, Gerald
Rabhi, Nabil
Jafari, Naser
Farmer, Stephen
Meshulam, Tova

PMID: 34813359; PMCID: PMC8765301; DOI: 10.1126/scisignal.abj2807;

Biagi CAO, Cury SS, Alves CP, Rabhi N, Silva WA, Farmer SR, Carvalho RF, Batista ML. Multidimensional Single-Nuclei RNA-Seq Reconstruction of Adipose Tissue Reveals Adipocyte Plasticity Underlying Thermogenic Response. Cells. 2021 11 08; 10(11).View Related Profiles.

Rabhi, Nabil
Farmer, Stephen

PMID: 34831295; PMCID: PMC8618495; DOI: 10.3390/cells10113073;

Rabhi N, Farmer SR. Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies. Genes Dev. 2021 11 01; 35(21-22):1395-1397.View Related Profiles.

Rabhi, Nabil
Farmer, Stephen

PMID: 34725126; PMCID: PMC8559673; DOI: 10.1101/gad.349053.121;

Rabhi N, Desevin K, Cortez BN, Hekman R, Lin JZ, Emili A, Farmer SR. The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice. Sci Rep. 2021 10 13; 11(1):20365.View Related Profiles.

Emili, Andrew
Rabhi, Nabil
Farmer, Stephen

PMID: 34645915; PMCID: PMC8514475; DOI: 10.1038/s41598-021-99871-z;

Wang D, Rabhi N, Yet SF, Farmer SR, Layne MD. Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A. Sci Rep. 2021 02 17; 11(1):3948.View Related Profiles.

Layne, Matthew
Rabhi, Nabil
Farmer, Stephen

PMID: 33597582; PMCID: PMC7889889; DOI: 10.1038/s41598-021-82941-7;

Batista ML, Meshulam T, Desevin K, Rabhi N, Farmer SR. Three-Dimensional Adipocyte Culture as a Model to Study Cachexia-Induced White Adipose Tissue Remodeling. J Vis Exp. 2021 01 18; (167).View Related Profiles.

Rabhi, Nabil
Farmer, Stephen
Meshulam, Tova

PMID: 33522508

Rabhi N, Belkina AC, Desevin K, Cortez BN, Farmer SR. Shifts of Immune Cell Populations Differ in Response to Different Effectors of Beige Remodeling of Adipose Tissue. iScience. 2020 Dec 18; 23(12):101765.View Related Profiles.

Belkina, Anna
Rabhi, Nabil
Farmer, Stephen

PMID: 33294778; PMCID: PMC7683338; DOI: 10.1016/j.isci.2020.101765;

Kim S, Rabhi N, Blum BC, Hekman R, Wynne K, Emili A, Farmer S, Schlezinger JJ. Triphenyl phosphate is a selective PPAR? modulator that does not induce brite adipogenesis in vitro and in vivo. Arch Toxicol. 2020 09; 94(9):3087-3103.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Schlezinger, Jennifer
Rabhi, Nabil
Farmer, Stephen

PMID: 32683515; PMCID: PMC7443879; DOI: 10.1007/s00204-020-02815-1;

Dubois V, Gheeraert C, Vankrunkelsven W, Dubois-Chevalier J, Dehondt H, Bobowski-Gerard M, Vinod M, Zummo FP, Güiza F, Ploton M, Dorchies E, Pineau L, Boulinguiez A, Vallez E, Woitrain E, Baugé E, Lalloyer F, Duhem C, Rabhi N, van Kesteren RE, Chiang CM, Lancel S, Duez H, Annicotte JS, Paumelle R, Vanhorebeek I, Van den Berghe G, Staels B, Lefebvre P, Eeckhoute J. Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver. Mol Syst Biol. 2020 05; 16(5):e9156. PMID: 32407006; PMCID: PMC7224309; DOI: 10.15252/msb.20199156;

Jones JEC, Rabhi N, Orofino J, Gamini R, Perissi V, Vernochet C, Farmer SR. The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet. Sci Rep. 2020 02 11; 10(1):2380.View Related Profiles.

Jones, Jessica
Rabhi, Nabil
Farmer, Stephen
Perissi, Valentina

PMID: 32047213; PMCID: PMC7012923; DOI: 10.1038/s41598-020-59284-w;

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P, Marot G, Boulter A, Tavernier S, Berod L, Longhi MP, Paget C, Janssens S, Staumont-Sallé D, Aksoy E, Staels B, Dombrowicz D. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell. 2019 Jun 27; 178(1):263. PMID: 31251916; DOI: 10.1016/j.cell.2019.06.017;

Rabhi N, Farmer SR. Adipose Progenitor Cells Contribute to Lipid Spillover during Obesity. Trends Endocrinol Metab. 2019 07; 30(7):416-418.View Related Profiles.

