Morgan Gilman | Profiles RNS

Morgan Gilman, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Geisel School of Medicine
MS, University of Maine
BS, University of Maine

Websites

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ORCID : 0000-0001-6746-6284

Dr. Morgan Gilman is scrutinizing a set of molecular mechanisms that nearly all bacteria use to build their cell walls – in order to help break them down. Several antibiotics, like penicillin, work by blocking the synthesis of peptidoglycan – a key component of bacterial cell walls – at specific stages of its assembly. However, many bacteria have developed resistance to these antibiotics. Dr. Gilman hopes to lay the groundwork for the development of new antibiotics that target regulators of cell wall synthesis using a combination of biochemical and structural approaches.

BU Research

Molecular Mechanisms of Bacterial Cell Wall Synthesis by a SEDS Protein Complex
08/01/2025 - 07/31/2027 (PI)
Howard Hughes Medical Institute

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Gilman MSA, Shlosman I, Guerra DDS, Domecillo M, Fivenson EM, Bourett C, Bernhardt TG, Polizzi NF, Loparo JJ, Kruse AC. Conformational regulation of two essential activators of bacterial cell elongation. Proc Natl Acad Sci U S A. 2025 Nov 11; 122(45):e2514198122. PMID: 41183199; DOI: 10.1073/pnas.2514198122;

Gilman MSA, Skiba MA. Hidden gems bring proteins into view. Nat Chem Biol. 2025 Aug 15. PMID: 40817134; DOI: 10.1038/s41589-025-01959-4;

Gilman MSA, Shlosman I, Guerra DDS, Domecillo M, Fivenson EM, Bourett C, Bernhardt TG, Polizzi NF, Loparo JJ, Kruse AC. MreC-MreD structure reveals a multifaceted interface that controls MreC conformation. bioRxiv. 2024 Oct 08. PMID: 39416049; PMCID: PMC11482812; DOI: 10.1101/2024.10.08.617240;

Pahil KS, Gilman MSA, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, Dey F, Muri D, Baettig R, Lobritz M, Bradley K, Kruse AC, Kahne D. Author Correction: A new antibiotic traps lipopolysaccharide in its intermembrane transporter. Nature. 2024 Jul; 631(8022):E18. PMID: 38992181; PMCID: PMC11269167; DOI: 10.1038/s41586-024-07645-0;

Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC. Antibodies expand the scope of angiotensin receptor pharmacology. Nat Chem Biol. 2024 Dec; 20(12):1577-1585. PMID: 38744986; PMCID: PMC11561159; DOI: 10.1038/s41589-024-01620-6;

Pahil KS, Gilman MSA, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, Dey F, Muri D, Baettig R, Lobritz M, Bradley K, Kruse AC, Kahne D. A new antibiotic traps lipopolysaccharide in its intermembrane transporter. Nature. 2024 Jan; 625(7995):572-577. PMID: 38172635; PMCID: PMC10794137; DOI: 10.1038/s41586-023-06799-7;

Pahil KS, Gilman MSA, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, Dey F, Muri D, Baettig R, Lobritz M, Bradley K, Kruse AC, Kahne D. Author Correction: A new antibiotic traps lipopolysaccharide in its intermembrane transporter. Nature. 2024 Jan; 625(7996):E27. PMID: 38200318; PMCID: PMC10808052; DOI: 10.1038/s41586-024-07035-6;

Skiba MA, Sterling SM, Rawson S, Gilman MSA, Xu H, Nemeth GR, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Wingler LM, Kruse AC. Antibodies Expand the Scope of Angiotensin Receptor Pharmacology. bioRxiv. 2023 Aug 24. PMID: 37662341; PMCID: PMC10473732; DOI: 10.1101/2023.08.23.554128;

Shlosman I, Fivenson EM, Gilman MSA, Sisley TA, Walker S, Bernhardt TG, Kruse AC, Loparo JJ. Allosteric activation of cell wall synthesis during bacterial growth. Nat Commun. 2023 Jun 10; 14(1):3439. PMID: 37301887; PMCID: PMC10257715; DOI: 10.1038/s41467-023-39037-9;

Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021 Oct; 17(10):1057-1064. PMID: 34168368; PMCID: PMC8463502; DOI: 10.1038/s41589-021-00832-4;

Showing 10 of 32 results. Show More

Mukhamedova M, Wrapp D, Shen CH, Gilman MSA, Ruckwardt TJ, Schramm CA, Ault L, Chang L, Derrien-Colemyn A, Lucas SAM, Ransier A, Darko S, Phung E, Wang L, Zhang Y, Rush SA, Madan B, Stewart-Jones GBE, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Doria-Rose NA, Morabito KM, DeKosky BJ, Gaudinski MR, Chen GL, Crank MC, Misasi J, Sullivan NJ, Douek DC, Kwong PD, Graham BS, McLellan JS, Mascola JR. Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses. Immunity. 2021 Apr 13; 54(4):769-780.e6.View Related Profiles.

Misasi, John
Gilman, Morgan
Sullivan, Nancy

PMID: 33823129; PMCID: PMC8099422; DOI: 10.1016/j.immuni.2021.03.004;

Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Apr 08; 64(7):3658-3676. PMID: 33729773; DOI: 10.1021/acs.jmedchem.0c01882;

Taher NM, Hvorecny KL, Burke CM, Gilman MSA, Heussler GE, Adolf-Bryfogle J, Bahl CD, O'Toole GA, Madden DR. Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia. Curr Res Struct Biol. 2021; 3:72-84. PMID: 34235487; PMCID: PMC8244358; DOI: 10.1016/j.crstbi.2021.02.002;

Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. bioRxiv. 2020 Nov 11. PMID: 33200136; PMCID: PMC7668743; DOI: 10.1101/2020.11.11.378778;

Rutten L, Gilman MSA, Blokland S, Juraszek J, McLellan JS, Langedijk JPM. Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers. Cell Rep. 2020 Mar 31; 30(13):4540-4550.e3. PMID: 32234486; PMCID: PMC7118701; DOI: 10.1016/j.celrep.2020.03.025;

Sjodt M, Rohs PDA, Gilman MSA, Erlandson SC, Zheng S, Green AG, Brock KP, Taguchi A, Kahne D, Walker S, Marks DS, Rudner DZ, Bernhardt TG, Kruse AC. Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol. 2020 Jun; 5(6):813-820. PMID: 32152588; PMCID: PMC7540724; DOI: 10.1038/s41564-020-0687-z;

Gilman MSA, Liu C, Fung A, Behera I, Jordan P, Rigaux P, Ysebaert N, Tcherniuk S, Sourimant J, Eléouët JF, Sutto-Ortiz P, Decroly E, Roymans D, Jin Z, McLellan JS. Structure of the Respiratory Syncytial Virus Polymerase Complex. Cell. 2019 Sep 19; 179(1):193-204.e14. PMID: 31495574; PMCID: PMC7111336; DOI: 10.1016/j.cell.2019.08.014;

Gilman MSA, Furmanova-Hollenstein P, Pascual G, B van 't Wout A, Langedijk JPM, McLellan JS. Transient opening of trimeric prefusion RSV F proteins. Nat Commun. 2019 May 08; 10(1):2105. PMID: 31068578; PMCID: PMC6506550; DOI: 10.1038/s41467-019-09807-5;

Graham BS, Gilman MSA, McLellan JS. Structure-Based Vaccine Antigen Design. Annu Rev Med. 2019 Jan 27; 70:91-104. PMID: 30691364; PMCID: PMC6936610; DOI: 10.1146/annurev-med-121217-094234;

Jones HG, Wrapp D, Gilman MSA, Battles MB, Wang N, Sacerdote S, Chuang GY, Kwong PD, McLellan JS. Iterative screen optimization maximizes the efficiency of macromolecular crystallization. Acta Crystallogr F Struct Biol Commun. 2019 Feb 01; 75(Pt 2):123-131. PMID: 30713164; PMCID: PMC6360444; DOI: 10.1107/S2053230X18017338;

