Jose Rafael Romero, MD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

MD, Escuela Colombiana de Medicina



Dr. Romero completed residency training in neurology at Boston University Medical Campus and fellowship training in vascular neurology at Boston University Medical Campus. He received his medical degree from the Escuela Cololmbiana de Medicina in Colombia. He also completed studies for a Master in Epidemiology at Boston University School of Public Health.
Dr. Romero is an active investigator in the Framingham Heart Study since 2006.

Research Interests
Dr. Romero’s research interests center on the study of cerebrovascular disease in subclinical stages, prevention of stroke, cognitive impairment and dementia and use of neuroimaging in the epidemiological study of cerebrovascular disease. His focus is in the interplay of cerebrovascular disease with the neurodegenerative process, and contributions to clinical stroke and dementia. Much of his current work centers on the epidemiological study of brain MRI markers of cerebral small vessel disease, their determinants and clinical consequences. As a board-certified neurologist and vascular neurologist, his clinical interests are in the prevention, diagnosis, treatment and rehabilitation of patients with stroke, with particular emphasis in racial minority populations. He runs a stroke prevention clinic and is an active member in the Stroke Unit at Boston Medical Center. He is the site PI of several clinical trials for acute stroke treatment and secondary prevention. He has written widely on stroke, cerebrovascular disease in subclinical stages, and epidemiology of stroke and dementia. He has participated as study section reviewer in the NIH- and has obtained grant funding from NIH-NIA for his research support. Dr. Romero has presented the results of his research widely at national and international level and has been invited to participate in several international consortia of experts in cerebrovascular disease. Dr. Romero has contributed significantly to our understanding of cerebral microbleeds in the general population and is now leading the study of enlarged perivascular spaces in the Framingham Heart Study cohorts.

Investigator
Framingham Heart Study




Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences
08/01/2019 - 04/30/2024 (PI)
NIH/National Institute on Aging
5R01AG059725-05

Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and Dementia
08/15/2018 - 04/30/2023 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIA
5R01AG057709-05

Precursors of Stroke Incidence and Prognosis
12/01/2017 - 02/28/2023 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NINDS
5R01NS017950-37

Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults
12/01/2017 - 01/31/2021 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
7R01AG049607-05

Cerebral Microbleeds in Young Adults: Risk Factors, Biomarkers and Genetic Determinants
06/01/2015 - 05/31/2018 (PI)
NIH/National Institute on Aging
5R03AG048180-02

Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study
08/15/2011 - 05/31/2017 (PI)
NIH/National Institute on Aging
5K23AG038444-05

Investigation of lipoprotein phospholipase A2 (Lp-PLA2) and cerebral microbleeds (CMBs) in the Framingham Heart Study
11/01/2009 - 06/30/2011 (PI)
GlaxoSmithKline LLC



Comparison of Anti-coagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
04/01/2023 - 08/31/2026 (PI)
University of Cincinnati National Institute o
5U01NS117450-02

Sleep for Stroke Management and Recovery Trial (Sleep SMART)
08/15/2019 - 07/31/2024 (PI)
University of Cincinnati National Institute o
5U01NS099043-02

Multi-arm Optimization of Stroke Thrombolysis (MOST) Stroke Trial-NCC Admin
06/01/2018 - 04/30/2024 (PI)
University of Cincinnati National Institute o
1U01NS100699-01A1

New England Regional Coordinating Center for the NINDS Stroke Trials Network
08/01/2018 - 07/31/2023 (PI)
The General Hospital Corporation / MGH National Institute o
1U24NS107243-01

CV006004
08/24/2016 - 07/01/2019 (PI)
Bristol-Myers Squibb Company

POINT Study: Platelet-Oriented Inhibition in New TIA
02/01/2010 - 04/30/2019 (PI)
EMMES Corporation NIH-NINDS
2U01NS062835-06

Mild and Rapidly improving stroke symptoms 'MaRISS' Research Study No. NEA-31
04/01/2015 - 04/01/2019 (PI)
American Heart Association/AHA

New England Regional Coordinating Center for the NINDS Stroke Trials Network
09/30/2013 - 07/31/2018 (PI)
Mass General Hosp NIH-NINDS


Title


Yr Title Project-Sub Proj Pubs
2023 Longitudinal Risk Factor Changes and Early Recognition of Cerebral Small Vessel Disease 1R21NS135268-01
2023 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-05
2023 Precursors of Stroke Incidence and Prognosis 2R01NS017950-38A1
2022 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-04
2021 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-03 1
2020 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-02 1
2019 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 1R01AG059725-01A1 1
2016 Cerebral Microbleeds in Young Adults: risk factors, biomarkers and genetics 5R03AG048180-02 14
2015 Cerebral Microbleeds in Young Adults: risk factors, biomarkers and genetics 1R03AG048180-01A1 14
2015 Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study 5K23AG038444-05 23
Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Hannawi Y, Vaishnav A, Coskun EP, Gangadhara S, Romero JR. Covert Cerebral Small Vessel Disease: Ready for Clinical Prime Time. J Am Heart Assoc. 2023 Dec 19; 12(24):e029891. PMID: 38108239
     
