Jose Rafael Romero, MD
Associate Professor
Boston University School of Medicine
Dept of Neurology

MD, Escuela Colombiana de Medicina

Dr. Romero completed residency training in neurology at Boston University Medical Campus and fellowship training in vascular neurology at Boston University Medical Campus. He received his medical degree from the Escuela Cololmbiana de Medicina in Colombia. He also completed studies for a Master in Epidemiology at Boston University School of Public Health.
Dr. Romero is an active investigator in the Framingham Heart Study since 2006.

Research Interests
Dr. Romero’s research interests center on the study of cerebrovascular disease in subclinical stages, prevention of stroke, cognitive impairment and dementia and use of neuroimaging in the epidemiological study of cerebrovascular disease. His focus is in the interplay of cerebrovascular disease with the neurodegenerative process, and contributions to clinical stroke and dementia. Much of his current work centers on the epidemiological study of brain MRI markers of cerebral small vessel disease, their determinants and clinical consequences. As a board-certified neurologist and vascular neurologist, his clinical interests are in the prevention, diagnosis, treatment and rehabilitation of patients with stroke, with particular emphasis in racial minority populations. He runs a stroke prevention clinic and is an active member in the Stroke Unit at Boston Medical Center. He is the site PI of several clinical trials for acute stroke treatment and secondary prevention. He has written widely on stroke, cerebrovascular disease in subclinical stages, and epidemiology of stroke and dementia. He has participated as study section reviewer in the NIH- and has obtained grant funding from NIH-NIA for his research support. Dr. Romero has presented the results of his research widely at national and international level and has been invited to participate in several international consortia of experts in cerebrovascular disease. Dr. Romero has contributed significantly to our understanding of cerebral microbleeds in the general population and is now leading the study of enlarged perivascular spaces in the Framingham Heart Study cohorts.

Framingham Heart Study

2010-2010 Department of Neurology: resident teaching

Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences
08/01/2019 - 04/30/2024 (PI)
NIH/National Institute on Aging

Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and Dementia
08/15/2018 - 04/30/2023 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIA

Precursors of Stroke Incidence and Prognosis
12/01/2017 - 02/28/2021 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NINDS

Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults
12/01/2017 - 01/31/2020 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA

Cerebral Microbleeds in Young Adults: Risk Factors, Biomarkers and Genetic Determinants
06/01/2015 - 05/31/2018 (PI)
NIH/National Institute on Aging

Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study
08/15/2011 - 05/31/2017 (PI)
NIH/National Institute on Aging

Investigation of lipoprotein phospholipase A2 (Lp-PLA2) and cerebral microbleeds (CMBs) in the Framingham Heart Study
11/01/2009 - 06/30/2011 (PI)
GlaxoSmithKline LLC

Sleep for Stroke Management and Recovery Trial (Sleep SMART)
08/15/2018 - 07/31/2024 (PI)
Univ of Cincinnati NIH-NINDS

Multi-arm Optimization of Stroke Thrombolysis (MOST) Stroke Trial-NCC Admin
06/01/2018 - 04/30/2024 (PI)
Univ of Cincinnati NIH-NINDS

New England Regional Coordinating Center for the NINDS Stroke Trials Network
08/01/2018 - 07/31/2023 (PI)
Mass General Hosp NIH-NINDS

NIH StrokeNet Clinical Coordinating Center Master Trial Agreement (MTA) - Satellites
09/30/2013 - 05/31/2020 (PI)
Univ of Cincinnati NIH-NINDS

08/24/2016 - 07/01/2019 (PI)

POINT Study: Platelet-Oriented Inhibition in New TIA
02/01/2010 - 04/30/2019 (PI)

Mild and Rapidly Improving Stroke Symptoms 'MaRISS' Research Study No. NEA-31
04/01/2015 - 04/01/2019 (PI)
American Heart Assoc

New England Regional Coordinating Center for the NINDS Stroke Trials Network
09/30/2013 - 07/31/2018 (PI)
Mass General Hosp NIH-NINDS


