Laurence Beck | Profiles RNS

Laurence H. Beck Jr, MD, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Nephrology

MD, Harvard Medical School
PhD, Harvard University
BA, Princeton University

Websites

Boston Medical Center Provider Profile

ORCID : 0000-0003-1482-4089

Laurence H. Beck, Jr., MD, PhD, completed his Internal Medicine residency and Nephrology fellowship at Boston Medical Center. He joined the Renal Section in 2006, and continues to conduct basic science research in the laboratory of Dr. David Salant on the pathogenesis of membranous nephropathy. His clinical roles include a weekly clinic and attending time on the consult and dialysis/transplant services. He also has expertise in immune-mediated glomerular disease.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BMC Research
NIH RePORTER Research

Investigating the functional capacity of autoantibodies in primary membranous nephropathy
09/20/2021 - 06/30/2025 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
1R01DK126978-01A1

A PHASE 2, 12-WEEK, ADAPTIVE, OPEN LABEL, SEQUENTIAL COHORT TRIAL TO EVALUATE THE EFFICACY, …
10/17/2019 - 10/16/2024 (PI)
Pfizer, Inc

Redefining Membranous Nephropathy by Autoantibody-specific Subclassification
01/22/2013 - 12/31/2018 (PI)
NIH-NIDDK
1R01DK097053-03

Redifining Membranous Nephropathy by Autoantibody-specific Subclassification
01/22/2013 - 12/31/2018 (PI)
NIH-NIDDK
5R01DK097053-05

Investigation of Anti-PLA2R-Associated Membranous Nephropathy at the Molecular Level
09/01/2011 - 06/30/2013 (PI)
The Halpin Foundation

Detection of anti-phospholipase A2 receptor autoantibodies in idiopathic membranous nephropathy
07/01/2009 - 06/30/2013 (PI)
Amer Soc Nephrology

Identification of the endogenous antigen and development of an ELISA for the detection of autoantibo
07/01/2007 - 06/30/2013 (PI)
AMGEN, INC

Identification of the Endogenous Antigen and Development of an ELISA for the Detection of Autoantibo
07/01/2007 - 06/30/2009 (PI)
The Halpin Foundation

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Investigating the functional capacity of autoantibodies in primary membranous nephropathy	5R01DK126978-03
2022	Investigating the functional capacity of autoantibodies in primary membranous nephropathy	5R01DK126978-02
2021	Investigating the functional capacity of autoantibodies in primary membranous nephropathy	1R01DK126978-01A1
2017	Redefining membranous nephropathy by autoantibody-specific subclassification	5R01DK097053-05	18
2016	Redefining membranous nephropathy by autoantibody-specific subclassification	4R01DK097053-04	18
2015	Redefining membranous nephropathy by autoantibody-specific subclassification	5R01DK097053-03	18
2014	Redefining membranous nephropathy by autoantibody-specific subclassification	5R01DK097053-02	18
2013	Redefining membranous nephropathy by autoantibody-specific subclassification	1R01DK097053-01	18

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Zee J, Hogan JJ, Abdullah A, Liu L, Kiryluk K, Beck LH. Noninvasive Diagnostic Strategies for Membranous Nephropathy in the Nephrotic Syndrome Study Network. Clin J Am Soc Nephrol. 2025 Feb 28. PMID: 40019793; DOI: 10.2215/CJN.0000000671;

Hayashi N, Kumar S, Trivin-Avillach C, Fan X, Stoddard SV, Akai R, Fujimoto K, Iwawaki T, Yokoyama H, Furuichi K, Beck LH. Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury. Am J Physiol Renal Physiol. 2025 Feb 01; 328(2):F289-F299.View Related Profiles.

Beck, Laurence
Kumar, Sudhir
Fan, Xueping

PMID: 39819080

Al-Rabadi LF, Storey A, Larsen CP, Hassen SI, Revelo MP, Singh RS, Lazar-Molnar E, Jain D, Ibrahim A, Darras F, Salam R, Al-Rabadi A, Wikan N, Redecke V, Talwar M, Haecker H, Beck LH, Caza TN. De novo Membranous Nephropathy in Renal Allografts is Associated With Protocadherin FAT1. Kidney Int Rep. 2025 Jan; 10(1):247-251. PMID: 39810776; PMCID: PMC11725789; DOI: 10.1016/j.ekir.2024.10.012;

Bharati J, Waguespack DR, Beck LH. Membranous Nephropathy: Updates on Management. Adv Kidney Dis Health. 2024 Jul; 31(4):299-308. PMID: 39084755

Vivarelli M, Barratt J, Beck LH, Fakhouri F, Gale DP, Goicoechea de Jorge E, Mosca M, Noris M, Pickering MC, Susztak K, Thurman JM, Cheung M, King JM, Jadoul M, Winkelmayer WC, Smith RJH. The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2024 Sep; 106(3):369-391. PMID: 38844295

Beck LH. Quantity Versus Quality of Anti-Phospholipase A2 Receptor 1 Autoantibodies in the Assessment of Clinical Outcome in Membranous Nephropathy: The Debate Continues. Am J Kidney Dis. 2024 May; 83(5):566-568. PMID: 38260930

Trivin-Avillach C, Jaberi A, Henderson JM, Beck LH, Francis J. Eculizumab Use in Scleroderma Renal Crisis With Thrombotic Microangiopathy: A Case Report. Kidney Med. 2024 Jan; 6(1):100753.View Related Profiles.

