Michelle Long | Profiles RNS

Michelle T. Long, MD

Assistant Professor

Boston Medical Center

Dept of Medicine

Gastroenterology

MD, Tufts University School of Medicine

I am an early career physician scientist primarily interested in patient-oriented research investigating fibrosis and inflammation in patients with non-alcoholic fatty liver disease (NAFLD). My clinical and research interests center on the relationship between NAFLD and cardiovascular disease. My research is primarily based at the Framingham Heart Study where I am the PI of a study evaluating the prevalence and risk factors for liver fat (steatosis) and fibrosis. I am investigating the clinical and genetic correlates of hepatic steatosis and fibrosis as measured by transient elastography. I have expertise in epidemiology, visceral fat, liver imaging including computed tomography, ultrasound, and transient elastography. I am also a clinical gastroenterologist and endoscopist.

I am additionally interested in novel therapeutics for NAFLD and Non-alcoholic steatohepatitis (NASH) and run the clinical trials for the BMC Fatty Liver Clinic.

My other research interests include alcoholic liver disease, hepatitis C, outcomes in end-stage liver disease/cirrhosis.

2016 Boston University School of Medicine: Women's Leadership Conference Selected Participant

2016 Boston University School of Medicine: Faculty Development and Diversity Grant Recipient

2015-2019 Boston University School of Medicine: NIH Loan Repayment Program Recipient

2014 Boston University School of Medicine: 3rd Place, Evans Research Day

2009 Tufts University School of Medicine: Massachusetts Medical Society Scholars Award

2009 Tufts University School of Medicine: Phi Delta Epsilon Fraternity Award

2009 Tufts University School of Medicine: Glasgow-Rubin Citation for Academic Achievement

2009 Tufts University School of Medicine: Alpha Omega Alpha

2008 Tufts University School of Medicine: Ada Draper, MD Scholarship

2008 Tufts University School of Medicine: Magna cum laude Scientific electronic exhibit award

2006-2007 Tufts University School of Medicine: Boston Albert Schweitzer Fellowship

2006-2008 Tufts University School of Medicine: USA Funds Scholarship

2004 Middlebury College: Magna cum laude

Prevalence and risk factors for hepatic steatosis and fibrosis as measured by transient elastography
03/15/2016 - 05/31/2019 (PI)
Echosens

Identifying clinical and genetic correlates of hepatic fibrosis from fatty liver disease in the…
01/12/2018 - 11/30/2022 (PI)
NIH-NIDDK
1K23DK113252-01A1

MB130-068
12/06/2018 - 12/06/2021 (PI)
Bristol-Myers

Determining the burden, heritability, and clinical implications of increased liver stiffness from…
01/02/2019 - 01/01/2021 (PI)
Gilead Sciences

A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating …
05/16/2017 - 05/16/2020 (PI)
Intercept Pharmaceuticals, Inc.

A Double-Blind, Placebo-Controlled Trial of Obeticholic Acid in Patients with moderately severe A…
10/06/2016 - 10/05/2018 (PI)
Indiana University NIH-NIAAA
4U01AA021840-05

Yr	Title	Project-Sub Proj	Pubs
2019	Identifying clinical and genetic correlates of hepatic fibrosis from fatty liver disease in the community	5K23DK113252-02	6
2018	Identifying clinical and genetic correlates of hepatic fibrosis from fatty liver disease in the community	1K23DK113252-01A1	6

