Jose Rafael Romero, MD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

MD, Escuela Colombiana de Medicina



Dr. Romero completed residency training in neurology at Boston University Medical Campus and fellowship training in vascular neurology at Boston University Medical Campus. He received his medical degree from the Escuela Cololmbiana de Medicina in Colombia. He also completed studies for a Master in Epidemiology at Boston University School of Public Health.
Dr. Romero is an active investigator in the Framingham Heart Study since 2006.

Research Interests
Dr. Romero’s research interests center on the study of cerebrovascular disease in subclinical stages, prevention of stroke, cognitive impairment and dementia and use of neuroimaging in the epidemiological study of cerebrovascular disease. His focus is in the interplay of cerebrovascular disease with the neurodegenerative process, and contributions to clinical stroke and dementia. Much of his current work centers on the epidemiological study of brain MRI markers of cerebral small vessel disease, their determinants and clinical consequences. As a board-certified neurologist and vascular neurologist, his clinical interests are in the prevention, diagnosis, treatment and rehabilitation of patients with stroke, with particular emphasis in racial minority populations. He runs a stroke prevention clinic and is an active member in the Stroke Unit at Boston Medical Center. He is the site PI of several clinical trials for acute stroke treatment and secondary prevention. He has written widely on stroke, cerebrovascular disease in subclinical stages, and epidemiology of stroke and dementia. He has participated as study section reviewer in the NIH- and has obtained grant funding from NIH-NIA for his research support. Dr. Romero has presented the results of his research widely at national and international level and has been invited to participate in several international consortia of experts in cerebrovascular disease. Dr. Romero has contributed significantly to our understanding of cerebral microbleeds in the general population and is now leading the study of enlarged perivascular spaces in the Framingham Heart Study cohorts.

Investigator
Framingham Heart Study




Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences
08/01/2019 - 04/30/2024 (PI)
NIH/National Institute on Aging
5R01AG059725-04

Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and Dementia
08/15/2018 - 04/30/2023 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIA
5R01AG057709-05

Precursors of Stroke Incidence and Prognosis
12/01/2017 - 02/28/2023 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NINDS
5R01NS017950-37

Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults
12/01/2017 - 01/31/2021 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
7R01AG049607-05

Cerebral Microbleeds in Young Adults: Risk Factors, Biomarkers and Genetic Determinants
06/01/2015 - 05/31/2018 (PI)
NIH/National Institute on Aging
5R03AG048180-02

Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study
08/15/2011 - 05/31/2017 (PI)
NIH/National Institute on Aging
5K23AG038444-05

Investigation of lipoprotein phospholipase A2 (Lp-PLA2) and cerebral microbleeds (CMBs) in the Framingham Heart Study
11/01/2009 - 06/30/2011 (PI)
GlaxoSmithKline LLC



Sleep for Stroke Management and Recovery Trial (Sleep SMART)
08/15/2018 - 07/31/2024 (PI)
Univ of Cincinnati NIH-NINDS

Multi-arm Optimization of Stroke Thrombolysis (MOST) Stroke Trial-NCC Admin
06/01/2018 - 04/30/2024 (PI)
Univ of Cincinnati NIH-NINDS
1U01NS100699-01A1

New England Regional Coordinating Center for the NINDS Strok
08/01/2018 - 07/31/2023 (PI)
The General Hospital Corporation / MGH National Institute o
5U24NS107243-04

NIH StrokeNet Clinical Coordinating Center Master Trial Agreement (MTA) - Satellites
09/30/2013 - 05/31/2020 (PI)
Univ of Cincinnati NIH-NINDS

CV006004
08/24/2016 - 07/01/2019 (PI)
Bristol-Myers

POINT Study: Platelet-Oriented Inhibition in New TIA
02/01/2010 - 04/30/2019 (PI)
EMMES Corporation NIH-NINDS
2U01NS062835-06

Mild and Rapidly Improving Stroke Symptoms 'MaRISS' Research Study No. NEA-31
04/01/2015 - 04/01/2019 (PI)
American Heart Assoc

New England Regional Coordinating Center for the NINDS Stroke Trials Network
09/30/2013 - 07/31/2018 (PI)
Mass General Hosp NIH-NINDS