Jaberi, Aala
Francis, Jean
Henderson, Joel
Beck, Laurence

PMID: 38225975; PMCID: PMC10788495; DOI: 10.1016/j.xkme.2023.100753;

Beck LH. The latest model has just arrived! A new experimental mouse model of PLA2R1-associated membranous nephropathy. Kidney Int. 2023 Nov; 104(5):878-880. PMID: 37863634

Sethi S, Beck LH, Glassock RJ, Haas M, De Vriese AS, Caza TN, Hoxha E, Lambeau G, Tomas NM, Madden B, Debiec H, D'Agati VD, Alexander MP, Amer H, Appel GB, Barbour SJ, Caravaca-Fontan F, Cattran DC, Casal Moura M, D'Avila DO, Eick RG, Garovic VD, Greene EL, Herrera Hernandez LP, Jennette JC, Lieske JC, Markowitz GS, Nath KA, Nasr SH, Nast CC, Pani A, Praga M, Remuzzi G, Rennke HG, Ruggenenti P, Roccatello D, Soler MJ, Specks U, Stahl RAK, Singh RD, Theis JD, Velosa JA, Wetzels JFM, Winearls CG, Yandian F, Zand L, Ronco P, Fervenza FC. Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification. Mayo Clin Proc. 2023 Nov; 98(11):1671-1684. PMID: 37804268

Sethi S, Beck LH, Glassock RJ, Haas M, De Vriese AS, Caza TN, Hoxha E, Lambeau G, Tomas NM, Madden B, Debiec H, D'Agati VD, Alexander MP, Amer H, Appel GB, Barbour SJ, Caravaca-Fontan F, Cattran DC, Casal Moura M, D'Avila DO, Eick RG, Garovic VD, Greene EL, Herrera Hernandez LP, Jennette JC, Lieske JC, Markowitz GS, Nath KA, Nasr SH, Nast CC, Pani A, Praga M, Remuzzi G, Rennke HG, Ruggenenti P, Roccatello D, Soler MJ, Specks U, Stahl RAK, Singh RD, Theis JD, Velosa JA, Wetzels JFM, Winearls CG, Yandian F, Zand L, Ronco P, Fervenza FC. Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification. Kidney Int. 2023 Dec; 104(6):1092-1102. PMID: 37795587

Showing 10 of 102 results. Show More

Kouri AM, Caza TN, Beck LH, Misurac JM, Evans MD, Phillips CL, Eadon MT, Larsen CP, Andreoli SP, Bu L, Rheault MN, Khalid M. Clinical and Histopathologic Characteristics of Pediatric Patients With Primary Membranous Nephropathy. Kidney Int Rep. 2023 Nov; 8(11):2368-2375. PMID: 38025223; PMCID: PMC10658230; DOI: 10.1016/j.ekir.2023.08.018;

Avasare R, Andeen N, Beck L. Novel Antigens and Clinical Updates in Membranous Nephropathy. Annu Rev Med. 2024 Jan 29; 75:219-332. PMID: 37552894

Beck LH, Ayoub I, Caster D, Choi MJ, Cobb J, Geetha D, Rheault MN, Wadhwani S, Yau T, Whittier WL. KDOQI US Commentary on the 2021 KDIGO Clinical Practice Guideline for the Management of Glomerular Diseases. Am J Kidney Dis. 2023 Aug; 82(2):121-175. PMID: 37341661

Al-Rabadi LF, Beck LH. Neuronal Proteins as Antigenic Targets in Membranous Nephropathy. Nephron. 2023; 147(8):451-457. PMID: 36580905

Burbelo PD, Olson SW, Keller JM, Joshi M, Schwartz DM, Chuang YJ, Lambeau G, Beck LH, Waldman M. Prediagnostic Appearance of Thrombospondin Type-1 Domain 7A Autoantibodies in Membranous Nephropathy. Kidney360. 2023 Feb 01; 4(2):217-225. PMID: 36821613; PMCID: PMC10103354; DOI: 10.34067/KID.0005112022;

Sealfon R, Mariani L, Kretzler M, Beck LH. Authors' Reply: In Silico-Based Approach to the Discovery of New Antigens in Membranous Nephropathy. J Am Soc Nephrol. 2022 Dec; 33(12):2322-2323. PMID: 36175144; PMCID: PMC9731634; DOI: 10.1681/ASN.2022080921;

Manral P, Caza TN, Storey AJ, Beck LH, Borza DB. The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy. Front Immunol. 2022; 13:952235. PMID: 35874690; PMCID: PMC9301376; DOI: 10.3389/fimmu.2022.952235;

Sealfon R, Mariani L, Avila-Casado C, Nair V, Menon R, Funk J, Wong A, Lerner G, Hayashi N, Troyanskaya O, Kretzler M, Beck LH. Molecular Characterization of Membranous Nephropathy. J Am Soc Nephrol. 2022 Jun; 33(6):1208-1221. PMID: 35477557; PMCID: PMC9161788; DOI: 10.1681/ASN.2021060784;

Kamel MH, Jaberi A, Gordon CE, Beck LH, Francis J. The Complement System in the Modern Era of Kidney Transplantation: Mechanisms of Injury and Targeted Therapies. Semin Nephrol. 2022 Jan; 42(1):14-28.View Related Profiles.

