Jose Rafael Romero, MD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Neurology

MD, Escuela Colombiana de Medicina

Dr. Romero completed residency training in neurology at Boston University Medical Campus and fellowship training in vascular neurology at Boston University Medical Campus. He received his medical degree from the Escuela Cololmbiana de Medicina in Colombia. He also completed studies for a Master in Epidemiology at Boston University School of Public Health.
Dr. Romero is an active investigator in the Framingham Heart Study since 2006.

Research Interests
Dr. Romero’s research interests center on the study of cerebrovascular disease in subclinical stages, prevention of stroke, cognitive impairment and dementia and use of neuroimaging in the epidemiological study of cerebrovascular disease. His focus is in the interplay of cerebrovascular disease with the neurodegenerative process, and contributions to clinical stroke and dementia. Much of his current work centers on the epidemiological study of brain MRI markers of cerebral small vessel disease, their determinants and clinical consequences. As a board-certified neurologist and vascular neurologist, his clinical interests are in the prevention, diagnosis, treatment and rehabilitation of patients with stroke, with particular emphasis in racial minority populations. He runs a stroke prevention clinic and is an active member in the Stroke Unit at Boston Medical Center. He is the site PI of several clinical trials for acute stroke treatment and secondary prevention. He has written widely on stroke, cerebrovascular disease in subclinical stages, and epidemiology of stroke and dementia. He has participated as study section reviewer in the NIH- and has obtained grant funding from NIH-NIA for his research support. Dr. Romero has presented the results of his research widely at national and international level and has been invited to participate in several international consortia of experts in cerebrovascular disease. Dr. Romero has contributed significantly to our understanding of cerebral microbleeds in the general population and is now leading the study of enlarged perivascular spaces in the Framingham Heart Study cohorts.

Framingham Heart Study

Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences
08/01/2019 - 04/30/2024 (PI)
NIH/National Institute on Aging

Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and Dementia
08/15/2018 - 04/30/2023 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIA

Precursors of Stroke Incidence and Prognosis
12/01/2017 - 02/28/2023 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NINDS

Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults
12/01/2017 - 01/31/2021 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA

Cerebral Microbleeds in Young Adults: Risk Factors, Biomarkers and Genetic Determinants
06/01/2015 - 05/31/2018 (PI)
NIH/National Institute on Aging

Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study
08/15/2011 - 05/31/2017 (PI)
NIH/National Institute on Aging

Investigation of lipoprotein phospholipase A2 (Lp-PLA2) and cerebral microbleeds (CMBs) in the Framingham Heart Study
11/01/2009 - 06/30/2011 (PI)
GlaxoSmithKline LLC

Sleep for Stroke Management and Recovery Trial (Sleep SMART)
08/15/2018 - 07/31/2024 (PI)
Univ of Cincinnati NIH-NINDS

Multi-arm Optimization of Stroke Thrombolysis (MOST) Stroke Trial-NCC Admin
06/01/2018 - 04/30/2024 (PI)
Univ of Cincinnati NIH-NINDS

New England Regional Coordinating Center for the NINDS Strok
08/01/2018 - 07/31/2023 (PI)
The General Hospital Corporation / MGH National Institute o

NIH StrokeNet Clinical Coordinating Center Master Trial Agreement (MTA) - Satellites
09/30/2013 - 05/31/2020 (PI)
Univ of Cincinnati NIH-NINDS

08/24/2016 - 07/01/2019 (PI)

POINT Study: Platelet-Oriented Inhibition in New TIA
02/01/2010 - 04/30/2019 (PI)

Mild and Rapidly Improving Stroke Symptoms 'MaRISS' Research Study No. NEA-31
04/01/2015 - 04/01/2019 (PI)
American Heart Assoc

New England Regional Coordinating Center for the NINDS Stroke Trials Network
09/30/2013 - 07/31/2018 (PI)
Mass General Hosp NIH-NINDS


