Lan Zhou, MD; PhD
Professor
Boston University School of Medicine
Dept of Neurology

MD, Shanghai Medical University
PhD, University of Cincinnati College of Medicine




Dr. Zhou is a physician scientist. She is a neurologist, a neuromuscular pathologist, and a muscle research scientist.

Dr. Zhou received an MD degree from Shanghai Medical University (now Fudan University Medical School) in 1989 and a PhD degree in developmental biology from the University of Cincinnati in 1995. She completed her neurology residency at the Wayne State University in 2002 and neuromuscular medicine fellowship at the Johns Hopkins University in 2003. She became a staff neurologist at the Cleveland Clinic in 2003, an associate professor of neurology and pathology at the Icahn School of Medicine at Mount Sinai in 2012, and a professor of neurology and pathology at the University of Texas Southwestern Medical Center in 2017. She joined Boston University Medical Center in 2019 and became a professor of neurology and pathology in the Departments of Neurology and Pathology, and Vice Chair for research in the Department of Neurology.

Dr. Zhou is a renowned neuromuscular specialist. She treats patients with neuromuscular diseases, performs muscle, nerve, and skin biopsies, and interprets biopsies. She has mentored many fellows, residents, and medical students to conduct clinical and basic research. Her clinical research interest in in neuromuscular diseases, such as myopathies and small fiber neuropathy. Her basic research that has been continuously funded by NIH for over 13 years focuses on the molecular and cellular mechanisms underlying muscle inflammation and fibrosis associated with muscular dystrophy and acute skeletal muscle injury repair. Her research team has published extensively in the biomedical journals. She has given many invited talks and lectures nationally and internationally. Her clinical research goal is to improve the diagnosis and management of neuromuscular diseases. Her basic research goal is to develop novel pharmacotherapies to modify inflammation, reduce fibrosis, promote regeneration, and improve muscle function and muscular dystrophy phenotype.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2013 Icahn School of Medicine at Mount Sinai Department of Neurology: Outstanding Teaching Award
2007 American Society of Clinical Investigation/Association of American Physicians: Travel Award
2001-2002 Wayne State University Department of Neurology: Chief Resident
1995 University of Cincinnati College of Medicine: Honorable Mentioning, Fifteenth Annual Graduate Student Research Forum
1994 The Albert J. Ryan Foundation: Albert J. Ryan Fellowship


Origins and Functions of Intramuscular Macrophages in Duchenne Muscular Dystrophy
08/05/2019 - 06/30/2024 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
1R01AR074428-01A1



Title


Yr Title Project-Sub Proj Pubs
2020 Origins and Functions of Intramuscular Macrophages in Duchenne Muscular Dystrophy 5R01AR074428-02
2019 Origins and Functions of Intramuscular Macrophages in Duchenne Muscular Dystrophy 1R01AR074428-01A1
2015 Targeting fibrocytes in Duchenne muscular dystrophy 5R01AR059702-06 5
2014 Targeting fibrocytes in Duchenne muscular dystrophy 5R01AR059702-05 5
2013 Targeting fibrocytes in Duchenne muscular dystrophy 5R01AR059702-04 5
2012 Targeting fibrocytes in Duchenne muscular dystrophy 5R01AR059702-03 5
2011 Targeting fibrocytes in Duchenne muscular dystrophy 1R01AR059702-01A1 5
2011 Targeting fibrocytes in Duchenne muscular dystrophy 7R01AR059702-02 5
2010 Role of TGF-B1 in Duchenne Muscular Dystrophy 5K08NS049346-05 7
2009 Role of TGF-B1 in Duchenne Muscular Dystrophy 5K08NS049346-04 7
Showing 10 of 13 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Anand P, Slama MCC, Kaku M, Ong C, Cervantes-Arslanian AM, Zhou L, David WS, Guidon AC. Comment on COVID-19 in patients with myasthenia gravis: Author response. Muscle Nerve. 2020 Sep 16.View Related Profiles. PMID: 32954519
     
  2. Wang X, Sathe AA, Smith GR, Ruf-Zamojski F, Nair V, Lavine KJ, Xing C, Sealfon SC, Zhou L. Heterogeneous origins and functions of mouse skeletal muscle-resident macrophages. Proc Natl Acad Sci U S A. 2020 08 25; 117(34):20729-20740. PMID: 32796104
     
  3. Anand P, Slama MCC, Kaku M, Ong C, Cervantes-Arslanian AM, Zhou L, David WS, Guidon AC. COVID-19 in patients with myasthenia gravis. Muscle Nerve. 2020 08; 62(2):254-258.View Related Profiles. PMID: 32392389
     
  4. Rubenstein AB, Smith GR, Raue U, Begue G, Minchev K, Ruf-Zamojski F, Nair VD, Wang X, Zhou L, Zaslavsky E, Trappe TA, Trappe S, Sealfon SC. Single-cell transcriptional profiles in human skeletal muscle. Sci Rep. 2020 01 14; 10(1):229. PMID: 31937892; DOI: 10.1038/s41598-019-57110-6;
     
  5. Zhou L, Burns DK, Cai C. A Case-Based Guide to Neuromuscular Pathology. Springer. 2020.
  6. Zhou L. Small Fiber Neuropathy. Semin Neurol. 2019 10; 39(5):570-577. PMID: 31639840
     
  7. Jin P, Cheng L, Chen M, Zhou L. Low Sensitivity of Skin Biopsy in Diagnosing Small Fiber Neuropathy in Chinese Americans. J Clin Neuromuscul Dis. 2018 Sep; 20(1):1-6. PMID: 30124554; DOI: 10.1097/CND.0000000000000223;
     
  8. Castoro R, Simmons M, Ravi V, Huang D, Lee C, Sergent J, Zhou L, Li J. SCN11A Arg225Cys mutation causes nociceptive pain without detectable peripheral nerve pathology. Neurol Genet. 2018 Aug; 4(4):e255. PMID: 30046661; DOI: 10.1212/NXG.0000000000000255;
     
  9. Zhao W, Wang X, Sun KH, Zhou L. a-smooth muscle actin is not a marker of fibrogenic cell activity in skeletal muscle fibrosis. PLoS One. 2018; 13(1):e0191031.View Related Profiles. PMID: 29320561; DOI: 10.1371/journal.pone.0191031;
     
  10. Wang X, Zhao W, Ransohoff RM, Zhou L. Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair. J Neuroimmunol. 2018 04 15; 317:55-66.View Related Profiles. PMID: 29325905; DOI: 10.1016/j.jneuroim.2018.01.004;
     
Showing 10 of 57 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 57 publications over 22 distinct years, with a maximum of 7 publications in 2011

YearPublications
19941
19951
19964
19971
20022
20031
20043
20052
20073
20082
20093
20102
20117
20124
20131
20142
20153
20163
20172
20184
20191
20205

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Skeletal Muscle
Inflammation
Fibrosis
Regeneration
Muscular Dystrophy
muscle injury repair

Available to Mentor as: (Review Mentor Role Definitions):
  • Career Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')
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