Ji Yi, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine

PhD, Northwestern University
MS, Northwestern University

Our focus is to develop novel optical techniques for fundamental research and clinical applications. The research includes the development of inverse spectroscopic optical coherence tomography (ISOCT) and metabolic optical coherence tomography applicable in vivo, with ISOCT being sensitive to nanoscale tissue structural changes and metabolic OCT being able to quantify tissue oxygen metabolism. In addition, we also develop methods for label-free optical angiography on live animals. We are also interested in novel optical endoscopy, super resolution microscopy for fundamental science, biosensing and computational optics. The clinical applications encompass cancer early detection, eye diseases such as glaucoma, and aging diseases etc.

2014-2015 Juvenile Diabetes Research Foundation International (JDRF) postdoctoral fellowship
2013 Baxter Young Investigator Award
2013-2014 Illinois society of the prevention of blindness (ISPB) seed grant

Exploration of optical markers for glaucoma early detection
07/01/2017 - 06/30/2019 (PI)
BrightFocus Foundation

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Song W, Zhou L, Yi J. Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT). J Vis Exp. 2018 08 04; (138). PMID: 30124648.
  2. Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. J Biophotonics. 2018 Nov; 11(11):e201800053.View Related Profiles. PMID: 29855165.
  3. Song W, Zhou L, Zhang S, Ness S, Desai M, Yi J. Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina. Biomed Opt Express. 2018 Jul 01; 9(7):3464-3480.View Related Profiles. PMID: 29984110.
  4. Zhang L, Song W, Shao D, Zhang S, Desai M, Ness S, Roy S, Yi J. Volumetric fluorescence retinal imaging in vivo over a 30-degree field of view by oblique scanning laser ophthalmoscopy (oSLO). Biomed Opt Express. 2018 01 01; 9(1):25-40.View Related Profiles. PMID: 29359085.
  5. Zhang L, Capilla A, Song W, Mostoslavsky G, Yi J. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan. Sci Rep. 2017 Aug 17; 7(1):8591.View Related Profiles. PMID: 28819250.
  6. Song W, Zhang L, Ness S, Yi J. Wavelength-dependent optical properties of melanosomes in retinal pigmented epithelium and their changes with melanin bleaching: a numerical study. Biomed Opt Express. 2017 Sep 01; 8(9):3966-3980.View Related Profiles. PMID: 29026682.
  7. Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V. Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J. 2015 Dec 1; 109(11):2218-26.View Related Profiles. PMID: 26636933; PMCID: PMC4675813; DOI: 10.1016/j.bpj.2015.10.014;.
  8. Ji Yi, Wenzhong Liu, Siyu Chen, Vadim Backman, Nader Sheibani, Amani A. Fawzi, Robert A. Linsenmeier, and Hao F. Zhang. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation. Light: Science & Applications. 2015; e334(4). View Publication
  9. Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD. In vivo capture and label-free detection of early metastatic cells. Nat Commun. 2015; 6:8094. PMID: 26348915; PMCID: PMC4563812; DOI: 10.1038/ncomms9094;.
  10. Liu W, Yi J, Chen S, Jiao S, Zhang HF. Measuring retinal blood flow in rats using Doppler optical coherence tomography without knowing eyeball axial length. Med Phys. 2015 Sep; 42(9):5356-62. PMID: 26328984; PMCID: PMC4545096; DOI: 10.1118/1.4928597;.
Showing 10 of 34 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 34 publications over 10 distinct years, with a maximum of 9 publications in 2015

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biophotonics, Optical coherence tomography, Biosensing, Detection of ultrastructural change in diseases, Oxygen metabolism, Ophthalmic imaging
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Google Map

Yi's Networks
Click the "See All" links for more information and interactive visualizations
Similar People
Same Department