Yr Title Project-Sub Proj Pubs
2022 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-04
2021 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-03 1
2020 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 5R01AG059725-02 1
2019 Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences 1R01AG059725-01A1 1
2016 Cerebral Microbleeds in Young Adults: risk factors, biomarkers and genetics 5R03AG048180-02 14
2015 Cerebral Microbleeds in Young Adults: risk factors, biomarkers and genetics 1R03AG048180-01A1 14
2015 Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study 5K23AG038444-05 23
2014 Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study 5K23AG038444-04 23
2013 Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study 5K23AG038444-03 23
2012 Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study 5K23AG038444-02 23
Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study. Lancet Neurol. 2022 08; 21(8):714-725.View Related Profiles. PMID: 35841910; PMCID: PMC9389452; DOI: 10.1016/S1474-4422(22)00208-3;
  2. Lara FR, Scruton AL, Pinheiro A, Demissie S, Parva P, Charidimou A, Francis M, Himali JJ, DeCarli C, Beiser A, Seshadri S, Romero JR. Aging, prevalence and risk factors of MRI-visible enlarged perivascular spaces. Aging (Albany NY). 2022 Jul 15; 14(17):6844-6858.View Related Profiles. PMID: 35852852; PMCID: PMC9512514; DOI: 10.18632/aging.204181;
  3. Petrie BK, Sturzoiu T, Shulman J, Abbas S, Masoud H, Romero JR, Filina T, Nguyen TN, Lau H, Clark J, Auerbach S, Pyatkevich YG, Aparicio HJ. Questionnaire and Portable Sleep Test Screening of Sleep Disordered Breathing in Acute Stroke and TIA. J Clin Med. 2021 Aug 13; 10(16).View Related Profiles. PMID: 34441863; PMCID: PMC8396899; DOI: 10.3390/jcm10163568;
  4. Carneiro T, Dashkoff J, Leung L, Nobleza COS, Marulanda-Londono E, Hathidara M, Koch S, Sur N, Boske A, Voetsch B, Daneshmand A, Shulman J, Curiale G, Greer DM, Romero JR, Anand P, Cervantes-Arslanian AM. Response to the Letter to the Editor: Consideration Needed for Early Anticoagulation Following Intravenous tPA in Patients with COVID-19. J Stroke Cerebrovasc Dis. 2021 07; 30(7):105789.View Related Profiles. PMID: 33840594; PMCID: PMC8006190; DOI: 10.1016/j.jstrokecerebrovasdis.2021.105789;
  5. Nogueira RG, Qureshi MM, Abdalkader M, Martins SO, Yamagami H, Qiu Z, Mansour OY, Sathya A, Czlonkowska A, Tsivgoulis G, Aguiar de Sousa D, Demeestere J, Mikulik R, Vanacker P, Siegler JE, Kõrv J, Biller J, Liang CW, Sangha NS, Zha AM, Czap AL, Holmstedt CA, Turan TN, Ntaios G, Malhotra K, Tayal A, Loochtan A, Ranta A, Mistry EA, Alexandrov AW, Huang DY, Yaghi S, Raz E, Sheth SA, Mohammaden MH, Frankel M, Bila Lamou EG, Aref HM, Elbassiouny A, Hassan F, Menecie T, Mustafa W, Shokri HM, Roushdy T, Sarfo FS, Alabi TO, Arabambi B, Nwazor EO, Sunmonu TA, Wahab K, Yaria J, Mohammed HH, Adebayo PB, Riahi AD, Ben Sassi S, Gwaunza L, Ngwende GW, Sahakyan D, Rahman A, Ai Z, Bai F, Duan Z, Hao Y, Huang W, Li G, Li W, Liu G, Luo J, Shang X, Sui Y, Tian L, Wen H, Wu B, Yan Y, Yuan Z, Zhang H, Zhang J, Zhao W, Zi W, Leung TW, Chugh C, Huded V, Menon B, Pandian JD, Sylaja PN, Usman FS, Farhoudi M, Hokmabadi ES, Horev A, Reznik A, Hoffmann RS, Ohara N, Sakai N, Watanabe D, Yamamoto R, Doijiri R, Tokuda N, Yamada T, Terasaki T, Yazawa Y, Uwatoko T, Dembo T, Shimizu H, Sugiura Y, Miyashita F, Fukuda H, Miyake K, Shimbo J, Sugimura Y, Yagita Y, Takenobu Y, Matsumaru Y, Yamada S, Kono R, Kanamaru T, Yamazaki H, Sakaguchi M, Todo K, Yamamoto N, Sonoda K, Yoshida T, Hashimoto H, Nakahara I, Kondybayeva A, Faizullina K, Kamenova S, Zhanuzakov M, Baek JH, Hwang Y, Lee JS, Lee SB, Moon J, Park H, Seo JH, Seo KD, Sohn SI, Young CJ, Ahdab R, Wan Zaidi WA, Aziz ZA, Basri HB, Chung LW, Ibrahim AB, Ibrahim KA, Looi I, Tan WY, Yahya NW, Groppa S, Leahu P, Al Hashmi AM, Imam YZ, Akhtar N, Pineda-Franks MC, Co CO, Kandyba D, Alhazzani A, Al-Jehani H, Tham CH, Mamauag MJ, Venketasubramanian N, Chen CH, Tang SC, Churojana A, Akil E, Aykaç O, Ozdemir AO, Giray S, Hussain SI, John S, Le Vu H, Tran AD, Nguyen HH, Pham TN, Nguyen TH, Nguyen TQ, Gattringer T, Enzinger C, Killer-Oberpfalzer M, Bellante F, De Blauwe S, Vanhooren G, De Raedt S, Dusart A, Lemmens R, Ligot N, Rutgers MP, Yperzeele