Jaberi, Aala
Francis, Jean
Beck, Laurence
Kamel, Mohamed

PMID: 35618392

Caza TN, Al-Rabadi LF, Beck LH. How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy. Front Immunol. 2021; 12:800242. PMID: 34899763; PMCID: PMC8662735; DOI: 10.3389/fimmu.2021.800242;

Watts AJB, Keller KH, Lerner G, Rosales I, Collins AB, Sekulic M, Waikar SS, Chandraker A, Riella LV, Alexander MP, Troost JP, Chen J, Fermin D, Yee JL, Sampson MG, Beck LH, Henderson JM, Greka A, Rennke HG, Weins A. Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. J Am Soc Nephrol. 2022 01; 33(1):238-252.View Related Profiles.

Henderson, Joel
Beck, Laurence
Waikar, Sushrut

PMID: 34732507; PMCID: PMC8763186; DOI: 10.1681/ASN.2021060794;

Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J. Membranous nephropathy. Nat Rev Dis Primers. 2021 09 30; 7(1):69. PMID: 34593809

Bomback AS, Appel GB, Gipson DS, Hladunewich MA, Lafayette R, Nester CM, Parikh SV, Smith RJH, Trachtman H, Heeger PS, Ram S, Rovin BH, Ali S, Arceneaux N, Ashoor I, Bailey-Wickins L, Barratt J, Beck L, Cattran DC, Cravedi P, Erkan E, Fervenza F, Frazer-Abel AA, Fremeaux-Bacchi V, Fuller L, Gbadegesin R, Hogan JJ, Kiryluk K, le Quintrec-Donnette M, Licht C, Mahan JD, Pickering MC, Quigg R, Rheault M, Ronco P, Sarwal MM, Sethna C, Spino C, Stegall M, Vivarelli M, Feldman DL, Thurman JM. Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Am J Kidney Dis. 2022 04; 79(4):570-581. PMID: 34571062

Nasr SH, Leung N, Said SM, Alkhateeb HB, Madden BJ, Charlesworth MC, Beck LH, Larsen CP, Sethi S. Membranous Nephropathy With Extensive Tubular Basement Membrane Deposits Following Allogeneic Hematopoietic Cell Transplant: A Report of 5 Cases. Am J Kidney Dis. 2022 Jun; 79(6):904-908. PMID: 34508832

Molina Andújar A, Castrejon de Anta N, Rodriguez-Espinosa D, Hermida E, Larque AB, Esforzado N, Torregrosa JV, Cucchiari D, Blasco M, Rodríguez-Villar C, Beck LH, García Herrera A, Quintana LF. Antiphospholipase A2 receptor antibody-positive membranous nephropathy in the kidney donor: Lessons from a serendipitous transplantation. Am J Transplant. 2022 01; 22(1):299-303. PMID: 34431212

Idrees N, Beck LH. Multitarget Combination Immunosuppressive Therapy for Primary Membranous Nephropathy. Am J Kidney Dis. 2021 12; 78(6):774-776. PMID: 34465505

Caza TN, Hassen SI, Kenan DJ, Storey A, Arthur JM, Herzog C, Edmondson RD, Bourne TD, Beck LH, Larsen CP. Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy. Kidney360. 2021 Aug 26; 2(8):1275-1286. PMID: 35369660; PMCID: PMC8676385; DOI: 10.34067/KID.0001492021;

Al-Rabadi LF, Caza T, Trivin-Avillach C, Rodan AR, Andeen N, Hayashi N, Williams B, Revelo MP, Clayton F, Abraham J, Lin E, Liou W, Zou CJ, Ramkumar N, Cummins T, Wilkey DW, Kawalit I, Herzog C, Storey A, Edmondson R, Sjoberg R, Yang T, Chien J, Merchant M, Arthur J, Klein J, Larsen C, Beck LH. Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. J Am Soc Nephrol. 2021 Jul; 32(7):1666-1681. PMID: 33952630; PMCID: PMC8425645; DOI: 10.1681/ASN.2020101395;

Lerner GB, Virmani S, Henderson JM, Francis JM, Beck LH. A conceptual framework linking immunology, pathology, and clinical features in primary membranous nephropathy. Kidney Int. 2021 08; 100(2):289-300.View Related Profiles.

Francis, Jean
Henderson, Joel
Beck, Laurence

PMID: 33857571

Beck LH, Berasi SP, Copley JB, Gorman D, Levy DI, Lim CN, Henderson JM, Salant DJ, Lu W. PODO: Trial Design: Phase 2 Study of PF-06730512 in Focal Segmental Glomerulosclerosis. Kidney Int Rep. 2021 Jun; 6(6):1629-1633.View Related Profiles.