Title


Yr Title Project-Sub Proj Pubs
2023 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-05
2023 Precursors of Stroke Incidence and Prognosis 2R01NS017950-38A1
2022 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-04
2021 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-03 1
2020 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-02 1
2019 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 1R01AG059725-01A1 1
2016 Cerebral Microbleeds in Young Adults: risk factors, biomarkers and genetics 5R03AG048180-02 14
2015 Cerebral Microbleeds in Young Adults: risk factors, biomarkers and genetics 1R03AG048180-01A1 14
2015 Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study 5K23AG038444-05 23
2014 Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study 5K23AG038444-04 23
Showing 10 of 13 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Hingorani KS, Barnes E, Carneiro T, Sader E, Anand P, Ong CJ, Chung D, Daneshmand A, Suchdev K, Takahashi C, Greer D, Shulman JG, Aparicio HJ, Nguyen TN, Romero JR, AbdalKader M, Feske SK, Kimmel SD, Weinstein ZM, Fagan M, Dobrilovic N, Awtry E, Cervantes-Arslanian AM. Strokes in Patients With Injection Drug Use and Tricuspid Valve Endocarditis - A Case Series. Neurohospitalist. 2023 Jul; 13(3):272-277.View Related Profiles. PMID: 37441214; PMCID: PMC10334046; DOI: 10.1177/19418744231159460;
     
  2. Duperron MG, Knol MJ, Le Grand Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Trégouët DA, Romero JR, Frenzel S, Luciano M, Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bülow R, Carrera C, Chen C, Cheng CY, Deary IJ, Gampawar PG, Himali JJ, Jiang J, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Muñoz Maniega S, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Valdés Hernández MC, Vernooij MW, Völker U, Wittfeld K, Wong TY, Wright MJ, Zhang J, Zhao W, Zhu YC, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Lathrop M, Paus T, Fernandez-Cadenas I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease. Nat Med. 2023 Apr; 29(4):950-962.View Related Profiles. PMID: 37069360; PMCID: PMC10115645; DOI: 10.1038/s41591-023-02268-w;
     
  3. Charisis S, Rashid T, Liu H, Ware JB, Jensen PN, Austin TR, Li K, Fadaee E, Hilal S, Chen C, Hughes TM, Romero JR, Toledo JB, Longstreth WT, Hohman TJ, Nasrallah I, Bryan RN, Launer LJ, Davatzikos C, Seshadri S, Heckbert SR, Habes M. Assessment of Risk Factors and Clinical Importance of Enlarged Perivascular Spaces by Whole-Brain Investigation in the Multi-Ethnic Study of Atherosclerosis. JAMA Netw Open. 2023 Apr 03; 6(4):e239196.View Related Profiles. PMID: 37093602; PMCID: PMC10126873; DOI: 10.1001/jamanetworkopen.2023.9196;
     
  4. Rashid T, Liu H, Ware JB, Li K, Romero JR, Fadaee E, Nasrallah IM, Hilal S, Bryan RN, Hughes TM, Davatzikos C, Launer L, Seshadri S, Heckbert SR, Habes M. Deep Learning Based Detection of Enlarged Perivascular Spaces on Brain MRI. Neuroimage Rep. 2023 Mar; 3(1).View Related Profiles. PMID: 37035520; PMCID: PMC10078801; DOI: 10.1016/j.ynirp.2023.100162;
     
  5. Ekenze O, Pinheiro A, Demissie S, Charidimou A, Beiser AS, Vasan RS, Benjamin EJ, DeCarli C, Seshadri S, Romero JR. Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study. Neurobiol Aging. 2023 Jul; 127:12-22.View Related Profiles. PMID: 37018882; PMCID: PMC10198814; DOI: 10.1016/j.neurobiolaging.2023.03.001;
     
  6. Marini S, Chung J, Han X, Sun X, Parodi L, Farrer LA, Rosand J, Romero JR, Anderson CD. Pleiotropy analysis between lobar intracerebral hemorrhage and CSF ß-amyloid highlights new and established associations. Int J Stroke. 2023 Aug; 18(7):804-811.View Related Profiles. PMID: 36705426
     
