Professor Laura Lowery discovered her love of academia and biomedical research while an undergrad at the University of California, San Diego. In the lab of Dr. Bill Schafer, she studied the neural circuitry underlying worm egg-laying behavior. In 2008, Prof Lowery received her PhD from the Massachusetts Institute of Technology, working in the lab of Dr. Hazel Sive at the Whitehead Institute, where she pioneered research studying early brain ventricle morphogenesis. Prof Lowery then did post-doctoral research in the Department of Cell Biology at Harvard Medical School, in the labs of Dr. David Van Vactor and Dr. Gaudenz Danuser, where she became fascinated by the inner workings of the neuronal growth cone and axon guidance. She began as an Assistant Professor at Boston College in 2014, she was promoted to Associate Professor in 2018, and she moved to Boston University Medical Center in 2020. (Prof Lowery will be an Associate Professor in the Department of Medicine in the Section of Heme/Onc, but temporarily has a Clinical Instructor appointment until Associate Professor appointment becomes official.)
Prof. Lowery leads a comprehensive, multi-faceted research program that investigates how cytoskeletal dynamics are regulated to drive cell motility in both normal and pathological conditions. Her lab uses this research focus as a platform to further the understanding of the cell biological defects that underlie neurodevelopmental disorders, various developmental disorders affecting other organ systems, as well as cancer metastasis, using Xenopus laevis as a model system. Her long-term goal is to continue to expand on this work, as well as collaborate with other cell and developmental biologists to elucidate mechanisms underlying complex cell biological processes.
The lab currently consists of one research technician, two PhD students, and several undergraduate students. We are a group of enthusiastic and motivated researchers excited about making a positive difference in the world. The lab's research has been funded by multiple external grants from the NIH, NSF, American Cancer Society, and the March of Dimes foundation. Please check out the lab's website (lowerylab.org) for more information.
2018 Charles H. Hood Foundation Bridge Funding Award
2017 Boston College “Ever to Excel” Reverend John R Trzaska SJ Award
2016 American Cancer Society Research Scholar Award
2016 March of Dimes Research Award
2013 North East Society of Developmental Biology Poster Presentation Award
2012 Growth Cones and Axon Regeneration RegenBase Oral Presentation Award
2012 Growth Cones and Axon Regeneration RegenBase Travel Award
2012 North East Society of Developmental Biology Best Oral Presentation Award
2012 NIH K99 Pathway to Independence Award
2011 North East Society of Developmental Biology Best Oral Presentation Award
2008 NIH/NINDS Ruth L. Kirschstein NRSA Post-doctoral Fellowship
2005 Developmental Biology Gordon Conference Poster Award
2005 NIH/NIMH Ruth L. Kirschstein NRSA Pre-doctoral Fellowship
2004 Abraham J. Siegel Fellowship, Whitehead Institute
2004 North East Society of Developmental Biology Poster Award
2000 Revelle College Outstanding Academic and Leadership Excellence Award, UC San Diego
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 38 results.
Erdogan B, St Clair RM, Cammarata GM, Zaccaro T, Ballif BA, Lowery LA. Investigating the impact of the phosphorylation status of tyrosine residues within the TACC domain of TACC3 on microtubule behavior during axon growth and guidance. Cytoskeleton (Hoboken). 2020 07; 77(7):277-291. PMID: 32543081
Ori-McKenney K, Lowery LA. Regulation of cytoskeletal dynamics and transport. Mol Biol Cell. 2020 03 15; 31(6):406. PMID: 32163351
Singh MD, Jensen M, Lasser M, Huber E, Yusuff T, Pizzo L, Lifschutz B, Desai I, Kubina A, Yennawar S, Kim S, Iyer J, Rincon-Limas DE, Lowery LA, Girirajan S. NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. PLoS Genet. 2020 02; 16(2):e1008590. PMID: 32053595
Hu Y, Lyu W, Lowery LA, Koleske AJ. Regulation of MT dynamics via direct binding of an Abl family kinase. J Cell Biol. 2019 12 02; 218(12):3986-3997. PMID: 31699690; DOI: 10.1083/jcb.201812144;
Lasser M, Pratt B, Monahan C, Kim SW, Lowery LA. The Many Faces of Xenopus: Xenopus laevis as a Model System to Study Wolf-Hirschhorn Syndrome. Front Physiol. 2019; 10:817. PMID: 31297068; DOI: 10.3389/fphys.2019.00817;
Slater PG, Cammarata GM, Samuelson AG, Magee A, Hu Y, Lowery LA. XMAP215 promotes microtubule-F-actin interactions to regulate growth cone microtubules during axon guidance in Xenopuslaevis. J Cell Sci. 2019 04 30; 132(9). PMID: 30890650; DOI: 10.1242/jcs.224311;
Mills A, Bearce E, Cella R, Kim SW, Selig M, Lee S, Lowery LA. Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis. Front Physiol. 2019; 10:431. PMID: 31031646; DOI: 10.3389/fphys.2019.00431;
Slater PG, Cammarata GM, Monahan C, Bowers JT, Yan O, Lee S, Lowery LA. Characterization of Xenopus laevis guanine deaminase reveals new insights for its expression and function in the embryonic kidney. Dev Dyn. 2019 04; 248(4):296-305. PMID: 30682232; DOI: 10.1002/dvdy.14;
Lasser M, Tiber J, Lowery LA. The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders. Front Cell Neurosci. 2018; 12:165. PMID: 29962938; DOI: 10.3389/fncel.2018.00165;
Erdogan B, Cammarata GM, Lee EJ, Pratt BC, Francl AF, Rutherford EL, Lowery LA. The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development. Neural Dev. 2017 Feb 15; 12(1):3. PMID: 28202041; DOI: 10.1186/s13064-017-0080-7;
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Available to Mentor as: (Review Mentor Role Definitions)
Mentoring is one of the most important and influential roles that I have as a professor, and it is an endeavor that I highly value. In addition to providing intensive mentoring for personnel in my lab, I am also available for mentoring in areas such as being a woman in science, balancing academia and family life, and teaching.
Research in my lab is extremely collaborative, with everyone being expected to work together and promote each other's success as a team, even when working on individual research projects. This collaborative focus has been very successful for my lab, and the majority of my lab members have been co-authors on publications from their research. Since my lab began in 2014, I have mentored two postdoctoral fellows, four PhD graduate students, and over forty undergraduate students. My trainees have received numerous talk and poster presentation awards at conferences. My undergraduate students have gone on to top medical and graduate schools in the country (MIT, Columbia, UCLA, University of Pittsburgh, and many more). Thus far, two of my PhD students have graduated, and they are currently doing postdoctoral research at Harvard University and University of Oregon.
In the past, I have obtained both governmental and foundation grants for training undergraduate students (from NSF and Beckman Foundation). I have been on many thesis defense committees in the Boston area. I have also been an invited speaker at many university leadership events and conferences.
Mentoring has been and will continue to be a major focus of my life and career mission. In 2016, several lab members made a video to highlight my focus on mentoring in my lab: https://vimeo.com/194616402
Co-Mentor or Peer Mentor
Research / Scholarly Mentor
Work / Life Integration Mentor