Levy, Daniel
Salant, David
Henderson, Joel
Beck, Laurence
Lu, Weining

PMID: 34169203; PMCID: PMC8207305; DOI: 10.1016/j.ekir.2021.03.892;

Hogan JJ, Zee J, Beck LH. Towards optimizing use of PLA2R antibody testing in membranous nephropathy. J Nephrol. 2021 Apr; 34(2):557-559. PMID: 33502725

Haddad G, Lorenzen JM, Ma H, de Haan N, Seeger H, Zaghrini C, Brandt S, Kölling M, Wegmann U, Kiss B, Pál G, Gál P, Wüthrich RP, Wuhrer M, Beck LH, Salant DJ, Lambeau G, Kistler AD. Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy. J Clin Invest. 2021 03 01; 131(5).View Related Profiles.

Salant, David
Beck, Laurence

PMID: 33351779; PMCID: PMC7919733; DOI: 10.1172/JCI140453;

Alsharhan L, Beck LH. Membranous Nephropathy: Core Curriculum 2021. Am J Kidney Dis. 2021 03; 77(3):440-453. PMID: 33487481

Hayashi N, Beck LH. Moore's law for membranous nephropathy. Kidney Int. 2020 11; 98(5):1081-1084. PMID: 33126969

Gallan AJ, Garg A, Collins AB, Beck LH, Trivin-Avillach C, Henriksen KJ, Chang A. Anti-LRP2 Nephropathy. Kidney Int Rep. 2020 Dec; 5(12):2365-2370. PMID: 33305133; PMCID: PMC7710829; DOI: 10.1016/j.ekir.2020.09.011;

Xie J, Liu L, Mladkova N, Li Y, Ren H, Wang W, Cui Z, Lin L, Hu X, Yu X, Xu J, Liu G, Caliskan Y, Sidore C, Balderes O, Rosen RJ, Bodria M, Zanoni F, Zhang JY, Krithivasan P, Mehl K, Marasa M, Khan A, Ozay F, Canetta PA, Bomback AS, Appel GB, Sanna-Cherchi S, Sampson MG, Mariani LH, Perkowska-Ptasinska A, Durlik M, Mucha K, Moszczuk B, Foroncewicz B, Paczek L, Habura I, Ars E, Ballarin J, Mani LY, Vogt B, Ozturk S, Yildiz A, Seyahi N, Arikan H, Koc M, Basturk T, Karahan G, Akgul SU, Sever MS, Zhang D, Santoro D, Bonomini M, Londrino F, Gesualdo L, Reiterova J, Tesar V, Izzi C, Savoldi S, Spotti D, Marcantoni C, Messa P, Galliani M, Roccatello D, Granata S, Zaza G, Lugani F, Ghiggeri G, Pisani I, Allegri L, Sprangers B, Park JH, Cho B, Kim YS, Kim DK, Suzuki H, Amoroso A, Cattran DC, Fervenza FC, Pani A, Hamilton P, Harris S, Gupta S, Cheshire C, Dufek S, Issler N, Pepper RJ, Connolly J, Powis S, Bockenhauer D, Stanescu HC, Ashman N, Loos RJF, Kenny EE, Wuttke M, Eckardt KU, Köttgen A, Hofstra JM, Coenen MJH, Kiemeney LA, Akilesh S, Kretzler M, Beck LH, Stengel B, Debiec H, Ronco P, Wetzels JFM, Zoledziewska M, Cucca F, Ionita-Laza I, Lee H, Hoxha E, Stahl RAK, Brenchley P, Scolari F, Zhao MH, Gharavi AG, Kleta R, Chen N, Kiryluk K. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nat Commun. 2020 03 30; 11(1):1600. PMID: 32231244; PMCID: PMC7105485; DOI: 10.1038/s41467-020-15383-w;

Pisarek-Horowitz A, Fan X, Kumar S, Rasouly HM, Sharma R, Chen H, Coser K, Bluette CT, Hirenallur-Shanthappa D, Anderson SR, Yang H, Beck LH, Bonegio RG, Henderson JM, Berasi SP, Salant DJ, Lu W. Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure. Am J Pathol. 2020 04; 190(4):799-816.View Related Profiles.

Pisarek-Horowitz, Anna Justyna
Salant, David
Chen, Hui
Henderson, Joel
Beck, Laurence
Bonegio, Ramon
Kumar, Sudhir
Lu, Weining
Fan, Xueping

PMID: 32220420; PMCID: PMC7217334; DOI: 10.1016/j.ajpath.2019.12.009;

Sachdeva M, Beck LH, Miller I, Bijol V, Fishbane S. Phospholipase A2 Receptor Antibody-Positive Pregnancy: A Case Report. Am J Kidney Dis. 2020 10; 76(4):586-589. PMID: 32093980

Beck LH, Salant DJ. Refining Our Understanding of the PLA2R-Antibody Response in Primary Membranous Nephropathy: Looking Forward, Looking Back. J Am Soc Nephrol. 2020 01; 31(1):8-11.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 31871252; PMCID: PMC6935005; DOI: 10.1681/ASN.2019111195;

Safar-Boueri L, Piya A, Beck LH, Ayalon R. Membranous nephropathy: diagnosis, treatment, and monitoring in the post-PLA2R era. Pediatr Nephrol. 2021 01; 36(1):19-30.View Related Profiles.