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Wilechansky RM, Pedley A, Massaro JM, Hoffmann U, Benjamin EJ, Long MT. Relations of liver fat with prevalent and incident chronic kidney disease in the Framingham Heart Study: a secondary analysis. Liver Int. 2019 Apr 29.View Related Profiles.
Benjamin, Emelia
Massaro, Joseph
Long, Michelle
PMID: 31033142.
Pratt PK, Nunes D, Long MT, Farraye FA. Improved Antibody Response to Three Additional Hepatitis B Vaccine Doses Following Primary Vaccination Failure in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2019 Apr 03.View Related Profiles.
Nunes, David
Farraye, Francis
Long, Michelle
PMID: 30945037.
Brunner KT, Henneberg CJ, Wilechansky RM, Long MT. Nonalcoholic Fatty Liver Disease and Obesity Treatment. Curr Obes Rep. 2019 Apr 03. PMID: 30945129.
Long MT, Ko D, Arnold LM, Trinquart L, Sherer JA, Keppel SS, Benjamin EJ, Helm RH. Gastrointestinal and liver diseases and atrial fibrillation: a review of the literature. Therap Adv Gastroenterol. 2019; 12:1756284819832237.View Related Profiles.
Benjamin, Emelia
Trinquart, Ludovic
Long, Michelle
Helm, Robert
PMID: 30984290.
Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds LM, Ghanbari M, Muka T, van Meurs JBJ, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SLR, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Darwish Murad S, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease. Diabetes. 2019 May; 68(5):1073-1083. PMID: 30936141.
Mukthinuthalapati VVPK, Akinyeye S, Fricker ZP, Syed M, Orman ES, Nephew L, Vilar-Gomez E, Slaven J, Chalasani N, Balakrishnan M, Long MT, Attar BM, Ghabril M. Early predictors of outcomes of hospitalization for cirrhosis and assessment of the impact of race and ethnicity at safety-net hospitals. PLoS One. 2019; 14(3):e0211811.View Related Profiles.
Long, Michelle
Fricker, Zachary
PMID: 30840670.
Hennein R, Liu C, McKeown NM, Hoffmann U, Long MT, Levy D, Ma J. Increased Diet Quality is Associated with Long-Term Reduction of Abdominal and Pericardial Fat. Obesity (Silver Spring). 2019 Apr; 27(4):670-677. PMID: 30825267.
Ma J, Nano J, Ding J, Zheng Y, Hennein R, Liu C, Speliotes EK, Huan T, Song C, Mendelson MM, Joehanes R, Long MT, Liang L, Smith JA, Reynolds L, Ghanbari M, Muka T, van Meurs J, Alferink LJM, Franco OH, Dehghan A, Ratliff S, Zhao W, Bielak L, Kardia SL, Peyser PA, Ning H, VanWagner LB, Lloyd-Jones DM, Carr JJ, Greenland P, Lichtenstein AH, Hu FB, Liu Y, Hou L, Murad SD, Levy D. A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Non-Alcoholic Fatty Liver Disease. Diabetes. 2019 Feb 22. PMID: 30796027.
Simon TG, Deng X, Liu CT, Chung RT, Long MT. The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study. Liver Int. 2018 Dec 29.View Related Profiles.
Liu, Ching-Ti
Long, Michelle
PMID: 30597691.
Fricker ZP, Pedley A, Massaro JM, Vasan RS, Hoffmann U, Benjamin EJ, Long MT. Liver Fat Is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study. Clin Gastroenterol Hepatol. 2019 May; 17(6):1157-1164.e4.View Related Profiles.
Benjamin, Emelia
Massaro, Joseph
Long, Michelle
Fricker, Zachary
PMID: 30476583.

