Michael Smith | Profiles RNS

Michael Smith, PhD

Associate Professor

Boston University College of Engineering

Biomedical Engineering

PhD, University of Virginia
MS, University of Virginia
BS, University of Memphis

Websites

	LinkedIn
	ResearchGate
	College of Engineering Faculty
	Matrix Mechanotransduction Laboratory
	BU Nanotechnology Innovation Center (BUnano)

ORCID : 0000-0002-7453-4430

My lab investigates the role of the extracellular matrix in mechanobiology. First, we study the relationship between molecular mechanics and the bulk material properties of fibronectin fibers, with a focus on how these multiscale properties regulate cell behavior. We have provided the first estimates of molecular density in fibronectin matrix fibers, which is required to understand the intermolecular architecture of fibronectin matrix, and the first predictions of force on molecules within fibronectin matrix fibers, which determines molecular conformation. In our second project, we are investigating how cell signaling and microenvironmental properties regulate the maintenance of tension in single cells and multicellular clusters. This project is facilitated by the development of novel tools for regulating the local microenvironment of cells while simultaneously measuring cell stiffness, prestress, and contractility. Furthermore, we disseminate these tools for free, with the goal of making measurement of traction and cell stiffness broadly accessible to mechanobiologists.

BU Research

Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom
06/04/2018 - 03/31/2024 (Multi-PI)
PI: Michael Smith, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
5R25EB025788-05

Effects of stretch and intercellular force transmission on tensional homeostasis in multicellular clusters
06/15/2019 - 11/30/2023 (Multi-PI)
PI: Michael Smith, PhD
National Science Foundation
CMMI-1910401

Joint estimation of motion model, model parameters, and particle trajectories in single particle tracking
09/20/2017 - 08/31/2023 (Multi-PI)
PI: Michael Smith, PhD
NIH/National Institute of General Medical Sciences
5R01GM117039-05

Maintenance of Mechanical Tension for Normal Tissue Function Requires Intercellular Cooperation
08/01/2014 - 01/31/2019 (Co-Investigator)
PI: Dimitrije Stamenovic, PhD
National Science Foundation
CMMI-1362922

CAREER: Regulation of Multicellular Behavior with an Extracellular Matrix Signaling Scaffold
02/01/2012 - 07/31/2018 (PI)
National Science Foundation
CBET-1150467

BILLING AGREEMENT: OFF-CAMPUS FUNDING FOR KAYLE SHAPERO
09/01/2012 - 08/31/2013 (PI)
The Children's Hospital Corporation

BILLING AGREEMENT: OFF-CAMPUS FUNDING FOR KAYLE SHAPERO
09/01/2011 - 08/31/2012 (PI)
The Children's Hospital Corporation

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Xu H, Bunde KA, Figueiredo J, Seruca R, Smith ML, Stamenovic D. Differential Impacts on Tensional Homeostasis of Gastric Cancer Cells Due to Distinct Domain Variants of E-Cadherin. Cancers (Basel). 2022 May 29; 14(11).View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 35681670; PMCID: PMC9179447; DOI: 10.3390/cancers14112690;

Bunde KA, Stamenovic D, Smith ML. Pattern Generation for Micropattern Traction Microscopy. J Vis Exp. 2022 02 17; (180).View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 35253805

Stamenovic D, Smith ML. Reply to the 'Comment on "Tensional homeostasis at different length scales" by J. Humphrey and C. Cyron, Soft Matter, 2022, 18, DOI: 10.1039/D1SM01151K'. Soft Matter. 2022 Jan 19; 18(3):680-682.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 34985478; DOI: 10.1039/d1sm01495a;

Figueiredo J, Ferreira RM, Xu H, Gonçalves M, Barros-Carvalho A, Cravo J, Maia AF, Carneiro P, Figueiredo C, Smith ML, Stamenovic D, Morais-de-Sá E, Seruca R. Integrin ß1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells. Gastric Cancer. 2022 01; 25(1):124-137.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 34486077; PMCID: PMC8732838; DOI: 10.1007/s10120-021-01239-9;

Stamenovic D, Smith ML. Tensional homeostasis at different length scales. Soft Matter. 2020 Aug 14; 16(30):6946-6963.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 32696799; DOI: 10.1039/d0sm00763c;

Xu H, Donegan S, Dreher JM, Stark AJ, Canovic EP, Stamenovic D, Smith ML. Focal adhesion displacement magnitude is a unifying feature of tensional homeostasis. Acta Biomater. 2020 09 01; 113:372-379.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 32634483; DOI: 10.1016/j.actbio.2020.06.043;

Vishwanath N, Monis WJ, Hoffmann GA, Ramachandran B, DiGiacomo V, Wong JY, Smith ML, Layne MD. Mechanisms of aortic carboxypeptidase-like protein secretion and identification of an intracellularly retained variant associated with Ehlers-Danlos syndrome. J Biol Chem. 2020 07 10; 295(28):9725-9735.View Related Profiles.