Beck, Laurence
Ayalon, Rivka

PMID: 31811540

Trivin-Avillach C, Beck LH. Management of Membranous Nephropathy after MENTOR. Clin J Am Soc Nephrol. 2020 03 06; 15(3):415-417. PMID: 31740571; PMCID: PMC7057305; DOI: 10.2215/CJN.10240819;

Leon J, Pérez-Sáez MJ, Batal I, Beck LH, Rennke HG, Canaud G, Legendre C, Pascual J, Riella LV. Membranous Nephropathy Posttransplantation: An Update of the Pathophysiology and Management. Transplantation. 2019 10; 103(10):1990-2002. PMID: 31568231

Leon J, Pérez-Sáez MJ, Batal I, Beck LH, Rennke HG, Canaud G, Legendre C, Pascual J, Riella LV. Membranous Nephropathy Post-Transplantation: An Update of the Pathophysiology and Management. Transplantation. 2019 Apr 10. PMID: 30985736

Zaghrini C, Seitz-Polski B, Justino J, Dolla G, Payré C, Jourde-Chiche N, Van de Logt AE, Booth C, Rigby E, Lonnbro-Widgren J, Nystrom J, Mariat C, Cui Z, Wetzels JFM, Ghiggeri G, Beck LH, Ronco P, Debiec H, Lambeau G. Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy. Kidney Int. 2019 03; 95(3):666-679. PMID: 30784662

Keri KC, Blumenthal S, Kulkarni V, Beck L, Chongkrairatanakul T. Primary membranous nephropathy: comprehensive review and historical perspective. Postgrad Med J. 2019 Jan; 95(1119):23-31. PMID: 30683678

Stoddard SV, Welsh CL, Palopoli MM, Stoddard SD, Aramandla MP, Patel RM, Ma H, Beck LH. Structure and function insights garnered from in silico modeling of the thrombospondin type-1 domain-containing 7A antigen. Proteins. 2019 02; 87(2):136-145. PMID: 30520531; PMCID: PMC6876118; DOI: 10.1002/prot.25640;

Beck LH, Salant DJ. Deep pockets are not necessarily a good thing in membranous nephropathy: evidence for a modifier allele. Kidney Int. 2018 11; 94(5):855-857.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 30348302

Luo W, Olaru F, Miner JH, Beck LH, van der Vlag J, Thurman JM, Borza DB. Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy. Front Immunol. 2018; 9:1433. PMID: 29988342; PMCID: PMC6023961; DOI: 10.3389/fimmu.2018.01433;

Malatesta-Muncher R, Eldin KW, Beck LH, Michael M. Idiopathic membranous nephropathy in children treated with rituximab: report of two cases. Pediatr Nephrol. 2018 06; 33(6):1089-1092. PMID: 29546599

Larsen CP, Trivin-Avillach C, Coles P, Collins AB, Merchant M, Ma H, Wilkey DW, Ambruzs JM, Messias NC, Cossey LN, Rosales IA, Wooldridge T, Walker PD, Colvin RB, Klein J, Salant DJ, Beck LH. LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease. J Am Soc Nephrol. 2018 02; 29(2):644-653.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 29074737; PMCID: PMC5791069; DOI: 10.1681/ASN.2017060664;

Al-Rabadi L, Quillen K, Shashar M, Al Marji C, Jaberi A, Chitalia V, Henderson J, Salant D, Beck LH. Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy. Kidney Int Rep. 2018 Mar; 3(2):476-481.View Related Profiles.

Jaberi, Aala
Salant, David
Henderson, Joel
Quillen, Karen
Beck, Laurence
Chitalia, Vipul

PMID: 29725652; PMCID: PMC5931958; DOI: 10.1016/j.ekir.2017.08.005;

Beck LH. PLA2R and THSD7A: Disparate Paths to the Same Disease? J Am Soc Nephrol. 2017 Sep; 28(9):2579-2589. PMID: 28674044; PMCID: PMC5576947; DOI: 10.1681/ASN.2017020178;

Burbelo PD, Beck LH, Waldman M. Detection and monitoring PLA2R autoantibodies by LIPS in membranous nephropathy. J Immunol Methods. 2017 May; 444:17-23. PMID: 28167276; PMCID: PMC5376496; DOI: 10.1016/j.jim.2017.02.001;

Havasi A, Lu W, Cohen HT, Beck L, Wang Z, Igwebuike C, Borkan SC. Blocking peptides and molecular mimicry as treatment for kidney disease. Am J Physiol Renal Physiol. 2017 Jun 01; 312(6):F1016-F1025.View Related Profiles.

Havasi, Andrea
Cohen, Herbert
Beck, Laurence
Borkan, Steven
Lu, Weining
Wang, Zhiyong

PMID: 27654896; PMCID: PMC5495884; DOI: 10.1152/ajprenal.00601.2015;

Hoxha E, Beck LH, Wiech T, Tomas NM, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl PR, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant DJ, Stahl RA. An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy. J Am Soc Nephrol. 2017 Feb; 28(2):520-531.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 27436855; PMCID: PMC5280014; DOI: 10.1681/ASN.2016010050;

Waldman M, Beck LH, Braun M, Wilkins K, Balow JE, Austin HA. Membranous nephropathy: Pilot study of a novel regimen combining cyclosporine and Rituximab. Kidney Int Rep. 2016 Jul; 1(2):73-84. PMID: 27942609; PMCID: PMC5138549; DOI: 10.1016/j.ekir.2016.05.002;

Francis JM, Beck LH, Salant DJ. Membranous Nephropathy: A Journey From Bench to Bedside. Am J Kidney Dis. 2016 Jul; 68(1):138-47.View Related Profiles.