  7. Liu M, Khasiyev F, Sariya S, Spagnolo-Allende A, Sanchez DL, Andrews H, Yang Q, Beiser A, Qiao Y, Thomas EA, Romero JR, Rundek T, Brickman A, Manly JJ, Elkind MS, Seshadri S, Chen C, Sacco RL, Hilal S, Wasserman BA, Tosto G, Fornage M, Gutierrez J. Chromosome 10q24.32 Variants Associate with Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study. medRxiv. 2023 Feb 01.View Related Profiles. PMID: 36778463; PMCID: PMC9915818; DOI: 10.1101/2023.01.31.23285251;
     
  8. Nguyen TN, Qureshi MM, Klein P, Yamagami H, Mikulik R, Czlonkowska A, Abdalkader M, Sedova P, Sathya A, Lo HC, Mansour OY, Vanguru HR, Lesaine E, Tsivgoulis G, Loochtan AI, Demeestere J, Uchino K, Inoa V, Goyal N, Charidimou A, Siegler JE, Yaghi S, Aguiar de Sousa D, Mohammaden M, Haussen DC, Kristoffersen ES, Lereis VP, Scollo SD, Campbell BCV, Ma A, Thomas JO, Parsons MW, Singhal S, Slater LA, Martins RT, Enzinger C, Gattringer T, Rahman A, Bonnet T, Ligot N, De Raedt S, Lemmens R, Vanacker P, Vandervorst F, Conforto AB, Hidalgo RCT, de Oliveira Neves L, Martins RT, Mora Cuervo DL, Rebello LC, Santiago IB, Lameirinhas da Silva I, Sakelarova T, Kalpachki R, Alexiev F, Catanese L, Cora EA, Goyal M, Hill MD, Kelly ME, Khosravani H, Lavoie P, Peeling L, Pikula A, Rivera R, Chen HS, Chen Y, Huo X, Miao Z, Yang S, Bedekovic MR, Bralic M, Budincevic H, Corredor-Quintero AB, Lara-Sarabia OE, Cabal M, Tenora D, Fibrich P, Herzig R, Hlavácová H, Hrabanovska E, Hlinovsky D, Jurak L, Kadlcikova J, Karpowicz I, Klecka L, Kovar M, Lauer D, Neumann J, Palouskova H, Reiser M, Rekova P, Rohan V, Skoda O, Škorna M, Sobotková L, Sramek M, Zakova L, Christensen H, Drenck N, Iversen HK, Truelsen TC, Wienecke T, Sobh K, Ylikotila P, Alpay K, Strbian D, Bernady P, Casenave P, Dan M, Faucheux JM, Gentric JC, Magro E, Sabben C, Reiner P, Rouanet F, Bohmann FO, Boskamp S, Mbroh J, Nagel S, Nolte C, Ringleb PA, Rosenkranz M, Poli S, Thomalla G, Karapanayiotides T, Koutroulou I, Kargiotis O, Palaiodimou L, Barrientos Guerra JD, Huded V, Menon B, Nagendra S, Prajapati C, Sylaja PN, Krishna Pramana NA, Sani AF, Ghoreishi A, Farhoudi M, Hokmabadi ES, Raya TA, Kalmanovich SA, Ronen L, Sabetay SI, Acampa M, Adami A, Castellan L, Longoni M, Ornello R, Renieri L, Bigliani CR, Romoli M, Sacco S, Salmaggi A, Sangalli D, Zini A, Doijiri R, Fukuda H, Fujinaka T, Fujita K, Imamura H, Sakai N, Kanamaru T, Kimura N, Kono R, Miyake K, Sakaguchi M, Sakai K, Sonoda K, Todo K, Miyashita F, Tokuda N, Matsumaru Y, Matsumoto S, Ohara N, Shindo S, Takenobu Y, Yoshimoto T, Toyoda K, Uwatoko T, Yagita Y, Yamada T, Yamamoto N, Yamamoto R, Yazawa Y, Sugiura Y, Waweru PK, Baek JH, Lee SB, Seo KD, Sohn SI, Arsovska AA, Chan YC, Wan Zaidi WA, Jaafar AS, Gongora-Rivera F, Martinez-Marino M, Infante-Valenzuela A, Groppa S, Leahu P, Coutinho JM, Rinkel LA, Dippel DWJ, van Dam-Nolen DHK, Ranta A, Wu TY, Adebayo TT, Bello AH, Nwazor EO, Sunmonu TA, Wahab KW, Ronning OM, Sandset EC, Al Hashimi AM, Ahmad S, Rashid U, Rodriguez-Kadota L, Vences MÁ, Yalung PM, Hao Dy JS, Pineda-Franks MC, Co CO, Brola W, Debiec A, Dorobek M, Karlinski MA, Labuz-Roszak BM, Lasek-Bal A, Sienkiewicz-Jarosz H, Staszewski J, Sobolewski P, Wiacek M, Zielinska-Turek J, Araujo AP, Rocha M, Castro P, Cruz VT, Ferreira PV, Ferreira P, Nunes AP, Fonseca L, Marto JP, Pinho E Melo T, Rodrigues M, Silva ML, Dimitriade A, Falup-Pecurariu C, Hamid MA, Venketasubramanian N, Krastev G, Mako M, Ayo-Martin O, Hernández-Fernández F, Blasco J, Rodríguez-Vázquez A, Cruz-Culebras A, Moniche F, Montaner J, Perez-Sanchez S, García Sánchez MJ, Rodríguez MG, Jood K, Nordanstig A, Mazya MV, Moreira TTP, Bernava G, Beyeler M, Bolognese M, Carrera E, Dobrocky T, Karwacki GM, Keller E, Hsieh CY, Boonyakarnkul S, Churojana A, Aykac O, Ozdemir A, Bajrami A, Senadim S, Hussain SI, John S, Banerjee S, Kwan J, Krishnan K, Lenthall R, Matthews A, Wong K, Zhang L, Altschul D, Asif KS, Bahiru Z, Below K, Biller J, Ruland S, Chaudry SA, Chen M, Chebl A, Cibulka J, Cistrunk L, Clark J, Colasurdo M, Czap A, de Havenon A, D'Amato S, Dharmadhikari S, Grimmett KB, Dmytriw AA, Etherton MR, Ezepue C, Farooqui M, Feske SK, Fink L, Gasimova U, Guzik AK, Hakemi M, Hovingh M, Khan M, Jillela D, Kan PT, Khatri R, Khawaja AM, Khoury NN, Kiley NL, Kim BS, Kolikonda MK, Kuhn AL, Lara S, Linares G, Linfante I, Lukovits TG, Lycan S, Male SS, Maali L, Mancin J, Masoud H, Mohamed GA, Monteiro A, Nahab F, Nalleballe K, Gutierrez SO, Puri AS, Radaideh Y, et al. GlobaView Related Profiles. PMID: 36257718; PMCID: PMC9897052; DOI: 10.1212/WNL.0000000000201426;
     