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Baril AA, Beiser AS, Mysliwiec V, Sanchez E, DeCarli CS, Redline S, Gottlieb DJ, Maillard P, Romero JR, Satizabal CL, Zucker JM, Seshadri S, Pase MP, Himali JJ. Slow-wave Sleep and MRI Markers of Brain Aging in a Community-based Sample. Neurology. 2020 Dec 22.View Related Profiles. PMID: 33361258
  2. Ortega-Gutierrez S, Farooqui M, Zha A, Czap A, Sebaugh J, Desai S, Jadhav A, Vora N, Rai V, Jovin TG, Thon JM, Heslin M, Thau L, Zevallos C, Quispe-Orozco D, Jillella DV, Nahab F, Mohammaden MH, Nogueira RG, Haussen DC, Nguyen TN, Romero JR, Aparicio HJ, Osman M, Haq IU, Liebeskind D, Hassan AE, Zaidat O, Siegler JE. Decline in mild stroke presentations and intravenous thrombolysis during the COVID-19 pandemic: The Society of Vascular and Interventional Neurology Multicenter Collaboration. Clin Neurol Neurosurg. 2020 Dec 15; 201:106436.View Related Profiles. PMID: 33383463; DOI: 10.1016/j.clineuro.2020.106436;
  3. Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, de Sa Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. J Neurol Sci. 2020 Nov 08; 117224. PMID: 33183779
  4. Penton AA, Lau H, Babikian VL, Shulman J, Cervantes-Arslanian A, Gangadhara S, Greer D, Aparicio HJ, Romero JR. Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group. Stroke. 2020 Nov; 51(11):3348-3351.View Related Profiles. PMID: 33019895
  5. Petrea RE, O'Donnell A, Beiser AS, Habes M, Aparicio H, DeCarli C, Seshadri S, Romero JR. Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study. Hypertension. 2020 Sep; 76(3):707-714.View Related Profiles. PMID: 32755403
  6. Carneiro T, Dashkoff J, Leung LY, Nobleza COS, Marulanda-Londono E, Hathidara M, Koch S, Sur N, Boske A, Voetsch B, Aboul Nour H, Miller DJ, Daneshmand A, Shulman J, Curiale G, Greer DM, Romero JR, Anand P, Cervantes-Arslanian AM. Intravenous tPA for Acute Ischemic Stroke in Patients with COVID-19. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105201.View Related Profiles. PMID: 33066885
  7. Lioutas VA, Beiser AS, Aparicio HJ, Himali JJ, Selim MH, Romero JR, Seshadri S. Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016. JAMA Neurol. 2020 Jun 08.View Related Profiles. PMID: 32511690
  8. Ford T, Curiale G, Nguyen TN, Aparicio H, Hamlyn EK, Gangadhara S, Cervantes-Arslanian AM, Greer D, Romero JR, Shulman JG. Optimization of resources and modifications in acute ischemic stroke care in response to the global COVID-19 pandemic. J Stroke Cerebrovasc Dis. 2020 Aug; 29(8):104980.View Related Profiles. PMID: 32689645
  9. Baradaran H, Demissie S, Himali JJ, Beiser A, Gupta A, Polak JF, DeCarli C, Seshadri S, Romero JR. The progression of carotid atherosclerosis and imaging markers of dementia. Alzheimers Dement (N Y). 2020; 6(1):e12015.View Related Profiles. PMID: 32296732
  10. Charidimou A, Frosch MP, Al-Shahi Salman R, Baron JC, Cordonnier C, Hernandez-Guillamon M, Linn J, Raposo N, Rodrigues M, Romero JR, Schneider JA, Schreiber S, Smith EE, van Buchem MA, Viswanathan A, Wollenweber FA, Werring DJ, Greenberg SM. Advancing diagnostic criteria for sporadic cerebral amyloid angiopathy: Study protocol for a multicenter MRI-pathology validation of Boston criteria v2.0. Int J Stroke. 2019 12; 14(9):956-971. PMID: 31514686
Showing 10 of 65 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 65 publications over 18 distinct years, with a maximum of 9 publications in 2020

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75 E. Newton St Collamore Building
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