Cheng HD, Grimm SK, Gilman MS, Gwom LC, Sok D, Sundling C, Donofrio G, Karlsson Hedestam GB, Bonsignori M, Haynes BF, Lahey TP, Maro I, von Reyn CF, Gorny MK, Zolla-Pazner S, Walker BD, Alter G, Burton DR, Robb ML, Krebs SJ, Seaman MS, Bailey-Kellogg C, Ackerman ME. Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. JCI Insight. 2018 Mar 08; 3(5). PMID: 29515029; PMCID: PMC5922287; DOI: 10.1172/jci.insight.97018;

Jones HG, Ritschel T, Pascual G, Brakenhoff JPJ, Keogh E, Furmanova-Hollenstein P, Lanckacker E, Wadia JS, Gilman MSA, Williamson RA, Roymans D, van 't Wout AB, Langedijk JP, McLellan JS. Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies. PLoS Pathog. 2018 Mar; 14(3):e1006935. PMID: 29509814; PMCID: PMC5856423; DOI: 10.1371/journal.ppat.1006935;

Goodwin E, Gilman MSA, Wrapp D, Chen M, Ngwuta JO, Moin SM, Bai P, Sivasubramanian A, Connor RI, Wright PF, Graham BS, McLellan JS, Walker LM. Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity. 2018 Feb 20; 48(2):339-349.e5. PMID: 29396163; PMCID: PMC6005179; DOI: 10.1016/j.immuni.2018.01.005;

Rossey I, Gilman MSA, Kabeche SC, Sedeyn K, Wrapp D, Kanekiyo M, Chen M, Mas V, Spitaels J, Melero JA, Graham BS, Schepens B, McLellan JS, Saelens X. Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state. Nat Commun. 2017 Nov 29; 8:16165. PMID: 29184149; PMCID: PMC5717039; DOI: 10.1038/ncomms16165;

Rossey I, Gilman MS, Kabeche SC, Sedeyn K, Wrapp D, Kanekiyo M, Chen M, Mas V, Spitaels J, Melero JA, Graham BS, Schepens B, McLellan JS, Saelens X. Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state. Nat Commun. 2017 Feb 13; 8:14158. PMID: 28194013; PMCID: PMC5316805; DOI: 10.1038/ncomms14158;

Gilman MS, Castellanos CA, Chen M, Ngwuta JO, Goodwin E, Moin SM, Mas V, Melero JA, Wright PF, Graham BS, McLellan JS, Walker LM. Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors. Sci Immunol. 2016 Dec 16; 1(6). PMID: 28111638; PMCID: PMC5244814; DOI: 10.1126/sciimmunol.aaj1879;

Misasi J, Gilman MS, Kanekiyo M, Gui M, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS, Xiang Y, Sullivan NJ, McLellan JS. Structural and molecular basis for Ebola virus neutralization by protective human antibodies. Science. 2016 Mar 18; 351(6279):1343-6.View Related Profiles.

Misasi, John
Gilman, Morgan
Sullivan, Nancy

PMID: 26917592; PMCID: PMC5241105; DOI: 10.1126/science.aad6117;

Gilman MS, Moin SM, Mas V, Chen M, Patel NK, Kramer K, Zhu Q, Kabeche SC, Kumar A, Palomo C, Beaumont T, Baxa U, Ulbrandt ND, Melero JA, Graham BS, McLellan JS. Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein. PLoS Pathog. 2015 Jul; 11(7):e1005035. PMID: 26161532; PMCID: PMC4498696; DOI: 10.1371/journal.ppat.1005035;

Ribaudo R, Gilman M, Kingston RE, Chomczynski P, Sacchi N. Preparation of RNA from tissues and cells. Curr Protoc Neurosci. 2001 May; Appendix 1:Appendix 1I. PMID: 18428440

Muthuswamy SK, Gilman M, Brugge JS. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol. 1999 Oct; 19(10):6845-57. PMID: 10490623

Simon KJ, Grueneberg DA, Gilman M. Protein and DNA contact surfaces that mediate the selective action of the Phox1 homeodomain at the c-fos serum response element. Mol Cell Biol. 1997 Nov; 17(11):6653-62. PMID: 9343429

Harrison DA, Binari R, Nahreini TS, Gilman M, Perrimon N. Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 1995 Jun 15; 14(12):2857-65. PMID: 7796812

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 14 distinct years, with a maximum of 5 publications in 2024