Showing 10 of 37 results. Show More

Long MT, Gurary EB, Massaro JM, Ma J, Hoffmann U, Chung RT, Benjamin EJ, Loomba R. Parental non-alcoholic fatty liver disease increases risk of non-alcoholic fatty liver disease in offspring. Liver Int. 2019 Apr; 39(4):740-747.View Related Profiles.
Benjamin, Emelia
Massaro, Joseph
Long, Michelle
PMID: 30179294.
Tran AN, Sachdev R, Fricker ZP, Leber M, Zahorian T, Shah B, Nunes DP, Long MT. Intensive Pharmacy Care Improves Outcomes of Hepatitis C Treatment in a Vulnerable Patient Population at a Safety-Net Hospital. Dig Dis Sci. 2018 12; 63(12):3241-3249.View Related Profiles.
Nunes, David
Long, Michelle
Fricker, Zachary
PMID: 30078116.
Ma J, Hennein R, Liu C, Long MT, Hoffmann U, Jacques PF, Lichtenstein AH, Hu FB, Levy D. Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease. Gastroenterology. 2018 07; 155(1):107-117.View Related Profiles.
Liu, Chunyu
Long, Michelle
PMID: 29604292.
Long MT, Pedley A, Massaro JM, Hoffmann U, Ma J, Loomba R, Chung RT, Benjamin EJ. A simple clinical model predicts incident hepatic steatosis in a community-based cohort: The Framingham Heart Study. Liver Int. 2018 08; 38(8):1495-1503.View Related Profiles.
Benjamin, Emelia
Massaro, Joseph
Long, Michelle
PMID: 29377504.
Lee JJ, Pedley A, Hoffmann U, Massaro JM, Levy D, Long MT. Visceral and Intrahepatic Fat Are Associated with Cardiometabolic Risk Factors Above Other Ectopic Fat Depots: The Framingham Heart Study. Am J Med. 2018 Jun; 131(6):684-692.e12.View Related Profiles.
Massaro, Joseph
Long, Michelle
PMID: 29518370.
Long MT, Benjamin EJ. Prevalent Cardiovascular Disease Events and T1 Mapping Defined Hepatic Fibrosis. Circ Cardiovasc Imaging. 2018 Mar; 11(3):e007553.View Related Profiles.
Benjamin, Emelia
Long, Michelle
PMID: 29523556.
Datta S, Sherva RM, De La Cruz M, Long MT, Roy P, Backman V, Chowdhury S, Roy HK. Single Nucleotide Polymorphism Facilitated Down-Regulation of the Cohesin Stromal Antigen-1: Implications for Colorectal Cancer Racial Disparities. Neoplasia. 2018 03; 20(3):289-294.View Related Profiles.
Roy, Hemant
Long, Michelle
Sherva, Richard
Chowdhury, Sanjib
Datta, Somenath
PMID: 29471289; DOI: 10.1016/j.neo.2018.01.003;.
Shah RV, Yeri AS, Murthy VL, Massaro JM, D'Agostino R, Freedman JE, Long MT, Fox CS, Das S, Benjamin EJ, Vasan RS, O'Donnell CJ, Hoffmann U. Association of Multiorgan Computed Tomographic Phenomap With Adverse Cardiovascular Health Outcomes: The Framingham Heart Study. JAMA Cardiol. 2017 Nov 01; 2(11):1236-1246.View Related Profiles.
Benjamin, Emelia
Long, Michelle
D'Agostino, Ralph
Ramachandran, Vasan
PMID: 28975197.
O'Sullivan JF, Morningstar JE, Yang Q, Zheng B, Gao Y, Jeanfavre S, Scott J, Fernandez C, Zheng H, O'Connor S, Cohen P, Vasan RS, Long MT, Wilson JG, Melander O, Wang TJ, Fox C, Peterson RT, Clish CB, Corey KE, Gerszten RE. Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes. J Clin Invest. 2017 12 01; 127(12):4394-4402.View Related Profiles.
Long, Michelle
Yang, Qiong
Ramachandran, Vasan
PMID: 29083323.
Lee JJ, Pedley A, Hoffmann U, Massaro JM, O'Donnell CJ, Benjamin EJ, Long MT. Longitudinal Associations of Pericardial and Intrathoracic Fat With Progression of Coronary Artery Calcium (from the Framingham Heart Study). Am J Cardiol. 2018 01 15; 121(2):162-167.View Related Profiles.
Benjamin, Emelia
Massaro, Joseph
Long, Michelle
PMID: 29146023.
Li W, Dorans KS, Wilker EH, Rice MB, Long MT, Schwartz J, Coull BA, Koutrakis P, Gold DR, Fox CS, Mittleman MA. Residential Proximity to Major Roadways, Fine Particulate Matter, and Hepatic Steatosis: The Framingham Heart Study. Am J Epidemiol. 2017 Oct 01; 186(7):857-865. PMID: 28605427.
Kimberly WT, O'Sullivan JF, Nath AK, Keyes M, Shi X, Larson MG, Yang Q, Long MT, Vasan R, Peterson RT, Wang TJ, Corey KE, Gerszten RE. Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis. JCI Insight. 2017 May 04; 2(9).View Related Profiles.
Larson, Martin
Long, Michelle
Yang, Qiong
PMID: 28469090; DOI: 10.1172/jci.insight.92989;.
Long MT, Yin X, Larson MG, Ellinor PT, Lubitz SA, McManus DD, Magnani JW, Staerk L, Ko D, Helm RH, Hoffmann U, Chung RT, Benjamin EJ. Relations of Liver Fat With Prevalent and Incident Atrial Fibrillation in the Framingham Heart Study. J Am Heart Assoc. 2017 May 02; 6(5).View Related Profiles.
Benjamin, Emelia
Larson, Martin
Long, Michelle
Helm, Robert
PMID: 28465298; DOI: 10.1161/JAHA.116.005227;.
