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PhD, Ludwig-Maximilians-Universität München

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Research
Publications

BU Research
NIH RePORTER Research

Development of Tumor Stroma-Directed Therapies
05/01/2015 - 04/30/2019 (PI)
Department of Defense/Army Medical Research Acquisition Activity

Lysyl Oxidase Propeptide: Breast Cancer Inhibitor
04/12/2010 - 01/31/2016 (Subcontract PI)
NIH/National Cancer Institute NIH NCI
5R01CA143108-05

Development of Inhibitors Targeting p130Cas/BCAR1 Family Proteins
08/09/2010 - 02/08/2014 (PI)
Susan G. Komen for the Cure

Lysyl Oxidase Inhibition of Ras-Mediated Transformation
09/01/1999 - 04/30/2010 (Co-PI)
NIH/National Cancer Institute
5 R01 CA82742 10

Molecular and Transgenic Analysis of the Adapter Protein p130Cas/BCAR1 in Normal and Cancerous Mammary Gland
03/01/2006 - 12/31/2009 (Dept Sponsor)
Department of Defense/Army

The Role of p130Cas in Sporadic Breast Cancer
04/01/2005 - 09/30/2005 (Dept Sponsor)
American Foundation for Aging Research

Molecular Mechanisms in Kidney Function and Disease
02/01/2002 - 03/31/2004 (PI)
March of Dimes

Title

Yr	Title	Project-Sub Proj	Pubs
2009	Functional role of p130Cas/BCAR1 in breast cancer	5R01CA106468-05	10
2008	Functional role of p130Cas/BCAR1 in breast cancer	5R01CA106468-04	10
2007	Functional role of p130Cas/BCAR1 in breast cancer	5R01CA106468-03	10
2006	Functional role of p130Cas/BCAR1 in breast cancer	5R01CA106468-02	10
2005	Functional role of p130Cas/BCAR1 in breast cancer	1R01CA106468-01A1	10

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

de la Cueva A, Emmerling M, Lim SL, Yang S, Trackman PC, Sonenshein GE, Kirsch KH. A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer. Carcinogenesis. 2018 07 03; 39(7):921-930.View Related Profiles.

Kirsch, Kathrin
Trackman, Philip
Yang, Shi

PMID: 29579155; PMCID: PMC6692853; DOI: 10.1093/carcin/bgy045;

Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. J Cell Biochem. 2017 Aug; 118(8):2347-2356.View Related Profiles.

Kirsch, Kathrin
Trackman, Philip

PMID: 28106301; DOI: 10.1002/jcb.25893;

Kumbrink J, de la Cueva A, Soni S, Sailer N, Kirsch KH. A truncated phosphorylated p130Cas substrate domain is sufficient to drive breast cancer growth and metastasis formation in vivo. Tumour Biol. 2016 Aug; 37(8):10665-73.View Related Profiles.

Kumbrink, Joerg
Kirsch, Kathrin

PMID: 26867768; DOI: 10.1007/s13277-016-4902-8;

Rouka E, Simister PC, Janning M, Kumbrink J, Konstantinou T, Muniz JR, Joshi D, O'Reilly N, Volkmer R, Ritter B, Knapp S, von Delft F, Kirsch KH, Feller SM. Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3). J Biol Chem. 2015 Oct 16; 290(42):25275-92.View Related Profiles.

Ritter, Brigitte
Kumbrink, Joerg
Kirsch, Kathrin

PMID: 26296892; PMCID: PMC4646179; DOI: 10.1074/jbc.M115.637207;

Kumbrink J, Soni S, Laumbacher B, Loesch B, Kirsch KH. Identification of Novel Crk-associated Substrate (p130Cas) Variants with Functionally Distinct Focal Adhesion Kinase Binding Activities. J Biol Chem. 2015 May 8; 290(19):12247-55.View Related Profiles.

Kumbrink, Joerg
Kirsch, Kathrin

PMID: 25805500; PMCID: PMC4424356; DOI: 10.1074/jbc.M115.649947;

Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE. Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. PLoS One. 2013; 8(10):e77288.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip

PMID: 24167568; PMCID: PMC3805583; DOI: 10.1371/journal.pone.0077288;

Chen CH, Ho YC, Ho HH, Chang IC, Kirsch KH, Chuang YJ, Layne MD, Yet SF. Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration. Cardiovasc Res. 2013 Dec 1; 100(3):461-71.View Related Profiles.

Kirsch, Kathrin
Layne, Matthew

PMID: 23975851; PMCID: PMC3826702; DOI: 10.1093/cvr/cvt207;

Chakrabarti P, Kim JY, Singh M, Shin YK, Kim J, Kumbrink J, Wu Y, Lee MJ, Kirsch KH, Fried SK, Kandror KV. Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway. Mol Cell Biol. 2013 Sep; 33(18):3659-66.View Related Profiles.