L, Alexiev F, Sakelarova T, Bedekovic MR, Budincevic H, Cindric I, Hucika Z, Ozretic D, Saric MS, Pfeifer F, Karpowic I, Cernik D, Sramek M, Skoda M, Hlavacova H, Klecka L, Koutny M, Vaclavik D, Skoda O, Fiksa J, Hanelova K, Nevsimalova M, Rezek R, Prochazka P, Krejstova G, Neumann J, Vachova M, Brzezanski H, Hlinovsky D, Tenora D, Jura R, Jurák L, Novak J, Novak A, Topinka Z, Fibrich P, Sobolova H, Volny O, Christensen HK, Drenck N, Iversen HK, Simonsen CZ, Truelsen TC, Wienecke T, Vibo R, Gross-Paju K, Toomsoo T, Antsov K, Caparros F, Cordonnier C, Dan M, Faucheux JM, Mechtouff L, Eker O, Lesaine E, Ondze B, Peres R, Pico F, Piotin M, Pop R, Rouanet F, Gubeladze T, Khinikadze M, Lobjanidze N, Tsikaridze A, Nagel S, Ringleb PA, Rosenkranz M, Schmidt H, Sedghi A, Siepmann T, Szabo K, Thomalla G, Palaiodimou L, Sagris D, Kargiotis O, Klivenyi P, Szapary L, Tarkanyi G, Adami A, Bandini F, Calabresi P, Frisullo G, Renieri L, Sangalli D, Pirson AV, Uyttenboogaart M, van den Wijngaard I, Kristoffersen ES, Brola W, Fudala M, Horoch-Lyszczarek E, Karlinski M, Kazmierski R, Kram P, Rogoziewicz M, Kaczorowski R, Luchowski P, Sienkiewicz-Jarosz H, Sobolewski P, Fryze W, Wisniewska A, Wiszniewska M, Ferreira P, Ferreira P, Fonseca L, Marto JP, Pinho E Melo T, Nunes AP, Rodrigues M, Cruz VT, Falup-Pecurariu C, Krastev G, Mako M, Alonso de Leciñana M, Arenillas JF, Ayo-Martin O, Culebras AC, Tejedor ED, Montaner J, Pérez-Sánchez S, Tola Arribas MA, Vasquez AR, Mazya M, Bernava G, Brehm A, Machi P, Fischer U, Gralla J, Michel PL, Psychogios MN, Strambo D, Banerjee S, Krishnan K, Kwan J, Butt A, Catanese L, Demchuk A, Field T, Haynes J, Hill MD, Khosravani H, Mackey A, Pikula A, Saposnik G, Scott CA, Shoamanesh A, Shuaib A, Yip S, Barboza MA, Barrientos JD, Portillo Rivera LI, Gongora-Rivera F, Novarro-Escudero N, Blanco A, Abraham M, Alsbrook D, Altschul D, Alvarado-Ortiz AJ, Bach I, Badruddin A, Barazangi N, Brereton C, Castonguay A, Chaturvedi S, Chaudhry SA, Choe H, Choi JH, et al. GlobaView Related Profiles. PMID: 33766997; PMCID: PMC8205458; DOI: 10.1212/WNL.0000000000011885;
  6. Lioutas VA, Ivan CS, Himali JJ, Aparicio HJ, Leveille T, Romero JR, Beiser AS, Seshadri S. Incidence of Transient Ischemic Attack and Association With Long-term Risk of Stroke. JAMA. 2021 01 26; 325(4):373-381.View Related Profiles. PMID: 33496774; PMCID: PMC7838926; DOI: 10.1001/jama.2020.25071;
  7. Baril AA, Beiser AS, Mysliwiec V, Sanchez E, DeCarli CS, Redline S, Gottlieb DJ, Maillard P, Romero JR, Satizabal CL, Zucker JM, Seshadri S, Pase MP, Himali JJ. Slow-Wave Sleep and MRI Markers of Brain Aging in a Community-Based Sample. Neurology. 2021 03 09; 96(10):e1462-e1469.View Related Profiles. PMID: 33361258; PMCID: PMC8055313; DOI: 10.1212/WNL.0000000000011377;
  8. Ortega-Gutierrez S, Farooqui M, Zha A, Czap A, Sebaugh J, Desai S, Jadhav A, Vora N, Rai V, Jovin TG, Thon JM, Heslin M, Thau L, Zevallos C, Quispe-Orozco D, Jillella DV, Nahab F, Mohammaden MH, Nogueira RG, Haussen DC, Nguyen TN, Romero JR, Aparicio HJ, Osman M, Haq IU, Liebeskind D, Hassan AE, Zaidat O, Siegler JE. Decline in mild stroke presentations and intravenous thrombolysis during the COVID-19 pandemic: The Society of Vascular and Interventional Neurology Multicenter Collaboration. Clin Neurol Neurosurg. 2021 02; 201:106436.View Related Profiles. PMID: 33383463; PMCID: PMC7836428; DOI: 10.1016/j.clineuro.2020.106436;
  9. Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, de Sa Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. J Neurol Sci. 2021 01 15; 420:117224.View Related Profiles. PMID: 33183779
  10. Penton AA, Lau H, Babikian VL, Shulman J, Cervantes-Arslanian A, Gangadhara S, Greer D, Aparicio HJ, Romero JR. Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group. Stroke. 2020 11; 51(11):3348-3351.View Related Profiles. PMID: 33019895; PMCID: PMC7606816; DOI: 10.1161/STROKEAHA.119.028688;
Showing 10 of 71 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 71 publications over 20 distinct years, with a maximum of 9 publications in 2020


2010-2010 Department of Neurology: resident teaching
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75 E. Newton St Collamore Building
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