Wong, Joyce
Layne, Matthew
Smith, Michael

PMID: 32482891; PMCID: PMC7363150; DOI: 10.1074/jbc.RA120.013902;

Stamenovic D, Krishnan R, Canovic EP, Smith ML. As the endothelial cell reorients, its tensile forces stabilize. J Biomech. 2020 05 22; 105:109770.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 32278526; DOI: 10.1016/j.jbiomech.2020.109770;

White JA, Gaver DP, Butera RJ, Choi B, Dunlop MJ, Grande-Allen KJ, Grosberg A, Hitchcock RW, Huang-Saad AY, Kotche M, Kyle AM, Lerner AL, Linehan JH, Linsenmeier RA, Miller MI, Papin JA, Setton L, Sgro A, Smith ML, Zaman M, Lee AP. Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations. Ann Biomed Eng. 2020 Mar; 48(3):905-912.View Related Profiles.

White, John
Dunlop, Mary
Smith, Michael
Zaman, Muhammad

PMID: 32026231

Li J, Barbone PE, Smith ML, Stamenovic D. Effect of correlation between traction forces on tensional homeostasis in clusters of endothelial cells and fibroblasts. J Biomech. 2020 02 13; 100:109588.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 31902611; DOI: 10.1016/j.jbiomech.2019.109588;

Showing 10 of 50 results. Show More

Hoffmann GA, Wong JY, Smith ML. On Force and Form: Mechano-Biochemical Regulation of Extracellular Matrix. Biochemistry. 2019 11 26; 58(47):4710-4720.View Related Profiles.

Wong, Joyce
Smith, Michael

PMID: 31144496

Bradshaw MJ, Hoffmann GA, Wong JY, Smith ML. Fibronectin fiber creep under constant force loading. Acta Biomater. 2019 04 01; 88:78-85.View Related Profiles.

Wong, Joyce
Smith, Michael

PMID: 30780000; PMCID: PMC6777959; DOI: 10.1016/j.actbio.2019.02.022;

Zollinger AJ, Xu H, Figueiredo J, Paredes J, Seruca R, Stamenovic D, Smith ML. Dependence of Tensional Homeostasis on Cell Type and on Cell-Cell Interactions. Cell Mol Bioeng. 2018 Jun; 11(3):175-184.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 31719884; PMCID: PMC6816663; DOI: 10.1007/s12195-018-0527-x;

Jacobsen MM, Li D, Gyune Rim N, Backman D, Smith ML, Wong JY. Silk-fibronectin protein alloy fibres support cell adhesion and viability as a high strength, matrix fibre analogue. Sci Rep. 2017 04 05; 7:45653.View Related Profiles.

Wong, Joyce
Smith, Michael

PMID: 28378749; PMCID: PMC5381220; DOI: 10.1038/srep45653;

Myers DR, Qiu Y, Fay ME, Tennenbaum M, Chester D, Cuadrado J, Sakurai Y, Baek J, Tran R, Ciciliano JC, Ahn B, Mannino RG, Bunting ST, Bennett C, Briones M, Fernandez-Nieves A, Smith ML, Brown AC, Sulchek T, Lam WA. Single-platelet nanomechanics measured by high-throughput cytometry. Nat Mater. 2017 02; 16(2):230-235. PMID: 27723740; PMCID: PMC5266633; DOI: 10.1038/nmat4772;

Zollinger AJ, Smith ML. Fibronectin, the extracellular glue. Matrix Biol. 2017 07; 60-61:27-37. PMID: 27496349; DOI: 10.1016/j.matbio.2016.07.011;

Canovic EP, Zollinger AJ, Tam SN, Smith ML, Stamenovic D. Tensional homeostasis in endothelial cells is a multicellular phenomenon. Am J Physiol Cell Physiol. 2016 09 01; 311(3):C528-35.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 27488661; DOI: 10.1152/ajpcell.00037.2016;

Tam SN, Smith ML, Stamenovic D. Modeling tensional homeostasis in multicellular clusters. Int J Numer Method Biomed Eng. 2017 03; 33(3).View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 27163337; DOI: 10.1002/cnm.2801;

Hubbard B, Buczek-Thomas JA, Nugent MA, Smith ML. Fibronectin Fiber Extension Decreases Cell Spreading and Migration. J Cell Physiol. 2016 Aug; 231(8):1728-36.View Related Profiles.