Lee JJ, Pedley A, Therkelsen KE, Hoffmann U, Massaro JM, Levy D, Long MT. Upper Body Subcutaneous Fat Is Associated with Cardiometabolic Risk Factors. Am J Med. 2017 Aug; 130(8):958-966.e1.View Related Profiles.
Massaro, Joseph
Long, Michelle
PMID: 28238696; DOI: 10.1016/j.amjmed.2017.01.044;.
Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Aug 20; 27(6):313-327.View Related Profiles.
Shao, Di
Seta, Francesca
Roy, Hemant
Behring, Jessica
Fry, Jessica
Han, Jingyan
Bachschmid, Markus
Long, Michelle
Matsui, Reiko
Cohen, Richard
PMID: 27958883; DOI: 10.1089/ars.2016.6716;.
Ma J, Hwang SJ, Pedley A, Massaro JM, Hoffmann U, Chung RT, Benjamin EJ, Levy D, Fox CS, Long MT. Bi-directional analysis between fatty liver and cardiovascular disease risk factors. J Hepatol. 2017 Feb; 66(2):390-397.View Related Profiles.
Benjamin, Emelia
Massaro, Joseph
Long, Michelle
Hwang, Shih-Jen
PMID: 27729222; DOI: 10.1016/j.jhep.2016.09.022;.
Ko D, Riles EM, Marcos EG, Magnani JW, Lubitz SA, Lin H, Long MT, Schnabel RB, McManus DD, Ellinor PT, Ramachandran VS, Wang TJ, Gerszten RE, Benjamin EJ, Yin X, Rienstra M. Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study). Am J Cardiol. 2016 Nov 15; 118(10):1493-1496.View Related Profiles.
Benjamin, Emelia
Lin, Honghuang
Long, Michelle
Ramachandran, Vasan
PMID: 27666170; DOI: 10.1016/j.amjcard.2016.08.010;.
Cui J, Chen CH, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner DA, Sirlin CB, Loomba R, For The Genetics Of Nafld In Twins Consortium. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology. 2016 Nov; 64(5):1547-1558. PMID: 27315352; DOI: 10.1002/hep.28674;.
Long MT, Pedley A, Massaro JM, Hoffmann U, Fox CS. The Association between Non-Invasive Hepatic Fibrosis Markers and Cardiometabolic Risk Factors in the Framingham Heart Study. PLoS One. 2016; 11(6):e0157517.View Related Profiles.
Massaro, Joseph
Long, Michelle
PMID: 27341207; PMCID: PMC4920364; DOI: 10.1371/journal.pone.0157517;.
Long MT, Pedley A, Colantonio LD, Massaro JM, Hoffmann U, Muntner P, Fox CS. Development and Validation of the Framingham Steatosis Index to Identify Persons With Hepatic Steatosis. Clin Gastroenterol Hepatol. 2016 Aug; 14(8):1172-1180.e2.View Related Profiles.
Massaro, Joseph
Long, Michelle
PMID: 27046482; PMCID: PMC4955680; DOI: 10.1016/j.cgh.2016.03.034;.
Long MT, Fox CS. The Framingham Heart Study--67 years of discovery in metabolic disease. Nat Rev Endocrinol. 2016 Mar; 12(3):177-83. PMID: 26775764; DOI: 10.1038/nrendo.2015.226;.
Long MT, Pedley A, Massaro JM, Hoffmann U, Esliger DW, Vasan RS, Fox CS, Murabito JM. Hepatic steatosis is associated with lower levels of physical activity measured via accelerometry. Obesity (Silver Spring). 2015 Jun; 23(6):1259-66.View Related Profiles.
Murabito, Joanne
Massaro, Joseph
Long, Michelle
Ramachandran, Vasan
PMID: 25959049; PMCID: PMC4446168; DOI: 10.1002/oby.21058;.
Long MT, Leszczynski A, Thompson KD, Wasan SK, Calderwood AH. Female authorship in major academic gastroenterology journals: a look over 20 years. Gastrointest Endosc. 2015; 81(6):1440-1447.e3.View Related Profiles.
Calderwood, Audrey
Long, Michelle
Wasan, Sharmeel
PMID: 25887727; DOI: 10.1016/j.gie.2015.01.032;.
Long MT, Wang N, Larson MG, Mitchell GF, Palmisano J, Vasan RS, Hoffmann U, Speliotes EK, Vita JA, Benjamin EJ, Fox CS, Hamburg NM. Nonalcoholic fatty liver disease and vascular function: cross-sectional analysis in the Framingham heart study. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1284-91.View Related Profiles.
Benjamin, Emelia
Vita, Joseph
Larson, Martin
Long, Michelle
Hamburg, Naomi
Ramachandran, Vasan
PMID: 25745056; PMCID: PMC4520415; DOI: 10.1161/ATVBAHA.114.305200;.
Long M, Lichtenstein D. Review: in high-risk ulcers, intermittent and continuous PPI therapy do not differ for recurrent bleeding. Ann Intern Med. 2015 Jan 20; 162(2):JC8. PMID: 25599368; DOI: 10.7326/ACPJC-2015-162-2-008;.
Rosenquist KJ, Massaro JM, Pedley A, Long MT, Kreger BE, Vasan RS, Murabito JM, Hoffmann U, Fox CS. Fat quality and incident cardiovascular disease, all-cause mortality, and cancer mortality. J Clin Endocrinol Metab. 2015 Jan; 100(1):227-34.View Related Profiles.
Kreger, Bernard
Murabito, Joanne
Massaro, Joseph
Long, Michelle
Ramachandran, Vasan
PMID: 25226289; DOI: 10.1210/jc.2013-4296;.
Mendel JB, Long M, Slanetz PJ. CT-guided core needle biopsy of breast lesions visible only on MRI. AJR Am J Roentgenol. 2007 Jul; 189(1):152-4. PMID: 17579165.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 6 distinct years, with a maximum of 9 publications in 2018