  9. Romero JR, Pinheiro A, Aparicio HJ, DeCarli CS, Demissie S, Seshadri S. MRI Visible Perivascular Spaces and Risk of Incident Dementia: The Framingham Heart Study. Neurology. 2022 Sep 29; 99(23):e2561-71.View Related Profiles. PMID: 36175148; PMCID: PMC9754649; DOI: 10.1212/WNL.0000000000201293;
     
  10. Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study. Lancet Neurol. 2022 08; 21(8):714-725.View Related Profiles. PMID: 35841910; PMCID: PMC9389452; DOI: 10.1016/S1474-4422(22)00208-3;
     
Showing 10 of 80 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 80 publications over 21 distinct years, with a maximum of 9 publications in 2020

YearPublications
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20095
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Combination of Two Common Cariovascular Drugs Could Improve Outcomes in Lacunar Stroke

Neurology Today 6/8/2023

Stroke rehab improves recovery. So why aren't Hispanic survivors getting enough of it?

American Heart Association 5/22/2023

Having ideal heart health may lessen the risk for brain vessel disease

American Heart Association News 8/17/2022

AHA News: Having Ideal Heart Health May Lessen the Risk for Brain Vessel Disease

Health Day 8/17/2022

Sustained high blood pressure may damage brain vessels

Health Day 7/31/2020

2010-2010 Department of Neurology: resident teaching
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stroke prevention
Subclinical cerebropvascular disease
Cerebral microbleeds
Enlarged perivascular spaces
Stroke epidemiology
Brain recovery
Vascular cognitive impairment
Dementias
Carotid Artery Disease
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