Ji Yi, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine

PhD, Northwestern University
MS, Northwestern University

Our focus is to develop novel optical techniques for fundamental research and clinical applications. The research includes the development of inverse spectroscopic optical coherence tomography (ISOCT) and metabolic optical coherence tomography applicable in vivo, with ISOCT being sensitive to nanoscale tissue structural changes and metabolic OCT being able to quantify tissue oxygen metabolism. In addition, we also develop methods for label-free optical angiography on live animals. We are also interested in novel optical endoscopy, super resolution microscopy for fundamental science, biosensing and computational optics. The clinical applications encompass cancer early detection, eye diseases such as glaucoma, and aging diseases etc.

2014-2015 Juvenile Diabetes Research Foundation International (JDRF) postdoctoral fellowship
2013 Baxter Young Investigator Award
2013-2014 Illinois society of the prevention of blindness (ISPB) seed grant

Predictive markers for diabetic retinopathy via quantitative imaging of retinal capillary functions
09/30/2018 - 06/30/2023 (PI)

Sensitive detection of malignancy in primary acquired melanosis by advanced optical imaging
09/01/2018 - 08/31/2020 (PI)

Wide-field volumetric fluorescence angiography for sensitive detection of RPE permeability in AMD
07/01/2018 - 06/30/2020 (PI)
BrightFocus Foundation

Protein S-glutathionylation and vascular dysfunction with aging
08/01/2018 - 05/31/2020 (PI)
Trustees of Boston University NIH-NIA

Exploration of optical markers for glaucoma early detection
07/01/2017 - 06/30/2019 (PI)
BrightFocus Foundation

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lee HJ, Zhang L, Zhang S, Yi J. Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence. Transl Vis Sci Technol. 2019 May; 8(3):16.View Related Profiles. PMID: 31114716.
  2. Song W, Zhou L, Yi J. Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT). J Vis Exp. 2018 08 04; (138). PMID: 30124648.
  3. Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. J Biophotonics. 2018 Nov; 11(11):e201800053.View Related Profiles. PMID: 29855165.
  4. Song W, Zhou L, Zhang S, Ness S, Desai M, Yi J. Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina. Biomed Opt Express. 2018 Jul 01; 9(7):3464-3480.View Related Profiles. PMID: 29984110.
  5. Zhang L, Song W, Shao D, Zhang S, Desai M, Ness S, Roy S, Yi J. Volumetric fluorescence retinal imaging in vivo over a 30-degree field of view by oblique scanning laser ophthalmoscopy (oSLO). Biomed Opt Express. 2018 01 01; 9(1):25-40.View Related Profiles. PMID: 29359085.
  6. Zhang L, Capilla A, Song W, Mostoslavsky G, Yi J. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan. Sci Rep. 2017 08 17; 7(1):8591.View Related Profiles. PMID: 28819250.
  7. Song W, Zhang L, Ness S, Yi J. Wavelength-dependent optical properties of melanosomes in retinal pigmented epithelium and their changes with melanin bleaching: a numerical study. Biomed Opt Express. 2017 Sep 01; 8(9):3966-3980.View Related Profiles. PMID: 29026682.
  8. Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V. Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J. 2015 Dec 1; 109(11):2218-26.View Related Profiles. PMID: 26636933; PMCID: PMC4675813; DOI: 10.1016/j.bpj.2015.10.014;.
  9. Ji Yi, Wenzhong Liu, Siyu Chen, Vadim Backman, Nader Sheibani, Amani A. Fawzi, Robert A. Linsenmeier, and Hao F. Zhang. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation. Light: Science & Applications. 2015; e334(4). View Publication
  10. Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD. In vivo capture and label-free detection of early metastatic cells. Nat Commun. 2015; 6:8094. PMID: 26348915; PMCID: PMC4563812; DOI: 10.1038/ncomms9094;.
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 11 distinct years, with a maximum of 9 publications in 2015

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biophotonics, Optical coherence tomography, Biosensing, Detection of ultrastructural change in diseases, Oxygen metabolism, Ophthalmic imaging
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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