Rabhi, Nabil
Farmer, Stephen

PMID: 31153731

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P, Marot G, Boulter A, Tavernier S, Berod L, Longhi MP, Paget C, Janssens S, Staumont-Sallé D, Aksoy E, Staels B, Dombrowicz D. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell. 2019 05 16; 177(5):1201-1216.e19. PMID: 31031005; DOI: 10.1016/j.cell.2019.03.018;

Lin JZ, Rabhi N, Farmer SR. Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis. Cell Rep. 2018 05 15; 23(7):1977-1987.View Related Profiles.

Rabhi, Nabil
Farmer, Stephen

PMID: 29768198; PMCID: PMC6675460; DOI: 10.1016/j.celrep.2018.04.057;

Rabhi N, Hannou SA, Gromada X, Salas E, Yao X, Oger F, Carney C, Lopez-Mejia IC, Durand E, Rabearivelo I, Bonnefond A, Caron E, Fajas L, Dani C, Froguel P, Annicotte JS. Cdkn2a deficiency promotes adipose tissue browning. Mol Metab. 2018 02; 8:65-76. PMID: 29237539; PMCID: PMC5985036; DOI: 10.1016/j.molmet.2017.11.012;

Rabhi N, Hannou SA, Froguel P, Annicotte JS. Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease. Front Endocrinol (Lausanne). 2017; 8:304. PMID: 29163371; PMCID: PMC5675844; DOI: 10.3389/fendo.2017.00304;

Cerezo M, Lehraiki A, Millet A, Rouaud F, Plaisant M, Jaune E, Botton T, Ronco C, Abbe P, Amdouni H, Passeron T, Hofman V, Mograbi B, Dabert-Gay AS, Debayle D, Alcor D, Rabhi N, Annicotte JS, Héliot L, Gonzalez-Pisfil M, Robert C, Moréra S, Vigouroux A, Gual P, Ali MMU, Bertolotto C, Hofman P, Ballotti R, Benhida R, Rocchi S. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell. 2016 06 13; 29(6):805-819. PMID: 27238082; DOI: 10.1016/j.ccell.2016.04.013;

Rabhi N, Denechaud PD, Gromada X, Hannou SA, Zhang H, Rashid T, Salas E, Durand E, Sand O, Bonnefond A, Yengo L, Chavey C, Bonner C, Kerr-Conte J, Abderrahmani A, Auwerx J, Fajas L, Froguel P, Annicotte JS. KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Rep. 2016 05 03; 15(5):1051-1061. PMID: 27117420; DOI: 10.1016/j.celrep.2016.03.079;

Rabhi N, Salas E, Froguel P, Annicotte JS. Role of the unfolded protein response in ß cell compensation and failure during diabetes. J Diabetes Res. 2014; 2014:795171. PMID: 24812634; PMCID: PMC4000654; DOI: 10.1155/2014/795171;

Salas E, Rabhi N, Froguel P, Annicotte JS. Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions. J Diabetes Res. 2014; 2014:873679. PMID: 24672805; PMCID: PMC3941170; DOI: 10.1155/2014/873679;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 11 distinct years, with a maximum of 6 publications in 2021

Bar chart showing 30 publications over 11 distinct years, with a maximum of 6 publications in 2021

Year	Publications
2014	2
2016	2
2017	2
2018	1
2019	3
2020	4
2021	6
2022	3
2023	4
2024	2
2025	1

2019 TOS/Nutrition Obesity Research Center (NORC) Joint Symposium at the obesity week meeting: Early career investigators speaker

2016 Lille 2 University, Lille, France: High honors and distinction degree, the Doctoral School “Biology and Health”

2016 Société Francophone du Diabète (SFD, Francophone Society of Diabetes): Young Francophone Researcher award

2015 Travel grant from SFD to participate at the annual meeting of the French society of diabetes (SFD)

2015 Travel grant from SFD to participate at the 75th meeting of the American diabetes association (ADA)

2014 Travel grant from SFD to participate the annual meeting of the French society of diabetes (SFD)

2014 Travel grant from SFD to participate at the 74th meeting of the American diabetes association (ADA)

2012 Financed Lille metropole research grant (3 years) for PHD program

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