Kathleen Morgan, PhD
Professor
Boston University College of Health & Rehabilitation Sciences: Sargent College
Dept of Health Sciences

PhD, University of Cincinnati




Scholarly interests include: the interactions between signaling proteins and cytoskeletal proteins; the differentiated smooth muscle cell; mechanisms of trafficking of signaling molecules; stroke, hypertension, vascular dementia and pre-term labor.

The Morgan lab works on the intersection of signaling pathways with the cytoskeleton of the contractile vascular smooth muscle cell. We have demonstrated that the nonmuscle cortical cytoskeleton and the adhesion plaques attached to it undergo dynamic rearrangements during stimulus-induced alterations in vascular tone and that this is one factor that regulates vascular contractility and compliance.

Recently we have become especially interested in the possible role of the vascular cytoskeleton, and its connection to matrix proteins through integrins, in the determination of known aging-associated increases aortic stiffness. Aging-associated aortic stiffness is known to be an independent and early predictor for adverse cardiovascular outcomes. We are currently testing the idea that cytoskeletal protein interactions may offer novel therapeutic targets for the regulation of aortic stiffness, and, as a consequence, vascular dementia.

As a result of the fact that fully differentiated vascular smooth muscle cells are not readily transfectable we have developed a number of special techniques/reagents that may be of use to others. For example, we have designed and used a number of dominant negative, cell permeant, peptide constructs and we have developed morpholino approaches to knocking down smooth muscle proteins in organ culture.

Member
Boston University
Whitaker Cardiovascular Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Director
Boston University College of Health & Rehabilitation Sciences: Sargent College
Cytoskeleton & Signaling Lab


Dean ad interim (previously held: 6/2013 – 8/2014)
Boston University College of Health & Rehabilitation Sciences: Sargent College


Chair (previously held: 10/2006 - 8/2015)
Boston University College of Health & Rehabilitation Sciences: Sargent College
Health Sciences


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2006-2011 The University of Manchester: Honorary Faculty Fellow, Faculty of Medical and Human Sciences
1998 Cardiovascular Section of the American Physiological Society: Fellow
1992-1993 Wellcome Visiting Professor in the Basic Medical Sciences
1984-1989 American Heart Association : Established Investigator
1975-1976 Ryan Fellow


Role of Smooth Muscle Calponin in Vascular Pathoglology/URF AWD 00002824
12/15/2018 - 10/31/2022 (Subcontract PI)
University of Rochester NIH NHLBI
1R01HL136224-01A1

Actin and focal adhesion remodeling as therapeutic targets in cardiovascular disease
09/01/2017 - 05/31/2022 (PI)
NIH/National Institute on Aging
5R01AG053274-04

The Role of the Cytoskeleton in Vascular Aging
09/01/2015 - 10/31/2017 (PI)
NIH/National Institute on Aging
5R21AG050599-02

Actin and focal adhesion remodeling as therapeutic targets in cardiovascular disease
09/15/2016 - 08/31/2017 (PI)
NIH/National Institute on Aging
1R56AG053274-01

DYNAMICS OF THE VASCULAR SMOOTH MUSCLE CYTOSKELETON
07/01/2007 - 06/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5P01HL086655-05



Title


Yr Title Project-Sub Proj Pubs
2020 Actin and focal adhesion remodeling as therapeutic targets in cardiovascular disease 5R01AG053274-04
2019 Actin and focal adhesion remodeling as therapeutic targets in cardiovascular disease 3R01AG053274-03S1
2019 Actin and focal adhesion remodeling as therapeutic targets in cardiovascular disease 5R01AG053274-03
2018 Actin and focal adhesion remodeling as therapeutic targets in cardiovascular disease 5R01AG053274-02
2017 Actin and focal adhesion remodeling as therapeutic targets in cardiovascular disease 1R01AG053274-01A1
2016 Actin and focal adhesion remodeling as therapeutic targets in cardiovascular disease 1R56AG053274-01
2016 The Role of the Cytoskeleton in Vascular Aging 5R21AG050599-02
2015 The Role of the Cytoskeleton in Vascular Aging 1R21AG050599-01
2011 Dynamics of the Vascular Smooth Muscle Cytoskeleton 5P01HL086655-05 69
2011 Plasticity of the Vascular Smooth Muscle Cytoskeleton 5P01HL086655-05-1 69
Showing 10 of 66 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Taylor EN, Huang N, Wisco J, Wang Y, Morgan KG, Hamilton JA. The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds. J Transl Med. 2020 07 08; 18(1):277.View Related Profiles. PMID: 32641073
     
  2. Nicholson CJ, Singh K, Saphirstein RJ, Gao YZ, Li Q, Chiu JG, Leavis P, Verwoert GC, Mitchell GF, Porter T, Morgan KG. Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces. J Am Heart Assoc. 2018 07 18; 7(15).View Related Profiles. PMID: 30021807
     
  3. Vetterkind S, Lin QQ, Morgan KG. A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1. Sci Rep. 2017 08 24; 7(1):9302. PMID: 28839270
     
  4. Nicholson CJ, Seta F, Lee S, Morgan KG. MicroRNA-203 mimics age-related aortic smooth muscle dysfunction of cytoskeletal pathways. J Cell Mol Med. 2017 Jan; 21(1):81-95.View Related Profiles. PMID: 27502584; DOI: 10.1111/jcmm.12940;
     
  5. Brozovich FV, Nicholson CJ, Degen CV, Gao YZ, Aggarwal M, Morgan KG. Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders. Pharmacol Rev. 2016 Apr; 68(2):476-532. PMID: 27037223; PMCID: PMC4819215; DOI: 10.1124/pr.115.010652;
     
  6. Fry JL, Shiraishi Y, Turcotte R, Yu X, Gao YZ, Akiki R, Bachschmid M, Zhang Y, Morgan KG, Cohen RA, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. J Am Heart Assoc. 2015 Sep; 4(9):e002384.View Related Profiles. PMID: 26376991; PMCID: PMC4599512; DOI: 10.1161/JAHA.115.002384;
     
  7. Saphirstein RJ, Gao YZ, Lin QQ, Morgan KG. Cortical actin regulation modulates vascular contractility and compliance in veins. J Physiol. 2015 Sep 1; 593(17):3929-41. PMID: 26096914; PMCID: PMC4575578; DOI: 10.1113/JP270845;
     
  8. Gao YZ, Saphirstein RJ, Yamin R, Suki B, Morgan KG. Aging impairs smooth muscle-mediated regulation of aortic stiffness: a defect in shock absorption function? Am J Physiol Heart Circ Physiol. 2014 Oct 15; 307(8):H1252-61. PMID: 25128168; PMCID: PMC4200340; DOI: 10.1152/ajpheart.00392.2014;
     
  9. Saphirstein RJ, Morgan KG. The contribution of vascular smooth muscle to aortic stiffness across length scales. Microcirculation. 2014 Apr; 21(3):201-7. PMID: 24635219; DOI: 10.1111/micc.12101;
     
  10. Jensen MH, Morris EJ, Gallant CM, Morgan KG, Weitz DA, Moore JR. Mechanism of calponin stabilization of cross-linked actin networks. Biophys J. 2014 Feb 18; 106(4):793-800.View Related Profiles. PMID: 24559982; PMCID: PMC3944828; DOI: 10.1016/j.bpj.2013.12.042;
     
Showing 10 of 177 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 169 publications over 40 distinct years, with a maximum of 10 publications in 1991 and 1996

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Contact for Mentoring:

635 Commonwealth Ave
Boston MA 02215
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