  2. Liu M, Khasiyev F, Sariya S, Spagnolo-Allende A, Sanchez DL, Andrews H, Yang Q, Beiser A, Qiao Y, Thomas EA, Romero JR, Rundek T, Brickman AM, Manly JJ, Elkind MS, Seshadri S, Chen C, Hilal S, Wasserman BA, Tosto G, Fornage M, Gutierrez J. Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study. J Am Heart Assoc. 2023 Dec 05; 12(23):e030935.View Related Profiles. PMID: 38038215; PMCID: PMC10727334; DOI: 10.1161/JAHA.123.030935;
     
  3. Rodriguez Lara F, Toro AR, Pinheiro A, Demissie S, Ekenze O, Martinez O, Parva P, Charidimou A, Ghosh S, DeCarli C, Seshadri S, Habes M, Maillard P, Romero JR. Relation of MRI-Visible Perivascular Spaces and Other MRI Markers of Cerebral Small Vessel Disease. Brain Sci. 2023 Sep 14; 13(9).View Related Profiles. PMID: 37759924; PMCID: PMC10527297; DOI: 10.3390/brainsci13091323;
     
  4. Hingorani KS, Barnes E, Carneiro T, Sader E, Anand P, Ong CJ, Chung D, Daneshmand A, Suchdev K, Takahashi C, Greer D, Shulman JG, Aparicio HJ, Nguyen TN, Romero JR, AbdalKader M, Feske SK, Kimmel SD, Weinstein ZM, Fagan M, Dobrilovic N, Awtry E, Cervantes-Arslanian AM. Strokes in Patients With Injection Drug Use and Tricuspid Valve Endocarditis - A Case Series. Neurohospitalist. 2023 Jul; 13(3):272-277.View Related Profiles. PMID: 37441214; PMCID: PMC10334046; DOI: 10.1177/19418744231159460;
     
  5. Duperron MG, Knol MJ, Le Grand Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Trégouët DA, Romero JR, Frenzel S, Luciano M, Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bülow R, Carrera C, Chen C, Cheng CY, Deary IJ, Gampawar PG, Himali JJ, Jiang J, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Muñoz Maniega S, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Valdés Hernández MC, Vernooij MW, Völker U, Wittfeld K, Wong TY, Wright MJ, Zhang J, Zhao W, Zhu YC, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Lathrop M, Paus T, Fernandez-Cadenas I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease. Nat Med. 2023 Apr; 29(4):950-962.View Related Profiles. PMID: 37069360; PMCID: PMC10115645; DOI: 10.1038/s41591-023-02268-w;
     
  6. Charisis S, Rashid T, Liu H, Ware JB, Jensen PN, Austin TR, Li K, Fadaee E, Hilal S, Chen C, Hughes TM, Romero JR, Toledo JB, Longstreth WT, Hohman TJ, Nasrallah I, Bryan RN, Launer LJ, Davatzikos C, Seshadri S, Heckbert SR, Habes M. Assessment of Risk Factors and Clinical Importance of Enlarged Perivascular Spaces by Whole-Brain Investigation in the Multi-Ethnic Study of Atherosclerosis. JAMA Netw Open. 2023 Apr 03; 6(4):e239196.View Related Profiles. PMID: 37093602; PMCID: PMC10126873; DOI: 10.1001/jamanetworkopen.2023.9196;
     
  7. Rashid T, Liu H, Ware JB, Li K, Romero JR, Fadaee E, Nasrallah IM, Hilal S, Bryan RN, Hughes TM, Davatzikos C, Launer L, Seshadri S, Heckbert SR, Habes M. Deep Learning Based Detection of Enlarged Perivascular Spaces on Brain MRI. Neuroimage Rep. 2023 Mar; 3(1).View Related Profiles. PMID: 37035520; PMCID: PMC10078801; DOI: 10.1016/j.ynirp.2023.100162;
     
  8. Ekenze O, Pinheiro A, Demissie S, Charidimou A, Beiser AS, Vasan RS, Benjamin EJ, DeCarli C, Seshadri S, Romero JR. Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study. Neurobiol Aging. 2023 Jul; 127:12-22.View Related Profiles. PMID: 37018882; PMCID: PMC10198814; DOI: 10.1016/j.neurobiolaging.2023.03.001;
     
  9. Marini S, Chung J, Han X, Sun X, Parodi L, Farrer LA, Rosand J, Romero JR, Anderson CD. Pleiotropy analysis between lobar intracerebral hemorrhage and CSF ß-amyloid highlights new and established associations. Int J Stroke. 2023 Aug; 18(7):804-811.View Related Profiles. PMID: 36705426
     
  10. Liu M, Khasiyev F, Sariya S, Spagnolo-Allende A, Sanchez DL, Andrews H, Yang Q, Beiser A, Qiao Y, Thomas EA, Romero JR, Rundek T, Brickman A, Manly JJ, Elkind MS, Seshadri S, Chen C, Sacco RL, Hilal S, Wasserman BA, Tosto G, Fornage M, Gutierrez J. Chromosome 10q24.32 Variants Associate with Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study. medRxiv. 2023 Feb 01.View Related Profiles. PMID: 36778463; PMCID: PMC9915818; DOI: 10.1101/2023.01.31.23285251;
     
Showing 10 of 88 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 88 publications over 21 distinct years, with a maximum of 12 publications in 2023

YearPublications
20024
20041
20051
20061
20072
20082
20095
20102
20115
20122
20133
20143
20154
20164
20176
20184
20197
202010
20215
20225
202312

2010-2010 Department of Neurology: resident teaching
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75 E. Newton St Collamore Building
Boston MA 02118
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