Nugent, Matthew
Smith, Michael

PMID: 26621030; DOI: 10.1002/jcp.25271;

Kubow KE, Vukmirovic R, Zhe L, Klotzsch E, Smith ML, Gourdon D, Luna S, Vogel V. Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix. Nat Commun. 2015 Aug 14; 6:8026. PMID: 26272817; PMCID: PMC4539566; DOI: 10.1038/ncomms9026;

Canovic EP, Seidl DT, Barbone PE, Smith ML, Stamenovic D. Stiffness versus prestress relationship at subcellular length scale. J Biomech. 2014 Sep 22; 47(12):3222-5.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 25138630; PMCID: PMC4164390; DOI: 10.1016/j.jbiomech.2014.08.004;

Canovic EP, Seidl DT, Polio SR, Oberai AA, Barbone PE, Stamenovic D, Smith ML. Biomechanical imaging of cell stiffness and prestress with subcellular resolution. Biomech Model Mechanobiol. 2014 Jun; 13(3):665-78.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 24022327

Polio SR, Parameswaran H, Canovic EP, Gaut CM, Aksyonova D, Stamenovic D, Smith ML. Topographical control of multiple cell adhesion molecules for traction force microscopy. Integr Biol (Camb). 2014 Mar; 6(3):357-65.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 24441735; DOI: 10.1039/c3ib40127h;

Polio SR, Smith ML. Patterned hydrogels for simplified measurement of cell traction forces. Methods Cell Biol. 2014; 121:17-31. PMID: 24560500; DOI: 10.1016/B978-0-12-800281-0.00002-6;

Hubbard B, Buczek-Thomas JA, Nugent MA, Smith ML. Heparin-dependent regulation of fibronectin matrix conformation. Matrix Biol. 2014 Feb; 34:124-31.View Related Profiles.

Nugent, Matthew
Smith, Michael

PMID: 24148804; PMCID: PMC3992196; DOI: 10.1016/j.matbio.2013.10.006;

Bradshaw MJ, Cheung MC, Ehrlich DJ, Smith ML. Using molecular mechanics to predict bulk material properties of fibronectin fibers. PLoS Comput Biol. 2012; 8(12):e1002845. PMID: 23300425

Krishnan R, Canovic EP, Iordan AL, Rajendran K, Manomohan G, Pirentis AP, Smith ML, Butler JP, Fredberg JJ, Stamenovic D. Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretches. Am J Physiol Cell Physiol. 2012 Aug 15; 303(4):C368-75.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 22700796

Bradshaw MJ, Smith ML. Contribution of unfolding and intermolecular architecture to fibronectin fiber extensibility. Biophys J. 2011 Oct 05; 101(7):1740-8. PMID: 21961600

Polio SR, Rothenberg KE, Stamenovic D, Smith ML. A micropatterning and image processing approach to simplify measurement of cellular traction forces. Acta Biomater. 2012 Jan; 8(1):82-8.View Related Profiles.

Stamenovic, Dimitrije
Smith, Michael

PMID: 21884832; PMCID: PMC3375107; DOI: 10.1016/j.actbio.2011.08.013;

Andreasson-Ochsner M, Romano G, Håkanson M, Smith ML, Leckband DE, Textor M, Reimhult E. Single cell 3-D platform to study ligand mobility in cell-cell contact. Lab Chip. 2011 Sep 07; 11(17):2876-83. PMID: 21773619

Ochsner M, Textor M, Vogel V, Smith ML. Dimensionality controls cytoskeleton assembly and metabolism of fibroblast cells in response to rigidity and shape. PLoS One. 2010 Mar 23; 5(3):e9445. PMID: 20351781

Chabria M, Hertig S, Smith ML, Vogel V. Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope. Nat Commun. 2010; 1:135. PMID: 21139580

Little WC, Schwartlander R, Smith ML, Gourdon D, Vogel V. Stretched extracellular matrix proteins turn fouling and are functionally rescued by the chaperones albumin and casein. Nano Lett. 2009 Dec; 9(12):4158-67. PMID: 19743815