Salant, David
Francis, Jean
Beck, Laurence

PMID: 27085376; PMCID: PMC4921260; DOI: 10.1053/j.ajkd.2016.01.030;

Gupta G, Fattah H, Ayalon R, Kidd J, Gehr T, Quintana LF, Kimball P, Sadruddin S, Massey HD, Kumar D, King AL, Beck LH. Pre-transplant phospholipase A2 receptor autoantibody concentration is associated with clinically significant recurrence of membranous nephropathy post-kidney transplantation. Clin Transplant. 2016 Apr; 30(4):461-9.View Related Profiles.

Beck, Laurence
Ayalon, Rivka

PMID: 26854647; DOI: 10.1111/ctr.12711;

El-Husseini A, Saxon D, Jennings S, Cornea V, Beck L, Sawaya BP. Idiopathic Membranous Nephropathy: Diagnostic and Therapeutic Challenges. Am J Nephrol. 2016; 43(2):65-70. PMID: 26914654; DOI: 10.1159/000444593;

Larsen CP, Cossey LN, Beck LH. THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. Mod Pathol. 2016 Apr; 29(4):421-6. PMID: 26847174; PMCID: PMC4820679; DOI: 10.1038/modpathol.2016.32;

Grupper A, Cornell LD, Fervenza FC, Beck LH, Lorenz E, Cosio FG. Recurrent Membranous Nephropathy After Kidney Transplantation: Treatment and Long-Term Implications. Transplantation. 2016 12; 100(12):2710-2716. PMID: 26720301

Al-Rabadi L, Ayalon R, Bonegio RG, Ballard JE, Fujii AM, Henderson JM, Salant DJ, Beck LH. Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report. Am J Kidney Dis. 2016 May; 67(5):775-8.View Related Profiles.

Fujii, Alan
Salant, David
Henderson, Joel
Beck, Laurence
Bonegio, Ramon
Ayalon, Rivka

PMID: 26744127; PMCID: PMC4837089; DOI: 10.1053/j.ajkd.2015.10.031;

Abudayyeh A, Truong LD, Beck LH, Weber DM, Rezvani K, Abdelrahim M. Membranous nephropathy in autologous hematopoietic stem cell transplant: autologous graft-versus-host disease or autoimmunity induction? Clin Kidney J. 2015 Aug; 8(4):440-4. PMID: 26251713; PMCID: PMC4515891; DOI: 10.1093/ckj/sfv036;

Kattah A, Ayalon R, Beck LH, Sethi S, Sandor DG, Cosio FG, Gandhi MJ, Lorenz EC, Salant DJ, Fervenza FC. Anti-phospholipase A2 receptor antibodies in recurrent membranous nephropathy. Am J Transplant. 2015 May; 15(5):1349-59.View Related Profiles.

Sandor, Dana
Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 25766759; PMCID: PMC4472303; DOI: 10.1111/ajt.13133;

Beck LH. Lessons from a rare disease: IgG subclass and disease severity in alloimmune antenatal membranous nephropathy. Kidney Int. 2015 Mar; 87(3):494-7. PMID: 25723631; DOI: 10.1038/ki.2014.367;

Menn-Josephy H, Beck LH. Recurrent glomerular disease in the kidney allograft. Front Biosci (Elite Ed). 2015; 7:135-48.View Related Profiles.

Menn-Josephy, Hanni
Beck, Laurence

PMID: 25553369

Tomas NM, Beck LH, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RA, Lambeau G. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med. 2014 Dec 11; 371(24):2277-87.View Related Profiles.

Salant, David
Ma, Hong
Beck, Laurence

PMID: 25394321; PMCID: PMC4278759; DOI: 10.1056/NEJMoa1409354;

Beck LH. The dominant humoral epitope in phospholipase A2 receptor-1: presentation matters when serving up a slice of p. J Am Soc Nephrol. 2015 Feb; 26(2):237-9. PMID: 25288604; PMCID: PMC4310670; DOI: 10.1681/ASN.2014090877;

Timmermans SA, Damoiseaux JG, Heerings-Rewinkel PT, Ayalon R, Beck LH, Schlumberger W, Salant DJ, van Paassen P, Tervaert JW. Evaluation of anti-PLA2R1 as measured by a novel ELISA in patients with idiopathic membranous nephropathy: a cohort study. Am J Clin Pathol. 2014 Jul; 142(1):29-34.View Related Profiles.

Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 24926082; DOI: 10.1309/AJCP8QMOY5GLRSFP;

Beck LH, Salant DJ. Membranous nephropathy: from models to man. J Clin Invest. 2014 Jun 2; 124(6):2307-14.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 24892704; PMCID: PMC4089468; DOI: 10.1172/JCI72270;

Behnert A, Schiffer M, Müller-Deile J, Beck LH, Mahler M, Fritzler MJ. Antiphospholipase A2 receptor autoantibodies: a comparison of three different immunoassays for the diagnosis of idiopathic membranous nephropathy. J Immunol Res. 2014; 2014:143274. PMID: 24812637; PMCID: PMC4000632; DOI: 10.1155/2014/143274;

Hladunewich MA, Cattran D, Beck LH, Odutayo A, Sethi S, Ayalon R, Leung N, Reich H, Fervenza FC. A pilot study to determine the dose and effectiveness of adrenocorticotrophic hormone (H.P. Acthar® Gel) in nephrotic syndrome due to idiopathic membranous nephropathy. Nephrol Dial Transplant. 2014 Aug; 29(8):1570-7.View Related Profiles.

Beck, Laurence
Ayalon, Rivka

PMID: 24714414; PMCID: PMC4106642; DOI: 10.1093/ndt/gfu069;

Ayalon R, Beck LH. Membranous nephropathy: not just a disease for adults. Pediatr Nephrol. 2015 Jan; 30(1):31-9.View Related Profiles.

Beck, Laurence
Ayalon, Rivka

PMID: 24375012; PMCID: PMC4074564; DOI: 10.1007/s00467-013-2717-z;

Ma H, Sandor DG, Beck LH. The role of complement in membranous nephropathy. Semin Nephrol. 2013 Nov; 33(6):531-42.View Related Profiles.

Sandor, Dana
Ma, Hong
Beck, Laurence

PMID: 24161038; PMCID: PMC4274996; DOI: 10.1016/j.semnephrol.2013.08.004;

Timmermans SA, Ayalon R, van Paassen P, Beck LH, van Rie H, Wirtz JJ, Verseput GH, Frenken LA, Salant DJ, Cohen Tervaert JW. Anti-phospholipase A2 receptor antibodies and malignancy in membranous nephropathy. Am J Kidney Dis. 2013 Dec; 62(6):1223-5.View Related Profiles.

Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 24021909; DOI: 10.1053/j.ajkd.2013.07.019;

Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH, Somers MJ, Trachtman H, Waldman M. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis. Am J Kidney Dis. 2013 Sep; 62(3):403-41. PMID: 23871408; DOI: 10.1053/j.ajkd.2013.06.002;

Borza DB, Zhang JJ, Beck LH, Meyer-Schwesinger C, Luo W. Mouse models of membranous nephropathy: the road less travelled by. Am J Clin Exp Immunol. 2013; 2(2):135-45. PMID: 23885331; PMCID: PMC3714174

Beck LH. Monoclonal anti-PLA2R and recurrent membranous nephropathy: another piece of the puzzle. J Am Soc Nephrol. 2012 Dec; 23(12):1911-3. PMID: 23138482; DOI: 10.1681/ASN.2012101023;

Irazabal MV, Eirin A, Lieske J, Beck LH, Sethi S, Borland TM, Dillon JJ, Nachman PH, Nasr SH, Cornell LD, Leung N, Cattran DC, Fervenza FC. Low- and high-molecular-weight urinary proteins as predictors of response to rituximab in patients with membranous nephropathy: a prospective study. Nephrol Dial Transplant. 2013 Jan; 28(1):137-46. PMID: 22987142; PMCID: PMC3616763; DOI: 10.1093/ndt/gfs379;

Bomback AS, Canetta PA, Beck LH, Ayalon R, Radhakrishnan J, Appel GB. Treatment of resistant glomerular diseases with adrenocorticotropic hormone gel: a prospective trial. Am J Nephrol. 2012; 36(1):58-67.View Related Profiles.

Beck, Laurence
Ayalon, Rivka

PMID: 22722778; DOI: 10.1159/000339287;

Khosroshahi A, Ayalon R, Beck LH, Salant DJ, Bloch DB, Stone JH. IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor. Int J Rheumatol. 2012; 2012:139409.View Related Profiles.

Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 22654915; PMCID: PMC3357948; DOI: 10.1155/2012/139409;

Beck LH. Monoclonal antibodies for the treatment of the C3 glomerulopathies. Clin J Am Soc Nephrol. 2012 May; 7(5):704-6. PMID: 22498497; DOI: 10.2215/CJN.03010312;

Surindran S, Ayalon R, Hasan N, Beck LH, Salant DJ, Barisoni L, Skolnik EY, Beara-Lasic L. Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A(2) receptor antibody-positive membranous nephropathy. Clin Kidney J. 2012 Apr; 5(2):162-165.View Related Profiles.

Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 22833809; PMCID: PMC3341840; DOI: 10.1093/ckj/sfr149;

Blosser CD, Ayalon R, Nair R, Thomas C, Beck LH. Very early recurrence of anti-Phospholipase A2 receptor-positive membranous nephropathy after transplantation. Am J Transplant. 2012 Jun; 12(6):1637-42.View Related Profiles.

Beck, Laurence
Ayalon, Rivka

PMID: 22390840; DOI: 10.1111/j.1600-6143.2011.03957.x;

Laurence H. Beck, David J. Salant. Tubulointerstitial Diseases of the Kidney. Harrison's Principles of Internal Medicine; Longo, Fauci, Kasper, Hauser, Jameson, and Loscalzo, eds. McGraw-Hill. New York. 2012; 2367-2374.