Kumbrink, Joerg
Kirsch, Kathrin
Kandror, Konstantin
Chakrabarti, Partha
Fried, Susan
Wu, Yuanyuan

PMID: 23858058; PMCID: PMC3753874; DOI: 10.1128/MCB.01584-12;

Zhao Y, Kumbrink J, Lin BT, Bouton AH, Yang S, Toselli PA, Kirsch KH. Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression. Carcinogenesis. 2013 Dec; 34(12):2880-90.View Related Profiles.

Kumbrink, Joerg
Kirsch, Kathrin
Toselli, Paul
Yang, Shi
Zhao, Yingshe

PMID: 23825155; PMCID: PMC3845889; DOI: 10.1093/carcin/bgt238;

Kumbrink J, Kirsch KH. p130Cas acts as survival factor during PMA-induced apoptosis in HL-60 promyelocytic leukemia cells. Int J Biochem Cell Biol. 2013 Mar; 45(3):531-5.View Related Profiles.

Kumbrink, Joerg
Kirsch, Kathrin

PMID: 23287717; PMCID: PMC3891586; DOI: 10.1016/j.biocel.2012.12.017;

Showing 10 of 40 results. Show More

Yu Z, Sato S, Trackman PC, Kirsch KH, Sonenshein GE. Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide. PLoS One. 2012; 7(3):e33287.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip

PMID: 22438909; PMCID: PMC3305320; DOI: 10.1371/journal.pone.0033287;

Bais MV, Nugent MA, Stephens DN, Sume SS, Kirsch KH, Sonenshein GE, Trackman PC. Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts. PLoS One. 2012; 7(2):e31188.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Bais, Manish
Nugent, Matthew
Trackman, Philip
Sume, Siddika

PMID: 22363577; PMCID: PMC3280126; DOI: 10.1371/journal.pone.0031188;

Kumbrink J, Kirsch KH. Regulation of p130(Cas)/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2. Neoplasia. 2012 Feb; 14(2):108-20.View Related Profiles.

Kumbrink, Joerg
Kirsch, Kathrin

PMID: 22431919; PMCID: PMC3306256; DOI: 10.1593/neo.111760;

Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits ß-catenin transcriptional activity in lung cancer cells. Mol Cell Biol. 2011 Aug; 31(16):3286-97.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip

PMID: 21690299; PMCID: PMC3147807; DOI: 10.1128/MCB.01426-10;

Sato S, Trackman PC, Mäki JM, Myllyharju J, Kirsch KH, Sonenshein GE. The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Mol Cell Biol. 2011 Jul; 31(13):2683-95.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip

PMID: 21536655; PMCID: PMC3133379; DOI: 10.1128/MCB.01148-10;

Min C, Zhao Y, Romagnoli M, Trackman PC, Sonenshein GE, Kirsch KH. Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis. J Cell Biochem. 2010 Dec 1; 111(5):1160-8.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip
Zhao, Yingshe

PMID: 20717927; PMCID: PMC3907072; DOI: 10.1002/jcb.22828;

Kumbrink J, Kirsch KH, Johnson JP. EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin. J Cell Biochem. 2010 Sep 1; 111(1):207-17.View Related Profiles.

Kumbrink, Joerg
Kirsch, Kathrin

PMID: 20506119; PMCID: PMC2930072; DOI: 10.1002/jcb.22690;

Vora SR, Guo Y, Stephens DN, Salih E, Vu ED, Kirsch KH, Sonenshein GE, Trackman PC. Characterization of recombinant lysyl oxidase propeptide. Biochemistry. 2010 Apr 6; 49(13):2962-72.View Related Profiles.

Salih, Erdjan
Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip

PMID: 20192271; PMCID: PMC2847845; DOI: 10.1021/bi902218p;

Min C, Yu Z, Kirsch KH, Zhao Y, Vora SR, Trackman PC, Spicer DB, Rosenberg L, Palmer JR, Sonenshein GE. A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer. Cancer Res. 2009 Aug 15; 69(16):6685-93.View Related Profiles.