Kubow KE, Klotzsch E, Smith ML, Gourdon D, Little WC, Vogel V. Crosslinking of cell-derived 3D scaffolds up-regulates the stretching and unfolding of new extracellular matrix assembled by reseeded cells. Integr Biol (Camb). 2009 Dec; 1(11-12):635-48. PMID: 20027372

Klotzsch E, Smith ML, Kubow KE, Muntwyler S, Little WC, Beyeler F, Gourdon D, Nelson BJ, Vogel V. Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18267-72. PMID: 19826086

Meinel AJ, Kubow KE, Klotzsch E, Garcia-Fuentes M, Smith ML, Vogel V, Merkle HP, Meinel L. Optimization strategies for electrospun silk fibroin tissue engineering scaffolds. Biomaterials. 2009 Jun; 30(17):3058-67. PMID: 19233463

Little WC, Smith ML, Ebneter U, Vogel V. Assay to mechanically tune and optically probe fibrillar fibronectin conformations from fully relaxed to breakage. Matrix Biol. 2008 Jun; 27(5):451-61. PMID: 18417335

Smith ML, Gourdon D, Little WC, Kubow KE, Eguiluz RA, Luna-Morris S, Vogel V. Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biol. 2007 Oct 02; 5(10):e268. PMID: 17914904

Ochsner M, Dusseiller MR, Grandin HM, Luna-Morris S, Textor M, Vogel V, Smith ML. Micro-well arrays for 3D shape control and high resolution analysis of single cells. Lab Chip. 2007 Aug; 7(8):1074-7. PMID: 17653351

Sperandio M, Frommhold D, Babushkina I, Ellies LG, Olson TS, Smith ML, Fritzsching B, Pauly E, Smith DF, Nobiling R, Linderkamp O, Marth JD, Ley K. Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation. Eur J Immunol. 2006 Dec; 36(12):3207-15. PMID: 17111351

Dusseiller MR, Smith ML, Vogel V, Textor M. Microfabricated three-dimensional environments for single cell studies. Biointerphases. 2006 Mar; 1(1):P1. PMID: 20408607

Chesnutt BC, Smith DF, Raffler NA, Smith ML, White EJ, Ley K. Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin. Microcirculation. 2006 Mar; 13(2):99-109. PMID: 16459323; DOI: 10.1080/10739680500466376;

Smith ML, Olson TS, Ley K. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med. 2004 Oct 04; 200(7):935-9. PMID: 15466624; PMCID: PMC2213284; DOI: 10.1084/jem.20040424;

Koszalka P, Ozüyaman B, Huo Y, Zernecke A, Flögel U, Braun N, Buchheiser A, Decking UK, Smith ML, Sévigny J, Gear A, Weber AA, Molojavyi A, Ding Z, Weber C, Ley K, Zimmermann H, Gödecke A, Schrader J. Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res. 2004 Oct 15; 95(8):814-21. PMID: 15358667

Long DS, Smith ML, Pries AR, Ley K, Damiano ER. Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10060-5.View Related Profiles.

Damiano, Edward
Smith, Michael

PMID: 15220478

Smith ML, Sperandio M, Galkina EV, Ley K. Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin. J Leukoc Biol. 2004 Nov; 76(5):985-93. PMID: 15075351; DOI: 10.1189/jlb.1003483;

Smith ML, Long DS, Damiano ER, Ley K. Near-wall micro-PIV reveals a hydrodynamically relevant endothelial surface layer in venules in vivo. Biophys J. 2003 Jul; 85(1):637-45.View Related Profiles.

Damiano, Edward
Smith, Michael

PMID: 12829517; PMCID: PMC1303118; DOI: 10.1016/s0006-3495(03)74507-x;

Sperandio M, Smith ML, Forlow SB, Olson TS, Xia L, McEver RP, Ley K. P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J Exp Med. 2003 May 19; 197(10):1355-63. PMID: 12756271

Shin HY, Smith ML, Toy KJ, Williams PM, Bizios R, Gerritsen ME. VEGF-C mediates cyclic pressure-induced endothelial cell proliferation. Physiol Genomics. 2002 Dec 03; 11(3):245-51. PMID: 12388793; DOI: 10.1152/physiolgenomics.00068.2002;

Smith ML, Smith MJ, Lawrence MB, Ley K. Viscosity-independent velocity of neutrophils rolling on p-selectin in vitro or in vivo. Microcirculation. 2002 Dec; 9(6):523-36. PMID: 12483549; DOI: 10.1038/sj.mn.7800165;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 50 publications over 20 distinct years, with a maximum of 5 publications in 2020