Beck LH. Childhood membranous nephropathy and dietary antigens. Am J Kidney Dis. 2012 Feb; 59(2):174-6. PMID: 22014402; DOI: 10.1053/j.ajkd.2011.09.009;

Beck LH, Fervenza FC, Beck DM, Bonegio RG, Malik FA, Erickson SB, Cosio FG, Cattran DC, Salant DJ. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol. 2011 Aug; 22(8):1543-50.View Related Profiles.

Salant, David
Beck, Laurence
Bonegio, Ramon

PMID: 21784898; PMCID: PMC3148709; DOI: 10.1681/ASN.2010111125;

Fervenza FC, Downer G, Beck LH, Sethi S. IgG4-related tubulointerstitial nephritis with membranous nephropathy. Am J Kidney Dis. 2011 Aug; 58(2):320-4. PMID: 21705127; DOI: 10.1053/j.ajkd.2011.05.006;

Cravedi P, Abbate M, Gagliardini E, Galbusera M, Buelli S, Sabadini E, Marasà M, Beck LH, Salant DJ, Benigni A, D'Agati V, Remuzzi G. Membranous nephropathy associated with IgG4-related disease. Am J Kidney Dis. 2011 Aug; 58(2):272-5.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 21658826; DOI: 10.1053/j.ajkd.2011.05.002;

Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z. Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol. 2011 Jun; 22(6):1137-43.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 21566055; PMCID: PMC3103733; DOI: 10.1681/ASN.2010090967;

Hofstra JM, Beck LH, Beck DM, Wetzels JF, Salant DJ. Anti-phospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol. 2011 Jun; 6(6):1286-91.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 21474589; PMCID: PMC3109923; DOI: 10.2215/CJN.07210810;

Bonegio RG, Beck LH, Kahlon RK, Lu W, Salant DJ. The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int. 2011 May; 79(10):1099-112.View Related Profiles.

Salant, David
Beck, Laurence
Bonegio, Ramon
Lu, Weining

PMID: 21270765; PMCID: PMC5033618; DOI: 10.1038/ki.2010.553;

Chakera A, Lasserson D, Beck LH, Roberts IS, Winearls CG. Membranous nephropathy after use of UK-manufactured skin creams containing mercury. QJM. 2011 Oct; 104(10):893-6. PMID: 21062753; DOI: 10.1093/qjmed/hcq209;

Beck LH. Membranous nephropathy and malignancy. Semin Nephrol. 2010 Nov; 30(6):635-44. PMID: 21146128; DOI: 10.1016/j.semnephrol.2010.09.011;

Beck LH, Salant DJ. Membranous nephropathy: recent travels and new roads ahead. Kidney Int. 2010 May; 77(9):765-70.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 20182413; DOI: 10.1038/ki.2010.34;

Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009 Jul 2; 361(1):11-21.View Related Profiles.

Salant, David
Beck, Laurence
Bonegio, Ramon

PMID: 19571279; PMCID: PMC2762083; DOI: 10.1056/NEJMoa0810457;

Beck LH, Salant DJ. Treatment of membranous lupus nephritis: where are we now? J Am Soc Nephrol. 2009 Apr; 20(4):690-1.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 19279123; DOI: 10.1681/ASN.2009020216;

Beck LH, Salant DJ. Glomerular and tubulointerstitial diseases. Prim Care. 2008 Jun; 35(2):265-96, vi.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 18486716; DOI: 10.1016/j.pop.2008.01.002;

Beck LH, Goodwin AM, D'Amore PA. Culture of large vessel endothelial cells on floating collagen gels promotes a phenotype characteristic of endothelium in vivo. Differentiation. 2004 Apr; 72(4):162-70. PMID: 15157239

Hirschi KK, Rohovsky SA, Beck LH, Smith SR, D'Amore PA. Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ Res. 1999 Feb 19; 84(3):298-305. PMID: 10024303

Day SC, Norcini JJ, Diserens D, Cebul RD, Schwartz JS, Beck LH, Webster GD, Schnabel TG, Elstein A. The validity of an essay test of clinical judgment. Acad Med. 1990 Sep; 65(9 Suppl):S39-40. PMID: 2400498

Norcini JJ, Diserens D, Day SC, Cebul RD, Schwartz JS, Beck LH, Webster GD, Schnabel TG, Elstein A. The scoring and reproducibility of an essay test of clinical judgment. Acad Med. 1990 Sep; 65(9 Suppl):S41-2. PMID: 2400499

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 102 publications over 21 distinct years, with a maximum of 14 publications in 2021

Bar chart showing 102 publications over 21 distinct years, with a maximum of 14 publications in 2021

Year	Publications
1990	2
1999	1
2004	1
2008	1
2009	2
2010	3
2011	7
2012	8
2013	5
2014	6
2015	6
2016	7
2017	4
2018	4
2019	7
2020	5
2021	14
2022	6
2023	7
2024	4
2025	2

Media Mentions

ASN Announces Inaugural Midcareer Award Winners

Kidney News 10/8/2019

2019 American Society of Nephrology: Distinguished Researcher Award

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

anti-phospholipase A2 receptor autoantibodies
membranous nephropathy
PLA2R

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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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