Sonenshein, Gail
Palmer, Julie
Kirsch, Kathrin
Rosenberg, Lynn
Trackman, Philip
Zhao, Yingshe

PMID: 19654310; PMCID: PMC2729564; DOI: 10.1158/0008-5472.CAN-08-4818;

Palamakumbura AH, Vora SR, Nugent MA, Kirsch KH, Sonenshein GE, Trackman PC. Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling. Oncogene. 2009 Sep 24; 28(38):3390-400.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Nugent, Matthew
Trackman, Philip

PMID: 19597471; PMCID: PMC2753565; DOI: 10.1038/onc.2009.203;

Soni S, Lin BT, August A, Nicholson RI, Kirsch KH. Expression of a phosphorylated p130(Cas) substrate domain attenuates the phosphatidylinositol 3-kinase/Akt survival pathway in tamoxifen resistant breast cancer cells. J Cell Biochem. 2009 May 15; 107(2):364-75. PMID: 19330798; PMCID: PMC2743319; DOI: 10.1002/jcb.22136;

Zhao Y, Min C, Vora SR, Trackman PC, Sonenshein GE, Kirsch KH. The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells. J Biol Chem. 2009 Jan 16; 284(3):1385-93.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip
Zhao, Yingshe

PMID: 19029090; PMCID: PMC2615524; DOI: 10.1074/jbc.M802612200;

Gaidos G, Soni S, Oswald DJ, Toselli PA, Kirsch KH. Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation. J Cell Sci. 2007 Jul 15; 120(Pt 14):2366-77.View Related Profiles.

Kirsch, Kathrin
Toselli, Paul

PMID: 17606992

Wu M, Min C, Wang X, Yu Z, Kirsch KH, Trackman PC, Sonenshein GE. Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells. Cancer Res. 2007 Jul 1; 67(13):6278-85.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip

PMID: 17616686

Wang X, Belguise K, Kersual N, Kirsch KH, Mineva ND, Galtier F, Chalbos D, Sonenshein GE. Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol. 2007 Apr; 9(4):470-8.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin

PMID: 17369819; PMCID: PMC2394707

Min C, Kirsch KH, Zhao Y, Jeay S, Palamakumbura AH, Trackman PC, Sonenshein GE. The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer. Cancer Res. 2007 Feb 1; 67(3):1105-12.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip
Zhao, Yingshe

PMID: 17283144

Reichlin A, Gazumyan A, Nagaoka H, Kirsch KH, Kraus M, Rajewsky K, Nussenzweig MC. A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells. J Exp Med. 2004 Mar 15; 199(6):855-65. PMID: 15024049; PMCID: PMC2212724

Kirsch K, Kensinger M, Hanafusa H, August A. A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling. BMC Cell Biol. 2002 Jul 15; 3:18. PMID: 12119061; PMCID: PMC117778

Zvara A, Fajardo JE, Escalante M, Cotton G, Muir T, Kirsch KH, Birge RB. Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II. Oncogene. 2001 Feb 22; 20(8):951-61. PMID: 11314030

Georgescu MM, Kirsch KH, Kaloudis P, Yang H, Pavletich NP, Hanafusa H. Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res. 2000 Dec 15; 60(24):7033-8. PMID: 11156408

Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H. The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J Biol Chem. 2001 Feb 16; 276(7):4957-63. PMID: 11067845

Georgescu MM, Kirsch KH, Akagi T, Shishido T, Hanafusa H. The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10182-7. PMID: 10468583; PMCID: PMC17863

Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H. CMS: an adapter molecule involved in cytoskeletal rearrangements. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6211-6. PMID: 10339567; PMCID: PMC26861

Georgescu MM, Kirsch KH, Shishido T, Zong C, Hanafusa H. Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB. Mol Cell Biol. 1999 Feb; 19(2):1171-81. PMID: 9891051; PMCID: PMC116046

Kirsch KH, Georgescu MM, Hanafusa H. Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G. J Biol Chem. 1998 Oct 2; 273(40):25673-9. PMID: 9748234

Schwarz MJ, Müller N, Körschenhausen D, Kirsch KH, Penning R, Ackenheil M, Johnson JP, Hampel H. Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator mader in normal human CNS. Neuroimmunomodulation. 1998 Sep-Oct; 5(5):270-6. PMID: 9730695

Kirsch KH, Korradi Y, Johnson JP. Mader: a novel nuclear protein over expressed in human melanomas. Oncogene. 1996 Mar 7; 12(5):963-71. PMID: 8649813

Sers C, Kirsch K, Rothbächer U, Riethmüller G, Johnson JP. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8514-8. PMID: 8378324; PMCID: PMC47387

Elendt D, Kirsch K, Malberg K. Clq, the first component of complement, binds to activated human platelets. Platelets. 1991; 2(1):51-2. PMID: 21043962; DOI: 10.3109/09537109109005503;

Wersuhn G, Kirsch K, Gienapp R. Herbicide tolerant regenerates of potato. Theor Appl Genet. 1987 Aug; 74(4):480-2. PMID: 24241804; DOI: 10.1007/BF00289825;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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